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| 1 | Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles for enhanced delivery and antitumor efficacy of paclitaxel显示文摘结合的指向的药交货在细胞质的快速的药版本是强大的策略提高反癌症药的功效和还原剂离开目标效果。此处,我们描述由 pH 应答的共聚物 D 组成的一个双功能的混合 micellar 系统 -- tocopheryl 聚乙烯乙二醇 1000-blockpoly-( 氨基的酉旨)(TPGS-b-PBAE, TP ) 并且 AS1411 aptamer (恰当) 装饰了 TPGS 聚合物(Apt-TPGS ) ,它在癌症房间的血浆膜上认出过去表示的 nucleolin。反癌症药 paclitaxel (PTX ) 在恰当混合的微粒被包含,并且这些装载药的微粒有一种合适的粒子尺寸和 116.3 nm eir single-crystalline-like 的希腊语的第六个字母潜力远程的电子连接, VN MCNS 交付 1.44 的电的传导性 ??? 汰獵瀭畬 ?? ￣吗? | Jinming Zhang Rule Chen Xiefan Fang Fengqian Chen Yitao Wang Meiwan Chen | 2015 | Nano Research2015，0，1： | 6 |
| 2 | Development of a gradient reversed-phase HPLC method for the determination of sodium ferulate in beagle dog plasma 显示文摘 | FengQian L Shu X Hua S | 2007 | Journal of Chromatography B2007，846，： | 1 |
| 3 | Detection of epithelial ovarian cancer using <sup>1</sup>H‐NMR‐based metabonomics显示文摘 | KunleOdunsi Robert M.Wollman Christine B.Ambrosone AlanHutson Susan E.McCann JonathanTammela John P.Geisler GregoryMiller ThomasSellers WilliamCliby FengQian BernadetteKeitz MarilynIntengan ShashikantLele James L.Alderfer | 2004 | Int J Cancer2004，，5： | 1 |
| 4 | Anchoring of ulcx europaeus agglutinin to chitosan nanoparticles -in-microparti cles and thcir in citeo binding activity to bovine submaxillary gland mucin显示文摘 | Li FengQian Fei YiBo Chen Xu | 2009 | Chem Pharm Bull(Tokyo)2009，57，10： | 1 |
| 5 | A mechanicalmodelforpredic-tingcasingcreeploadinhightemperaturewells显示文摘 | FengQian DeliGao | 2011 | JournalofNaturalGasScienceandEngineering2011，，3： | 1 |
| 6 | Radical Carbonylation under Low CO Pressure:Synthesis of Esters from Activated Alkylamines at Transition Metal-Free Conditions显示文摘Main observation and conclusion High CO pressure(>40 bar)is usually needed in radical carbonylation reactions in the absence of metal catalyst.In this communication,we developed a transition-metal-free radical carbonylation of activated alkylamines with phenols and alcohols under low CO pressure(1-6 bar).Various esters were obtained in moderate to excellent yields under simple reaction conditions with good functional group compatibility. | Fengqian Zhao Han-Jun Ai Xiao-Feng Wu | 2021 | Chinese Journal of Chemistry2021，39，4： | 1 |
| 7 | Preparation and characterization of sodium ferulate entrapped bovine serum albumin nanoparticles for liver targeting显示文摘 | LI Fengqian SU Hua WANG Jing | | 0，，： | 1 |
| 8 | LIFECYCLE SAFETY GUARANTEE OF STRUCTURES显示文摘The principles for lifecycle safety guarantee of engineering structures are proposed, and theconception is developed for developing the safety guarantee system by integrating the monitoringsystem, analysis system and maintenance system together on the basis of multi-sensor, distribu-tion-measurement, data fusion and digital-signal-processor (DSP) technologies as well asthree-dimensional (3D) fatigue fracture unified theory. As all the systems should work in situs and inreal-time, micromation and integration are important. Damage detectability is introduced to clarify therelationship of life prediction and healthy monitoring or faulty diagnosis. The research work to realizethe lifecycle safety guarantee system is summarized and perspectives for future efforts are outlined. | GuoWanlin ZhangBin FengQian LiChun | 2005 | Chinese Journal of Mechanical Engineering2005，18，2： | 1 |
| 9 | Anchoring of ulex europaeus agglutinin to chitosan nanoparticles-in-microparti- cles and their in vitro binding activity to bovine submaxillary gland muein显示文摘 | Li FengQian Fei YiBo Chen Xu | 2009 | Chem Pharm Bull (Tokyo)2009，57，10： | 1 |
| 10 | Cetirizine dihydro- chloride loaded microparticles design using ionotropic cross linked chitosan nanoparticles by spray-drying method 显示文摘 | Li FengQian Ji RuiRui Chen Xu | 2010 | Arch Pharm Res2010，33，12： | 1 |
| 11 | A novel spray-dried nanoparticles-in-microparticles system for formulating scopol amine hydrobromide into orally disintegrating tablets 显示文摘 | Li FengQian Yan Cheng Bi Juan | 2011 | Int J Nanomedicine2011，6，8： | 1 |
| 12 | Black tantalic oxide submicro-particles coating on PEEK fibers woven into fabrics as artificial ligaments with photothermal antibacterial effect and osteogenic activity for promoting ligament-bone healing显示文摘Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction. | Fan Wang Mengyao Wang Qingsong He Xuehong Wang Ping Sun Yinjun Ji Yunfei Niu Fengqian Li Jie Wei | 2023 | Journal of Materials Science & Technology2023，，2： | 0 |
| 13 | Continuous morphing trailing-edge wing concept based on multi-stable nanomaterial显示文摘Morphing technology is one of the most effective methods to improve the flight efficiency of aircraft.Traditional control surfaces based morphing method is mature and widely used on current civil and military aircraft,but insufficiently effective for the entire flight envelope.Recent research on morphing wing still faces the challenge that the skin material for morphing should be both deformable and stiff.In this study,a continuous morphing trailing-edge wing with a new multi-stable nano skin material fabricated using surface mechanical attrition treatment technology was proposed and designed.Computational fluid dynamics simulation was used to study the aerodynamic performance of the continuous morphing trailing-edge wing.Results show that the lift coefficient increases with the increase of deflection angle and so does the lift-drag ratio at a small angle of attack.More importantly,compared with the wing using flaps,the continuous morphing trailing-edge wing can reduce drag during the morphing process and its overall aerodynamic performance is improved at a large angle of attack range.Flow field analysis reveals that the continuous morphing method can delay flow separation in some situations. | Fengqian HAO Tao TANG Yuan GAO Yimeng LI Shenghui YI Jian LU | 2021 | Chinese Journal of Aeronautics2021，34，7： | 0 |
| 14 | Simple Statistical Tests Used in Positive Accounting Research: a Thing to be Noted显示文摘 | Fengqian Gong | 2005 | Chinese Business Review2005，4，1： | 0 |
| 15 | Self-assembling nacre-like high-strength and extremely tough polymer composites with new toughening mechanism显示文摘Achieving high strength,deformability and toughness in polymers is important for practical industrial applications.This has remained challenging because of the mutually opposing effects of improvements to each of these properties.Here,a self-assembling nacre-like polymer composite is designed to achieve ex-tremely tough with increasing strength.This special design significantly improved polymer’s mechanical properties,including an ultra-high fracture strain of 1180%,a tensile strength of 55.4 MPa and a toughness of 506.9 MJ/m^(3),which far exceed the highest values previously reported for polymer composites.This ex-cellent combination of properties can be attributed to a novel toughening mechanism,achieved by the synergy of the domain-limiting effect of metallic glass fragments with the strain-gradient-induced orien-tation and crystallisation within the polymer during stretching.Our approach opens a promising avenue for designing robust polymer materials in armour and aerospace engineering for a range of innovative applications. | Yu Bu Xu Wang Xiuming Bu Zhengyi Mao Zhou Chen Zebiao Li Fengqian Hao Johnny C.Ho Jian Lu | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
| 16 | Nanoparticle(NP)-mediated APOC1 silencing to inhibit MAPK/ERK and NF-κB pathway and suppress breast cancer growth and metastasis显示文摘Breast cancer is one of the most common malignant tumors with high mortality and poor prognosis in women.There is an urgent need to discover new therapeutic targets for breast cancer metastasis.Herein,we identified that Apolipoprotein C1(APOC1)was up-regulated in primary tumor of breast cancer patient that recurrence and metastasis by immunohistochemistry(IHC).Kaplan-Meier Plotter database showed that high levels of APOC1 in breast cancer patients were strongly associated with worse overall survival(OS)and relapse-free survival(RFS).Mechanistically,APOC1 silencing significantly inhibits MAPK/ERK kinase pathway and restrains the NF-κB to decrease the transcription of target genes related to growth and metastasis in vitro.Based on this regulatory mechanism,we developed these findings into potential therapeutic drugs,glutathione(GSH)responsive nanoparticles(NPs)were used for systemic APOC1 siRNA delivery,NPs(siAPOC1)silenced APOC1 expression,and subsequently resulted in positive anti-tumor effects in orthotopic and liver metastasis models in vivo.Taken together,GSH responsive NPmediated siAPOC1 delivery was proved to be effective in regulating growth and metastasis in multiple tumor models.These findings show that APOC1 could be a potential biomarker to predict the prognosis of breast cancer patients and NP-mediated APOC1 silencing could be new strategies for exploration of new treatments for breast cancer metastasis. | Shaomin Liu Fengqian Zhang Yixia Liang Guo Wu Rong Liu Xiuling Li Phei Er Saw Zhonghan Yang | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
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