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| 1 | FIRMLY MARCH ON THE PATH OF SOCIALISM WITH CHINESE CHARACTERISTICS AND STRIVE TO COMPLETE THE BUILDING OF A MODERATELY PROSPEROUS SOCIETY IN ALL RESPECTS Report to the Eighteenth National Congress of the Communist Party of China显示文摘 | Hu Jintao | 2012 | Qiu Shi2012，4，4： | 37 |
| 2 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 3 | Pressure fluctuation propagation of a pump turbine at pump mode under low head condition显示文摘Pressure fluctuation at the vaneless space and vanes passages is one of the most important problems for the stable operation of a pump turbine.The fluctuation appears in any operating condition.Much research has been done on the pressure fluctuation of hydraulic machinery.However,the details of pressure fluctuation propagation of the pump turbine at the pump mode have not been revealed.The modern pump turbine with high water head requires the runner to be'flat',which would induce pressure fluctuation more easily than the low head pump turbine.In this article,a high head pump turbine model is used as the research object.As the pressure fluctuation at off-design point is more serious than at the design point,the low head condition is chosen as the research condition.Pressure fluctuation at the vaneless space and vanes passages is predicted by the computational fluid dynamics method based on k-?shear stress transport model.The experiment conducted on the test rig of the Harbin Institute of Large Electrical Machinery is used to verify the simulation method.It proves that the numerical method is a feasible way to research the fluctuation under this operating condition.The pressure fluctuation along the passage direction is analyzed at time and frequency domains.It is affected mainly by the interaction between the runner and vanes.In the circumferential direction,the influence of the special stay vane on the pressure fluctuation is got.The amplitude in the high-pressure side passage of that vane is lower than that in the other side.The study provides a basic understanding of the pressure fluctuation of a pump turbine and could be used as a reference to improve the operation stability of it. | GUO Lei LIU JinTao WANG LeQin QIN DaQing WEI XianZhu | 2014 | Science China(Technological Sciences)2014，57，4： | 19 |
| 4 | Advances in thermoacoustic engine and its application to pulse tube refrigeration显示文摘Thermoacoustically driven pulse tube refrigerator, a novel cryocooler without any moving components using heat energy as driving power, attracts much effortsfrom the researchers in the field of cryogenics and refrigeration in the past decades. After a short introduction of the history about thermoacoustics, we presented the key technology, followed by a detailed review on theoretical and experimental developments and advances of thermoacoustics.The prospective research emphases are also presented at the end of this review. | CHENGuobang TANGKe JINTao | 2004 | Chinese Science Bulletin2004，49，13： | 16 |
| 5 | Macro/meso failure behavior of surrounding rock in deep roadway and its control technology显示文摘Engineering disasters occur frequently and violently with the increase in mining depth, which is mostly due to insufficient study on the failure mechanism of the deep rock mass. In this paper, theoretical and experimental researches on the failure behaviors and deformation control of deep surrounding rock in recent years were reviewed. Macro/meso failure mechanism of deep rock or coal-rock combined body under different loading conditions have been systematically investigated. Stress gradient failure theory of surrounding rock, uniform strength support in the deep roadway, and the analogous hyperbola movement model of overlying strata were preliminary established and a combined grouting control technology for surface and underground was proposed. Abovementioned achievements are expected to offer theoretical bases and technical supports for the exploitation of China's deep mineral resources in the future. | Jianping Zuo Jintao Wang Yunqian Jiang | 2019 | International Journal of Coal Science & Technology2019，6，3： | 16 |
| 6 | High energy soliton pulse generation by a magnetron-sputtering-deposition-grown MoTe_2 saturable absorber显示文摘The pulse energy in the ultrafast soliton fiber laser oscillators is usually limited by the well-known wave-breaking phenomenon owing to the absence of a desirable real saturable absorber(SA) with high power tolerance and large modulation depth. Here, we report a type of microfiber-based MoTe_2 SA fabricated by the magnetron-sputtering deposition(MSD) method. High-energy wave-breaking free soliton pulses were generated with pulse duration/pulse energy/average output power of 229 fs/2.14 nJ/57 mW in the 1.5 μm regime and 1.3 ps/13.8 nJ/212 mW in the 2 μm regime, respectively. To our knowledge, the generated soliton pulses at 1.5 μm had the shortest pulse duration and the highest output power among the reported erbium-doped fiber lasers mode locked by transition metal dichalcogenides. Moreover, this was the first demonstration of a MoTe_2-based SA in fiber lasers in the 2 μm regime, and the pulse energy/output power are the highest in the reported thulium-doped fiber lasers mode locked by two-dimensional materials. Our results suggest that a microfiber-based MoTe_2 SA could be used as an excellent photonic device for ultrafast pulse generation, and the MSD technique opens a promising route to produce a high-performance SA with high power tolerance and large modulation depth, which are beneficial for high-energy wave-breaking free pulse generation. | JINTAO WANG ZIKE JIANG HAO CHEN JIARONG LI JINDE YIN JINZHANG WANG TINGCHAO HE PEIGUANG YAN SHUANGCHEN RUAN | 2018 | Photonics Research2018，6，6： | 14 |
| 7 | Admission clinical characteristics and early clinical outcomes among acute ischemic stroke patients显示文摘The purpose of the present study was to investigate the association between admission clinical characteristics and outcomes at discharge among acute ischemic stroke patients in the Chinese population.A total of 2,673 patients with acute ischemic stroke were included in the present study.The clinical characteristics at admission and other study variables were collected for all patients.The study outcome was defined as neurological deficiency(National Institute of Health Stroke Scale score ≥ 10) at discharge or in-hospital death.Compared with the subjects without neurological deficiency at discharge or in-hospital death,the subjects with neurological deficiency at discharge or in-hospital death had a significantly higher prevalence of hyperglycemia or history of atrial fibrillation at admission.Age≥ 80 years,hyperglycemia,hypertension,and history of atrial fibrillation were significantly associated with neurological deficiency at discharge or in-hospital death after adjustment for other variables.It is concluded that old age(≥ 80 years),hyperglycemia,hypertension and history of atrial fibrillation are significantly associated with neurological deficiency at discharge or in-hospital death among patients with acute ischemic stroke. | Xin Gao Jintao Zhang Ying Peng Huanqing Fan Mei Chen Tan Xu Yonghong Zhang | 2012 | The Journal of Biomedical Research2012，26，3： | 13 |
| 8 | A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals显示文摘Background:Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease.Therefore,development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary.Method:A novel colloidal gold immunochromatography assay(GICA)strip was developed for detecting Schistosoma japonicum in domestic animals.The colloidal gold was conjugated with recombinant streptococcal protein G(rSPG).As the test and control lines,the schistosome soluble egg antigen and rSPG,respectively,were blotted on nitrocellulose membrane.Results:The lowest detectable serum dilution was 1∶640 for schistosome-infected buffaloes.The cross-reaction rate of GICA was 14.29%with Paramphistomum sp.in buffaloes,16.67%with Haemonchus sp.in goats,and 33.33%with Orientobilharzia sp.in goats.These results were slightly lower and similar to those obtained through ELISA.Moreover,the strips for detecting S.japonicum in mice,rabbits,buffaloes,and goats showed high sensitivity(100.00%,100.00%,100.00%,and 100.00%,respectively)and specificity(100.00%,100.00%,94.23%,and 88.64%,respectively).And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature.When compared with ELISA,the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice,rabbits,buffaloes,and goats.Besides,only 5μl of serum are required for the test and the detection can be completed within 5 min.Conclusion:This study is the first to develop a GICA strip using gold-rSPG conjugate for the diagnosing of schistosomiasis in domestic animals,and preliminary results showed that the developed strip may be suitable for large-scale screening of schistosomiasis in endemic areas. | Rui Xu Jintao Feng Yang Hong Chao Lv Dengyun Zhao Jiaojiao Lin Ke Lu Hao Li Jinming Liu Xiaodan Cao Tao Wang Jinli Zai Zhaozhe Wang Bingguang Jia Qian Han Chuangang Zhu | 2017 | Infectious Diseases of Poverty2017，6，1： | 12 |
| 9 | Suppression or knockout of SaF/SaM overcomes the Sa-mediated hybrid male sterility in rice显示文摘Hybrids between the indica and japonica subspecies of rice(Oryza sativa) are usually sterile, which hinders utilization of heterosis in the inter-subspecific hybrid breeding. The complex locus Sa comprises two adjacently located genes, SaF and SaM, which interact to cause abortion of pollen grains carrying the japonica allele in japonica-indica hybrids. Here we showed that silencing of SaF or SaM by RNA interference restored male fertility in indica-japonica hybrids with heterozygous Sa. We further used clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9-based genome editing to knockout the SaF and SaM alleles, respectively, of an indica rice line to create hybrid-compatible lines. The resultant artificial neutral alleles did not affect pollen viability and other agricultural traits, but did break down the reproductive barrier in the hybrids. We found that some rice lines have natural neutral allele Sa-n, which was compatible with the typical japonica or indica Sa alleles in hybrids. Our results demonstrate that SaF and SaM are required for hybrid male sterility, but are not essential for pollen development. This study provides effective approaches for the generation of hybrid-compatible lines by knocking out the Sa locus or using the natural Sa-n allele to overcome hybrid male sterility in rice breeding. | Yongyao Xie Baixiao Niu Yunming Long Gousi Li Jintao Tang Yaling Zhang Ding Ren Yao-Guang Liu Letian Chen | 2017 | Journal of Integrative Plant Biology2017，59，9： | 11 |
| 10 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 11 | Effects of Dietary Stachyose on Growth Performance, Digestive Enzyme Activities and Intestinal Morphology of Juvenile Turbot(Scophthalmus maximus L)显示文摘A 12-week feeding trial was conducted to evaluate the effects of dietary stachyose on the growth performance, digestive enzymes activities and intestinal structures of juvenile turbot(Scophthalmus maximus L). Five isonitrogenous(49.58% crude protein) and isolipidic(10.50% crude lipid) diets were formulated to contain 0(Control), 0.625%(S-0.625), 1.25%(S-1.25), 2.5%(S-2.5) and 5%(S-5) stachyose, respectively. With the increase of stachyose level, the growth performance and feed utilization of turbot, such as the specific growth rate, final mean body weight, weight gain rate and feed efficiency, increased significantly(P < 0.05) and then stabilized. The feed intake of fish fed S-5 was significantly higher(P < 0.05) than that of fish in other groups. The activities of trypsin, intestinal caseinolytic, stomach and intestinal amylase were significantly influenced by stachyose(P < 0.05). The highest values of trypsin and intestinal caseinolytic activities were observed in group S-1.25, while the highest activity of stomach amylase and the lowest activity of intestine amylase were observed in group S-5. No lesion or damage was found on the distal intestine structures of fish from all treatments, while the height of simple folds in the distal intestine was significantly increased(P< 0.05) when 1.25% or 2.5% stachyose was added in the diets. These results indicated that moderate level of stachyose(1.25%) improves the growth performance, feed utilization, digestive enzyme activities and the distal intestine structures of juvenile turbot. | HU Haibin ZHANG Yanjiao MAI Kangsen AI Qinghui XU Wei ZHANG Wenbing LI Yanxian LIU Jintao | 2015 | Journal of Ocean University of China2015，14，5： | 10 |
| 12 | Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota显示文摘Background:Salmonella pullorum is one of the most harmful pathogens to avian species.Magnolol and honokiol,natural compounds extracted from Magnolia officinalis,exerts anti-inflammatory,anti-oxidant and antibacterial activities.This study was conducted to evaluate the effects of dietary supplemental magnolol and honokiol in broilers infected with S.pullorum.A total of 360 one-day-old broilers were selected and randomly divided into four groups with six replicates:the negative control group(CTL),S.pullorum-infected group(SP),and the S.pulloruminfected group supplemented with 300 mg/kg honokiol(SPH)or magnolol(SPM).Results:The results showed that challenging with S.pullorum impaired growth performance in broilers,as indicated by the observed decreases in body weight(P<0.05)and average daily gains(P<0.05),along with increased spleen(P<0.01)and bursa of Fabricus weights(P<0.05),serum globulin contents,and the decreased intestine villus height and villus/crypt ratios(P<0.05).Notably,supplemental magnolol and honokiol attenuated these adverse changes,and the effects of magnolol were better than those of honokiol.Therefore,we performed RNA-Seq in ileum tissues and 16S rRNA gene sequencing of ileum bacteria.Our analysis revealed that magnolol increased the α-diversity(observed species,Chao1,ACE,and PD whole tree)and β-diversity of the ileum bacteria(P<0.05).In addition,magnolol supplementation increased the abundance of Lactobacillus(P<0.01)and decreased unidentified Cyanobacteria(P<0.05)both at d 14 and d 21.Further study confirmed that differentially expressed genes induced by magnolol and honokiol supplementation enriched in cytokine-cytokine receptor interactions,in the intestinal immune network for IgA production,and in the cell adhesion molecule pathways.Conclusions:Supplemental magnolol and honokiol alleviated S.pullorum-induced impairments in growth performance,and the effect of magnolol was better than that of honokiol,which could be partially due to magnolol’s ability to improve the intestinal microbial and mucosal barrier. | Fang Chen Hao Zhang Encun Du Qiwen Fan Na Zhao Feng Jin Wei Zhang Wanzheng Guo Shaowen Huang Jintao Wei | 2022 | Journal of Animal Science and Biotechnology2022，13，1： | 9 |
| 13 | Projecting distributions of Argentine shortfin squid(Illex argentinus)in the Southwest Atlantic using a complex integrated model显示文摘We developed an approach that integrates generalized additive model(GAM) and neural network model(NNM)for projecting the distribution of Argentine shortfin squid(Illex argentinus). The data for this paper was based on commercial fishery data and relevant remote sensing environmental data including sea surface temperature(SST), sea surface height(SSH) and chlorophyll a(Chl a) from January to June during 2003 to 2011. The GAM was used to identify the significant oceanographic variables and establish their relationships with the fishery catch per unit effort(CPUE). The NNM with the GAM identified significant variables as input vectors was used for predicting spatial distribution of CPUE. The GAM was found to explain 53.8% variances for CPUE. The spatial variables(longitude and latitude) and environmental variables(SST, SSH and Chl a) were significant. The CPUE had nonlinear relationship with SST and SSH but a linear relationship with Chl a. The NNM was found to be effective and robust in the projection with low mean square errors(MSE) and average relative variances(ARV).The integrated approach can predict the spatial distribution and explain the migration pattern of Illex argentinus in the Southwest Atlantic Ocean. | WANG Jintao CHEN Xinjun CHEN Yong | 2018 | Acta Oceanologica Sinica2018，37，8： | 8 |
| 14 | Erosion behavior and failure mechanism of Ti/TiAlN multilayer coatings eroded by silica sand and glass beads显示文摘Severe erosion by hard particles is a crucial problem to engine blades when aircraft take off and land in harsh environments, especially for the developed lightweight titanium alloy components. Here, we deposited the Ti/TiAlN multilayer coatings with various cycles on Ti–6 Al–4 V substrates by a home-made hybrid multisource cathodic arc system. The effects of the silica sand and glass beads on erosion behavior of the coatings were focused. Results showed that the Ti/TiAlN multilayer coatings eroded by the silica sand exhibited the predominant 'layer by layer' failure mechanism. In particular, increasing the number of cycles led to the dramatic increase in erosion rate for Ti/TiAlN multilayer coatings, due to the deterioration of their mechanical properties. Different from the silica sand case, however, the erosion rate of the coatings treated by glass beads indicated faint dependence upon the number of cycles, where the coating failure was dominated by the 'piece by piece' failure mechanism. Noted that the Ti layers along with the formed interfaces enhanced the erosion resistance of the coatings, although the failure mechanisms were differently eroded by silica sand and glass beads. Meanwhile, the Ti layers and interfaces hindered the propagation of radial cracks and restrained the lateral cracks within one single TiAlN layer. | Jintao Shuai Xiao Zuo Zhenyu Wang Lili Sun Rende Chen Li Wang Aiying Wang Peiling Ke | 2021 | Journal of Materials Science & Technology2021，，21： | 8 |
| 15 | Research and application of kapok fiber as an absorbing material: A mini review显示文摘Kapok fiber corresponds to the seed hairs of the kapok tree(Ceiba pentandra), and is a typical cellulosic fiber with the features of thin cell wall, large lumen, low density and hydrophobic–oleophilic properties. As a type of renewable natural plant fiber, kapok fiber is abundant,biocompatible and biodegradable, and its full exploration and potential application have received increasing attention in both academic and industrial fields. Based on the structure and properties of kapok fiber, this review provides a summary of recent research on kapok fiber including chemical and physical treatments, kapok fiber-based composite materials, and the application of kapok fiber as an absorbent material for oils, metal ions, dyes, and sound,with special attention to its use as an oil-absorbing material, one predominant application of kapok fiber in the coming future. | Yian Zheng Jintao Wang Yongfeng Zhu Aiqin Wang | 2015 | Journal of Environmental Sciences2015，27，1： | 7 |
| 16 | Investigation of acetylated kapok fibers on the sorption of oil in water显示文摘Kapok fibers have been acetylated for oil spill cleanup in the aqueous environment. The structures of raw and acetylated kapok fiber were characterized using Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). Without severe damage to the lumen structures, the kapok fibers were successfully acetylated and the resulting fibers exhibited a better oil sorption capacity than raw fibers for diesel and soybean oil. Compared with high viscosity soybean oil, low viscosity diesel shows a better affinity to the surface of acetylated fibers. Sorption kinetics is fitted well by the pseudo second-order model, and the equilibrium data can be described by the Freundlich isotherm model. The results implied that acetylated kapok fiber can be used as the substitute for non-biodegradable oil sorption materials. | Jintao Wang Yian Zheng Aiqin Wang | 2013 | Journal of Environmental Sciences2013，25，2： | 7 |
| 17 | SIGNAL FEATURE EXTRACTION BASED UPON INDEPENDENT COMPONENT ANALYSIS AND WAVELET TRANSFORM显示文摘It is an important precondition for machine fault diagnosis that vibration signal can be extracted effectively. Based on the characteristic of noise interfused during the course of sampling vibration signal, independent component analysis (ICA) method is combined with wavelet to de-noise. Firstly, The sampled signal can be separated with ICA, then the function of frequency band chosen with multi-resolution wavelet transform can be used to judge whether the stochastic disturbance singular signal is interfused. By these ways, the vibration signals can be extracted effectively,which provides favorable condition for subsequent feature detection of vibration signal and fault diagnosis. | JiZhong JinTao QinShuren | 2005 | Chinese Journal of Mechanical Engineering2005，18，1： | 7 |
| 18 | Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. | 无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou | 2020 | Neuroscience Bulletin2020，36，3： | 7 |
| 19 | A Method for Detection of Main Metabolites in Aromatic Rice Seeds显示文摘[Objective] A method was developed for the analysis of main metabolites in aromatic rice seeds by gas chromatography-mass spectrometry( GC-MS).[Method]The main metabolites in seeds of 9 different aromatic rice varieties were compared and analyzed with two methods. Method 1: the compound was extracted by the mixture of anhydrous ethanol and methylene chloride( V/V = 1∶ 1) at 60 ℃ for 3 h in water bath; the extract was isolated and detected by gas chromatography-mass spectrometry using HP-5 capillary column with scan monitoring mode. Method 2: the main metabolites in aromatic rice seeds were detected using headspace solid phase micro-extraction and gas chromatography mass spectrometry( GC-MS). [Result]Fifteen types of common metabolites were found in 9 different aromatic rice varieties. Method 1 was more effective than method 2 in detecting the main metabolites in aromatic rice seeds. [Conclusion]This study provides an important reference for clarifying the metabolic pathway of main metabolites in aromatic rice and lays the foundation for further rice breeding. | Bo PENG Dongyan KONG Xiaohua SONG Huilong LI Lulu HE Andong GONG Yanfang SUN Ruihua PANG Lin LIU Jintao LI Qiying ZHOU Yaqin HUANG Bin DUAN Shizhi SONG Hongyu YUAN | 2018 | Agricultural Biotechnology2018，7，1： | 6 |
| 20 | Effects of Yishendaluo decoction on axonal degeneration,inflammatory reaction,and neurological function in a mouse model of experimental autoimmune encephalomyelitis显示文摘<正>BACKGROUND:Yishendaluo decoction reduces production of inflammatory mediators,relieves damage due to inflammatory reactions,and improves neural functions during experimental autoimmune encephalomyelitis. OBJECTIVE:To investigate the effects of Yishendaluo decoction on a mouse model of experimental autoimmune encephalomyelitis. DESIGN,TIME AND SETTING:The randomized,controlled,neuropathological,and molecular biological animal study was performed at the Key Laboratory of Chinese Internal Medicine,Ministry of Education,Dongzhimen Hospital of Beijing University of Chinese Medicine and Center for Neuroinformatics,General Hospital of Chinese PLA from 2005 to 2006. MATERIALS:Yishendaluo decoction pieces consisting of prepared rehmannia root,colla cornus cervi,cape jasmine fruit,and grassleaf sweetflag rhizome were purchased from the Dongzhimen Hospital of Beijing University of Chinese Medicine.Rabbit anti-mouseβ-amyloid precursor protein and p38 polyclonal antibody(Zhongshan Goldenbridge Biotechnology,China),as well interferon-γand interleukin-4 ELISA kit(Boster,China),were used in this study. METHODS:A total of 96 healthy,female,SJL/J mice,aged 8-12 weeks,were equally and randomly assigned to normal,model,hormone,and Chinese medicine groups.A total of 0.2 mL antigen preparation,supplemented with 150μg PLP139-151 and 400μg H37RA,was subcutaneously injected into the upper abdomen of mice from the model,hormone,and Chinese medicine groups. Mouse models of experimental autoimmune encephalomyelitis were established by intravenous injection of 0.1 mL Bordetella pertussis solution containing 0.6×10~6 Bordetella pertussis at days 1 and 3.Mice from the model,Chinese medicine,and hormone groups were respectively subjected to 0.2 mL saline,2 g/kg Yishendaluo decoction,and 0.078 mg/kg prednisone acetate,once daily for 14 consecutive days.Mice from the normal group were left intact. MAIN OUTCOME MEASURES:Pathological changes were observed using hematoxylin-eosin staining and Luxol fast blue staining.Expression ofβ-amyloid precursor protein and p38 protein was determined by immunohistochemistry.Levels of interferon-γand interleukin-4 were detected by ELISA.Behavioral changes were assessed in mice according to scores of neurological function. RESULTS:A few inflammatory cell infiltration,nerve fiber breakage and slight demyelination were detected in the central nervous system of mice from the Chinese medicine and hormone groups compared with the model group.Expression ofβ-amyloid precursor protein and p38 protein was significantly diminished in the central nervous system of mice from the Chinese medicine and hormone groups compared with the model group(P<0.05 or P<0.01),and the decrease was greatest in the Chinese medicine group.The decrease in mouse weight was not significant,and neurological function scores were less in the Chinese medicine and hormone groups compared with the model group(P<0.05 or P<0.01).Interferon-γlevels were significantly reduced(P<0.01),and interleukin-4 levels were significantly increased(P<0.01) in the brains of the Chinese medicine and hormone groups,compared with the model group. CONCLUSION:Yishendaluo decoction improved neurological function in mice with experimental autoimmune encephalomyelitis by downregulatingβ-amyloid precursor protein expression,resisting axonal degeneration,and relieving inflammatory reaction.The anti-inflammatory mechanism was regulated by inhibition of the p38 mitogen-activated protein kinase signal pathway. | Xiaoling Shang Ying Gao Ling Yin Jintao Zhang Shuoren Wang | 2009 | Neural Regeneration Research2009，4，11： | 6 |
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