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| 1 | Optimal configuration for a finite high-temperature source heat engine cycle with the complex heat transfer law显示文摘The optimal configuration of a heat engine operating between a finite high-temperature source and an infinite low-temperature reservoir is derived by using finite time thermodynamics based on a complex heat transfer law,including Newtonian heat transfer law,linear phenomenological heat transfer law,radiative heat transfer law,Dulong-Petit heat transfer law,generalized convective heat transfer law and generalized radiative heat transfer law,q ∝(△T n). In the engine model the only irreversibility of finite rate heat transfer is considered. The optimal relation between the power output and efficiency of the heat engine is also derived by using an equivalent temperature of the hot reservoir. The obtained results include those obtained in recent literature and can provide some theoretical guidance for the designs of practical engines. | LI Jun CHEN LinGen SUN FengRui | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，4： | 22 |
| 2 | Response of runoff and soil loss to reforestation and rainfall type in red soil region of southern China显示文摘To evaluate the long-term effects of reforestation types on soil erosion on degraded land, vegetation and soil properties under conventional sloping farmland (CSF) and three different reforestation types including a Pinus massoniana secondary forest (PSF), an Eucommia ulmoides artificial economic forest (EEF) and a natural succession type forest (NST), were investigated at runoff plot scale over a six-year period in a red soil region of southern China. One hundred and thirty erosive rainfall events generating runoff in plots were grouped into four rainfall types by means of K-mean clustering method. Erosive rainfall type I is the dominant rainfall type. The amount of runoff and the soil loss under erosive rainfall type III were the most, followed by rain-fall type II, IV and I. Compared with CSF treatment, reforestation treatments decreased the average annual runoff depth and the soil loss by 25.5%-61.8% and 93.9%- 96.2% during the study period respectively. Meanwhile, runoff depth at PSF and EEF treatments was significantly lower than that in NST treatment, but no significant difference existed in soil erosion modulus among the three reforestation treatments. This is mainly due to the improved vegetation properties (i.e., vegetation coverage, biomass of above- and below-ground and litter-fall mass) and soil properties (i.e., bulk density, total porosity, infiltration rate and organic carbon content) in the three reforestation treatments compared to CSF treatment. The PSF and EEF are recommended as the preferred reforestation types to control runoff and soil erosion in the red soil region of southern China, with the NST potentially being used as an important supplement. | Zhigang Huang Zhiyun Ouyang Fengrui Li Hua Zheng Xiaoke Wang | 2010 | Journal of Environmental Sciences2010，22，11： | 18 |
| 3 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 4 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 5 | Effects of shrub presence and shrub species on ground beetle assemblages (Carabidae,Curculionidae and Tenebrionidae) in a sandy desert,northwestern China显示文摘Shrub presence has an important effect on the structuring of ground beetles in desert ecosystems. In this study, in order to determine how shrubs and different species influence ground beetle assemblages in a sandy desert scrubland dominated by two different shrub species, namely Calligonum mongolicum and Nitraria sphaerocarpa, we sampled the ground beetles using pitfall traps during spring, summer and autumn in 2012. At the community level, the activity density of the ground beetles was shown to be significantly higher under shrubs than in intershrub bare habitats in spring; but an opposite pattern occurred in autumn, suggesting the presence of season-specific shrub effects on the activity density of the ground beetles. Meanwhile, at the trophic group level, the activity density and species richness of predators were significantly greater under shrubs than in intershrub bare habitats in spring, whereas an opposite trend occurred on the activity density in autumn. N. sphaerocarpa shrubs had a positive effect on the activity density of herbivores in the three seasons, and C. mongolicum shrubs had a positive effect on the activity density of detritivores in spring and autumn. At the species level, more Microdera sp. was captured under shrubs than in intershrub bare habitats in spring. During the same time, we also found that C. mongolicum shrubs had a positive effect on Blaps gobiensis in spring, Carabus sp. in autumn, and Tentyria sp. in spring and autumn, and N. sphaerocarpa shrubs had a positive effect on Cyphogenia chinensis, Sternoplax setosa in spring and summer, and Curculionidae sp. 1 in summer and autumn. The study results suggest that shrub presence, shrub species and season variation are important factors for ground beetle assemblages in this desert ecosystem, but the responses of beetles differed among trophic and taxonomic levels. | JiLiang LIU WenZhi ZHAO FengRui LI | 2015 | Journal of Arid Land2015，7，1： | 4 |
| 6 | The effects of the identity of shrub species on the distribution and diversity of ground arthropods in a sandy desert ecosystem of northwestern China显示文摘Shrub is an important factor on structuring ground arthropod communities in desert ecosystems. In this study, in order to determine how shrubs and their species influence ground arthropod distribution patterns in a sandy desert scrubland dominated by two different shrub species, Calligonum mongolicum and Nitraria sphaerocarpa, the ground arthropods were sampled with pitfall traps during spring, summer and autumn. At the community level, total arthropod abundance was shown to be significantly higher under shrubs than in intershrub bare areas in spring; similar patterns occurred in terms of the richness of arthropod groups in the spring and over three seasons, suggesting season-specific shrub presence effects on arthropod activity. In addition, more arthropods were found under N. sphaerocarpa shrubs than under C. mongolicum shrubs in autumn, suggesting season-specific effects of shrub species of arthropod activity, whereas more arthropods taxa were captured under C. mongolicum than N. sphaerocarpa. At the trophic group level, the abundances of predator and herbivore arthropods were significantly greater under shrubs than in intershrub bare habitats, whereas herbivore arthropods were more abundant under N. sphaerocarpa than C. mongolicum, and an opposite rule was detected for predator arthropods. At the family level, the mean abundances of Carabidae, Curculionidae, Gnaphosidae and Lycosidae were significantly higher in the shrub microhabitats than in the intershrub bare habitat, there was no significant difference between habitats on the mean abundances of Formicidae and Tenebrionidae. The study results suggested that shrub presence and shrub species variation are important determinants of ground arthropod assemblages in this desert ecosystem, but the responses of arthropods differed among trophic and taxonomic groups. | JiLiang Liu WenZhi Zhao FengRui Li | 2014 | Research in Cold and Arid Regions2014，6，6： | 4 |
| 7 | Mechanism of Incompatible Herb Pairs, Panax ginseng and Veratrum nigrum L,: Material Basis and Metabolic Profiles of Ginsenosides in Rat Intestinal Bacteria显示文摘在繁体中文药理论,人参属人参和 Veratrum nigrum L。是重要不兼容的植物对。在老鼠的新陈代谢上的主要部件和影响的内容变化上的研究肠的细菌是有用的理解这的不兼容的机制植物对。在这研究,人参皂甙和他们的 metaboltic 的内容变化在 P 的摘录介绍。P 的人参和相容性。有 V 的人参。nigrum L。(G-V ) 用 electrospray 电离团 spectrometry (ESIMS ) 和 UPLCMS n , 分别地。大多数人参皂甙的相对内容在 G-V 的摘录被减少。而且,人参皂甙 Rb 1, Rb 2, Rc 和 Rd 能在老鼠被使产生代射变化到 Rd, F2 和 C-K 肠的细菌。在在 10:5, 10:7 和 10:10 和人参皂甙 Rb 1, Rb 2 的新陈代谢的率的比率的 G-V 摘录的 Rb 1, Rb 2 和 Rc 和到 Rd 的 Rc 的新陈代谢的速度,到在所有相容性摘录的 F2 的 Rd 在 P 是比那低的。人参摘录。在结论,这研究说明了机制由相对内容的比较和在 P 的相容性以后的人参皂甙的新陈代谢的侧面减少效果。人参和 V。nigrum L。 | Xiudong Yang Xue Li Ying Xu Zifeng Pi Na Lin Zhiqiang Liu Fengrui Song | 2015 | Chinese Journal of Chemistry2015，33，9： | 3 |
| 8 | 雨养农业:中国半干旱地区雨水灌溉土地上的水资源综合管理系统显示文摘雨养农业(RHA)最早是由甘肃省科学家在十几年前开发的,它是适用于半干旱地区靠雨水灌溉土地的一种水资源综合管理系统。这个系统由三个主要部分组成:雨水收集系统、节水灌溉系统和高效农作物生产系统。它的主要功能是为农民们提供一种能够在用水受限制的环境下获得满足家庭生活和农业所需要的水的途径。在甘肃省和中国西北地区的其他省份,RHA的最初设置表明RHA有能力改进靠雨水灌溉的农业系统的表现,并且能够致力于解决土壤侵蚀等一些环境问题。RHA系统规模小、成本低,很客易在农民家庭推广应用。但是,为了能够取得成功,需要把RHA系统纳入到一个综合农业管理系统之中:即RHA管理必须与其他农业技术与管理实践结合在一起运用。此外,在大范围内推广使用RHA需要考虑一系列技术、农业水文、生态、社会、文化、经济和政治因素。特别是需要向农民提供培训和技术指导,以开发和传播更为有效和廉价的RHA技术方式来更新换代并设计开发出替代性的政策工具和社会规则以便于RHA在实践中的应用。 | Li Fengrui Seth Cook Gordon T. Geballe William R. Burch | 2000 | AMBIO-人类环境杂志2000，29，8： | 3 |
| 9 | Preparation and SO2 Adsorption Behavior of Coconut Shell-Based Activated Carbon via Microwave-Assisted Oxidant Activation显示文摘A series of oxidants supported on coconut shell-based activated carbon(CAC) through microwave irradiation were prepared and characterized using scanning electron microscopy(SEM), N_2 adsorption/desorption analysis, and X-ray photoelectron spectroscopy(XPS). The SO_2 adsorption capacities and rates were evaluated by adsorption tests performed in a fixed bed reactor with a simulated flue gas, and the adsorption isotherm models were validated against the experimental results. The findings revealed that the SO_2 adsorption capacity decreased in the following order: MW-K_2Cr_2O_7-CAC > MWKMnO_4-CAC > MW-H_2O_2-CAC > MW-CAC. The SO_2 adsorption capacities and adsorption rates of the samples increased with an increasing oxidizability of the oxidants owing to the increment of mean pore size and oxygen-containing functional groups. In addition, a high initial SO_2 concentration and a low bed temperature could positively affect the SO2 adsorption. Finally, the Langmuir model validated that SO_2 was mainly adsorbed through chemical adsorption on the sample surfaces. | Jia Fengrui Li Zhou Wang Engang He Jicheng Dong Hui Liu Guangxin Jian Weiwei | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，1： | 3 |
| 10 | Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity显示文摘Dear Editor,The promptness and continuous expansion of the coronavirus disease 2019(COVID-19)pandemic,elicited by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,has presented an unprecedented impact on human health(WHO Coronavirus(COVID-19)Dashboard,2021).Although vaccination has attenuated the severe symptoms,there is no specific antiviral medication available for preventing the viral spread(Drayman et al.,2021). | Wenwen Wang Fengrui Yang Jie Lin Saravanakumar Muthusamy Shihao Du McKay Mullen Fatima Garba Wanjuan Wang Xu Liu Tao Li Zhihong Yang Xia Ding Felix Aikhionbare Xinjiao Gao Zhikai Wang Xing Liu Xuebiao Yao | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 11 | Effectiveness of second-line anti-HER2 treatment in HER2-positive metastatic breast cancer patients previously treated with trastuzumab:A real-world study显示文摘Objective:Several studies have demonstrated different benefits for patients whose disease progressed despite previous trastuzumab treatment.Due to limited real-world data,we evaluate the effectiveness of anti-human epidermal growth factor receptor 2(HER2)therapy(lapatinib or trastuzumab)plus chemotherapy or chemotherapy alone in patients who were previously treated with trastuzumab-containing regimens and investigate factors associated with effectiveness.And we further show the effectiveness of the two anti-HER2 therapy groups.Methods:A total of 342 HER2-positive metastatic breast cancer(MBC)patients whose disease progressed during prior anti-HER2(trastuzumab)and standard chemotherapy therapy from Department of Breast Oncology,the Fifth Medical Center of Chinese PLA General Hospital,from August 2010 to December 2016 were included.Seventy-eight patients received standard chemotherapy only,148 patients continued to receive trastuzumab and switched to other chemotherapy drugs,and 116 patients received tyrosine-kinase inhibitors(TKIs;lapatinib)and chemotherapy.The main outcome measures were progression-free survival(PFS),overall response rate(ORR),and clinical benefit rate(CBR).Subgroup analyses were conducted to identify patient characteristics associated with the greatest clinical benefit.Results:After a median follow-up of 26.2(range,2.0-56.0)months,PFS significantly improved with anti-HER2 therapy compared with chemotherapy alone:median 6.0 months with lapatinib[95%confidence interval(95%CI),4.53-7.47],4.5 months with trastuzumab(95%CI,3.99-5.01)vs.3.0 months with chemotherapy alone(95%CI,2.42-3.58);stratified hazard ratio(HR)=0.70,95%CI,0.60-0.81;P<0.0001.The ORR values were 33.6%,25.0%and 12.8%,respectively,the CBR values were 60.3%,48.6%and 26.9%,respectively.The effectiveness of lapatinib group and trastuzumab group were further analyzed.In multivariate analysis,lapatinib group was associated with a longer PFS,after controlling other potential confounders(HR=0.68,95%CI,0.52-0.90;P=0.006).Conclusions:The combination of TKIs and chemotherapy was effective in this cohort previously treated with trastuzumab treatment.Therefore,TKIs combined with chemotherapy is an option for Chinese HER2-positive MBC patients previously treated with trastuzumab treatment. | Wei Zhao Li Bian Tao Wang Shaohua Zhang Jianbin Li Fengrui Xu Zefei Jiang | 2020 | Chinese Journal of Cancer Research2020，32，3： | 1 |
| 12 | Effects of sim- ulated grazing on growth and persistence of Artemisia frigida in a semiarid sandy rangeland显示文摘 | Li Fengrui Zhao A F Zhou H Y | 2002 | Grass and Forage Science2002，57，3： | 1 |
| 13 | Patterns of reproductive allocation in Artemisia halodendron inhabiting two contrasting habitats显示文摘 | Li Fengrui Zhang Aisheng Duan Shunshan | 2005 | Acta Oecologica2005，28，： | 1 |
| 14 | Ecological Optimization Performance of An Irreversible Quantum Otto Cycle Working with an Ideal Fermi Gas显示文摘 | Feng Wu Lingen Chen Fengrui Sun Chih Wu Fangzhong Guo Qing Li | 2006 | Open Systems and Information Dynamics2006，，1： | 1 |
| 15 | Performance optimization for a two-stage thermoelectric heat-pump with internal and external irre- versibilities 显示文摘 | Chen Lingen Li Jun Sun Fengrui | 2008 | Applied Energy2008，，85： | 1 |
| 16 | Variations of sand transportation rates in sandy grasslands along a desertification gradient in northern China显示文摘 | Li Fengrui Zhang Hua Zhang Tonghui | 2003 | CATENA2003，53，3： | 1 |
| 17 | Water use patterns and agro- nomic performance for some cropping systems with and without fallow crops in a semi-arid environment of northwest China]显示文摘 | Li Fengrui Zhao Songling Geballe G T | 2000 | Agriculture Ecosystems and Environment2000，79，： | 1 |
| 18 | Water use patterns and agronomic performance for some cropping systems with and without fallow crops in a semi-arid environment of northwest China显示文摘 | Li Fengrui Zhao Songling Geballe G T | 2000 | Agriculture Ecosystems & Environment2000，79，23： | 1 |
| 19 | Mechanisms and regulation underlying membraneless organelle plasticity control显示文摘Evolution has enabled living cells to adopt their structural and functional complexity by organizing intricate cellular compartments,such as membrane-bound and membraneless organelles(MLOs),for spatiotemporal catalysis of physiochemical reactions essential for cell plasticity control.Emerging evidence and view support the notion that MLOs are built by multivalent interactions of biomolecules via phase separation and transition mechanisms.In healthy cells,dynamic chemical modifications regulate MLO plasticity,and reversible phase separation is essential for cell homeostasis.Emerging evidence revealed that aberrant phase separation results in numerous neurodegenerative disorders,cancer,and other diseases.In this review,we provide molecular underpinnings on(i)mechanistic understanding of phase separation,(ii)unifying structural and mechanistic principles that underlie this phenomenon,(iii)various mechanisms that are used by cells for the regulation of phase separation,and(iv)emerging therapeutic and other applications. | Hazrat Ismail Xu Liu Fengrui Yang Junying Li Ayesha Zahid Zhen Dou Xing Liu Xuebiao Yao | 2021 | Journal of Molecular Cell Biology2021，13，4： | 1 |
| 20 | Water use pattern and agronomic performance for some cropping systems with and without fallow crops in a semi-a rid environment of northwest China显示文摘 | Zhao Songling Geballe | | Agriculture Ecosystems and Environment0，79，： | 1 |
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