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| 1 | Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice显示文摘MicroRNAs (miRNAs ) 是植物开发和主人病毒相互作用的枢轴的调节的人。然而,角色和涉及病毒的感染和主人危险性的特定的 miRNAs 的行动模式仍然保持大部分不清楚。在这研究,我们给那瑞斯看引起 miR319 的增加的累积,但是减少的破旧绝技病毒(RRSV ) 感染调整 miR319 的 TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF ) 的表示基因,特别 TCP21,在米饭植物。转基因的米饭植物 overexpressing miR319 或 downregulating TCP21 展出了像疾病的显型并且与野类型的植物比较显示出显著地更高的危险性到 RRSV。相反,仅仅温和的疾病症状在感染 RRSV 的线 overexpressing TCP21 并且特别在转基因的植物 overexpressing 被观察 miR319 抵抗的 TCP21。miR319 的 RRSV 感染和 overexpression 在米饭与 JA 生合成和信号相关的基因的 downregulated 表示一起引起了减少的内长的 jasmonic 酸(JA ) 层次。然而,有甲基 jasmonate 的米饭植物的治疗减轻了 RRSV 引起并且减少了病毒累积的疾病症状。一起拿,我们的结果建议由在米饭的 RRSV 感染的 miR319 的正式就职压制调停 JA 的防卫便于病毒感染和症状开发。 | Chao Zhang Zuomei Ding Kangcheng Wu Liang Yang Yang Li Zhen Yang Shan Shi Xiaojuan Liu Shanshan Zhao Zhirui Yang Yu Wang Luping Zheng Juan Wei Zhenguo Du Aihong Zhang Hongqin Miao Yi Li Zujian Wu Jianguo Wu | 2016 | Molecular Plant2016，9，9： | 27 |
| 2 | Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat显示文摘OBJECTIVE:To study on effects of Lichong decoction on expression of apoptosis-controlling genes,Bcl-2 and Bcl-2-associated X protein(Bax) mRNAs in hysteromyoma tissue of the hysteromyoma model rat.METHODS:Fifty Wistar female rats were randomly divided into a normal group,a model group,a Lichong decoction group,a Guizifuling capsule group and a Mifepristone group.The hysteromyoma rat model was established by intraperitoneal injection of exogenous estrin and progestogens.Pathological examination of uterine tissue,uterine coefficient and uterine transverse diameter were made under optic microscope and expressions of Bcl-2 and Bax mRNAs in uterine tissue in the groups were detected with real-time fluorescent quantitative polymerase chain reaction(PCR) technique.RESULTS:After treatment,under microscope it was found that in the Lichong decoction group myometrium thinned,muscle fiber slightly overgrowth or long and thin,regular arrangement,inserting phenomenon of inner circular muscle and external longitudinal muscle was occasionally or not seen in the Lichong decoction group.The uterine coefficient and the uterine transverse diameter significantly decreased(P<0.01),and Bcl-2 mRNA expression significantly decreased(P<0.01) and Bax mRNA expression significantly increased in hysteromyoma tissue(P<0.01) in the Lichong decoction group as compared with the model group.CONCLUSION:Therapeutic effects of Lichong decoction on hysteromyoma is related with decrease of Bcl-2 mRNA expression and increase of Bax mRNA expression. | Donghua Li Xin Xu Ruiya Qian Jianguo Geng Yan Zhang Xiaolei Xie Yasong Wang Xiaoli Zou | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 24 |
| 3 | Identification of long-range transport pathways and potential sources of PM2.5 and PM10 in Beijing from 2014 to 2015显示文摘Trajectory clustering, potential source contribution function(PSCF) and concentration-weighted trajectory(CWT) methods were applied to investigate the transport pathways and identify potential sources of PM_(2.5)and PM_(10) in different seasons from June 2014 to May 2015 in Beijing.The cluster analyses showed that Beijing was affected by trajectories from the south and southeast in summer and autumn. In winter and spring, Beijing was not only affected by the trajectories from the south and southeast, but was also affected by trajectories from the north and northwest. In addition, the analyses of the pressure profile of backward trajectories showed that backward trajectories, which have important influence on Beijing, were mainly distributed above 970 h Pa in summer and autumn and below 950 h Pa in spring and winter. This indicates that PM_(2.5)and PM_(10) were strongly affected by the near surface air masses in summer and autumn and by high altitude air masses in winter and spring. Results of PSCF and CWT analyses showed that the largest potential source areas were identified in spring, followed by winter and autumn,then summer. In addition, potential source regions of PM_(10) were similar to those of PM_(2.5). There were a clear seasonal and spatial variation of the potential source areas of Beijing and the airflow in the horizontal and vertical directions. Therefore, more effective regional emission reduction measures in Beijing's surrounding provinces should be implemented to reduce emissions of regional sources in different seasons. | Deping Li Jianguo Liu Jiaoshi Zhang Huaqiao Gui Peng Du Tongzhu Yu Jie Wang Yihuai Lu Wenqing Liu Yin Cheng | 2017 | Journal of Environmental Sciences2017，29，6： | 22 |
| 4 | A novel method for purification of recombinant adeno-associated virus vectors on a large scale显示文摘A novel method for recombinant adeno-associ-ated virus (rAAV) purification on large scale is described. The method involves three steps, including chloroform treatment, PEG/NaCl precipitation and chloroform extraction. The whole procedure can be performed in four hours. Using this purification method, we can reproducibly obtain, from 4 × 109 of proviral cells cultured in roller bottles, purified rAAV-GFP stocks with titers of around 5×1013 particles/mL and purity greater than 95%. The infectious titers of the vector stocks were up to 2×1012 TU/mL, thus particle-to-infectivity rate was about 25. Under an electronic microscope, most rAAV particles appeared full and a few were in intermediate form. Empty particles were rarely seen. The purified rAAV-GFP stocks have been successfully used in in vitro and in vivo transfection experiments. Therefore, this new method offers a simple, rapid and cost-effective way for large-scale rAAV purification. | WU Xiaobing DONG Xiaoyan WU Zhijian CAO Hui NIU Dongbin QU Jianguo WANG Hong HOU Yunde | 2001 | Chinese Science Bulletin2001，46，6： | 21 |
| 5 | An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation显示文摘 | Rong Peijing Liu Aihua Zhang Jianguo Wang Yuping Yang Anchao Li Liang Ben Hui Li Liping Liu Rupeng He Wei Liu Huanguang Huang Feng Li Xia Wu Peng Zhu Bing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 6 | Cold adaptation in pigs depends on UCP3 in beige adipocytes显示文摘 | Jun Lin Chunwei Cao Cong Tao Rongcai Ye Meng Dong Qiantao Zheng Chao Wang Xiaoxiao Jiang Guosong Qin Changguo Yan Kui Li John R. Speakman Yanfang Wang Wanzhu Jin Jianguo Zhao | 2017 | Journal of Molecular Cell Biology2017，9，5： | 20 |
| 7 | Mechanical mechanism of overlying strata breaking and development of fractured zone during close-distance coal seam group mining显示文摘This study mainly investigates the mechanical mechanism of overlying strata breaking and the development of fractured zones during close-distance coal seam group mining in the Gaojialiang coal mine.First,a mechanical model for the second'activation'of broken overlying strata is established,and the related mechanical'activation'conditions are obtained.A recursive formula for calculating the separation distance of overlying strata is deduced.Second,a height determining method for predicting the height of fractured zones during close-distance coal seam group mining is proposed based on two values,namely,the separation distance and ultimate subsidence value of overlying strata.This method is applied to calculate the fractured zone heights in nos.20107 and 20307 mining faces.The calculated results are almost equal to the field observation results.Third,a modified formula for calculating the height of a waterflowing fractured zone is proposed.A comparison of the calculated and observed results shows that the errors are small.The height determining method and modified formula not only build a theoretical foundation for water conservation mining at the Gaojialiang coal mine,but also provide a reference for estimating the height of water-flowing fractured zones in other coal mines with similar conditions. | Jianguo Ning Jun Wang Yunliang Tan Qiang Xu | 2020 | International Journal of Mining Science and Technology2020，30，2： | 19 |
| 8 | Geochemical changes across the Ordovician-Silurian transition on the Yangtze Platform,South China显示文摘The trace element and rare earth element(REE) variations across the Ordovician-Silurian succession are presented from two outcrop sections on the Yangtze Platform:the Nanbazi section,Guizhou Province,deposited in a shallow platform interior setting,and the Wangjiawan section,Hubei Province,deposited in a deeper basinal environment.Geochemical analysis of closely spaced samples through three intervals,the Wufeng,Guanyinqiao and Longmaxi,revealed vast palaeoceanographic changes.Some geochemical proxies,including Th/U,Ni/Co,V/Cr,and V/(V+Ni) ratios,together with sedimentary facies and biotic data,indicate that an anoxic condition on the most of the Yangtze Platform during the Wufeng and Longmaxi intervals,but an oxic condition during the Guanyinqiao time.The shift of the anoxic to the oxic environment during the Guanyinqiao time coincided with a global sea-level lowstand,in parallel with the global glaciation.The Longmaxian anoxic environment was a result of a global sea-level rise,which may be synchronized with a mainly catastrophic event in the latest Ordovician.Although the two sections generally show similar variation patterns of trace and REE concentrations and some element ratios,a minor difference occurs between the Wangjiawan and Nanbazi sections,likely reflecting a difference in depositional setting during the accumulation.Such an oceanic oxygen-level variation may add a useful constraint to the current arguments on the cause and consequence of the latest Ordovician mass extinction. | YAN DeTian CHEN DaiZhao WANG QingChen WANG JianGuo | 2009 | Science China Earth Sciences2009，52，1： | 17 |
| 9 | Nonlinear dynamic analysis of cantilevered piezoelectric energy harvesters under simultaneous parametric and external excitations显示文摘The nonlinear dynamics of cantilevered piezoelectric beams is investigated under simultaneous parametric and external excitations. The beam is composed of a substrate and two piezoelectric layers and assumed as an Euler–Bernoulli model with inextensible deformation. A nonlinear distributed parameter model of cantilevered piezoelectric energy harvesters is proposed using the generalized Hamilton's principle. The proposed model includes geometric and inertia nonlinearity, but neglects the material nonlinearity. Using the Galerkin decomposition method and harmonic balance method, analytical expressions of the frequency–response curves are presented when the first bending mode of the beam plays a dominant role. Using these expressions, we investigate the effects of the damping, load resistance, electromechanical coupling, and excitation amplitude on the frequency–response curves. We also study the difference between the nonlinear lumped-parameter and distributedparameter model for predicting the performance of the energy harvesting system. Only in the case of parametric excitation, we demonstrate that the energy harvesting system has an initiation excitation threshold below which no energy can be harvested.We also illustrate that the damping and load resistance affect the initiation excitation threshold. | Fei Fang Guanghui Xia Jianguo Wang | 2018 | Acta Mechanica Sinica2018，34，3： | 16 |
| 10 | Tea-Grown Soils and Tea Quality in Sichuan and Chongqing, China显示文摘Made teas and typical tea-grown soils in Sichuan and Chongqing were collected to investigate soil nutrients, related soil properties and tea quality. The tea-grown soils in Sichuan and Chongqing are distributed mainly in mountainous areas. The high annual precipitation (over 1100 mm), precipitous soil slopes, low cohesion among soil particles and high soil porosity suggested that intensive erosion and leaching might occur in these soils. Moreover, they were very acidic and poor in mineral nutrients such as N, P, K, Ca and Mg except S. The average content of total S was 20.40 g kg-1, much higher than that of organic matter in these soils, revealing that S in the tea-grown soils existed mainly in inorganic forms and very little in organic forms. Water-extractable S accounted for only a small amount of total S, which showed that most parts of sulfur in these soils were insoluble in W8ter. K and S varied greatly in made teas. The concentrations of N and P, however, varied little in these teas even though they differentiated significantly in the tea-grown soils. The high concentration of nitrogen in made teas could result in the high free amino acids and low polyphenol of teas. Significantly positive correlation was established between potassium and polyphenol in made teas. Teas with high ratio of phenol to free amino acids were usually good in taste and appearance. | YUAN LING, WANG SHOUSHENG, WANG ZHIHUI and HUANG JIANGUO (College of Resources and Environment, Southwest Agricultural University, Chongqing 400716 (China)) | 2000 | Pedosphere2000，10，1： | 16 |
| 11 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 12 | Synthesis of Alumina-Coated Natural Graphite for Highly Cycling Stability and Safety of Li-Ion Batteries显示文摘The natural graphite(NG)urdformly coated with alumina ceramics(Al2O3)was successfully synthesized through sol-gel method.The aluminum plastic film soft-packed battery prepared using Al2O3-coated NG as anode material exhibits excellent cycle performance and safety performance.The cycling retention of AN-1 is 84.95% after 200 cycles at a rate of 1 C in a potential window ranging from 3.0 to 4.35 V,which is much greater than 75.07% of NG under the same test conditions.The result of the nail penetration tests shows that the successful nail penetration rate of the NG used as anode is 0%,while that of Al2O3 coated samples AN-1 is 100%.The test results show that the Al2O3 coating could act as a solid electrolyte to suppress side reactions,improve cycle stability,and prevent a thermal runaway under mechanical abuse. | Tao Xu Chengkun Zhou Haihui Zhou Zekun Wang Jianguo Ren | 2019 | Chinese Journal of Chemistry2019，37，4： | 13 |
| 13 | Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus显示文摘 | Zhang Wei Wan Jianguo Qian Kejian Liu Xiaoqing Xiao Zuke Sun Jian Zeng Zhenguo Wang Qi Zhang Jinxiang Jiang Guanghui Nie Cheng Jiang Rong Ding Chengzhi Li Ran Horby Peter Gao Zhancheng | 2014 | Chinese Medical Journal2014，，18： | 12 |
| 14 | Experimental investigation of penetration performance of shaped charge into concrete targets显示文摘为了开发一个双人脚踏车弹头,那能有效地破坏具体目标,这篇论文借助于实验与不同的锥角度和班机材料探索塑造的费用的穿入表演进具体目标。穿入过程和由塑造的费用和动能射弹的具体目标的破坏机制被分析并且比较。试验性的结果建议运动精力充沛的射弹和塑造的充电能够破坏损坏的具体目标,而是大小是不同的。与动能射弹相比,塑造的费用有穿入的更多的重要效果进目标,并且引起很大的 spalling 区域。因此,塑造的费用对双人脚踏车弹头的第一阶段的充电相当合适。当洞直径变得更大时,随塑造的费用班机锥角度的增加,穿入的深度逐渐地减少,这也被发现。有铜班机的穿入深度比铝班机大,但是洞直径相对更小,并且有钢班机的塑造的起诉在上述二诉讼之间。有 100 °的一个锥角度的塑造的费用能形成喷气射弹费用(JPC ) 。与 JPC,有具体目标上的最佳深度和直径的一个洞能被形成,它保证秒阶段弹头顺利渗透进洞并且在最佳深度爆炸在具体目标完成破坏的需要的水平。 | Cheng Wang Tianbao Ma Jianguo Ning | 2008 | Acta Mechanica Sinica2008，24，3： | 12 |
| 15 | Experiment Research on Fouling Resistance Grey Forecast Model for Circulating Water in Electromagnetic Field显示文摘以自行设计的实验平台为基础,通过获得的不同频率电磁场作用下实验管的污垢热阻及水质参数,建立了电磁场作用下循环水污垢热阻的新陈代谢不等时距加权预测模型和拓灰色预测模型。利用实验数据分析了2种模型的预测精度,拓灰色预测模型较不等时距加权预测模型预测精度更高,计及实验不确定度,预测结果表明2种模型的预测精度均在92%以上,能较精确预测污垢热阻的变化趋势,适应水质参数及环境的变化,为建立多水质参数的数学模型及探索电磁抑垢机制提供参考。 | WANG Jianguo LIU Gaosheng SUN Wei | 2013 | 中国电机工程学报2013，33，11： | 12 |
| 16 | Lichong decoction reduces Matrix Metalloproteinases-2 expression but increases Tissue Inhibitors of Matrix Metalloproteinases-2 ex-pression in a rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong decoction(LD) on expression of matrix metalloproteinase-2(MMP-2) and metalloproteinase-2(TIMP-2) in a rat model of uterine leiomyoma(UL).METHODS:UL was induced in rats using exogenous estrogen and progesterone.LD was administered(p.o.) for 4 weeks,and mifepristone(RU-486)used as a control.To observe the effect of LD on the uterine coefficient and uterine transverse diameter,a radioimmunoassay method was used to detect serum levels of sex hormones.Light microscopic analyses of pathologic changes in the tissues of UL rats were evaluated.Expression of the proteins of matrix metalloproteinases(MMPs) and tissue inhibitors of metalloproteinases(TIMPs) in uterine tissues was assessed by immunohistochemical staining and western blotting.RESULTS:A UL model in rats was established successfully.LD reduced uterine weight,uterine coefficient,and uterine transverse diameter compared with untreated controls.LD reduced levels of estradiol,progesterone,follicle-stimulating hormone,and luteinizing hormone in our UL models.LD improved the pathologic condition of uterine muscle.Expression of MMP-2 protein decreased to varying extents in LD-treated groups,but TIMP-2 levels were enhanced.LD appears to reduce MMP-2 expression and increase TIMP-2 expression in UL tissue.CONCLUSION:These data suggest that the mechanism of action of LD on ULs may involve reduction of MMP-2 expression and increase in TIMP-2 expression in rats. | Wang Yasong Li Donghua Xu Xin Qian Ruiya Zhang Yalan Huang Yuhua Geng Jianguo Zou Xiaoli Han Hon-gjuan Zhang Wufang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 12 |
| 17 | Haze insights and mitigation in China: An overview显示文摘The present article provides an overview of the chemical and physical features of haze in China, focusing on the relationship between haze and atmospheric fine particles, and the formation mechanism of haze. It also summarizes several of control technologies and strategies to mitigate the occurrence of haze. The development of instruments and the analysis of measurements of ambient particles and precursor concentrations have provided important information about haze formation. Indeed, the use of new instruments has greatly facilitated current haze research in China. Examples of insightful results include the relationship between fine particles and haze, the chemical compositions and sources of particles, the impacts of the aging process on haze formation, and the application of technologies that control the formation of haze. Based on these results, two relevant issues need to be addressed: understanding the relationship between haze and fine particles and understanding how to control PM2.5. | Xuliang Zhuang Yuesi Wang Hong He Jianguo Liu Xinming Wang Tingyu Zhu Maofa Ge Ju Zhou Guiqian Tang Jinzhu Ma | 2014 | Journal of Environmental Sciences2014，26，1： | 12 |
| 18 | Influence of desert sand on the mechanical properties of concrete subjected to impact loading显示文摘A74-mm-diameter Split Hopkinson pressure bar was used to carry out the dynamic compression experiment of concrete made of desert sand.The dynamic failure processes of concrete different in specimen size,impact velocity,desert sand replacement ratio,size and volume content of coarse aggregate were simulated.Research results showed that concrete made of desert sand had size-effect and was rate-dependent.The peak stress of concrete made of desert sand declined with the minimum size of coarse aggregate.However,the peak stress of concrete made of desert sand increased first,and then declined with the volume content and maximum size of coarse aggregate. | Liu Haifeng Ma Jurong Wang Yiying Ning Jianguo | 2017 | Acta Mechanica Solida Sinica2017，30，6： | 12 |
| 19 | A new contact material—Ag/SnO_2-La_2O_3-Bi_2O_3显示文摘A super-fine compound powder,Ag/SnO2+La2O3+Bi2O3,has been obtained using the chemical coprecipitation method.And a new contact material,Ag/SnO2+La2O3+Bi2O3,was produced by the powder metallurgy method.Its properties are as follows:the density is 9.75-9.93g/cm^3,the resistivity is 2.31-2.55μΩ.cm.the hardness is 880-985 MPa.Its microstructure shows that the fine oxides have a uniform distribution in the silver matrix.The results of make-break capacity and temperature rise testing show that the new material has better ability of anti-arc erosion and lower temperature rise than that of commonly used Ag/CdO. | LU Jianguo, WANG Jingqin, ZHAO Jingying, WEN Ming, WANG Baozhu, and WANG XiaohongInstitute of Electrical Apparatus, Hebei University of Technology, Tianjin, 300130, China | 2002 | Rare Metals2002，21，4： | 12 |
| 20 | Effect of Lichong Decoction on expression of IGF-I and proliferating cell nuclear antigen mRNA in rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong Decoction(Lichong Decoction for strengthening anti-pathogenic Qi and eliminating blood stasis) on the expression of insulin-like growth factor-I(IGF-I) and proliferating cell nuclear antigen(PCNA) mRNA in a rat model of uterine leiomyoma.METHODS:Fifty female Wistar rats were randomized into a normal control group,model group,Lichong Decoction group,Guizhifuling Capsule(Capsule containing Cassia Twig and Poria) group,and Mifepristone group.The uterine leiomyoma model was established by peritoneal injections of exogenous estrogen and progesterone hormone.The ultrastructural changes in cells of rat uterine tissues were observed with transmission electron microscopy,and the expression of IGF-I and PCNA mRNA was detected by real-time fluorescent quantitative PCR.RESULTS:Following treatment,cells in the Lichong Decoction group appeared to be arranged normally,the cellular morphology were almost in a normal state,hyperplasia and hypertrophy of the chondriosome was reduced,collagen fibers were arranged in a regular manner,without obvious hyperplasia,and the expression of IGF-I and PCNA mRNA was significantly decreased compared with the model group(P<0.01).CONCLUSIONS:The effect of Lichong Decoction on uterine leiomyoma is related to its function in reducing the expression of IGF-I and PCNA mRNA. | Donghua Li Yalan Zhang Hongjuan Han Jianguo Geng Xiaolei Xie Jiubo Zheng Yasong Wang Xiaoli Zou | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
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