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| 1 | Physical Location of the Rice Pi-5(t), Glh and RTSV Genes by ISH of BAC Clones显示文摘Mapplng of low of slngle-copy sequences on plant chromosomes has proven dirricult because ofvery low frequency or slgnal detectlon. Rlce BAC Ilbrary ls belng used wldely ln rlce genome research due tolts distlnctlve advantages over other llbrary systems. In tkls study, two blotln-Iabeled rice BAC clones closelylinked to a rlce blast reslstance, green Ieaf hopper reslstance and tungro spherlcal virus resistance gene,Pi-5(t),Glh, RTSV, were in situ hybrldlred to rlce ckromosomes. They were located on the long arm andshort arm of ckromosome 4 with FL value of 40% and 100% respectively-The rrequency of signal detectionreacked 46. 8% and 59- 2%- The slgnal location were conslstent wltk the selectlve marker on rice saturatedm0Iecular map. The results demonstrated the advautages to Iocate BAC cIones to ckromosomes by in sho hybrldization and will racilitate tke rlce low of slngle-copy gene Iocation by using the BAC library. | Yan Huimin, Song Yunchun, Li Lijia, Bi Xuezhi, Fu Binying(College of Life Sciences, Wuhan University, Wuhan 430072, China) | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 24 |
| 2 | Dendritic platinum-copper bimetallic nanoassemblies with tunable composition and structure: Arginine-driven self-assembly and enhanced electrocatalytic activity显示文摘 | Gengtao Fu Huimin Liu Nika You Jiayan Wu Dongmei Sun Lin Xu Yawen Tang Yu Chen | 2016 | Nano Research2016，9，3： | 6 |
| 3 | Artemisinin ameliorated proteinuria in rats with adriamycin-induced nephropathy through regulating nephrin and podocin expressions显示文摘OBJECTIVE:To investigate the effects of artemisinin against proteinuria and glomerular filtration barrier damage in rats with adriamycin-induced nephropathy,and the potential mechanism underpinned the action.METHODS:Forty adriamycin rats were randomly divided into two groups with the ratio of 1︰3;the small-number group served as control group(n=10),and the rats in the large-number group were treated with adriamycin to induce nephropathy;then they were further randomly assigned into 3subgroups:benazepril group(n=10),artemisiningroup(n=10),and adriamycin group(n=10).The benazepril group and artemisinin group were treated with benazepril suspl(5.0 mg/kg daily)and artemisinin suspl(150 mg/kg daily)respectively after being modeled;those in the control group and adriamycin group were intragastrically administered an equivalent volume of distilled water every day.The treatment after model establishment lasted for a total of 4 weeks.The 24 h uric protein,blood biochemicals,renal pathological changes,renal ultrastrutural changes,Nephrin and Podocin proteins and gene expressions were measured by Coomassie brilliant blue assay,completely automatic biochemical analyzer,light microscope,electron microscopy,Western blot and reverse transcription polymerase chain reaction,respectively.RESULTS:The rats in adriamycin group showed a significant increase in 24 h uric protein excretion,serum total cholesterol(TC),triglyceride(TG),blood urea nitrogen(BUN),serum creatinine(Scr)and decrease in albumin(Alb)(P<0.05 or P<0.01).Compared with adriamycin group,artemisinin could reduce uric protein excretion,decrease the serum TC,TG elevation,increase the serum Alb level,up-regulate the expressions of Nephrin and Podocin(P<0.05 or P<0.01),but no statistical significance effects on the levels of BUN,Scr in artemisinin group(P>0.05).The renal pathological and ultrastrutural observation indicate that artemisinin could attenuate the severity of foot process effacement and fusion in the nephropathic rats.CONCLUSION:Artemisinin might have an effect on the nephropathy in rats caused by adriamycin,which may be at least partly correlated with attenu-ation of the severity of foot process effacement and fusion,up-regulation of the expressions of Nephrin and Podocin in the glomeruli in the rats. | Xili Wu Peng An Bingyu Ye Xingmin Shi Huimin Dang Rongguo Fu Chenglin Qiao | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 5 |
| 4 | Annealed microstructure dependent corrosion behavior of Ti-6Al-3Nb-2Zr-1Mo alloy显示文摘Corrosion resistance of titanium(Ti)alloys is closely connected with their microstructure which can be adjusted and controlled via different annealing schemes.Herein,we systematically investigate the specific effects of annealing on the corrosion performance of Ti-6 Al-3 Nb-2 Zr-1 Mo(Ti80)alloy in 3.5 wt.%NaCl and 5 M HCl solutions,respectively,based on open circuit potential(OCP),potentiodynamic polarization,electrochemical impedance spectroscopy(EIS),static immersion tests and surface analysis.Results indicate that increasing annealing tempe rature endows Ti80 alloy with a higher volume fraction ofβphase and finerαphase,which in turn improves its corrosion resistance.Surface characterization demonstrates thatβphase is more resistant to corrosion thanαphase owing to a higher content of Nb,Mo,and Zr in the former;additionally,the decreased thickness of a phase alleviates segregation of elements to further restrain the micro-galvanic couple effects betweenαandβphases.Meanwhile,the influential mechanisms of environmental conditions on corrosion of Ti80 alloy are discussed in detail.As the formation of a highly compact and stable oxide film on surface,annealed Ti80 alloys exhibit a low corrosion current density(10^(-6)A/cm^(2))and high polarization impedance(10^(6)Ω·cm^(2))in 3.5 wt.%NaCl solution.However,they suffer severe corrosion in 5 M HCl solution,resulting from the breakdown of native oxide films(the conversion of TiO_(2)to aqueous Ti^(3+)),active dissolution of substrate Ti to aqueous Ti^(3+)and existence of micro-galvanic couple effects.Those findings could provide new insights to designing Ti alloys with high-corrosion resistance through microstructural optimization. | Baoxian Su Liangshun Luo Binbin Wang Yanqing Su Liang Wang Robert O.Ritchie Enyu Guo Ting Li Huimin Yang Haiguang Huang Jingjie Guo Hengzhi Fu | 2021 | Journal of Materials Science & Technology2021，，3： | 5 |
| 5 | Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure显示文摘Background and Aims:Nonbiological artificial liver(NBAL)is frequently used as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF).This study aimed to compare the therapeutic efficacy and cost-effectiveness ratio(CER)of comprehensive medical treatment,plasma exchange(PE),and double plasma molecular adsorption system(DPMAS)plus half-dose PE(DPMAS+PE)in patients with HBV-ACLF.Methods:A total of 186 patients with HBV-ACLF randomly received comprehensive medical treatment,PE,or DPMAS+PE and were prospectively evaluated.Patients were divided into four subgroups based on the pretreatment prothrombin activity(PTA):Group I(PTA>40%),group II(PTA 30–40%),group III(PTA 20–30%),and group IV(PTA<20%).The main outcome measures were 28 day effectiveness;90 day liver transplantation-free survival;change of biochemical parameters;and CER.Results:DPMAS+PE treatment was associated with significantly higher 28 day effectiveness and 90 day liver transplantation-free survival compared with PE treatment in patients with group I liver failure.Clearance of serum total bilirubin(TBIL),AST,and creatinine(Cr)were significantly higher in the DPMAS+PE group than in the PE group.For subjects with group I liver failure,DPMAS+PE treatment had advantages of lower CER values and better cost-effectiveness.Conclusions:Compared with comprehensive medical treatment and PE alone,DPMAS with halfdose sequential PE treatment more effectively improved TBIL,AST,and Cr in HBV-ACLF patients,improved 28 day effectiveness and 90 day survival rates in patients with group I liver failure,and was more cost effective.DPMAS+PE is a viable NBAL approach for treatment of HBV-ACLF. | Cichun Wu Wenting Peng Da Cheng Huimin Gu Fei Liu Shifang Peng Lei Fu | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 5 |
| 6 | N concentration of old leaves and twigs is more sensitive to stand density than that of young ones in Chinese fir plantations: a case study in subtropical China显示文摘Young leaves are conventionally used in the analysis to study the nutrient status of evergreen plants and their responses to environmental changes, but the role of old leaves remains poorly understood. We selected two stand types in 31-year-old Chinese fir(Cunninghamia lanceolata) plantations with similar soil conditions but different stand densities, to test the hypothesis that nitrogen(N) concentration of old leaves and twigs is more sensitive to stand density than that of young ones. Leaves and twigs were sampled and sorted into young(one-year-old) and old(two-and three-year-old) groups. Significant differences in N concentration and carbon: nitrogen ratio between the low-density stand and high-density stand were only found in the old leaves and twigs but not in the young ones.Although the N resorption efficiency did not vary significantly with stand density, the annual N resorption rates were increased in old leaves and relatively young twigs at high stand density. These results show the potential use of old tissues in the nutrient analysis in Chinese fir plantations. Testing the generality of these results could improve the use of foliar analysis as an indicator of nutrient status and environmental changes in evergreen tree species. | Yuebao Di Xiaoli Fu Huimin Wang Wenhua Li Silong Wang | 2018 | Journal of Forestry Research2018，29，1： | 5 |
| 7 | Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm显示文摘Abdominal aortic aneurysm(AAA) is an inflammatory vascular disorder with high mortality.Accumulating evidence shows that toll-like receptor 2(TLR2) plays a critical role in the regulation of wound-repairing process after tissue injury.We wondered if TLR2 signaling contributed to the pathogenesis of AAA and that targeting TLR2 would attenuate AAA development and progression.In this study,enhanced expression of TLR2 and its ligands were observed in human AAA tissue.Neutralization of TLR2 protected against AAA development and caused established AAA to regress in mouse models of AAA.In addition,TLR2-deficient mice also failed to develop AAA.The prophylactic and therapeutic effects of blocking TLR2 were accompanied by a significant resolution of inflammation and vascular remodeling,as indicated by the decreased expression or activity of MMP-2/9,α-SMA,inflammatory cytokines,and transcription factors NF-κB,AP-1 and STAT1/3 in AAA tissue.Mechanistically,blocking TLR2 decreased the expression and interaction of TLR2 and several endogenousligands,which diminished chronic inflammation and vascular remodeling in the vascular tissue of AAA.Our studies indicate that the interactions between TLR2 and its endogenous ligands contribute to the pathogenesis of AAA and that targeting TLR2 offers great potential toward the development of therapeutic agents against AAA. | Huimin Yan Bing Cui Xiaowei Zhang Xiaoming Fu Jun Yan Xiaoxing Wang Xiaoxi Lv Zhong Chen Zhuowei Hu | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 3 |
| 8 | Effects of argon gas flow rate and guide shell on oxygen concentration in Czochralski silicon growth显示文摘φ 2 00 公里硅单身者晶体在φ 4 被种 50 公里 aCzochralski (CZ ) 的热地区炉子。由修改模式和氩流动的速度,有不同的氧集中的硅壁炉晶体被获得。通过数字模拟,氩气体流动的速度第一次被阴谋。实验结果被分析,有最低的氧集中的氩流动的最佳条件被获得。 | REN Bingyan ZHAO Long ZHAO Xiuling WANG Huixian CAO Zhongqian ZHU Huimin FU Hongbo | 2006 | Rare Metals2006，25，1： | 3 |
| 9 | M2-specific reduction of CD1d switches NKT cell-mediated immune responses and triggers metaflammation in adipose tissue显示文摘Metaflammation is responsible for several metabolic syndromes,such as type 2 diabetes.However,the mechanisms by which metabolic disorders trigger metaflammation remain unclear.We identified a cell type-specific downregulation of CD1d expression in M2 macrophages during the progression of obesity prior to the onset of inflammation in visceral adipose tissues.A reduction in CD1d expression influenced the ability of M2 macrophages to present antigens and caused a change in antigen-presenting cells from M2 macrophages to M1 macrophages.With CD1d conditional knockout(KO)mice,we further demonstrated that natural killer T(NKT)cell activation by M2 macrophages inhibited metaflammation and insulin resistance by promoting Th2 responses and M2 polarization in visceral adipose tissues of obese mice,whereas NKT cell activation by M1 macrophages exacerbated metaflammation and insulin resistance by promoting Th1 responses and inhibiting M2 polarization.Our results suggest that an M2-specific reduction of CD1d is an initiating event that switches NKT cell-mediated immune responses and disrupts the immune balance in visceral adipose tissues in obese mice. | Huimin Zhang Rufeng Xue Shasha Zhu Sicheng Fu Zuolong Chen Rongbin Zhou Zhigang Tian Li Bai | 2018 | Cellular & Molecular Immunology2018，15，5： | 3 |
| 10 | Liuwei Dihuang formula(六味地黄方)protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor-α显示文摘OBJECTIVE:To evaluate the efficacy of Liuwei Dihuang formula(六味地黄方,LWDHF)on endothelial cells,and to study the mechanism behind the action of modulating expression of estrogen receptors.METHODS:Hydrogen peroxide(H_(2)O_(2))was applied to induce the apoptosis of human umbilical vein endothelial cells(HUVECs).The concentration of nitric oxide(NO),endothelial nitric oxide synthase(eNOS)and inducible NOS(iNOS)were measured by assay kits.Western blot and real-time polymerase chain reaction(RT-PCR)were used to detect the expression of iNOS,eNOS,b-cell lymphoma-2(Bcl-2),Bcl-2-associated X protein(Bax),estrogen receptor(ER)αand ERβ.Also,small interfering RNA(siRNA)was involved to confirm whether the protective effects of LWDHF was medicated by ERs.In vivo,the female rats were ovariectomized to establish postmenopausal vascular injury model.Then the model rats were divided into three groups and treated with saline,estradiol and LWDHF respectively.The concentration of NO and NOS in serum were measured by assay kits,and the expression of Bax,Bcl-2,ERαand ERβwere detected by western blot and immunohistochemistry.RESULTS:In vitro study,LWDHF significantly protected HUVECs from H_(2)O_(2)-induced apoptosis,with the increase of Bcl-2 and the decrease of Bax.The treatment with LWDHF inhibited concentration of NO and iNOS,and upregulated the expression of eNOS,ERαand ERβ.In addition,ERαsiRNA could block the protective effects of LWDHF,while ERβsiRNA showed little influence.In vivo,the treatment with LWDHF suppressed the vascular injury and reduced the level of NO and NOS.LWDHF increased the expression of Bcl-2,ERαand ERβ,as well as inhibiting the Bax expression.CONCLUSION:LWDHF could improve endothelial function and protect HUVECs from apoptosis via increasing the expression of ERα. | CHEN Qi QI Xu FU Yu JI Tingting CHAO Ying LI Jun MENG Qinghai BIAN Huimin LI Yu | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 3 |
| 11 | Experimentai Research on Saturated-Gain for Soft X-Ray Laser from Neon-Like Germanium Plasma显示文摘AmpliHcation of spontaneous emissions at 19.6,23.2 and 23.6 nm have been observed by a “ultiple-Target Series Coupling”design in Ge plasma,.The combined length for four targets is up to 56mm.The gain length product(GL)of small signal is up to 18 for both lines at 23.2 and 23.6 nmt and the effective GL is 16.4 and 15.7 for these two lines respectively.This two lines are obviously tending to saturation.The divergence of x-ray laser beam is about 4 mrad. | WANG Shiji GU Yuan ZHOU GuanUn NI Yuanlong YU Songyu FU Sizu MAO Chusheng TAO Zucong CHEN Wannian LIN Zunqi FAN Dianyuan ZHANG Guoping SHENG Jiatian YANG Minglun ZHANG Tanxin SHAO Yunfeng PENG Huimin HE Xiantu YU Min | 1991 | Chinese Physics Letters1991，8，12： | 3 |
| 12 | Modeling gross primary productivity for winter wheat-maize double cropping system using MODIS time series and CO2 eddy flux tower data显示文摘 | Yan Huimin Fu Yuling Xiao Xiangming | 2009 | Agriculture ecosystems & environment2009，129，4： | 1 |
| 13 | Association between maternal psychological status and fetal hemodynamic circulation in late pregnancy显示文摘 | Fu Jing Yang Ruifen Ma Xiaodong Xia Huimin | 2014 | Chinese Medical Journal2014，，13： | 1 |
| 14 | The formation environment and development modes of Cenozoic source rocks in the Qiongdongnan Basin显示文摘According to the drilling results,there are three sets of source rocks of the Cenozoic Group in the Qiongdongnan Basin,including the Yacheng Formation transitional facies mudstone,the Oligocene Lingshui Formation semi-enclosed marine facies mudstone,and the Miocene neritic-bathyal facies mudstone.The hydrocarbon generating conditions of the source rocks in the study area are mainly controlled by sedimentary environment and organic matter input.The abundance of organic matter in the Oligocene source rocks which were formed in a low-energy back shore environment is confined by organic matter input and hydrodynamic condition.The Miocene source rocks formed in the open marine environment lack terrestrial organic matter input,whose organic matter abundance is constrained by the primary production of the ocean and the preservation condition of organic matter.In addition,the redox conditions are also significant to the formation of source rocks in the study area.According to the differences in key factors controlling the development of source rocks in different time periods and structural belts revealed by drilling practice,three development patterns of source rocks have been put forward.The first one is the transitional facies model featuring a great deal of terrestrial organic matter and weakly hydrodynamic conditions which are apt to develop high effective source rocks in the Yacheng Formation.The second one is the semi-enclosed marine facies featuring abundant terrestrial organic matter,weakly hydrodynamic condition and fine preservation condition in the central depression zone,which are apt to form fine-quality source rocks in the Lingshui Formation.The third one is the marine facies model featuring strong hydrodynamics in the shore-shallow area of northern continental shelf and the lack of benthic algae which are against the development of source rocks.It can be predicted that the continental slope is the perfect place to form source rocks where adequate amounts of light favor the photosynthesis of plants,besides the fine preservation and weakly hydrodynamic conditions.In the deep sea area,although accompanied with weakly hydrodynamic conditions and a reduction environment,it is not suitable for the development of source rocks on account of less aquatic organisms causing low primary production. | LI Wenhao ZHANG Zhihuan LI Youchuan FU Ning HUANG Yanran ZAN Ling ZHANG Huimin | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 1 |
| 15 | Accumulation of residual soil microbial carbon in Chinese fir plantation soils after nitrogen and phosphorus additions显示文摘Nitrogen(N) and phosphorus(P) additions can affect soil microbial carbon(C) accumulation.However,the mechanisms that drive the changes in residual microbial C that occur after N and P additions have not been well-defined for Chinese fir plantations in subtropical China.We set up six different treatments, viz.a control(CK), two N treatments(N_1: 50 kg ha^(-1) a^(-1); N2:100 kg ha^(-1) a^(-1)), one P treatment(P: 50 kg ha^(-1) a^(-1)),and two combined N and P treatments(N_1P:50 kg ha^(-1) a^(-1) of N+50 kg ha^(-1) a^(-1) of P; N_2P:100 kg ha^(-1) a^(-1) of N+50 kg ha^(-1) a^(-1) of P).We then investigated the influences of N and P additions on residual microbial C.The results showed that soil pH and microbial biomass decreased after N additions, while microbial biomass increased after P additions.Soil organic carbon(SOC) and residual microbial C contents increased in the N and P treatments but not in the control.Residual microbial C accumulation varied according to treatment and declined in the order: N_2P>N_1P>N2>N_1>P>CK.Residual microbial C contents were positively correlated with available N, P, and SOC contents, but were negatively correlated with soil p H.The ratio of residual fungal C to residual bacterial C increased under P additions, but declined under combined N+P additions.The ratio of residual microbial C to SOC increased from 11 to 14%under the N_1P and N_2P treatments, respectively.Our results suggest that the concentrations of residual microbial C and the stability of SOC would increase under combined applications of N and P fertilizers in subtropical Chinese fir plantation soils. | Zhiqiang Ma Xinyu Zhang Chuang Zhang Huimin Wang Fusheng Chen Xiaoli Fu Xiangmin Fang Xiaomin Sun Qiuliang Lei | 2018 | Journal of Forestry Research2018，29，4： | 1 |
| 16 | Microcrystal induced emission enhancement of a small molecule probe and its use for highly efficient detection of 2,4,6-trinitrophenol in water显示文摘In this contribution, we reported a very simple and small molecule material, 2,5-dimethoxyterephthalaldehyde(DMA). It exhibited a relatively weak fluorescence in solution, while showed a steadily increased green fluorescence with typical aggregation-induced enhanced emission(AIE) effect for forming a cubic-like microcrystal structure in THF-H2 O mixed solvent.The microcrystals presented significantly higher fluorescence than that of amorphous aggregates. The DMA microcrystals suspension showed a good response to 2,4,6-trinitrophenol(TNP) with a LOD of 1.2×10^(-7) M, which is the best result of TNP detection in aqueous solution. Quantum chemical calculation revealed that DMA is a donor(D)-receptor(A) type molecule with methoxy unit as donor and carbonyl moiety as receptor. Its emission arises from an intramolecular charge transfer(ICT) from methoxy units to carbonyl units. NMR indicated that there is a strong hydrogen bond interaction between DMA and TNP.Hydrogen bond interaction can effectively decrease the intermolecular distance of DMA and TNP, which will increase the efficiency of photoinduced electron transfer(PET) and fluorescence resonance energy transfer(FRET), and hence will be advantageous for its selectivity. The microcrystal induced enhanced emission could be generally used for kinds of target molecules analysis. | Huan Liu Yanyan Fu Wei Xu Qingguo He Huimin Cao Guohua Liu Jiangong Cheng | 2018 | Science China Chemistry2018，61，7： | 1 |
| 17 | Intrinsically zincophobic protective layer for dendrite-free zinc metal anode显示文摘Aqueous zinc anodes have attracted the attention of many researchers owing to their high safety,low cost,and high theoretical specific capacity.However,its practical application is severely limited by the dendrite growth on zinc anode.Herein,we develop an intrinsically zincophobic barium-titanate protective layer with a porous structure to suppress the zinc dendrite formation by homogenizing the ion distribution on the anode surface,increasing the nucleation sites,and limiting the irregular zinc growth.Based on these synergistic effects,the coated zinc anode can exhibit long cycle life(840 h at 0.5 mA/cm^(2) for 0.5 mAh/cm^(2))and low voltage hysteresis(36 mV).This work can provide a feasible direction for the design of intrinsically zincophobic coating materials to uniformize the zinc stripping and plating. | Chunlin Xie Qi Zhang Zefang Yang Huimin Ji Yihu Li Huanhuan Li Liang Fu Dan Huang Yougen Tang Haiyan Wang | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 18 | Tension--tension Fatigue Behavior and Life Distribution of Unidirectional Graphite/Epoxy Composite显示文摘 | Yang Naibin Fu Huimin | 1986 | Journal of Reinforced Plastics and Composites1986，5，7： | 1 |
| 19 | Removing scattering effects of rugged topography using finitedifference method显示文摘 | Guan Huimin Wu Rushan Fu Liyun | 2000 | Expanded Abstracts of 70^th Annual International SECT Meeting2000，，： | 1 |
| 20 | Observation of directional change of core field inside flux ropes within one reconnection diffusion region in the Earth's magnetotail显示文摘Two consecutive magnetic flux ropes, separated by less than 30 s(Dt \ 30 s), are observed within one magnetic reconnection diffusion region without strong guide field in the Earth's magnetotail by Cluster multispacecraft. The flux ropes are characterized by bipolar signatures of the south–north magnetic field component Bz accompanied with strong core magnetic field By, intense current J and density depletions inside of them. In spite of the small but non-trivial global scale negative guide field(–By), there exists a directional change of the core fields of two flux ropes, i.e.,-Byfor the first one, and Byfor the second one. The directions of the core fields are the same as the ambient cross-tail magnetic field component(By) just outside of flux ropes. Therefore, we suggest that the core field of flux ropes is formed by compression of the local preexisting Byand that the directional change of core field is due to the change of local preexisting By. Such a change in ambient Bymight be caused by some microscale physics. | Shiyong Huang Ye Pang Zhigang Yuan Xiaohua Deng Jiansen He Meng Zhou Huishan Fu Song Fu Huimin Li Dedong Wang Haimeng Li | 2014 | Chinese Science Bulletin2014，59，34： | 1 |
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