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	题名	作者	年代	出处	被引量
1	E2FBP1 antagonizes the p16^(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability显示文摘Cellular senescence is an irreversible cell cycle arrest triggered by the activation of oncogenes or mitogenic signaling as well as the enforced expression of tumor suppressors such as p53, p16 INK4A and promyelocytic leukemia protein (PML) in normal cells. E2F-binding protein 1 (E2FBP1), a transcription regulator for E2F, induces PML reduction and suppresses the formation of PML-nuclear bodies, whereas the down-regulation of E2FBP1 provokes the PML-dependent premature senescence in human normal fibroblasts. Here we report that the depletion of E2FBP1 induces the accumulation of PML through the Ras-dependent activation of MAP kinase signaling. The cellular levels of p16 INK4A and p53 are elevated during premature senescence induced by depletion of E2FBP1, and the depletion of p16 INK4A , but not p53 rescued senescent cells from growth arrest. Therefore, the premature senescence induced by E2FBP1 depletion is achieved through the p16 INK4A -Rb pathway. Similar to human normal fibroblasts, the growth inhibition induced by E2FBP1 depletion is also observed in human tumor cells with intact p16 INK4A and Rb. These results suggest that E2FBP1 functions as a critical antagonist to the p16 INK4A -Rb tumor suppressor machinery by regulating PML stability.	Yayoi Fukuyo Akiko Takahashi Eiji Hara Nobuo Horikoshi Tej K. Pandita Takuma Nakajima	2011	International Journal of Oral Science2011，3，4：	11
2	Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives显示文摘	Fukuyo Y Inoue M Nakajima T	2008	Cancer Res2008，68，15：	1
3	Geldanamycin and its anti-cancer activities显示文摘	Fukuyo Y Hunt C R Horikoshi N	2010	Cancer Lett2010，290，1：	1
4	Application of computational fluid dynamics andpedestrian-behavior simulations to the design of task-ambient air-conditioning systems of a subway station显示文摘	Fukuyo K	2006	Energy2006，31，5：	1
5	Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway显示文摘	Eiji Sakai Masaki Fukuyo Ken Ohata Keisuke Matsusaka Noriteru Doi Yasunobu Mano Kiyoko Takane Hiroyuki Abe Koichi Yagi Nobuyuki Matsuhashi Junichi Fukushima Masashi Fukayama Kiwamu Akagi Hiroyuki Aburatani Atsushi Nakajima Atsushi Kaneda	2016	Int. J. Cancer2016，，：	1
6	An extensive cochlodinium bloom along the Western coast of Palawan, Philippines显示文摘	AZANZA R V DAVID L T BORJA R T BAUIA I U FUKUYO Y	2008	Harmful Algae2008，7，：	1
7	ICG fluorescence endoscope for visualization of the placental vascular network 显示文摘	Harada K Miwa M Fukuyo T	2009	Minim Invasive Ther Allied Technol2009，18，1：	1
8	Develop- mental Localization of Nephrin in Zebrafish and Medaka Pronephric Glomerulus 显示文摘	Ichimura K Fukuyo Y Nakamura T	2013	J Histochem Cytochem2013，，：	1
9	Application of Computational Fluid Dynamics and Pedestrian-Behavior Simulations to the Design of Task-Ambient Air-Conditioning Systems of a Subway Station显示文摘	Kazuhiro Fukuyo	2006	Energy2006，31，：	1
10	Superplasticity and Newtonian-viscous flow in fine-grained class I solid solution alloys显示文摘	Fukuyo H Tsai H C Oyama T	1991	ISIJ International1991，31，1：	1
11	Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros显示文摘	Fukuyo Y Nakamura T Bubenshchikova E	2014	Mol Med Rep2014，9，2：	1
12	Prevalence of Sarcocystis infection in horses in Mongolia显示文摘	Fukuyo M Battsetseg G Byambaa B	2002	Southeast Asian J Trop Med Public Health2002，33，4：	1
13	Geldanamycin and its anti-cancer activities显示文摘	Fukuyo Y Hunt CR Horikoshi N	2010	Cancer Lett2010，290，1：	1
14	Prevalence of Sarcocystis infection in meat-producing animals in Mongolia 显示文摘	Fukuyo M Battsetseg G Byambaa B	2002	Southeast Asian J Trop Med Public Health2002，33，3：	1
15	Superplasticity and Newtonian-Viscous Flow in Fine-Grained Class 1 Solid Solution Alloys显示文摘	H C Tsai T Oyama	1991	ISIJ International1991，31，1：	1
16	Application of computational fluid dynamics and pedestrian-behavior simulations to the design of task-ambient air-conditioning system of a subway station显示文摘	Kazuhiro Fukuyo	2006	Energy2006，31，：	1
17	Mammalian stem cells reprogramming in response to terahertz radiation显示文摘	Jonathan Bock Yayoi Fukuyo Sona Kang		0，，12：	1
18	Application of computational fluid dynamics andpedestrian-behavior simulations to the design of task-ambient air-conditioning systems of a subway station显示文摘		2006	Energy2006，31，5：	1
19	Kinetics of Reduc- ibility of Sinter 显示文摘	Sakamoto N Fukuyo H Iwata Y	1984	Tetsu-to-Hagan61984，70，6：	1
20	Molecular dynamics simulation of yttria-stabilized zirconia between 300 and 2 000 K 显示文摘	ARIMA T FUKUYO K IDEMITSU K	2004	J Mol Liq2004，113，1：	1

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