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| 1 | Lightweight,Flexible Cellulose-Derived Carbon Aerogel@Reduced Graphene Oxide/PDMS Composites with Outstanding EMI Shielding Performances and Excellent Thermal Conductivities显示文摘In order to ensure the operational reliability and infor-mation security of sophisticated electronic components and to protect human health,efficient electromagnetic interference(EMI)shielding materials are required to attenuate electromagnetic wave energy.In this work,the cellulose solution is obtained by dissolving cotton through hydrogen bond driving self-assembly using sodium hydroxide(NaOH)/urea solution,and cellulose aerogels(CA)are prepared by gelation and freeze-drying.Then,the cellulose carbon aerogel@reduced graphene oxide aerogels(CCA@rGO)are prepared by vacuum impregnation,freeze-drying followed by thermal annealing,and finally,the CCA@rGO/polydimethylsiloxane(PDMS)EMI shielding composites are prepared by backfilling with PDMS.Owing to skin-core structure of CCA@rGO,the complete three-dimensional(3D)double-layer con-ductive network can be successfully constructed.When the loading of CCA@rGO is 3.05 wt%,CCA@rGO/PDMS EMI shielding composites have an excellent EMI shielding effectiveness(EMI SE)of 51 dB,which is 3.9 times higher than that of the co-blended CCA/rGO/PDMS EMI shielding composites(13 dB)with the same loading of fillers.At this time,the CCA@rGO/PDMS EMI shielding composites have excellent thermal stability(T_(HRI) of 178.3℃)and good thermal conductivity coefficient(λ of 0.65 W m^(-1) K^(-1)).Excellent comprehensive performance makes CCA@rGO/PDMS EMI shielding composites great prospect for applications in lightweight,flexible EMI shielding composites. | Ping Song Bei Liu Chaobo Liang Kunpeng Ruan Hua Qiu Zhonglei Ma Yongqiang Guo Junwei Gu | 2021 | Nano-Micro Letters2021，13，6： | 19 |
| 2 | Quercetin alleviates high glucose-induced Schwann cell damage by autophagy显示文摘Quercetin can reverse high glucose-induced inhibition of neural cell proliferation, and therefore may have a neuroprotective effect in diabetic peripheral neuropathy. It is difficult to obtain primary Schwann cells and RSC96 cells could replace primary Schwann cells in studies of the role of autophagy in the mechanism underlying diabetic peripheral neuropathy. Here, we show that under high glucose conditions, there are fewer autophagosomes in immortalized rat RSC96 cells and primary rat Schwann cells than under control conditions, the proliferative activity of both cell types is significantly impaired, and the expression of Beclin-1 and LC3, the molecular markers for autophagy, is significantly lower. After intervention with quercetin, the autophagic and proliferative activity of both cell types is rescued. These results suggest that quercetin can alleviate high glucose-induced damage to Schwann cells by autophagy. | Ling Qu Xiaochun Liang Bei Gu Wei Liu | 2014 | Neural Regeneration Research2014，9，12： | 14 |
| 3 | A Multi-center,Randomized,Controlled and Open Clinical Trial of Heyan Kuntai Capsule (和颜坤泰胶囊) and Hormone Therapy in Perimenopausal Women显示文摘Objective: To evaluate the efficacy and safety of Heyan Kuntai Capsule(和颜坤泰胶囊, HYKT) and hormone therapy(HT) on perimenopausal syndromes(PMSs). Methods: From 2005 to 2008, 390 women with PMSs were recruited from 4 clinic centers. The inclusion criteria included ages 40 to 60 years, estradiol(E2) below 30 ng/L, and follicle stimulating hormone(FSH) above 40 IU/L, etc. The patients were randomly assigned to HYKT group or HT group by random number table method, administrated HYKT or conjugated estrogen with/without medroxyprogesterone acetate tablets for 12 months. During treatment, the patients were interviewed quarterly, Kupperman Menopausal Index(KMI) scores, hot flush scores, insomnia scores, Menopause-Specific Quality of Life(MENQOL) scores and adverse effects were used for evaluating drug efficacy and safety respectively. The last interview was made at the end of 12-month treatment. Results: After treatment, KMI scores of HYKT group and HT group were both significantly decreased compared with baseline(P<0.01) and there was no significant difference between groups(P>0.05), except that KMI of HYKT group was higher after 3-month treatment(P<0.05). After treatment, hot flush and insomnia scores were both improved significantly in two groups(P<0.01); and HT had a better performance than HYKT in improving hot flush(P<0.05). MENQOL were significantly improved in both groups after treatment(P<0.01); but there was no significant difference between two groups(P>0.05). The incidence of adverse event in the HYKT group was much lower than that in the HT group(P<0.01). Conclusions: HYKT could effectively relieve PMSs and improve patient quality of life without severe adverse reactions. Although HYKT exerted curative effects more slowly than hormone, it possessed better safety profile than hormone. | SUN Ai-jun WANG Ya-ping GU Bei ZHENG Ting-ping LIN Shou-qing BAI Wen-pei WEI Yang ZHANG Shao-fen ZHANG Ying | 2018 | Chinese Journal of Integrative Medicine2018，24，7： | 11 |
| 4 | Features and origin time of Mesozoic strike-slip structures in the Yilan-Yitong Fault Zone显示文摘The NE-striking Yilan-Yitong Fault Zone(YYFZ) with a length of ca. 900 km is an important major fault zone in northeastern China. Its origin has been a controversial issue for a long time. Detailed field investigation and comprehensive analyses show that strike-slip faults or ductile shear belts exist as the origination structures on the both shoulders of the Cretaceous-Paleogene grabens. These strike-slip structures are dominated by brittle transcurrent faults, and appear as ductile shear belts only in the Weiyuanpu-Yehe and Shulan parts in the south and middle of the fault zone, respectively. The shear belts strike NE-SW and show steep mylonitic foliation and gentle mineral elongation lineation. Outcrop structures, microstructures and quartz c-axis fabrics demonstrate a sinistral shear sense with minor reverse component for the ductile shear belts. The microstructures suggest deformation temperatures of 400–450°C for the Weiyuanpu-Yehe shear belts and 350–400°C for the Shulan shear belt. A series of zircon U-Pb dating results for deformed and undeformed plutons or dikes in the shear belts constrain the strike-slip motion to the time between 160 and 126 Ma. It is further inferred from ages of main geological events in this region that the fault zone originated in the earliest Early Cretaceous. It is suggested therefore that the southern and middle parts of the Tan-Lu Fault Zone, which originated in Middle Triassic, propagated into northeastern China along the sinistral YYFZ under the earliest Early Cretaceous regional compression that is referred to as the Yanshan B event. The earliest Early Cretaceous initiation of the YYFZ results from both the high-speed oblique subduction of the Izanagi Plate and the final closure of the Mongol-Okhotsk Ocean, but the Izanagi Plate subduction played a major dynamic role in the fault zone origin. | GU ChengChuan ZHU Guang ZHAI MingJian LIN ShaoZe SONG LiHong LIU Bei | 2016 | Science China(Information Sciences)2016，59，12： | 10 |
| 5 | Research of multilayers in EUV, soft X-ray and X-ray显示文摘To develop beam splitters for soft X-ray laser Michelson interferometer at 13.9 nm, Mo/Si multilayers of 100 nm thickness deposited on both sides of silicon nitride were fabricated by using DC magnetron sputtering. Initial evaluation of their reflectivity and transmission showed that reflectivity and transmission were above 10% and 25%. The broadband analyzers have been designed, fabricated and characterized for 13~20 nm polarization measurements. The measured results are in good agreement with the design. The supermirrors with different angular intervals at 0.154 nm have been designed, fabricated and characterized. | WANG Zhan-shan WANG Feng-li ZHANG Zhong WANG Hong-chang WU Wen-juan ZHANG Shu-min XU Yao GU Zhong-xiang CHENG Xin-bin L1 Cun-xia WU Yong-rong WANG Bei QIN Shu-jin CHEN Ling-yan | 2005 | 光学精密工程2005，13，4： | 6 |
| 6 | Porous Pt nanoframes decorated with Bi(OH)3 as highly efficient and stable electrocatalyst for ethanol oxidation reaction显示文摘High-quality Pt-based catalysts are highly desirable for ethanol oxidation reaction(EOR),which is of critical importance for the commercial applications of direct ethanol fuel cells(DEFCs).However,most of the Pt-based catalysts have suffered from high cost and low operation durability.Herein a two-step method has been developed to synthesize porous Pt nanoframes decorated with Bi(OH)3,which show excellent catalytic activity and operation durability in both alkaline and acidic media.For example,the nanoframes show a mass activity of 6.87 A·mgPt−1 in alkaline media,which is 13.5-fold higher than that of commercial Pt/C.More importantly,the catalyst can be reactivated simply,which shows negligible activity loss after running for 180,000 s.Further in situ attenuated total reflection-infrared(ATR-IR)absorption spectroscopy and CO-stripping experiments indicate that surface Bi(OH)3 species can greatly facilitate the formation of adsorbed OH species and subsequently remove carbonaceous poison,resulting in a significantly enhanced stability towards EOR.This work may favor the tailoring of desired electrocatalysts with high activity and durability for future commercial application of DEFCs. | Xiaolei Yuan Bei Jiang Muhan Cao Congyang Zhang Xiaozhi Liu Qinghua Zhang Fenglei Lyu Lin Gu Qiao Zhang | 2020 | Nano Research2020，13，1： | 3 |
| 7 | Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer:Results from 24 hospitals in China显示文摘BACKGROUND Whether regional lymphadenectomy(RL)should be routinely performed in patients with T1b gallbladder cancer(GBC)remains a subject of debate.AIM To investigate whether RL can improve the prognosis of patients with T1b GBC.METHODS We studied a multicenter cohort of patients with T1b GBC who underwent surgery between 2008 and 2016 at 24 hospitals in 13 provinces in China.The logrank test and Cox proportional hazards model were used to compare the overall survival(OS)of patients who underwent cholecystectomy(Ch)+RL and those who underwent Ch only.To investigate whether combined hepatectomy(Hep)improved OS in T1b patients,we studied patients who underwent Ch+RL to compare the OS of patients who underwent combined Hep and patients who did not.RESULTS Of the 121 patients(aged 61.9±10.1 years),77(63.6%)underwent Ch+RL,and 44(36.4%)underwent Ch only.Seven(9.1%)patients in the Ch+RL group had lymph node metastasis.The 5-year OS rate was significantly higher in the Ch+RL group than in the Ch group(76.3%vs 56.8%,P=0.036).Multivariate analysis showed that Ch+RL was significantly associated with improved OS(hazard ratio:0.51;95%confidence interval:0.26-0.99).Among the 77 patients who underwent Ch+RL,no survival improvement was found in patients who underwent combined Hep(5-year OS rate:79.5%for combined Hep and 76.1%for no Hep;P=0.50).CONCLUSION T1b GBC patients who underwent Ch+RL had a better prognosis than those who underwent Ch.Hep+Ch showed no improvement in prognosis in T1b GBC patients.Although recommended by both the National Comprehensive Cancer Network and Chinese Medical Association guidelines,RL was only performed in 63.6%of T1b GBC patients.Routine Ch+RL should be advised in T1b GBC. | Tai Ren Yong-Sheng Li Xue-Yi Dang Yang Li Zi-Yu Shao Run-Fa Bao Yi-Jun Shu Xu-An Wang Wen-Guang Wu Xiang-Song Wu Mao-Lan Li Hong Cao Kun-Hua Wang Hong-Yu Cai Chong Jin Hui-Han Jin Bo Yang Xiao-Qing Jiang Jian-Feng Gu Yun-Fu Cui Zai-Yang Zhang Chun-Fu Zhu Bei Sun Chao-Liu Dai Lin-Hui Zheng Jing-Yu Cao Zhe-Wei Fei Chang-Jun Liu Bing Li Jun Liu Ye-Ben Qian Yi Wang Ya-Wei Hua Xi Zhang Chang Liu Wan-Yee Lau Ying-Bin Liu | 2021 | World Journal of Gastrointestinal Surgery2021，13，2： | 3 |
| 8 | Site-directed mutagenesis identified the key active site residues of alcohol acyltransferase PpAAT1 responsible for aroma biosynthesis in peach fruits显示文摘The aroma of peach fruit is predominantly determined by the accumulation of γ-decalactone and ester compounds.A previous study showed that the biosynthesis of these aroma compounds in peach fruit is catalyzed by PpAAT1,an alcohol acyltransferase.In this work,we investigated the key active site residues responsible for γ-decalactone and ester biosynthesis.A total of 14 candidate amino acid residues possibly involved in internal esterification and 9 candidate amino acid residues possibly involved in esterification of PpAAT1 were assessed via site-directed mutagenesis.Analyses of the in vitro enzyme activities of PpAAT1 and its site-directed mutant proteins(PpAAT1-SMs)with different amino acid residue mutations as well as the contents of γ-decalactone in transgenic tobacco leaves and peach fruits transiently expressing PpAAT1 and PpAAT1-SMs revealed that site-directed mutation of H165 in the conserved HxxxD motif led to lost enzymatic activity of PpAAT1 in both internal esterification and its reactions,whereas mutation of the key amino acid residue D376 led to the total loss ofγ-decalactone biosynthesis activity of PpAAT1.Mutations of 9 and 7 other amino acid residues also dramatically affected the enzymatic activity of PpAAT1 in the internal esterification and esterification reactions,respectively.Our findings provide a biochemical foundation for the mechanical biosynthesis ofγ-decalactone and ester compounds catalyzed by PpAAT1 in peach fruits,which could be used to guide the molecular breeding of new peach species with more favorable aromas for consumers. | Zhi-Zhong Song Bin Peng Zi-Xia Gu Mei-Ling Tang Bei Li Mei-Xia Liang Li-Min Wang Xiao-Tong Guo Jian-Ping Wang Yu-Fen Sha Hong-Xia Zhang | 2021 | Horticulture Research2021，8，1： | 3 |
| 9 | Pharmacokinetic interactions between 20(S)- ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo显示文摘 | Jian SHI Bei CAO Wei-bin ZHA Xiao-lan WU Lin-sheng LIU Wen-jing XIAO Rong-rong GU Run-bin SUN Xiao-y YU Tian ZHENG Meng-jie LI Xin-wen WANG Jun ZHOU Yong MAO Chun GE Ting MA Wen-juan XIA Ji-ye AA Guang-ji WANG Chang-xiao LIU | 2013 | Acta Pharmacologica Sinica2013，34，10： | 3 |
| 10 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 11 | Ultrafast,accurate,and robust localization of anisotropic dipoles显示文摘The resolution of single molecule localization imaging techniques largely depends on the precision of localization algorithms.However,the commonly used Gaussian function is not appropriate for anisotropic dipoles because it is not the true point spread function.We derived the theoretical point spread function of tilted dipoles with restricted mobility and developed an algorithm based on an artifi cial neural network for estimating the localization,orientation and mobility of individual dipoles.Compared with fi tting-based methods,our algorithm demonstrated ultrafast speed and higher accuracy,reduced sensitivity to defocusing,strong robustness and adaptability,making it an optimal choice for both two-dimensional and threedimensional super-resolution imaging analysis. | Yongdeng Zhang Lusheng Gu Hao Chang Wei Ji Yan Chen Mingshu Zhang Lu Yang Bei Liu Liangyi Chen Tao Xu | 2013 | Protein & Cell2013，4，8： | 2 |
| 12 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 13 | Sleep-related symptoms in multiple system atrophy: determinants and impact on disease severity显示文摘Background: Sleep disorders are common but under-researched symptoms in patients with multiple system atrophy (MSA). We investigated the frequency and factors associated with sleep-related symptoms in patients with MSA and the impact of sleep disturbances on disease severity.Methods: This cross-sectional study involved 165 patients with MSA. Three sleep-related symptoms, namely Parkinson’s disease (PD)-related sleep problems (PD-SP), excessive daytime sleepiness (EDS), and rapid eye movement sleep behavior disorder (RBD), were evaluated using the PD Sleep Scale-2 (PDSS-2), Epworth Sleepiness Scale (ESS), and RBD Screening Questionnaire (RBDSQ), respectively. Disease severity was evaluated using the Unified MSA Rating Scale (UMSARS).Results: The frequency of PD-SP (PDSS-2 score of ≥18), EDS (ESS score of ≥10), and RBD (RBDSQ score of ≥5) in patients with MSA was 18.8%, 27.3%, and 49.7%, respectively. The frequency of coexistence of all three sleep-related symptoms was 7.3%. Compared with the cerebellar subtype of MSA (MSA-C), the parkinsonism subtype of MSA (MSA-P) was associated with a higher frequency of PD-SP and EDS, but not of RBD. Binary logistic regression revealed that the MSA-P subtype, a higher total UMSARS score, and anxiety were associated with PD-SP;that male sex, a higher total UMSARS score, the MSA-P subtype, and fatigue were associated with EDS;and that male sex, a higher total UMSARS score, and autonomic onset were associated with RBD in patients with MSA. Stepwise linear regression showed that the number of sleep-related symptoms (PD-SP, EDS, and RBD), disease duration, depression, fatigue, and total Montreal Cognitive Assessment score were predictors of disease severity in patients with MSA.Conclusions: Sleep-related disorders were associated with both MSA subtypes and the severity of disease in patients with MSA, indicating that sleep disorders may reflect the distribution and degree of dopaminergic/non-dopaminergic neuron degeneration in MSA. | Jun-Yu Lin Ling-Yu Zhang Bei Cao Qian-Qian Wei Ru-Wei Ou Yan-Bing Hou Kun-Cheng Liu Xin-Ran Xu Zheng Jiang Xiao-Jing Gu Jiao Liu Hui-Fang Shang | 2021 | Chinese Medical Journal2021，，6： | 2 |
| 14 | Improved Nitrogen Transport in Surface Nanocrystallized Low Carbon Steels during Gaseous Nitridation 显示文摘 | Gu J F Bei D H Pan J S | 2002 | Mater Lett2002，55，： | 1 |
| 15 | Saliva secreting functions in patients with TCM-Piyinxu显示文摘SalivasecretingfunctionsinpatientswithTCMPiyinxuGUANXueZhong,WEIMuXin,CHENDeZhen,GUYuChun,SUNZhenHeandBEIShuYingDepart... | GUAN Xue Zhong, WEI Mu Xin, CHEN De Zhen, GU Yu Chun, SUN Zhen He and BEI Shu Ying Department of Traditional Chinese Medicine, Zhongshan Staff Sanatorium, Nanjing 210014, China | 1997 | World Journal of Gastroenterology1997，3，3： | 1 |
| 16 | Improved nitrogen transport in surface nanocrystallized low-carbon steels during gaseous nitridation显示文摘 | Gu J F Bei D H Pan J S | 2002 | Materials Letters2002，55，： | 1 |
| 17 | Gaseous nitriding process of surface nanoerystallized (SNCed) steel显示文摘 | Bei Duohui Gu Jianfeng Pan Jiansheng | 2002 | J Mater Sci Techn2002，18，6： | 1 |
| 18 | hnproved nitrogen transport in surface nanocrystallized low-carbon steels during gaseous nitridation 显示文摘 | Gu J F Bei D H Lu K | 2002 | Materials Letters2002，55，5： | 1 |
| 19 | Necessary and sufficient conditions for boundedness of some commutators with weighted Lipschitz functions显示文摘 | Hu Bei Gu Jiajun | | 0，，01： | 1 |
| 20 | Improved nitrogen transport in surface nanocrystallized low-carbon steels during gaseous notarization显示文摘 | Gu J F Bei D H Lu K | 2002 | Materials Letters2002，55，： | 1 |
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