|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | 石英ESR测年信号衰退特征研究进展显示文摘电子自旋共振(ESR)测年法是第四纪地质年代学的重要测试方法之一,其测年范围广,特别是对于20万年至百万年尺度的第四纪样品有着重要意义。准确测量古剂量是影响ESR测年法精度和可信度的重要因素之一,而掌握ESR信号衰退特征及机制是获得准确、可信古剂量的重要前提。ESR测年法适用的地质样品种类较多,如热液石英脉、地质断层泥、水系沉积物等,不同样品的ESR信号衰退特征和机制有较大差异。近年来,国内外学者针对不同地质样品中石英ESR信号的衰退特征和机制深入开展了一系列的实验室模拟和野外观测研究,取得了诸多新认识。回顾了近年来在石英ESR信号衰退特征领域取得的进展,特别是水系沉积物石英ESR信号的衰退特征,并展望了这一领域的未来工作重点。 | 刘春茹 尹功明 Rainer Grün | 2013 | 地球科学进展2013，28，1： | 17 |
| 3 | Climate Change, Risk and Grain Yields in China显示文摘Adopting Just and Pope (1978, 1979) style yield functions, this paper proposes a method to analyze the impacts of regional climate change on grain production in China. We find that changes in climate will affect grain production in North and South China differently. Specifically, it emerges that a 1℃ increase in annual average temperature could reduce national grain output by 1.45% (1.74% reduction in North China and 1.19% reduction in South China), while an increase in total annual precipitation of around 100 mm could increase national grain output by 1.31% (3.0% increase in North China and 0.59% reduction in South China). | Rainer Holst Xiaohua Yu Carola Grün | 2013 | Journal of Integrative Agriculture2013，12，7： | 14 |
| 4 | Long-term effects of environmentally relevant concentrations of silver nanoparticles on microbial biomass, enzyme activity,and functional genes involved in the nitrogen cycle of loamy soil显示文摘The increasing production and use of engineered silver nanoparticles(AgNP) in industry and private households are leading to increased concentrations of AgNP in the environment. An ecological risk assessment of AgNP is needed, but it requires understanding the long term effects of environmentally relevant concentrations of AgNP on the soil microbiome. Hence, the aim of this study was to reveal the long-term effects of AgNP on soil microorganisms. The study was conducted as a laboratory incubation experiment over a period of one year using a loamy soil and AgNP concentrations ranging from 0.01 to 1 mg AgNP/kg soil. The short term effects of AgNP were, in general, limited.However, after one year of exposure to 0.01 mg AgNP/kg, there were significant negative effects on soil microbial biomass(quantified by extractable DNA; p = 0.000) and bacterial ammonia oxidizers(quantified by amo A gene copy numbers; p = 0.009). Furthermore, the tested AgNP concentrations significantly decreased the soil microbial biomass, the leucine aminopeptidase activity(quantified by substrate turnover; p = 0.014), and the abundance of nitrogen fixing microorganisms(quantified by nif H gene copy numbers; p = 0.001). The results of the positive control with Ag NO3 revealed predominantly stronger effects due to Ag+ion release. Thus, the increasing toxicity of AgNP during the test period may reflect the long-term release of Ag+ions. Nevertheless, even very low concentrations of AgNP caused disadvantages for the microbial soil community, especially for nitrogen cycling, and our results confirmed the risks of releasing AgNP into the environment. | Anna-Lena Grün Susanne Straskraba Stefanie Schulz Michael Schloter Christoph Emmerling | 2018 | Journal of Environmental Sciences2018，30，7： | 7 |
| 5 | Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis显示文摘 | Stefan Grün Julia Schumm Simon Greulich Anja Wagner Steffen Schneider Oliver Bruder Eva-Maria Kispert Stephan Hill Peter Ong Karin Klingel Reinhardt Kandolf Udo Sechtem Heiko Mahrholdt | 2012 | Journal of the American College of Cardiology2012，，18： | 2 |
| 6 | Prognostic relevance of minimal residual disease in colorectal cancer显示文摘Presence of occult minimal residual disease in patients with colorectal cancer(CRC)has a strong prognostic impact on survival.Minimal residual disease plays a major role in disease relapse and formation of metastases in CRC.Analysis of circulating tumor cells(CTC)in the blood is increasingly used in clinical practice for disease monitoring of CRC patients.In this review article the role of CTC,disseminated tumor cells(DTC)in the bone marrow and micrometastases and isolated tumor cells(ITC)in the lymph nodes will be discussed,including literature published until September 2013.Occult disease is a strong prognostic marker for patient survival in CRC and defined by the presence of CTC in the blood,DTC in the bone marrow and/or micrometastases and ITC in the lymph nodes.Minimal residual disease could be used in the future to identify patient groups at risk,who might benefit from individualized treatment options. | Ulrich Bork Robert Grützmann Nuh N Rahbari Sebastian Schlch Marius Distler Christoph Reissfelder Moritz Koch Jürgen Weitz | 2014 | World Journal of Gastroenterology2014，20，30： | 2 |
| 7 | 儿童通过2年校园基础计划形成的预期信念和主观任务值及其与体育课喜爱程度和体力活动的关系(英文)显示文摘目的:本研究旨在分析通过实施以'体力活动作为国民技能'计划形成的儿童预期信念与主观任务值模式,并探索其与体育课程喜爱程度和体力活动总量相关联。方法:研究样本包含芬兰东北部3个小城镇的401名9-13岁儿童。这些儿童在五至七年级2年时间内接受校园基础体力活动培养计划。2012-2014年通过3个阶段的问卷调查获得数据。结果:该计划成功的预期信念和主观任务价值水平都相对较高且发展稳定,特别在预期信念、实现价值和成本方面,而兴趣值和实用价值在特定阶段内下降。男生普遍认为自己身体素质比别人更具竞争力,而且比女生更加重视体力活动课程。此外,学生报告参与的体力活动越多,越喜爱体育课程。结论:当前的计划包括通过采用心理及生理校园环境调整提高学生体力活动,本研究表明该计划是防止儿童预期信念和任务值水平下降的有效策略。 | Arto Gr?stén | 2016 | Journal of Sport and Health Science2016，5，4： | 2 |
| 8 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 9 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 10 | Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys显示文摘 | Morin N Gr~ goire L Gomez-Mancilla B | 2010 | Neuropharmacology2010，58，7： | 1 |
| 11 | Slope stability analysis by finite elements显示文摘 | GR I F F I T H S D V L A N E P A | 1999 | Geotechnique1999，49，38： | 1 |
| 12 | Relationship between infective load of Helicobacter pyliri and reactive oxygen metabolite production in antral mucosa显示文摘 | Banatvala N Collins CE Sheaff MT | 1994 | Scand J Gastroenterol1994，29，1： | 1 |
| 13 | Review article : current treatment options and management of functional dyspepsia 显示文摘 | Lacy BE TaUey N J Locke GR | 2012 | Alimentary pharmacology & therapeutics2012，36，1： | 1 |
| 14 | The p21 Cdk interacting proteinCipl is a potent inhibitor of G1 cyclin dependent kinases 显示文摘 | Harper JW Adami GR Wei N | 1993 | Cell1993，75，： | 1 |
| 15 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 16 | R- esponse of thymectomy: clinical and pathological characteristics among seronegative and seropositive myasthenia gravis patients 显示文摘 | Guillermo GR Tfillez Zenteno JF Weder Cisneros N | 2004 | Acta Neurol Scand2004，109，3： | 1 |
| 17 | External assessment of the Early Mortality Risk Score in patients with adenocareinoma under- going panereaticoduodenectomy 显示文摘 | Joliat GR Petennann D Demartines N | 2015 | HPB ( Oxford )2015，17，7： | 1 |
| 18 | Novel associa- tions with dyspepsia: A community-based study of familial aggrega- tion, sleep dysfunction and somatization 显示文摘 | GATHAIYA N LOCKE GR GAMILLERI M | 2009 | Neurogastroenterol Mo- til2009，21，9： | 1 |
| 19 | Isolation of epsilon-haemoglobin-chain positive fetal cells with micromanipulation for prenatal diagnosis显示文摘 | Nagy GR Bán Z Sipos F | 2005 | Prenat Diagn2005，25，14： | 1 |
| 20 | Impact of initiating carvedilol before angiotensin-converting enzyme inhibitor therapy on cardiac function in newly diagnosed heart failure显示文摘 | Sliwa K Norton GR Kone N | 2004 | J Am Coll Cardiol2004，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员