|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 2 | “徒手针刺影响健康人和中风后遗症患者肱二头肌功能的即时效果的平行随机对照试验”的研究方案(英文)显示文摘背景:中风作为一种疾病,中医早在2 000多年前即有诸多经典著作对其进行描述。然而,大部分有关针刺对中风后遗症患者功能恢复的疗效的临床对照试验未能得出针刺具有长期疗效的结论。并且,很多试验以表面肌电图测量患者骨骼肌的电活动以评定针刺刺激的即时疗效的结论也不一致。这些研究结果对针刺在神经肌肉水平的作用提出了质疑。本研究旨在比较徒手针刺影响健康人和中风后肌张力亢进患者的肱二头肌功能及力量的即时效果。方法与设计:本研究拟开展含有4个平行对照组的随机单盲临床试验。分别针刺健康受试者及中风后遗症痉挛性轻瘫患者的曲池(LI11)及天泉(PC2)2个穴位。表面肌电图测量针刺对于肌肉功能的即时疗效及肱二头肌的等长张力作为主要结局指标。次要结局指标包括每组中医证候的出现频率及频率分布。讨论:本研究的临床试验设计在方法学上较之前的类似试验有些改善。预计这一研究能够证实针刺刺激对健康人及中风后遗症患者的神经肌肉的作用。临床试验注册:巴西临床试验注册(www.ensaiosclinicos.gov.br,注册号为RBR-5g7xqh). | Ana Paula de Sousa Fragoso Arthur de Sá Ferreira | 2012 | 中西医结合学报2012，10，3： | 8 |
| 3 | 土壤中的生物多样性与生态系统功能显示文摘我们回顾了目前关于土壤生物多样性及其在生态系统过程中的作用、对于人类目标的重要性及对胁迫和扰动的恢复能力等的研究进展。现存物种的数量远远大于人们已经描述的数量,即使是对于肉眼可见的分类群也是如此。而且也普遍缺乏在生物地理学上的综合描述。迫切需要在分类学和对新一代系统科学家培训上做更大努力。尤其是应当集中致力于就我们所知。对生态系统功能起关键作用的土壤生物类群方面。为了确定这种类群,需要对土壤生物区系的影响圈(sphere of Influence,SOI),如根的生物区系、有机物质破碎者(shredder)和土壤生物扰动者(bioturbator)加以识别,这些影响圈比如可能通过与植物的相互作用而控制着生态系统的过程。在这些SOI中,我们分析出了土壤有机体的功能类群。最迫切需要研究的问题是将物种按功能类群进行区分,并确定功能类群中的物种冗余。这种迫切性是根据为阐述与集约化农业、森林扰动、环境污染和全球环境变化有关的土壤功能丧失程度的需要而确定的。目前认为最处于危险的土壤生物区系是那些大型动物群的有机物破碎者、土壤生物扰动者、某些专门的细菌(如硝化细菌和固氮菌)以及形成真菌的菌根中贫乏物种的功能类群。在开展这些优先性研究时,需要使用长期的和大尺度的田间试验,以及地理统计学和地理信息系统等现代方法进行试验研究。 | Lijbert Brussaard Val M.Behan-Pelletier David E.Bignell Valerie K.Brown Wim Didden Patrica Folgarait Carlos Fragoso Diana Wall Freckman Vadakattu V.S.R.Gupta Tsutomu Hattori's David L.Hawkworth Carole Klopatek Patric Lavelle David W.Malloch Josef Rusek Bengt Sderstrom James M.Tiedje Ross A.Virginia 闵庆文 | 1997 | 人类环境杂志1997，26，8： | 6 |
| 4 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 5 | P38 Mitogen-activated pro- tein kinase regulates myelination 显示文摘 | Haines JD Fragoso G Hossain S | 2008 | J Mol Neurosci2008，35，1： | 1 |
| 6 | Prediction of red wine colour and phenolic parameters from the analysis of its grape extract 显示文摘 | Fragoso S Guaseh J Acena L | 2011 | International Journal of Food Science & Technol- ogy2011，46，12： | 1 |
| 7 | Autocrine VEGF loops,signaling pathways,and acute leukemia regulation显示文摘 | Fragoso R Elias AP Dias S | 2007 | Leuk Lymphoma2007，48，3： | 1 |
| 8 | Statistical-dynami- cal modeling of the cloud-to-ground lightning activity in Por- tugal 显示文摘 | Sousa J F Fragoso M Mendes S et 81 | 2013 | Atmospheric Research2013，13，2133： | 1 |
| 9 | Synthetic peptide vaccine against Taenia solium pig cysticercosis: successful vaccination in a controlled field trial in rural Mexico显示文摘 | Huerta M de Aluja A S Fragoso G | 2001 | Vaccine2001，20，12： | 1 |
| 10 | Hoo control for linear systems with Markovian jumping parameters显示文摘 | Carlos E S Fragoso M D | 1993 | Control Theory and Advanced Technology1993，9，2： | 1 |
| 11 | Autocrine VEGF loops, signaling pathways, and acute leukemia regulation 显示文摘 | Fragoso R Elias AP Dias S | 2007 | Leukemia Lymphoma2007，48，3： | 1 |
| 12 | Tumor ne- crosis factor alpha (TNF-alpha) in autoimmune diseases (AIDs): molecular biology and genetics显示文摘 | Fragoso J M Alarcon G V Morales S J | 2014 | Gac Med Mex2014，150，4： | 1 |
| 13 | Regulation of cadmium uptake by Saccharomyces cerevisiae 显示文摘 | Gomes D S Fragoso L C Riger C J | 2002 | Biochim Biophys Acta2002，1573，： | 1 |
| 14 | Vacuum pulse-assisted pickling whole jalape?o pepper optimization显示文摘 | Valdez Fragoso A Martínez Monteagudo S I Salais Fierro F | 2007 | Journal of Food Engineering2007，79，4： | 1 |
| 15 | Regulation of cadmium uptake by Saccharomyces cerevisiae显示文摘 | GOMES D S FRAGOSO L C RIGER C J | | 0，，： | 1 |
| 16 | Clinical heterogeneity of human neurocysticercosis results from complex interactions among parasite, host and environmental factors显示文摘 | Agnès Fleury Alfonso Escobar Gladis Fragoso Edda Sciutto Carlos Larralde | 2010 | Transactions of the Royal Society of Tropical Medicine and Hygiene2010，，： | 1 |
| 17 | Percutaneous epididymal sperm aspiration (PESA) in men with obstructive azoospermia 显示文摘 | Glina S Fragoso JB Martins FG | 2003 | Int Braz J Urol2003，29，2： | 1 |
| 18 | Regulation of immune responses and tolerance : the microRNA perspective 显示文摘 | Chen CZ Schaffert S Fragoso R | 2013 | Immu- nol Rev2013，253，1： | 1 |
| 19 | Interleukin 1 β (IL-1B) and IL-1 Antagonist Receptor (IL-1RN) Gene Polymorphisms are Associated With the Genetic Susceptibility and Steroid Dependence in Patients With Ulcerative Colitis显示文摘 | Jesús K. Yamamoto-Furusho Jean J. Santiago-Hernández Nonanzit Pérez-Hernández Silvestre Rami′rez-Fuentes José Manuel Fragoso Gilberto Vargas-Alarcón | 2011 | Journal of Clinical Gastroenterology2011，，6： | 1 |
| 20 | Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1显示文摘 | Fragoso R Mao T Wang S Schaffert S Gong X Yue S | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员