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| 1 | miR-486 sustains NF-KB activity by disrupting multiple NF-KB-negative feedback loops显示文摘 | Libing Song Chuyong Lin Hul Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2013 | Cell Research2013，23，2： | 6 |
| 2 | Genome sequences of five Sitopsis species of Aegilops and the origin of polyploid wheat B subgenome显示文摘Common wheat(Triticum aestivum,BBAADD)is a major staple food crop worldwide.The diploid progenitors of the A and D subgenomes have been unequivocally identified;that of B,however,remains ambiguous and controversial but is suspected to be related to species of Aegilops,section Sitopsis.Here,we report the assembly of chromosome-level genome sequences of all five Sitopsis species,namely Aegilops bicornis,Ae.longissima,Ae.searsii,Ae.sharonensis,and Ae.speltoides,as well as the partial assembly of the Amblyopyrum muticum(synonym Aegilops mutica)genome for phylogenetic analysis.Our results reveal that the donor of the common wheat B subgenome is a distinct,and most probably extinct,diploid species that diverged from an ancestral progenitor of the B lineage to which the still extant Ae.speltoides and Am.muticum belong.In addition,we identified interspecific genetic introgressions throughout the evolution of the Triticum/Aegilops species complex.The five Sitopsis species have various assembled genome sizes(4.11-5.89 Gb)with high proportions of repetitive sequences(85.99%-89.81%);nonetheless,they retain high collinearity with other genomes or subgenomes of species in the Triticum/Aegilops complex.Differences in genome size were primarily due to independent post-speciation amplification of transposons.We also identified a set of Sitopsis genes pertinent to important agronomic traits that can be harnessed for wheat breeding.These newly assembled genome resources provide a new roadmap for evolutionary and genetic studies of the Triticum/Aegilops complex,as well as for wheat improvement. | Lin-Feng Li Zhi-Bin Zhang Zhen-Hui Wang Ning Li Yan Sha Xin-Feng Wang Ning Ding Yang Li Jing Zhao Ying Wu Lei Gong Fabrizio Mafessoni Avraham A.Levy Bao Liu | 2022 | Molecular Plant2022，15，3： | 5 |
| 3 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 4 | The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage显示文摘Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm regulation.To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in 2019.We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD.Furthermore,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of miR-325.In addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland.We established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours.Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions.Finally,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3.Taken together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD.The clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,2015.Animal experiments were approved by Animal Care and Use Committee,School of Medicine,Soochow University,China(approval No.XD-2016-1)on January 15,2016. | Ning Sha Hua-Wei Wang Bin Sun Min Gong Po Miao Xiao-Lu Jiang Xiao-Feng Yang Mei Li Li-Xiao Xu Chen-Xi Feng Yuan-Yuan Yang Jie Zhang Wen-Jing Zhu Yuan-Yuan Gao Xing Feng Xin Ding | 2021 | Neural Regeneration Research2021，16，10： | 4 |
| 5 | Designandconstructionof athree-dimensionalelectrodewith biomass-derived carbon current collector andwater-soluble binder for high-sulfur-loading lithium-sulfur batteries显示文摘Lithium-sulfur batteries attract lots of attention due to their high specific capacity,low cost,and environmental friendliness.However,the low sulfur utilization and short cycle life extremely hinder their application.Herein,we design and fabricate a three-dimensional electrode by a simple filtration method to achieve a high-sulfur loading.Biomass porous carbon is employed as a current collector,which not only enhances the electronic transport but also effectively limits the volume expansion of the active material.Meanwhile,an optimized carboxymethyl cellulose binder is chosen.The chemical bonding restricts the shuttle effect,leading to improved electrochemical performance.Under the ultrahigh sulfur load of 28mg/cm2,the high capacity of 18mAh/cm2 is still maintained,and stable cycling performance is obtained.This study demonstrates a viable strategy to develop promising lithium-sulfur batteries with a three-dimensional electrode,which promotes sulfur loading and electrochemical performance. | Pengfei Wang Zhe Gong Ke Ye Vipin Kumar Kai Zhu Linna Sha Jun Yan Jinling Yin Kui Cheng Guiling Wang Dianxue Cao | 2020 | Carbon Energy2020，2，4： | 3 |
| 6 | Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo显示文摘Scopoletin 是拥有许多药理学活动的活跃香豆素,包括 anti-hyperuricemic 效果,但是与差的溶解度。改进它的口头的 bioavailability,我们试图包含 scopoletin 进 Soluplus 微粒(基于 Soluplus 的 scopoletin 微粒, Sco 女士) 并且评估了 Sco-Ms.Sco 女士的 hypouricemic 行动用一个薄电影的水和方法被准备。Sco 女士与 59.4 灭敬整祬戠潬正摥 ? 噓木椭摮 ' 讚?的一种平均尺寸显示了近球形的形状 ?? 桰獯桰牯汹瑡潩 ? 猠杵敧瑳湩 ? 桴瑡 ??? ‵捡楴杮甠獰牴慥? 景 ?? 愠摮瀠??偁欠湩獡 | Ying-chun ZENG Sha LI Chang LIU Tao GONG Xun SUN Yao FU Zhi-rong ZHANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 3 |
| 7 | Multi-class Classification Methods of Enhanced LS-TWSVM for Strip Steel Surface Defects显示文摘Considering strip steel surface defect samples,a multi-class classification method was proposed based on enhanced least squares twin support vector machines(ELS-TWSVMs)and binary tree.Firstly,pruning region samples center method with adjustable pruning scale was used to prune data samples.This method could reduce classifier′s training time and testing time.Secondly,ELS-TWSVM was proposed to classify the data samples.By introducing error variable contribution parameter and weight parameter,ELS-TWSVM could restrain the impact of noise samples and have better classification accuracy.Finally,multi-class classification algorithms of ELS-TWSVM were proposed by combining ELS-TWSVM and complete binary tree.Some experiments were made on two-dimensional datasets and strip steel surface defect datasets.The experiments showed that the multi-class classification methods of ELS-TWSVM had higher classification speed and accuracy for the datasets with large-scale,unbalanced and noise samples. | Mao-xiang CHU An-na WANG Rong-fen GONG Mo SHA | 2014 | Journal of Iron and Steel Research(International)2014，21，2： | 3 |
| 8 | NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions显示文摘Acute myeloid leukemia(AML) is an aggressive hematological malignancy, and the mechanism underlying immune system involvement in leukemia development is unclear. In the present study, we utilized a myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3(MLLT3/MLL-AF9)-induced AML mouse model with or without exposure to irradiation. We found that the leukemia cells could survive and expand in hosts with intact immune systems, whereas leukemia progression was accelerated in mice with impaired immune systems. Moreover, the leukemia cells escaped from host immunosurveillance via editing their immunogenicity, including the up-regulation of an inhibitory antigen(i.e., CD47) and the down-regulation of active antigens(i.e., CD86, CD54, retinoic acid early transcript(RAE), histocompatibility 2, D region locus b(H2-Db) and H2-Dd). Natural killer(NK) cells were activated in the early phase of AML progression, whereas T cells were stimulated in the late phase. Furthermore, NK cell depletion showed that NK cells were necessary for the elimination of leukemia cells in our AML mouse model. Notably, CD155/CD226 primarily mediated the interaction between NK cells and leukemia cells and contributed to the antitumor effects of NK cells during the early phase of AML. Clinical data from patients with diverse hematological malignancies showed that CD155 expression was decreased in hematological malignancies. Taken together, our results demonstrate that NK cells play a pivotal role in immunosurveillance against leukemia cells during the early stage of AML primarily through the CD226/CD155 interaction; however, NK cells are not sufficient to eliminate leukemia cells. | WANG YaJie CHEN Chen DONG Fang MA ShiHui XU Jing GONG YueMin CHENG Hui ZHOU Yuan CHENG Tao HAO Sha | 2015 | Science China(Life Sciences)2015，58，12： | 3 |
| 9 | Heat flow pattern,base of methane hydrates stability zones and BSRs in Shenhu Area,northern South China Sea显示文摘Using the collected 433 heat flow values,we estimated the bases of methane hydrate stability zone (BHSZ),in northern South China Sea (NSCS).Through comparing BHSZs with the depths of bottom simulating reflectors (BSRs),in Shenhu Area (SA),we found that there are big differences between them.In the north of SA,where the water depth is shallow,many slumps developed and the sedimentation rate is high,it appears great negative difference (as large as-192%).However,to the southeast of SA,where the water depth is deeper,sedimentation rate is relatively low and uplift basement topography exists,it changes to positive difference (as large as +45%).The differences change so great,which haven't been observed in other places of the world.After considering the errors from the process of heat flow measurement,the BSR depth,the relationship of thermal conductivity with the sediments depth,and the fluid flow activities,we conclude that the difference should be not caused by these errors.Such big disagreement may be due to the misunderstanding of BSR.The deviant 'BSRs' could represent the paleo-BSRs or just gas-bearing sediment layers,such as unconformities or the specific strata where have different permeability,which are not hydraterelated BSRs. | ZHANG Yi HE Lijuan WANG Jiyang XU Xing SHA Zhibing GONG Yuehua WANG Hongbing LIANG Jinqiang | 2011 | Acta Oceanologica Sinica2011，30，1： | 2 |
| 10 | Genome-wide identification of chitin-binding proteins and characterization of BmCBP1 in the silkworm, Bombyx mori显示文摘The insect cuticle plays important roles in numerous physiological functions to protect the body from invasion of pathogens, physical injury and dehydration. In this report, we conducted a comprehensive genome-wide search for genes encoding proteins with peritrophin A-type (ChtBD2) chitin-binding domain (CBD) in the silkworm, Bombyx mori. One of these genes, which encodes the cuticle protein BmCBP1, was additionally cloned, and its expression and location during the process of development and molting in B. mori were investigated. In total, 46 protein-coding genes were identified in the silkworm genome, including those encoding 15 cuticle proteins analogous to peritrophins with one CBD (CPAP1s), nine cuticle proteins analogous to peritrophins with three CBD (CPAP3s), 15 peritrophic membrane proteins (PMPs), four chitinases, and three chitin deacetylases, which contained at least one ChtBD2 domain. Microarray analysis indicated that CPAP-encoding genes were widely expressed in various tissues, whereas PMP genes were highly expressed in the midgut. Quantitative polymerase chain reaction and western blotting showed that the cuticle protein BmCBP1 was highly expressed in the epidermis and head, particularly during molting and metamorphosis. An immunofluorescence study revealed that chitin co-localized with BmCBP1 at the epidermal surface during molting. Additionally, BmCBP1 was notably up-regulated by 20-hydroxyecdysone treatment. These results provide a genome-level view of the chitin-binding protein in silkworm and suggest that BmCBP1 participates in the formation of the new cuticle during molting. | Zhi-Lang Li Sha Tian Huan Yang Xia Zhou Shu-Ping Xu Zi-Yu Zhang Jing Gong Yong Hou Qing-You Xia | 2019 | Insect Science2019，26，3： | 2 |
| 11 | Folding Kinetics of HDV Ribozyme with C13A:G82U and A16U:U79A Mutations显示文摘Gene mutations influence the folding kinetics of hepatitis delta virus(HDV) ribozyme. In this work, we study the effect of the double mutation on the folding kinetics of HDV ribozyme. By using the master equation method combined with RNA folding free energy landscape, we predict the folding kinetics of C13A:G82U and A16U:U79A mutated HDV sequences. Their folding pathways are identified by recursively searching the states with high net flux-in(out) population starting from the native state. The results indicate that the folding kinetics of C13A:G82U mutation sequence is bi-phasic, which is similar to the wild type(wt HDV) sequence. While the folding kinetics of A16U:U79A mutation sequence is mono-phasic, it quickly folds to the native state in 30 s. Thus, the folding kinetics of double mutated HDV ribozyme depends on the mutation sites. | ZOU Yanjuan WANG Yujie GONG Sha ZHANG Wenbing | 2015 | Wuhan University Journal of Natural Sciences2015，20，5： | 1 |
| 12 | The Expansion Problem of Anti Symmetric Matrix Under a Linear Constraint and the Optimal Approximation 显示文摘 | GONG Li sha HU Xi yan ZHANG Lei | 2006 | Journal of Computational and Applied Mathematics2006，197，： | 1 |
| 13 | Identification and characterization of Cynoglossus semilaevis microRNA response to Vibrio anguillarum infection through high- throughput sequencing 显示文摘 | Sha Z Gong G Wang S | 2014 | Developmental & Comparative Immunology2014，44，1： | 1 |
| 14 | Microstructures and thermal insulation capability of plasma-sprayed nanostructured ceria stabilized zirconia coatings显示文摘 | Gong W B Sha C K Sun D Q Wang W Q | 2006 | Surface and Coatings Technology2006，201，6： | 1 |
| 15 | Microstructures and thermal insulation of plasma-sprayed nanostructured ceria stabilized zirconia coatings 显示文摘 | Gong W B Sha G K Sun D Q | 2006 | Surface & Coatings Technology2006，201，： | 1 |
| 16 | Microstructures and thermal insulation capability of plasma sprayed nanostruetured ceria stabilized zirconia coatings 显示文摘 | Gong W B Sha C K Sun D Q | 2006 | Surface & Coatings Technology2006，201，6： | 1 |
| 17 | Recent Advances of Pure Organic Room Temperature Phosphorescence Materials for Bioimaging Applications显示文摘Bioimaging,as a powerful and helpful tool,which allows people to investigate deeply within living organisms,has contributed a lot for both clinical theranostics and scientific research.Pure organic room temperature phosphorescence(RTP)materials with the unique features of ultralong luminescence lifetime and large Stokes shift,can efficiently avoid biological autofluorescence and scattered light through a time-resolved imaging modality,and thus are attracting increasing attention.This review classifies pure organic RTP materials into three categories,including small molecule RTP materials,polymer RTP materials and supramolecular RTP materials,and summarizes the recent advances of pure organic RTP materials for bioimaging applications. | HOU Yazhen JIANG Guoyu GONG Jianye SHA Ren WANG Jianguo | 2021 | Chemical Research in Chinese Universities2021，37，1： | 1 |
| 18 | Fundamental research and demonstration project of evaporation treatment of wastewater from FGD in flue gas duct显示文摘 | JIANG D N SHA H W GONG G H | 2013 | Advanced Materials Research2013，86，4865： | 1 |
| 19 | Identification and charac- terization of Cynoglossus semilaevis microRNA response to Vibrio anguillarum infection through high-throughput sequencing 显示文摘 | Sha Z Gong G Wang S | 2014 | Developmental & Comparative Immuno- logy2014，44，1： | 1 |
| 20 | Effects of heat shock protein-antigen peptide complexes (HACs) in melanoma B16 cell line on transplanted tumor development in mice显示文摘目的 :建立黑色素瘤 B16细胞热休克蛋白 -抗原肽复合物 (HACs)的制备方法并测其抑瘤效应。方法 :应用 Sephacryl S- 2 0 0凝胶过滤制备 HAC粗提物 ,应用 SDS- PAGE纯化 HACs,并测其抑瘤效应。结果 :应用 SDS- PAGE纯化的 HAC6 0、 HAC75和 HAC97不同程度地降低肿瘤发生率 ,延迟肿瘤发生时间和减慢肿瘤生长速度。结论 :6 0 0 0 0~ 970 0 0 | GONG Shou liang,YANG Ying,LI Xiu juan,FU Shi bo,SUN Zu yue,CHEN Sha li,LI Xiu yi (MH Radiobiology Research Unit,Jilin University,Changchun 130021 China) | 2001 | 白求恩医科大学学报2001，27，5： | 0 |
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