|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neurons secrete miR-132.containing exosomes to regulate brain vascular integrity显示文摘脉管的完整帮助维持大脑微型环境动态平衡,它为中央神经系统的正常开发和函数是批评的。神经房间能调整大脑,这被知道脉管的正直。由于包含的神经与血管的相互作用的高复杂性,不管多么大脑的神经规定理解脉管的正直仍然是原始的。用未经触动的 zebrafish 幼虫和有教养的啮齿类动物大脑房间,我们发现神经原转移 miR-132,一高度保存了并且充实神经原的 microRNA,经由到 endothelial 房间(EC ) 到的 secreting exosomes 维持大脑脉管的正直。后面的 translocation 到通过 exosome 成为主观的 EC, miR-132 调整脉管的 endothelial cadherin (VE-cadherin ) 的表示,重要 adherens 连接蛋白质,由直接指向真核细胞的延伸因素 2 kinase (eef2k ) 。neuronal miR-132 表示或 exosome 分泌物的混乱,或脉管的 eef2k 的 overexpression 损害 VE-cadherin 表示和大脑脉管的正直。我们的学习显示 miR-132 作为调停的一个细胞间的信号扮演大脑的神经规定脉管的完整并且建议 neuronal exosome 是为神经与血管的通讯的一条新奇大街。 | Bing Xu Yu Zhang Xu-Fei Du Jia Li Hua-Xing Zi Ji-Wen Bu Yong Yan Hua Han Jiu-Lin Du | 2017 | Cell Research2017，27，7： | 46 |
| 2 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 3 | Comparison of the effect and safety of Kuntai capsule and hormone replacement therapy in patients with perimenopausal syndrome:a systematic review and Meta-analysis显示文摘OBJECTIVE: To assess the effectiveness and safety of Kuntai capsule and hormone replacement therapy in treatment of perimenopausal syndrome.METHODS: Articles were retrieved from the databases Cochrane Database of Systematic Reviews,Pub Med, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Only randomized controlled trials were included; 15 trials involving1243 patients were identified from January 2005 to April 2015. A systemic review and Meta-analysis of publications was performed. The review was limit-ed to randomized controlled trials that compared Kuntai capsule and hormone replacement therapy to treat perimenopausal syndrome for at least 3months. The primary outcome assessed was the treatment efficacy at 3 months, including effective rate of Kupperman menopausal scores, Kupperman menopausal scores, and blood estradiol(E2) or blood follicle stimulating hormone(FSH) levels.Other outcomes assessed were safety or adverse events, such as gastrointestinal complaints, breast distending pain, or vaginal bleeding.RESULTS: Kupperman menopausal scores showed no significant difference in effective rate [odds ratio(OR): 1.05, 95% confidence intervals(CI): 0.71 to1.55] and changes in FSH level [mean difference(MD): 2.14, 95% CI:-2.36 to 6.65]. There was a significant statistical difference in Kupperman menopausal scores(MD:-1.14, 95% CI:-2.03 to-0.25)and changes in E2level(MD:-16.41, 95% CI:-18.83to-13.69). There were fewer adverse events in the Kuntai capsule group than in the hormone replacement therapy group(OR: = 0.35, 95% CI: 0.25 to0.48, P < 0.01).CONCLUSION: Compared with hormone replacement therapy, Kuntai capsule can improve perimenopausal symptoms and blood E2 levels, and reduce the incidence of adverse events. | Du Xiaoqin Xu Lin Wang Lijun Heng Mingli Bu Huaien Hao Yu Tian Jinhui | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 28 |
| 4 | Suppression of Astroglial Scar Formation and Enhanced Axonal Regeneration Associated with Functional Recovery in a Spinal Cord Injury Rat Model by the Cell Cycle Inhibitor Olomoucine显示文摘Objective:To determine if a cell cycle inhibitior, olomoucine, would decrease neuronal cell death, limit astroglial proliferation and production of inhibitory CSPGs, and eventually enhance the functional compensation after SCI in rats. Methods: Three were used as un-operated controls and twelve as sham operated controls. Following spinal cord injury, 48 rats were randomly and blindly assigned to either olomoucine (n=24) or vehicle treatment (n=24) groups. Results: Up-regulations of cell cycle components were closely associated with neuronal cell death and astroglial proliferation as well as the production of CSPGs after SCI. Meanwhile, administration of olomoucine, a selective cell cycle kinase (CDK) inhibitor, has remarkably reduced the up-regulated cell cycle proteins and then decreased neuronal cell death, astroglial proliferation as well as accumulation of CSPGs. More importantly, the treatment with olomoucine has also increased expression of growth-associated proteins-43 (GAP-43), reduced the cavity formation, and improved functional deficits. Conclusion: Suppressing astroglial cell cycle in acute spinal cord injuries is beneficial to axonal growth. in turn, the future therapeutic strategies can be designed to achieve efficient axonal regeneration and functional compensation after traumatic CNS injury. | 宋宇锋 YU Zhi-yuan XIE Min-jie BU Bi-tao WITTE OW WANG Wei | 2006 | 神经损伤与功能重建2006，1，2： | 21 |
| 5 | Interspecific and intraspecific variation in specific root length drives aboveground biodiversity effects in young experimental forest stands显示文摘Aims Although the net biodiversity effect(NE)can be statistically partitioned into complementarity and selection effects(CE and SE),there are different underlying mechanisms that can cause a certain partitioning.Our objective was to assess the role of resource partitioning and species interactions as two important mechanisms that can bring about CEs by interspecific and intraspecific trait variation.Methods We measured tree height of 2493 living individuals in 57 plots and specific root length(SRL)on first-order roots of 368 of these individuals across different species richness levels(1,2,4,8 species)in a large-scale forest biodiversity and ecosystem functioning experiment in subtropical China(BEF-China)established in 2009.We describe the effects of resource partitioning between species by a fixed component of interspecific functional diversity(RaoQ)and further effects of species interactions by variable components of interspecific and intraspecific functional diversity(community weighted trait similarity and trait dissimilarity,CWS and CWD).Finally,we examined the relationships between biodiversity effects on stand-level tree height and functional diversity(RaoQ,CWS and CWD)in SRL using linear regression and assessed the relative importance of these three components of functional diversity in explaining the diversity effects.Important Findings Our results show that species richness significantly affected SRL in five and tree height in ten out of 16 species.A positive NE was generally brought about by a positive CE on stand-level tree height and related to high values of RaoQ and CWS in SRL.A positive CE was related to high values of all three components of root functional diversity(RaoQ,CWS and CWD).Our study suggests that both resource partitioning and species interactions are the underlying mechanisms of biodiversity effects on stand-level tree growth in subtropical forest. | Wensheng Bu Bernhard Schmid Xiaojuan Liu Ying Li Werner Härdtle Goddert von Oheimb Yu Liang Zhenkai Sun Yuanyuan Huang Helge Bruelheide Keping Ma | 2017 | Journal of Plant Ecology2017，10，1： | 18 |
| 6 | LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer显示文摘Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance. Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage Ⅰ and Ⅱ (P<0.05). Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn't meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage Ⅰ and Ⅱ gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage Ⅰ and Ⅱ gastric cancer (P<0.05). Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage Ⅰ and Ⅱ gastric cancer. | Zhaode Bu Zhixue Zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu Xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 17 |
| 7 | Experimental study of an aircraft fuel tank inerting system显示文摘In this work, a simulated aircraft fuel tank inerting system has been successfully established based on a model tank. Experiments were conducted to investigate the influences of different operating parameters on the inerting effectiveness of the system, including flow rate of the inert gas(nitrogen-enriched air), inert gas concentration, fuel load of the tank and different inerting approaches. The experimental results show that under the same operating conditions, the time span of a complete inerting process decreased as the flow rate of inert gas was increased; the time span using the inert gas with 5% oxygen concentration was much longer than that using pure nitrogen;when the fuel tank was inerted using the ullage washing approach, the time span increased as the fuel load was decreased; the ullage washing approach showed the best inerting performance when the time span of a complete inerting process was the evaluation criterion, but when the decrease of dissolved oxygen concentration in the fuel was also considered to characterize the inerting effectiveness, the approach of ullage washing and fuel scrubbing at the same time was the most effective. | Cai Yan Bu Xueqin Lin Guiping Sun Bing Zeng Yu Li Zixuan | 2015 | Chinese Journal of Aeronautics2015，28，2： | 15 |
| 8 | Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer显示文摘 | LIU Qiang SU Yu JIANG Guan-chao ZHOU Zu-li LIU Bao-cai BU Liang YANG Fan WANG Jun | 2013 | Chinese Medical Journal2013，，16： | 10 |
| 9 | Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning显示文摘Background: There is increasing research interest in using short-chain fatty acids(SCFAs) including butyrate as potential alternatives to antibiotic growth promoters in animal production. This study was conducted to evaluate the effects of supplementation of sodium butyrate(SB) in liquid feeds(milk, milk replacer, and the mixture of both)on the growth performance, rumen fermentation, and serum antioxidant capacity and immunoglobins in dairy calves before weaning. Forty healthy female Holstein calves(4-day-old, 40 ± 5 kg of body weight) were housed in individual hutches and randomly allocated to 1 of 4 treatment groups(n = 10 per group) using the RAND function in Excel. The control group was fed no SB(SB0), while the other three groups were supplemented with 15(SB15),30(SB30), or 45(SB45) g/d of SB mixed into liquid feeds offered. The calves were initially fed milk only(days 2 to 20), then a mixture of milk and milk replacer(days 21 to 23), and finally milk replacer only(days 24 to 60).Results: The SB supplementation enhanced growth and improved feed conversion into body weight gain compared with the SB0 group, and the average daily gain increased quadratically with increasing SB supplementation. No significant effect on rumen pH;concentrations of NH_3-N, individual and total VFAs;or acetate:propionate(A:P) ratio was found during the whole experimental period. Serum glutathione peroxidase activity increased linearly with the increased SB supplementation, while the serum concentration of maleic dialdehyde linearly decreased. Serum concentrations of immunoglobulin A, immunoglobulin G, or immunoglobulin M were not affected by the SB supplementation during the whole experimental period.Conclusions: Under the conditions of this study, SB supplementation improved growth performance and antioxidant function in pre-weaned dairy calves. We recommended 45 g/d as the optimal level of SB supplementation mixed into liquid feeds(milk or milk replacer) to improve the growth and antioxidant function of dairy calves before weaning. | Wenhui Liu ALa Teng Zhu La Alexander Evans Shengtao Gao Zhongtang Yu Dengpan Bu Lu Ma | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 10 |
| 10 | Curative effect of Dingqi analgesic patch on cancer pain:a single-blind randomized controlled trail显示文摘OBJECTIVE:To observe the curative effect of an acupoint application with a Dingqi analgesic patch on moderate to severe pain caused by liver cancer.METHODS:Forty patients with moderate to severe pain caused by liver cancer were randomly divided intoatreatmentgroup(TG)andacontrolgroup(CG).Patients with moderate pain were given 100 mg qd of a sustainably released tablet of tramadol hydrochloride;patientswithseverepainweregiven4.2mg q3d of the fentanyl transdermal system.The ashi points Ganshu(BL 18),Danshu(BL 19) and Qimen(LR 14) were chosen for the acupoint application intervention.CG patients were given a sham patch and TG patients were given a Dingqi analgesic patch.A visual analogue scale(VAS) was used before treatment and after 1,3,6,9 and 12 days of treatment.The Karnofsky score was measured before treatment and after 12 days of treatment.Any main adverse reactions(e.g.nausea,constipation,dizziness and headache) were recorded after 6 and 12 days of treatment.Any skin side effects(i.e.skin irritation and allergic reactions) were recorded.RESULTS:The VAS in TG was significantly lower than that in CG after 3,6,9 and 12 days of treatment(P<0.05).There was no significant difference in the Karnofsky score before treatment and after 12 days of treatment between CG and TG.There were also no significant differences in the main adverse reactions or skin side effects after 6 and 12 days of treatment between CG andTG(P>0.05).CONCLUSION:The Dingqi analgesic patch can enhance the analgesic effect of tramadol and fentanyl. | Changjun Wang Wei Tan Xuhui Huang Tingting Fu Juze Lin Junmin Bu Guojian Wei Yu Du | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 9 |
| 11 | Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation显示文摘AIM To clarify the mechanisms involved in the critical endoplasmic reticulum(ER) stress initiating unfolded protein response pathway modified by melatonin.METHODS Hepatoma cells, Hep G2, were cultured in vitro. Flow cytometry and TUNEL assay were used to measure Hep G2 cell apoptosis. Western blotting and quantitative reverse transcription-polymerase chain reaction methods were used to determine the protein and messenger RNA levels of ER stress and apoptosis related genes' expression, respectively. Tissue microarray construction from patients was verified by immunohistochemical analysis.RESULTS In the present study, we first identified that melatoninselectively blocked activating transcription factor 6(ATF-6) and then inhibited cyclooxygenase-2 (COX-2) expression, leading to enhanced liver cancer cell apoptosis under ER stress condition. Dramatically increased CCAAT-enhancer-binding protein homologous protein level, suppressed COX-2 and decreased Bcl-2/Bax ratio by melatonin or ATF-6 si RNA contributed the enhanced Hep G2 cell apoptosis under tunicamycin (an ER stress inducer) stimulation. In clinical hepatocellular carcinoma patients, the close relationship between ATF-6 and COX-2 was further confirmed.CONCLUSION These findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis. | Li-Jia Bu Han-Qing Yu Lu-Lu Fan Xiao-Qiu Li Fang Wang Jia-Tao Liu Fei Zhong Cong-Jun Zhang Wei Wei Hua Wang Guo-Ping Sun | 2017 | World Journal of Gastroenterology2017，23，6： | 9 |
| 12 | Detrital Zircon U-Pb Geochronology from Greywackes in the Niujuanzi Ophiolitic Mélange, Beishan Area, NW China: Provenance and Tectonic Implications显示文摘The Niujuanzi ophiolitic mélange represents the remnant of oceanic crust between the Dunhuang massif and Mingshui-Hanshan massif. Greywacke from different tectonic slices in the Niujuanzi ophiolitic mélange were analyzed for detrital zircon U-Pb geochronology, trace elements and whole-rock trace elements to infer their provenance and the evolution of the Niujuanzi Ocean. Sample N-76 s containing Carboniferous spores has the youngest zircon age of 323 Ma, while sample N-85 s without fossils has the youngest zircon age of 449 Ma. The two samples were deposited no earlier than 323 and 449 Ma, respectively. The greywackes are depleted in large ion lithophile elements, and are relatively enriched in high field strength elements. The age spectra and trace element concentrations indicate that the sediments may have been deposited near the trench. The Hf, U, and Yb contents of zircons from sample N-76 s vary widely, whereas those from sample N-85 s have a narrow range. Sample N-76 s contains both continental and oceanic zircons, while sample N-85 s contains only continental zircons. The sediments were derived from the continental arc and accretionary wedge. The Paleozoic oceanic crust zircons have ages of 430–500 Ma, indicating the timing of the expansion of the HongliuheNiujuanzi-Xichangjing Ocean expansion. The oldest Paleozoic continental zircon has an age of 470 Ma, suggesting that the northward subduction of the oceanic crust may have started at that time. | Shengdong Wang Kexin Zhang Bowen Song Shucai Li Jianxing Li Jiyuan Yu Jianjun Bu | 2018 | Journal of Earth Science2018，29，1： | 8 |
| 13 | Iterative Learning Control for a Class of Linear Discrete-time Switched Systems显示文摘在这份报纸,反复的学习控制(ILC ) 与任意的切换的信号为线性分离时间的交换系统的一个类被考虑。交换系统重复地在有限时间间隔期间被操作,这被假定,然后第一个顺序 P 类型 ILC 计划能被用来完成完美的追踪在上自始至终间隔。由超级向量途径,为在重复领域的如此的 ILC 系统的一个集中条件能被给。理论分析被模拟支持。 | BU Xu-Hui YU Fa-Shan HOU Zhong-Sheng WANG Fu-Zhong | 2013 | 自动化学报2013，39，9： | 8 |
| 14 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 15 | Water yield reduction due to forestation in arid mountainous regions, northwest China显示文摘Forestation has been encouraged worldwide due to increasing demand for forest products, and for its ecological benefits such as soil erosion control and sediment reduction. However, forestation reduces runoff, thus potentially aggravating water shortages in arid regions. In order to quantitatively estimate the possible water yield reductions caused by forestation in an arid region, a small watershed (the Pailugou watershed) in the Qilian Mountains of northwest China was chosen as a study area. The responses of hydrological dynamics to different forestation scenarios in the study area were simulated using the TOPOG model. The results showed that forestation could lead to a complete loss of runoff at the site scale. At the watershed scale, a 10% increase in forest coverage led to a runoff reduction of 25.6 mm, equivalent to 13% of the runoffin the un-forested watershed. However, due to climatological and topographical constraints, the potential forest distribution occupied only 46.3% of the watershed area, and runoff reduction was estimated to reach a maximum of 60% when the forest cover ratio increased from 0.41% to 46.1%. Actual forest coverage is 36% in the study area, thus the water yield will be reduced with any further increase in forest area. Our study suggested that a trade-off between the numerous benefits of forest coverage increase and its negative impact on water yield should be carefully addressed in arid regions with inherently severe water-shortage. | Pengtao YU Yanhui WANG Xudong WU Xiaohong DONG Wei XIONG Gaowa BU Shunli WANG Jinye WANG Xiande LIU Lihong XU | 2010 | International Journal of Sediment Research2010，25，4： | 7 |
| 16 | Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma显示文摘AIM:To study the expression profiles of MUC2 and MUC5AC in tumorigenesis of colorectal carcinoma and in its different pathologic types.METHODS:Formalin-fixed,paraffin-embedded human colorectal tissue specimens were immunostained with antibodies against MUC2 and MUC5AC.Six samples of normal mucosa(NM),12 samples of hyperplastic polyp(HP),15 samples of tubular adenoma with low-grade dysplasia(LGD),14 samples of tubular adenoma with high-grade dysplasia(HGD),26 samples of conventional colorectal adenocarcinoma(CCA),15 samples of mucinous carcinoma(MC),and 8 samples of signetring cell carcinoma(SRCC) were collected.RESULTS:MUC2 was the most widely expressed protein in each study group,although the number of MUC2positive cases was less in CCA group than in other groups(P < 0.05).The staining score for MUC2 was significantly decreased in the HP-LGD-HGD-CCA sequence(r =-0.73436,P < 0.0001).Among the neoplasms,MC and SRCC were more frequently associated with the high expression of MUC2(P < 0.05) than with that of CCA.MUC5AC expression was detected in all groups but not in NM group.Furthermore,the staining score for MUC5AC was higher in HP,LGD,HGD,MC and SRCC groups than in NM and CCA groups(P < 0.05).The frequency of simultaneous expression of MUC proteins was significantly higher in MC and SRCC groups than in CCA group(P < 0.05).CONCLUSION:Alterations in MUC expression occur during colorectal tumorigenesis.The transformation process in MC and SRCC may be different from that in the traditional adenoma-carcinoma sequence. | Xiao-Dong Bu Nan Li Xiao-Qiang Tian Pei-Lin Huang Li Li Jin-Song Wang Xiao-Jin Yu | 2010 | World Journal of Gastroenterology2010，16，32： | 7 |
| 17 | Intestinal stem cell marker LGR5 expression during gastric carcinogenesis显示文摘AIM:To investigate the differential expression of leu-cine-rich repeat-containing G protein-coupled receptor5(LGR5)in gastric cancer tissues and its significance related to tumor growth and spread.METHODS:Formalin-fixed biopsy specimens of intestinal metaplasia(n=90),dysplasia(n=53),gastric adenocarcinoma(n=180),metastases in lymph nodes and the liver(n=15),and lesion-adjacent normal gastric mucosa(controls;n=145)were obtained for analysis from the Peking University Cancer Hospital’s Department of Pathology and Gastrointestinal Surgery tissue archives(January 2003 to December 2011).The biopsied patients’demographic and clinicopathologic data were retrieved from the hospital’s medical records database.Each specimen was subjected to histopathological typing to classify the tumor node metastasis(TNM)stage and to immunohistochemistry staining to detect the expression of the cancer stem cell marker LGR5.The intergroup differences in LGR5 expression were assessed by Spearman’s rank correlation analysis,and the relationship between LGR5 expression level and the patients’clinicopathological characteristics was evaluated by theχ2test or Fisher’s exact test.RESULTS:Significantly more gastric cancer tissues showed LGR5+staining than normal control tissues(all P<0.01),with immunoreactivity detected in 72.2%(65/90)and 50.9%(27/53)of intestinal metaplasia and dysplasia specimens,respectively,52.8%(95/180)of gastric adenocarcinoma specimens,and 73.3%%(11/15)of metastasis specimens,but 26.9%(39/145)of lesion-adjacent normal gastric mucosa specimens.Comparison of the intensity of LGR5+staining showed an increasing trend that generally followed increasing dedifferentiation and tumor spread(normal tissue | Zhi-Xue Zheng Yu Sun Zhao-De Bu Lian-Hai Zhang Zi-Yu Li Ai-Wen Wu Xiao-Jiang Wu Xiao-Hong Wang Xiao-Jing Cheng Xiao-Fang Xing Hong Du Jia-Fu Ji | 2013 | World Journal of Gastroenterology2013，19，46： | 7 |
| 18 | Ground-based observation of aerosol optical properties in Lanzhou, China显示文摘Aerosol optical properties from August 2006 to July 2007 were obtained from ground-based and sky radiance measurements in Semi- Arid Climate and Environment Observatory of Lanzhou University (SACOL), China. High aerosol optical thickness (AOT) associated with low ngstrm exponent (α) was mainly observed in spring, which was consistent with the seasonal dust production from Hexi Corridor. The maximum monthly average value of AOT 0.56 occurred in March of 2007, which was two times larger than the minimum value of 0.28 in October of 2006. Approximately 60% of the AOT ranged between 0.3 and 0.5, and nearly 93% of α value varied from 0.1 to 0.8, which occurred in spring. The significant correlation between aerosol properties and water vapor content was not observed. The aerosol volume size distribution can be characterized by the bimodal logarithm normal structure: fine mode (r < 0.6 μm) and coarse mode (r > 0.6 μm). Aerosols in spring of SACOL were dominated by large particles with the volume concentration ratio of coarse to fine modes being 7.85. The average values of asymmetry factor (g) in the wavelength range 440-1020 nm were found to be 0.71, 0.67, 0.67 and 0.69 in spring, summer, autumn and winter, respectively. | YU Xingna ZHU Bin FAN Shuxian YIN Yan BU Xiaoli | 2009 | Journal of Environmental Sciences2009，21，11： | 7 |
| 19 | Identification of key factors governing chemistry in groundwater near the water course recharged by reclaimed water at Miyun County, Northern China显示文摘Reclaimed water was successfully used to recover the dry Chaobai River in Northern China, but groundwater may be polluted. To ensure groundwater protection, it is therefore critical to identify the governing factors of groundwater chemistry. Samples of reclaimed water, river and groundwater were collected monthly at Chaobai River from January to September in 2010. Fifteen water parameters were analyzed. Two kinds of reclaimed water were different in type (Na-Ca-Mg-Cl-HCO3 or Na-Ca-Cl-HCO3 ) and concentration of nitrogen. The ionic concentration and type in river were similar to reclaimed water. Some shallow wells near the river bed had the same type (Na-Ca-Mg-Cl-HCO3 ) and high concentration as reclaimed water, but others were consistent with the deep wells (Ca-Mg-HCO3 ). Using cluster analysis, the 9 months were divided into two periods (dry and wet seasons), and all samples were grouped into several spatial clusters, indicating different controlling mechanisms. Principal component analysis and conventional ionic plots showed that calcium, magnesium and bicarbonate were controlled by water-rock interaction in all deep and some shallow wells. This included the dissolution of calcite and carbonate weathering. Sodium, potassium, chloride and sulfate in river and some shallow wells recharged by river were governed by evaporation crystallization and mixing of reclaimed water. But groundwater chemistry was not controlled by precipitation. During the infiltration of reclaimed water, cation exchange took place between (sodium, potassium) and (calcium, magnesium). Nitrification and denitrification both happened in most shallow groundwater, but only denitrification in deep groundwater. | Yilei Yu Xianfang Song Yinghua Zhang Fandong Zheng Ji Liang Dongmei Han Ying Ma Hongmei Bu | 2013 | Journal of Environmental Sciences2013，25，9： | 6 |
| 20 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员