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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | The effect of flutamide on the physical working capacity and activity of some of the key enzymes for the energy supply in adult rats显示文摘学习的目的是在老鼠为精力供应在一些关键肌肉酶的物理工作能力和活动上估计雄激素受体对手的效果。年轻成年男 Wistar 老鼠被划分成二个组。一个组一个星期和作为控制为服务 8 个星期的另外的组每天收到了 flutamide 的 15 mg kg-1 6 天。在开始并且在实验的结束,所有老鼠受到 submaximal 跑耐力(SRE ) ,疲劳(MTE ) 的最大的时间,和最大的疾跑速度(女士) 测试。在试用的结束,最大的氧消费(VO2max ) 测试被执行并且睾丸激素,红血球,血红素以及 succinate 脱氢酶(同步数字系列) 的酶活动的层次,喂奶脱氢酶(LDH ) ,和 gastrocnemius 肌肉的 NAD.H2-cytochrome-c reductase (NAD.H2 ) 被测量。对待 flutamide 的老鼠的浆液睾丸激素比控制的高,它验证选择的剂量的有效性。anti-androgen-treated 组的 MTE 和 SRE 与起始的价值相比是更低的。Flutamide 处理减少了同步数字系列和 NAD.H2 的活动与控制相比。我们没在女士, VO2max,跑的经济, LDH 活动,和 hematological 变量上发现反雄激素处理的效果。我们的调查结果显示象一些关键酶的活动一样的 submaximal 和最大的跑耐力的维护把氧化能力与肌肉联系了与雄激素效果被连接由雄激素受体调停了。 | Katerina N Georgieva Penka A Angelova Fani D Gerginska Dora D Terzieva Mihaela S Shishmanova-Doseva Slavi D Delchev Valentine V Vasilev | 2017 | Asian Journal of Andrology2017，19，4： | 2 |
| 3 | Measurement of the dynamic displacements and of the modal frequencies of a shorkspan pedestrian bridge using GPS and an accelerometer显示文摘 | Fanis M Stathis S | 2011 | Engineering Structures2011，33，： | 1 |
| 4 | Comparing the effect of phenytoin syrup and tfiamcinolone acetonide ointment on aphthous ulcers in patients with behcet Is syn- drome显示文摘 | Fani MM Ebrahimi H Pourshahidi S | 2012 | Iran Red Crescent Med J2012，14，2： | 1 |
| 5 | ComBined Mitomycin C Application and Free Flap Conjunctival Autograft in Pterygium Surgery 显示文摘 | Fani S Simona J Noa G | 2003 | Cornea2003，22，7： | 1 |
| 6 | Genetic variability in European populations of aninvasive American crayfish: preliminary re- subs 显示文摘 | Barbarcsi S Fani R Gherardi F | 2003 | Biological Invasions2003，5，： | 1 |
| 7 | Scheduling multi-product tree-structure pipelines显示文摘 | MIRHASSANI S A FANI Jahromi H | 2011 | Computers & Chemical Engineering2011，35，1： | 1 |
| 8 | Genetics and invasion biology in fresh waters: a pilot study of Procambarus clarleii in Europe 显示文摘 | Barbarcsi S Fani R Gherardi F | 2007 | Biological Invaders in Inland Waters: Profiles Distribution and Threats2007，4，： | 1 |
| 9 | Labeling of monoclonal antibodies with 153Sm for potential use in radioimmunotherapy显示文摘 | Fani M Vranjes S Archimandritis SC | 2002 | Appl Radiat Isot2002，57，5： | 1 |
| 10 | Genetic variability in European populations of an invasive American crayfish:preliminary results显示文摘 | Barbaresi S Fani R Gherardi F | | 0，，03： | 1 |
| 11 | A randomly amplified polymorphic DNA marker specific for the Bacillus cereus group is diagnostic for Bacillus anthracis显示文摘 | Daffonchio D Borin S Frova G Gallo R Mori E Fani R Sorlini C | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 12 | Cus-tomer complaints and service policy in elec-tronic commerce 显示文摘 | FanY W Miao Y F Wu S C | 2013 | South African Journalof Business Management2013，44，3： | 1 |
| 13 | T cell polarization identiies distinct clinical phenotypes in scleroderma lung disease显示文摘 | Boin F De Fanis U Bartlett S l | 2008 | Arthritis Rheum2008，58，4： | 1 |
| 14 | Dietary gamma linolenic acid enhances mouse macrophage derived prostaglandin Elwhich inhibits vascular smooth muscle cell proliferation显示文摘 | FanY Y Ramos K S Chapkin R S | | 0，，09： | 1 |
| 15 | Genetic variability in European populations of an invasive American crayfish:preliminary results 显示文摘 | BARBARESI S R FANI R GHERARDI F | 2003 | Biological Invasions2003，5，： | 1 |
| 16 | Current control of induction machines in the field-weakened region显示文摘 | Gabriel G L Fani S G James E W | 2007 | IEEE Transactions on Industrial Applications2007，43，78： | 1 |
| 17 | Dry mycelium of Penicillium chrysogenum induces expression of pathogenesis-related protein genes and resistance against wilt diseases in Bt transgenic cotton显示文摘 | Dong H Z FanY Q | 2006 | Biological Control2006，39，： | 1 |
| 18 | Anthocyanins and color variables of Bulgarian aged red wines 显示文摘 | Silvia T S Stefan D Fany R | 2002 | J Food Compost Anal2002，15，6： | 1 |
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