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| 1 | Impacts of exercise interventions on different diseases and organ functions in mice显示文摘Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they are related to special diseases or physiological status. To furtherunderstand the effects of exercise interventions in treating or preventing diseases, it is important to establish a template for exercise interventionsthat can be used in future exercise-related studies.Methods'. PubMed was used as the data resource for articles. To identify studies related to the effectiveness of exercise interventions for treatingvarious diseases and organ functions in mice, we used the following search language: (exercise [Title] OR training [Title] OR physical activity[Title]) AND (mice [title/abstract] OR mouse [title/abstract] OR mus [title/abstract]). To limit the range of search results, we included 2 filters:one that limited publication dates to 'in 10 years,^ and one that sorted the results as 'best match^^. Then we grouped the commonly used exercisemethods according to their similarities and differences. We then evaluated the effectiveness of the exercise interventions for their impact on diseasesand organ functions in 8 different systems.Results'. A total of 331 articles were included in the analysis procedure. The articles were then segmented into 8 systems for which the exerciseinterventions were used in targeting and treating disorders: motor system (60 studies), metabolic system (45 studies), cardio-cerebral vascularsystem (58 studies), nervous system (74 studies), immune system (32 studies), respiratory system (7 studies), digestive system (1 study), and thesystem related to the development of cancer (54 studies). The methods of exercise interventions mainly involved the use of treadmills, voluntarywheel-running, forced wheel-running, swimming, and resistance training. It was found that regardless of the specific exercise method used, mostof them demonstrated positive effects on various systemic diseases and organ functions. Most diseases were remitted with exercise regardless ofthe exercise method used, although some diseases showed the best remission effects when a specific method was used.Conclusion-. Our review strongly suggests that exercise intervention is a cornerstone in disease prevention and treatment in mice. Because exerciseinterventions in humans typically focus on chronic diseases, national fitness, and body weight loss, and typically have low intervention com・pliance rates, it is important to use mice models to investigate the molecular mechanisms underlying the health benefits from exerciseinterventions in humans. | Shanshan Guo Yiru Huang Yan Zhang He Huang Shangyu Hong Tiemin Liu | 2020 | Journal of Sport and Health Science2020，9，1： | 5 |
| 2 | 缺血适应:构建跨越基础与临床之间鸿沟的桥梁显示文摘本文综述了缺血适应:心肌保护研究的现状,着眼于梳理缺血适应的基础研究与临床研究之间存在的转化问题,富于启发性。 | Yibing Nong Yiru Guo Roberto Bolli | 2017 | 中华高血压杂志2017，25，12： | 1 |
| 3 | Mechanism of cyclooxygenase-2 upregulation in late preconditioning 显示文摘 | Xuan Yu-Ting Guo Yiru Zhu Yanqing | 2003 | J Mol Cell Cardiol2003，35，： | 1 |
| 4 | Improvement of mieroalgae harvesting by magnetic nanocomposites coated with polyethylenimine 显示文摘 | Hu YiRu Guo Chen Wang Feng | 2014 | Chemical Engineering Journal2014，242，11： | 1 |
| 5 | Evidence for an essential role of cyclooxygenase-2 as a mediator of the late phase of ischemic preconditioning in mice显示文摘 | Yiru Guo Weike Bao Wen-Jian Wu Ken Shinmura Xian-Liang Tang Roberto Bolli | 2000 | Basic Research in Cardiology2000，，6： | 1 |
| 6 | Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium显示文摘 | Adam B. Stein Roberto Bolli Buddhadeb Dawn Santosh K. Sanganalmath Yanqing Zhu Ou-Li Wang Yiru Guo Roberto Motterlini Yu-Ting Xuan | 2011 | Journal of Molecular and Cellular Cardiology2011，，1： | 1 |
| 7 | Core-shell-structured Co@Co4N nanoparticles encapsulated into MnO-modified porous N-doping carbon nanocubes as bifunctional catalysts for rechargeable Zn–air batteries显示文摘Designing the highly catalytic activity and durable bifunctional catalysts toward oxygen reduction/evolution reaction(ORR/OER) is paramount for metal–air batteries. Metal–organic frameworks(MOFs)-based materials have attracted a great deal of attention as the potential candidate for effectively catalyzing ORR/OER due to their adjustable composition and porous structure. Herein, we first introduce the Mn species into zeolitic-imidazole frameworks(ZIFs) and then further pyrolyze the Mn-containing bimetallic ZIFs to synthesize core-shell-structured Co@Co4N nanoparticles embedded into MnO-modified porous N-doped carbon nanocubes(Co@Co4N/MnO–NC). Co@Co4N/MnO–NC exhibits the outstanding catalytic activity toward ORR and OER which is attributed to its abundant pyridinic/graphitic N and Co4N,the optimized content of MnO species, highly dispersed catalytic sites and porous carbon matrix. As a result, the Co@Co4N/MnO–NC-based Zn–air battery exhibits enhanced performances, including the high discharge capacity(762 mA h gZn-1), large power density(200.5 mW cm-2), stable potential profile over 72 h, low overpotential(<1.0 V) and superior cycling life(2800 cycles). Moreover, the belt-shaped Co@Co4N/MnO–NC cathode-based Zn–air batteries are also designed which exhibit the superb electrochemical properties at different bending/twisting conditions. | Fengmei Wang Huimin Zhao Yiru Ma Yu Yang Bin Li Yuanyuan Cui Ziyang Guo Lei Wang | 2020 | Journal of Energy Chemistry2020，29，11： | 1 |
| 8 | Exploring the role of autophagy during early human embryonic development through single-cell transcriptome and methylome analyses显示文摘Early human embryogenesis is a very sophisticated process due to its unique gene regulatory network.Autophagy has been suggested to play an important role in mediating the development of early embryonic cells in mammals.However,evidence showing how autophagy regulates early human embryogenesis remains to be further explored.In this study,we systematically investigated the human transcriptome and methylome patterns of autophagy-related(ATG)genes in early embryonic cells at single-cell resolution.We analyzed the transcriptomic data of 365 cells and methylome data of 265 cells.The results showed that most ATG genes remained epigenetically active and were expressed stably throughout early embryogenesis,whereas the dynamics varied among different developmental stages.This evidence indicated that the autophagy pathway was constitutively activated and exerted a fundamental role in early human embryo development.Our work,for the first time,comprehensively reveals the features of autophagy during early human embryo development. | Shi Song Qianying Guo Yiru Zhu Peng Yuan Zhiqiang Yan Liying Yan Jie Qiao | 2022 | Science China(Life Sciences)2022，65，5： | 1 |
| 9 | The late phase of preconditioning and its natural clinical application—gene therapy显示文摘 | Roberto Bolli Qian-Hong Li Xian-Liang Tang Yiru Guo Yu-Ting Xuan Gregg Rokosh Buddhadeb Dawn | 2007 | Heart Failure Reviews2007，，3： | 1 |
| 10 | Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor-κB-Dependent Pathway显示文摘 | Qianhong Li Yiru Guo Wei Tan Qinghui Ou Wen-Jian Wu Diana Sturza Buddhadeb Dawn Greg Hunt Chuanjue Cui Roberto Bolli | 2007 | Circulation2007，，14： | 1 |
| 11 | Intracoronaryadministration of cardiacstem cells in mice: a new, improved technique for cell therapy in murine models显示文摘 | LI Qianghong GUO Yiru QU Qinghui | 2011 | Basic Res Cardiol2011，106，5： | 1 |
| 12 | The late phase of ischemic preconditioning induces a prosurvival genetic program that results in marked attenuation of apoptosis显示文摘 | Adam B. Stein Roberto Bolli Yiru Guo Ou-Li Wang Wei Tan Wen-Jian Wu Xiaoping Zhu Yanqing Zhu Yu-Ting Xuan | 2007 | Journal of Molecular and Cellular Cardiology2007，，6： | 1 |
| 13 | Numerical simulation of flash reduction in a drop tube reactor with variable temperatures显示文摘A computational fluid dynamics(CFD)model was developed to accurately predict the flash reduction process,which is considered an efficient alternative ironmaking process.Laboratory-scale experiments were conducted in drop tube reactors to verify the accuracy of the CFD model.The reduction degree of ore particles was selected as a critical indicator of model prediction,and the simulated and experimental results were in good agreement.The influencing factors,including the particle size(20–110μm),peak temperature(1250–1550°C),and reductive atmosphere(H_(2)/CO),were also investigated.The height variation lines indicated that small particles(50μm)had a longer residence time(3.6 s)than large particles.CO provided a longer residence time(~1.29 s)than H_(2)(~1.09 s).However,both the experimental and analytical results showed that the reduction degree of particles in CO was significantly lower than that in H2 atmosphere.The optimum experimental particle size and peak temperature for the preparation of high-quality reduced iron were found to be 50μm and 1350°C in H2 atmosphere,and40μm and 1550°C in CO atmosphere,respectively. | Yiru Yang Qipeng Bao Lei Guo Zhe Wang Zhancheng Guo | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，2： | 1 |
| 14 | Stromal Cell–Derived Factor-1α Confers Protection Against Myocardial Ischemia/Reperfusion Injury: Role of the Cardiac Stromal Cell–Derived Factor-1α–CXCR4 Axis显示文摘 | Xiaofeng Hu Shujing Dai Wen-Jian Wu Wei Tan Xiaoping Zhu Jingyao Mu Yiru Guo Roberto Bolli Gregg Rokosh | 2007 | Circulation2007，，6： | 1 |
| 15 | Angular Dependence of Critical Current in Ag-Seathed Bi(2223)-Superconductor Tape显示文摘The critical current Ic(B.T.)of Ag-slcatled Bi(223)tape was uuceasured at 4.2 and 77K in magnetic field up to CT as a function of the tield direction.The maximn Ie is observed when the fnx line are along the CuO:planes.This effect is due to an in trinsic pinning between CuO_(2) layers.When H>0.5 T at 4.2K.I_(c) decreascs very slowly with the mlaguetic field.The resnlts nre colusistent with our early-proposed scaling luws for flux pining in Ag-sheathed tape. | GUO Shuquan QIN Xiaonnei ZHANG Jinlong WU Zu'an YE Bin ZENG Roung ZHOU Yiru ZHOU Min | 1993 | Chinese Physics Letters1993，10，9： | 0 |
| 16 | MnO_(2) nanosheet modified N, P co-doping carbon nanofibers on carbon cloth as lithiophilic host to construct high-performance anodes for Li metal batteries显示文摘Lithium (Li) metal batteries have attracted much attention owing to its ultra-high energy density.However,as important part of Li metal batteries,Li anodes still face many challenges,mainly including uncontrolled dendritic Li formation,dramatical volume variation and serious pulverization.Herein,manganese dioxide (MnO_(2)) nanosheet modified nitrogen (N),phosphorus (P) co-doping carbon nanofibers(NPC) on carbon cloth (CC)(MnO_(2)@NPC-CC) is successfully fabricated through electrodeposition approach and further treated with Li by the molten-infusion method to prepare Li based Mn@NPC-CC(Li-Mn@NPC-CC) electrode.The synergy of MnO_(2) and NPC obviously increases the reaction rate between MnO_(2)@NPC-CC and Li and guides even Li distribution over infusion process.Additionally,theoretical calculation,simulation and experimental results further indicate that N,P,Mn multi-doping effectively improves the superior lithiophilicity of Li-Mn@NPC-CC,which induces uniform Li deposition/dissolution to suppress dendrite growth over cycles.Moreover,conductive and porous NPC matrix not only effectively improves the stability of Li-Mn@NPC-CC,but also provides abundant spaces to accelerate the transfer of ion/electron and buffer electrode dimension variation during cycling.Hence,Li-Mn@NPC-CC-based symmetric cells exhibit extra-long cycling life (over 2200 h) with small hysteresis of 20 mV.When the LiMn@NPC-CC anode couples with air,Li iron phosphate (LiFePO_(4)),or hard carbon (C) cathode,the assembled full cells exhibit outstanding performance with low hysteresis and stable cycling properties.Especially,the corresponding pouch-typed Li–air cells also exhibit good performance at different bending angles and even power a series of electronic devices. | Xiaoqiang Liu Qian Zhang Yiru Ma Zhenzhen Chi Huixiang Yin Jie Liu Junfei Huang Ziyang Guo Lei Wang | 2022 | Journal of Energy Chemistry2022，31，6： | 0 |
| 17 | Structural characteristics and hydrocarbon accumulation inBashituo area, Tarim Basin显示文摘According to well logs, core, seismic and other geological data, the authors studied the tectonic evolution stages, trap formation stages, fault and fracture development in the Bashituo area, and furthermore, analyzed the time of hydrocarbon accumulation, hydrocarbon migration pathways and related controversial issues in the study area. It is believed that the tectonic evolution in the study area can be divided into three stages, namely Late Hercynian, the Early Himalayan and the Late Himalayan. In the Late Hercynian, tectonic movement led to folding and faulting, resulting in the embryonic form of anticlinal traps. In the Early Himalayan, affected by both tectonic movement and transformation, deep faults reactivated and cut through the Lower Tertiary strata. After the Early Himalayan tectonic movement, faulting stopped and no vertical migration pathway was available . Then hydrocarbon migrated laterally along the sand bodies in the Bachu Formation and accumulated in the Carboniferous reservoirs. However, the Carboniferous accumulation was formed late, and the tectonic movement was weak at the Late Himalayan, and faults were underdeveloped, so the reservoirs in the deep Bachu Formation were not disturbed. | GUO Yiru YU Minghui LI Zongyu BAYAN Xianmutihan JIA Yudong WANG Xinyu | 2021 | Global Geology2021，24，3： | 0 |
| 18 | CHDTEPDB:Transcriptome Expression Profile Database and Interactive Analysis Platform for Congenital Heart Disease显示文摘CHDTEPDB(URL:http://chdtepdb.com/)is a manually integrated database for congenital heart disease(CHD)that stores the expression profiling data of CHD derived from published papers,aiming to provide rich resources for investigating a deeper correlation between human CHD and aberrant transcriptome expression.The develop-ment of human diseases involves important regulatory roles of RNAs,and expression profiling data can reflect the underlying etiology of inherited diseases.Hence,collecting and compiling expression profiling data is of critical significance for a comprehensive understanding of the mechanisms and functions that underpin genetic diseases.CHDTEPDB stores the expression profiles of over 200 sets of 7 types of CHD and provides users with more convenient basic analytical functions.Due to the differences in clinical indicators such as disease type and unavoidable detection errors among various datasets,users are able to customize their selection of corresponding data for personalized analysis.Moreover,we provide a submission page for researchers to submit their own data so that increasing expression profiles as well as some other histological data could be supplemented to the database.CHDTEPDB is a user-friendly interface that allows users to quickly browse,retrieve,download,and analyze their target samples.CHDTEPDB will significantly improve the current knowledge of expression profiling data in CHD and has the potential to be exploited as an important tool for future research on the disease. | Ziguang Song Jiangbo Yu Mengmeng Wang Weitao Shen Chengcheng Wang Tianyi Lu Gaojun Shan Guo Dong Yiru Wang Jiyi Zhao | 2023 | Congenital Heart Disease2023，18，6： | 0 |
| 19 | The highly dispersed Co-based nanoparticles encapsulated into porous N-doping carbon polyhedral with the low content of Ru modification as a promising cathode catalyst for long-life Li-O_(2)batteries显示文摘Lithium(Li)-O_(2)batteries have triggered worldwide interest due to their ultrahigh theoretical energy density.However,it is a long shot for the grand-scale applications of Li-O_(2)battery at current stage owing to its significant polarization,inferior cycling life,and irreversible decomposition of Li2O_(2).Herein,a facile way of preparing the highly dispersed Co-based nanoparticles encapsulated into porous N-doping carbon polyhedral with the low content of Ru modification(LRu@HDCo-NC)is explored through the pyrolysis of Co/Zn based zeolitic imidazole frameworks(ZIFs)containing Ru-based ligands.Even with the very small amount of Ru introduction(1.8%),LRu@HDCo-NC still exhibits the superior oxygen evolution reaction/oxygen reduction reaction(OER/ORR)performance and also inhibits side reactions in Li-O_(2)battery because of the abundant pores,plentiful surface N heteroatoms,and highly dispersed metal-based sites which are induced by the volatilization of Zn,and conductive/stable carbon skeleton derived from ZIFs.When applied in Li-O_(2)batteries,LRu@HDCo-NC cathode delivers a high discharge capacity of 15,973 mAh·g^(-1)at 200 mA·g^(-1),good capacity retention at higher rate(12,362 mAh·g^(-1)at 500 mA·g^(-1))and outstanding stability for>300 cycles with low voltage polarization of<2.3 V under a cut-off capacity of 1,000 mAh·g^(-1)at 500 mA·g^(-1).More critically,a series of ex situ and in situ characterization technologies disclose that the LRu@HDCo-NC cathodes can effectively promote the reversible reactions in Li-O_(2)batteries. | Yiru Ma Huiqi Qu Zhenzhen Chi Xiaoqiang Liu Yueqin Yu Ziyang Guo Lei Wang | 2022 | Nano Research2022，15，4： | 0 |
| 20 | Graphdiyne scaffold anchored highly dispersed ruthenium nanoparticles as an efficient cathode catalyst for rechargeable Li-CO_(2) battery显示文摘Lithium (Li)-CO_(2) battery is rising as an attractive energy-storage system with the competence of CO_(2) conversion/fixation. However, its practical development is seriously hindered by the high overpotential. Herein, a rational design on a highly catalytic Li-CO_(2) battery electrode built by graphdiyne powder as a multi-functional laminar scaffold with anchored highly dispersed Ru nanoparticles is explored. The strong interaction between the abundant acetylenic bond sites of graphdiyne scaffold and Ru nanoparticles can effectively promote the electrochemical progress and reduce the voltage polarization. The unique channels architecture of the cathodic catalyst with enough space not only accelerates CO_(2) diffusion and electrons/Li+ transport, but also allows a large amount of accommodation for discharged product (Li2CO3) to assure an advanced capacity. The corresponding Li-CO_(2) battery displays an advanced discharged capacity of 15,030 mAh/g at 500 mA/g, great capacity retention of 8873 mAh/g at 2 A/g, high coulombic efficiency of 97.6% at 500 mA/g and superior life span for 120 cycles with voltage gap of 1.67 V under a restricted capacity of 1000 mAh/g at 500 mA/g. Ex/in-situ studies prove that synergy between Ru nanoparticles and acetylene bonds of GDY can boost the round-trip CO_(2)RR and CO_(2)ER kinetics. | Yiru Ma Huiqi Qu Wenna Wang Ziyang Guo Yueqin Yu Feng Liu Bin Yu Minge Tian Zhenjiang Li Bin Li Lei Wang | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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