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| 1 | Influence of nano-scale twins (NT) structure on passive film formed on nickel显示文摘 | Guozhe Meng Feilong Sun Yawei Shao Tao Zhang Fuhui Wang Chaofang Dong Xiaogang Li | 2009 | Electrochimica Acta2009，，7： | 1 |
| 2 | Tild-CRISPR可在小鼠和人类细胞中实现高效、精确的基因敲入显示文摘文章简介研究团队基于CRISPR/Cas9系统,设计了一种新的靶向整合策略Tild-CRISPR,通过PCR扩增或者精确酶切,获得含有800bp同源臂的转基因供体与Cas9 mRNA以及single-guide RNA一起注射到小鼠受精卵中。 | 姚璇 Meiling Zhang Xing Wang Wenqin Ying Xinde Hu Pengfei Dai Feilong Meng Linyu Shi Yun Sun Ning Yao Wanxia Zhong Yun Li Keliang Wu 李卫平 陈子江 杨辉 | 2019 | 科学新闻2019，0，2： | 0 |
| 3 | Flexible Dry Hydrogel with Lamella-Like Structure Engineered via Dehydration in Poor Solvent显示文摘Hydrogels are among the most promising biologic materials in recent technology with numerous desired applications,including serving as biosensors,drug delivery vehicles,and tissue-engineered products for cell matrices.However,they often dehydrate,and become stiff and brittle in air,causing loss of flexibility and functions.Several layered structures have been proven to increase the strength,toughness,and even flexibility of these materials,which might provide a new clue for the sustenance of the flexibility of drying gels.Herein,we report a novel solvent-dehydrated hydrogel engineering approach,aimed to change the inner structure and keep the flexibility of a dehydrated hydrogel in the air via solvent-induced dehydration,for example,acetonedehydrated polyacrylic acid hydrogel.This flexible dry gel could be folded,twisted,and stretched without any damage due to the assumed lamella-like structures,contrary to dry gels without these microstructures or those with porous structures,which retain brittle consistency.The flexible dry gel also exhibited excellent self-healing capability with the assistance of solvents.Fascinatingly,this flexible gel film displayed strain-visualizing paper writing/erasing performance properties,with water acting as invisible ink.Thus,this fabricated flexible hydrogel film might function as confidential information storage material.Our current approach is versatile,hence applicable to other hydrogels,and provides insight into the engineering of other functional gels for extended future applications. | Feilong Zhang Jiajia Zhou Zhen Gu Man Yang Siheng Li Yongyang Song Jun-Bing Fan Jingxin Meng Peiyi Wu Lei Jiang Shutao Wang | 2020 | CCS Chemistry2020，2，1： | 0 |
| 4 | Targeting HSPA1A in ARID2-deficient lung adenocarcinoma显示文摘Somatic mutations of the chromatin remodeling gene ARID2 are observed in~7%of human lung adenocarcinomas(LUADs).However,the role of ARID2 in the pathogenesis of LUADs remains largely unknown.Here we find that ARID2 expression is decreased during the malignant progression of both human and mice LUADs.Using two Kras^(G12D)-based genetically engineered murine models,we demonstrate that ARID2 knockout significantly promotes lung cancer malignant progression and shortens overall survival.Consistently,ARID2 knockdown significantly promotes cell proliferation in human and mice lung cancer cells.Through integrative analyses of Ch IP-Seq and RNA-Seq data,we find that Hspa1 a is up-regulated by Arid2 loss.Knockdown of Hspa1 a specifically inhibits malignant progression of Arid2-deficient but not Arid2-wt lung cancers in both cell lines as well as animal models.Treatment with an HSPA1 A inhibitor could significantly inhibit the malignant progression of lung cancer with ARID2 deficiency.Together,our findings establish ARID2 as an important tumor suppressor in LUADs with novel mechanistic insights,and further identify HSPA1 A as a potential therapeutic target in ARID2-deficient LUADs. | Xue Wang Yuetong Wang Zhaoyuan Fang Hua Wang Jian Zhang Longfu Zhang Hsinyi Huang Zhonglin Jiang Yujuan Jin Xiangkun Han Shenda Hou Bin Zhou Feilong Meng Luonan Chen Kwok-Kin Wong Jinfeng Liu Zhiqi Zhang Xin Zhang Haiquan Chen Yihua Sun Liang Hu Hongbin Ji | 2021 | National Science Review2021，8，10： | 0 |
| 5 | Single-electron pumping in a ZnO single-nanobelt quantum dot transistor显示文摘Diluted magnetic semiconductors(DMSs)have traditionally been employed to implement spin-based quantum computing and quantum information processing.However,their low Curie temperature is a major hurdle in their use in this field,which creates the necessity for wide bandgap DMSs operating at room temperature.In view of this,a single-electron transistor(SET)with a global back-gate was built using a wide bandgap ZnO nanobelt(NB).Clear Coulomb oscillations were observed at 4.2 K.The periodicity of the Coulomb diamonds indicates that the Coulomb oscillations arise from single quantum dots of uniform size,whereas quasi-periodic Coulomb diamonds correspond to the contribution of multi-dots present in the ZnO NB.By applying an AC signal to the global back-gate across a Coulomb peak with varying frequencies,single-electron pumping was observed;the increase in current was equal to the production of electron charge and frequency.The current accuracy of about 1%for both single-and double-electron pumping was achieved at a high frequency of 25 MHz.This accurate single-electron pumping makes the ZnO NB SET suitable for single-spin injection and detection,which has great potential for applications in quantum information technology. | Hassan Ali Jing Tang Kai Peng SiBai Sun Attia Falak FeiLong Song ShiYao Wu ChenJiang Qian Meng Wang XiTian Zhang Muhammad Aftab Rafiq XiuLai Xu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，6： | 0 |
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