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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Rogerio M Mauricio Fergus L Mould Mewa S Dhanoa Emyr Owen Kulwant S Channa Michael K Theodorou | 1999 | Animal Feed Science and Technology1999，，4： | 2 |
| 3 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 4 | Use offibrolytic enzymes to improve the nutritive value of ruminant diets A biochemical and in vitro runaen degradation assessment显示文摘 | Dario C Fergus L Mould M et (d | 2003 | Animal Feed Science and Technology2003，107，： | 1 |
| 5 | Visualizing and understanding convolu- tional neural networks 显示文摘 | ZEILER M D FERGUS R | 2013 | Arxiv Preprint Arxiv2013，，24： | 1 |
| 6 | Use of the scored Patient Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer 显示文摘 | Bauer J Capra S Fergus on M | 2002 | Eur J Clin Nutr2002，56，8： | 1 |
| 7 | Adolescent resilience:a framework for understanding healthy development in the face of risk显示文摘 | Fergus S Zimmerman M A | | 0，，： | 1 |
| 8 | Image-guided pleural biopsy显示文摘 | Najib M Rahman Fergus V Gleeson | 2008 | Current Opinion in Pulmonary Medicine2008，，： | 1 |
| 9 | Predicting feed quality-chemical analysis and in vitro evaluation显示文摘 | Fergus L M | 2003 | Field Crops Research2003，84，： | 1 |
| 10 | Preclinical and clinical pharmacology of rosuvastatin,a new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor显示文摘 | Fergus M Linda B Robert D | 2001 | Am J Cardiol2001，，： | 1 |
| 11 | Azygos arch valves:Prevalence and appearance at contrast-enhanced CT显示文摘 | Benjamin M Fergus V Henry W | 2004 | Radiology2004，230，： | 1 |
| 12 | Blood-brain barrierr permeability and long-term clinical and imaging outcomes in cerebral small vessel disease显示文摘 | Joanna M Wardlaw Fergus N | 2013 | Stroke2013，44，2： | 1 |
| 13 | Bilingualism: Consequences for mind and brain显示文摘 | Ellen B Fergus I M C Gigi L | 2012 | Trends in Cognitive Sciences2012，，4： | 1 |
| 14 | Predicting feed quality-chemical analysis and in vitro evaluation显示文摘 | Fergus L M | 2003 | Field Crops Research2003，84，： | 1 |
| 15 | Kinetics of volatile orgamic compared sortion/ desorption on day minerals显示文摘 | Fergus A M Mark E G | 1999 | Join''hal of Contaminant Hydrology1999，36，3： | 1 |
| 16 | Utilization of non-exchangeable soil potassium in relation to soil type, plant species and stage of growth显示文摘 | Memon Y M Fergus I F Hughes J D | 1988 | Aust J Soil Res1988，26，3： | 1 |
| 17 | Kinetics of volatile organic compound sorption/desorption on clay minerals显示文摘 | Fergus A M Mark E G | 1999 | Journal of Contaminant Hydrology1999，36，3： | 1 |
| 18 | Blood-brain barrier permeability and long term clinical and imaging outcomes in cerebral small vessel disease显示文摘 | Joanna M Wardlaw Fergus N Doubal Maria Valdes-Hernandez | 2013 | Stroke2013，44，2： | 1 |
| 19 | Blood-brain barrier permeability and long term clinical and imaging outcomes in cerebral small vessel disease显示文摘 | Joanna M Wardlaw Fergus N Doubal Maria Valdes-Hernandez | 2013 | Stroke2013，44，2： | 1 |
| 20 | A lpha-2 and imidazoline recepter agonists显示文摘 | Khan Z P Fergu son C N Jones R M | 1999 | Anaesthesia1999，54，2： | 1 |
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