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| 1 | Soluble triggering receptor expressed on myeloid cell-1 (sTREM- 1): a potential biomarker for the diagnosis of infectious diseases显示文摘为传染疾病的诊断和预后的敏感、有用的 biomarkers 广泛地被开发了。这些 biomarkers 的一个例子正在触发在 myeloid cell-1 (TREM-1 ) 上表示的受体,它是在单核白血球 / 巨噬细胞和 neutrophils 上表示的房间表面受体。TREM-1 由激活 TREM-1/DAP12 小径放大发炎。这条小径被细菌的 lipopolysaccharide 被和 ligands 或刺激的 TREM-1 的相互作用触发。因而,支持 inflammatory cytokines 和 chemokines 被分泌。可溶的 TREM-1 (sTREM-1 ) 是能直接为传染疾病在人的身体液体和著名 biomarker 被测试的 TREM-1 的一种特殊形式。 sTREM-1 水平能潜在地为早诊断和一些传染疾病的预后预言被使用,包括传染肋膜的流出,肺感染,败血,细菌的脑膜炎,病毒的感染(例如,克里米亚半岛的刚果出血性的发烧和登革热发烧),真菌的感染(例如,曲霉属菌感染),并且灼伤相关的感染。sTREM-1 比传统的索引是更敏感、特定的 biomarker,例如 C 反应的蛋白质和 procalcitonin 层次,为这些传染疾病。因此, sTREM-1 是为指向的治疗和传染疾病的快速、早的诊断的可行 biomarker。 | Changlin Cao Jingxian Gu Jingyao Zhang | 2017 | Frontiers of Medicine2017，11，2： | 62 |
| 2 | Clinical efficacy of 0.1% pranoprofen in treatment of dry eye patients:a multicenter, randomized, controlled clinical trial显示文摘 | Chen Jingyao Dong Fei Chen Wei Sun Xuguang Deng Yingping Hong Jing Zhang Mingchang Yang Wenzhao Liu Zuguo Xie Lixin | 2014 | Chinese Medical Journal2014，，13： | 18 |
| 3 | RAPD analysis of wild stock of penaeid shrimp (Penaeus chinensis )in Chinese coastal waters of the Huanghai Sea and coastal waters of the Bohai Sea显示文摘Genetic diversity of 32 individuals of P. chinensis in the Chinese coastal waters of the Huanghai and Bobal Seas was detected by RAPD technique. Twenty decamer primers of OPI were used for DNA amplification for each individual. The results showed that: Seventeen primers obtained reproducible fingerprints, and the bands were clear. Thirty--nine of 106 loci detected were polymorphic, amounting to 36. 8 %. Mean genetic distance was 0. 094 1 0. 020 6; 68 markers (63. 2 % of the total) showed stable homogeneity in all of the 32 individuals. | Liu Ping Kong Jie Shi Tuo Zhuang Zhimeng Deng Jingyao (l. Huanghai Sea Fisheries Research institute , Chinese Academy of Fishery Sciences, Qingdao 266071, China) | 2000 | Acta Oceanologica Sinica2000，19，1： | 18 |
| 4 | Chinese stalagmite paleoclimate researches: A review and perspective显示文摘Stalagmite is one kind of secondary carbonates formed in limestone caves(speleothem). After cave water droplets containing Ca2+and HCO3 drip onto floor, carbonate in the water might become supersaturated due to CO2 degassing under certain conditions, resulting in the formation of stalagmite in a process year after year. Stalagmite is one of important geological archives for paleoclimate research. The advantages include wide spatial distribution, suitable for U-Th and U-Pb dating, enriched in climate proxies, continuity, long time span, comparability and lower sampling cost etc. These factors have propelled stalagmite paleoclimate research to the forefront of global paleoclimatology with an irreplaceable role. The stalagmite paleoclimate study started in the western countries, mainly in Europe and America in 1960 s–1970 s, while the relevant research in China was progressively developed in the 1980 s–1990 s after the Reform and Opening up. Although there was a huge gap between the overall research level in China and western countries, a solid research foundation, as well as a number of talent teams were established during the period. In the 21 st century, starting from the publication of stalagmite records from Hulu Cave in Nanjing in 2001, the stalagmite paleoclimate research in China has ushered in a flourishing development and a real leap on the basis of international cooperation, resulting in significant international impacts. The landmark achievements, including establishment of the world’s longest(640000 years) East Asian monsoon stalagmite record, as well as the longest Indian monsoon(280000 years),South American monsoon(250000 years), North American westerly climate(330000 years), Central Asian westerly climate(135000 years), and northwestern China westerly climate(500000 years), have laid a milestone in the paleoclimate study in these climate domains. Importantly, these stalagmite records have revealed the relationship of Asian monsoon variations with solar insolation climate change in polar regions, and the South American monsoon changes on orbital-suborbital timescales, which have provided new geological observations for the development of orbital-suborbital climate theory;elaborated coupling and differentiation relationships between the Asian monsoon and the westerly climate;reconstructed the history of Asian monsoon changes in the Holocene in detail, and thus the hydrological and climate variances behind Chinese and Indian civilizationcultural evolutions. Furthermore, a large number of high-resolution stalagmite records over the past 2000 years have been reconstructed, which are important for understanding short-term climate variability and magnitude, events, cycles, and thus the future climate projection. The achievements have also involved the improvements of a number of important techniques, such as U-Th dating method, the establishments of various hydroclimatic proxies, as well as the contributions to the reconstruction of the atmosphere14C variation history over the past ~54000 years. On the perspective of the future, the Chinese stalagmite community should continue to develop key techniques, further clarify the hydroclimatic significance of stalagmite proxies, impel the integration of related disciplines, and concentrate on key scientific issues in global climate change and major social demands. | Hai CHENG Haiwei ZHANG Jingyao ZHAO Hanying LI Youfeng NING Gayatri KATHAYAT | 2019 | Science China Earth Sciences2019，62，10： | 17 |
| 5 | An experimental study exploring the influencing factors for ultrasonic-assisted extraction of flavonoid compounds from leaves of Amorpha fruticosa L.显示文摘In this paper,the ultrasonic-assisted extraction process of flavonoid compounds from leaves of Amorpha fruticosa is optimized.In single factor experiments,solid/liquid ratios,ultrasonic power,ethanol concentrations and extraction cycles were experimental factors.Box–Behnken central composite design and RSM analyzed the effects of the four factors on the yield of total flavonoids.The optimal extraction parameters were solid/liquid ratio 1:50 g/mL,ultrasonic power 316 W,ethanol concentration 50%,4 extraction cycles.In the optimized condition,the estimated value of the regression model was 66.6456 mg/g while the measured value was 66.4329 mg/g. | Jingyao Tian Siddique Muhammad Ai Chen Peng Chen Jinghong Wang Chengwu Yang Hui Yuan Zhensheng Wang | 2019 | Journal of Forestry Research2019，30，5： | 14 |
| 6 | Evaluation and Analysis of Provincial Differences in Resources and Environment Carrying Capacity in China显示文摘Resources and environment carrying capacity is central to not only regional sustainable development but also major function-oriented zoning. This paper presents an evaluation index system for resources and environment carrying capacity based on four aspects of carrying capacity(i.e., water resources, land resources, the environment, and ecosystems) by using a square deviation decision-making method, and on the basis of above effort evaluates the resources and environment carrying capacity across 31 provincial regions in China(not including Hong Kong, Macao and Taiwan regions of China). In addition, this paper evaluates the current state of socio-economic development, and analyzes the spatial distribution of resources and environment pressure. The results showed that distinct spatial differences in resources and environment carrying capacity and pressure across provincial regions. Resources and environment pressure is affected by both comprehensive resources and environment carrying capacity and socio-economic development. Regions subjected to lower degrees of resources and environment pressure will be restricted by resources and environmental problems through future courses of development owing to excessively low carrying capacities. By contrast, regions with higher comprehensive resources and environment carrying capacity will be subjected to excessively high levels of resources and environment pressure because of rapid socio-economic development. Both of resources and environment carrying capacity and pressure must therefore be considered in the allocation of country-binding targets to provincial regions. | CHENG Jingyao ZHOU Kan CHEN Dong FAN Jie | 2016 | Chinese Geographical Science2016，26，4： | 14 |
| 7 | MiR-124 retards bladder cancer growth by directly targeting CDK4显示文摘MicroRNAs (miRNAs ) 是由绑定充当基因表示的否定管理者到目标 mRNAs 的 3-untranslated 区域(3UTR ) 的非编码的小 RNA 的一个类。以便在膀胱癌症调查 miR-124 的生理的角色, miR-124 的目标基因被 TargetScan 预言软件,和 cyclin 依赖的 kinase (CDK4 ) ,作为房间周期的一个管理者被含有,为进一步的学习被选择。MiR-124 能显著地镇压由在 vitro 在 CDK4 的 3UTR 指向它的有约束力的地点的 CDK4 表示。在两根膀胱癌症房间线和纸巾, miR-124 的表示是显著地下面调整的,当 CDK4 表示是起来调整的时。在移植 HT1197 房间的 miR-124 的宫外的表示在老鼠肿瘤异种皮移植导致了肿瘤生长的延迟。并且 miR-124 和 CDK4 的表示证明在这些异种皮移植纸巾的明显的反的关联,它是也在人的膀胱癌症观察到组织取样。一起拿,我们的结果强烈建议 miR-124 能逮捕房间周期并且由直接指向 CDK4 制止膀胱癌症的生长。 | Ting Zhang Jingyao Wang Xiaofeng Zhai Hongjie Changying Li Jiwu Chang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 12 |
| 8 | Promoting the methanol oxidation catalytic activity by introducing surface nickel on platinum nanoparticles显示文摘高效甲醇氧化反应(粗腐殖质) 催化剂对吸引人的、直接甲醇燃料房间的表演批评。这里,我们使用表面学习 MOR 机制并且给的模型催化剂推进指导到新高效粗腐殖质催化剂的设计的控制 PtNi 合金 nanoparticles。PtNi 合金的提高的粗腐殖质活动主要被归因于提高哦由于表面 Ni 地点的吸附。这建议 MOR 经历 Langmuir-Hinshelwood 机制,由此吸附了公司,与帮助被移开吸附哦。在 PtNi 催化剂以内,磅提供甲醇吸附地点(在哪个甲醇被变换成吸附的公司) 并且 Ni 提供哦吸附地点。为粗腐殖质的优化 Pt-Ni 比率被发现是 1:1。这建议那 bifunctional 有公司的催化剂并且哦吸附地点能导致高度活跃的粗腐殖质催化剂。 | Siqi Lu Huiming Li Jingyao Sun Zhongbin Zhuang | 2018 | Nano Research2018，11，4： | 11 |
| 9 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 10 | Biodrying of municipal solid waste with high water content by combined hydrolytic-aerobic technology显示文摘The high water content of municipal solid waste(MSW)will reduce the effciency of mechanical sorting,consequently unfavorable for beneficial utilization.In this study,a combined hydrolytic-aerobic biodrying technology was introduced to remove water from MSW.The total water removals were proved to depend on the ventilation frequency and the temporal span in the hydrolytic stage. The ventilation frequency of 6 times/d was preferable in the hydrolytic stage.The hydrolytic span should not be prolonged more than 4 d.At this optimal scenario,the final water content was 50.5%reduced from the initial water content of 72.0%,presenting a high water removal effciency up to 78.5%.A positive correlation was observed between the organics losses and the water losses in both hydrolytic and aerobic stages(R=0.944,p<0.01).The evolutions of extracellular enzyme activities were shown to be consistent with the organics losses. | ZHANG, Dongqing HE, Pinjing SHAO, Liming JIN, Taifeng HAN, Jingyao | 2008 | Journal of Environmental Sciences2008，20，12： | 10 |
| 11 | Challenges and Opportunities of AI-Enabled Monitoring, Diagnosis & Prognosis: A Review显示文摘Prognostics and Health Management(PHM),including monitoring,diagnosis,prognosis,and health management,occupies an increasingly important position in reducing costly breakdowns and avoiding catastrophic accidents in modern industry.With the development of artificial intelligence(AI),especially deep learning(DL)approaches,the application of AI-enabled methods to monitor,diagnose and predict potential equipment malfunctions has gone through tremendous progress with verified success in both academia and industry.However,there is still a gap to cover monitoring,diagnosis,and prognosis based on AI-enabled methods,simultaneously,and the importance of an open source community,including open source datasets and codes,has not been fully emphasized.To fill this gap,this paper provides a systematic overview of the current development,common technologies,open source datasets,codes,and challenges of AI-enabled PHM methods from three aspects of monitoring,diagnosis,and prognosis. | Zhibin Zhao Jingyao Wu Tianfu Li Chuang Sun Ruqiang Yan Xuefeng Chen | 2021 | Chinese Journal of Mechanical Engineering2021，34，3： | 8 |
| 12 | Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome显示文摘Regulatory T(Treg) cells, a subtype of immunosuppressive CD4^+T cells, are vital for maintaining immune homeostasis in healthy people. Forkhead box protein P3(FOXP3), a member of the forkhead-wingedhelix family, is the pivotal transcriptional factor of Treg cells. The expression, post-translational modifications, and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg cells in vivo. In particular, the mutation of FOXP3 can result in immune dysregulation,polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome, which is a rare genetic disease mostly diagnosed in early childhood and can soon be fatal. IPEX syndrome is related to several manifestations,including dermatitis, enteropathy, type 1 diabetes, thyroiditis, and so on. Here, we summarize some recent findings on FOXP3 regulation and Treg cell function. We also review the current knowledge about the underlying mechanism of FOXP3 mutant-induced IPEX syndrome and some latest clinical prospects.At last, this review offers a novel insight into the role played by the FOXP3 complex in potential therapeutic applications in IPEX syndrome. | Qianru Huang Xu Liu Yujia Zhang Jingyao Huang Dan Li Bin Li | 2020 | Journal of Genetics and Genomics2020，47，1： | 8 |
| 13 | Orbital-scale Asian summer monsoon variations:Paradox and exploration显示文摘The Asian summer monsoon(ASM) is a vast climate system, whose variability is critical to the livelihoods of billions of people across the Asian continent. During the past half-century, much progress has been made in understanding variations on a wide range of timescales, yet several significant issues remain unresolved. Of note are two long-standing problems concerning orbital-scale variations of the ASM.(1) Chinese loess magnetic susceptibility records show a persistent glacial-interglacial dominated ~100 kyr(thousand years) periodicity, while the cave oxygen-isotope(δ18 O) records reveal periodicity in an almost pure precession band(~20 kyr periodicity)—the 'Chinese 100 kyr problem'.(2) ASM records from the Arabian Sea and other oceans surrounding the Asian continent show a significant lag of 8–10 kyr to Northern Hemisphere summer insolation(NHSI), whereas the Asian cave δ18 O records follow NHSI without a significant lag—a discrepancy termed the 'sea-land precession-phase paradox'. How can we reconcile these differences? Recent and more refined model simulations now provide spatial patterns of rainfall and wind across the precession cycle, revealing distinct regional divergences in the ASM domain, which can well explain a large portion of the disparities between the loess, marine, and cave proxy records. Overall, we also find that the loess, marine, and cave records are indeed complementary rather than incompatible, with each record preferentially describing a certain aspect of ASM dynamics. Our study provides new insight into the understanding of different hydroclimatic proxies and largely reconciles the 'Chinese 100 kyr problem' and 'sea-land precession-phase paradox'. | Hai CHENG Haiwei ZHANG Yanjun CAI Zhengguo SHI Liang YI Chenglong DENG Qingzhen HAO Youbing PENG Ashish SINHA Hanying LI Jingyao ZHAO Ye TIAN Jonathan BAKER Carlos PEREZ-MEJIAS | 2021 | Science China Earth Sciences2021，64，4： | 6 |
| 14 | Clinical and Genetic Investigation of a Multi-generational Chinese Family Afflicted with Von Hippel-Lindau Disease显示文摘 | Jingyao Zhang Jie Ma Xiaoyun Du Dapeng Wu Hong Ai Jigang Bai Shunbin Dong Qinling Yang Kai Qu Yi Lyu Robert K Valenzuela Chang Liu | 2015 | Chinese Medical Journal2015，，1： | 6 |
| 15 | Deformation Calculation of Cross-section Based on Virtual Force in Thin-walled Tube Bending Process显示文摘Cross-section deformation is one of important factors affecting the quality of tube formation,and the tube's capability of transporting liquid and gas will be reduced because of the cross-section ellipse deformation due to the effect of shear load in plastic bending process.When the tube is bent,the extrados-wall bears the tension stress and the intrados-wall bears the compression stress,synchronously the cross-section is affected by the circumferential stress.According to the above,the distribution function and curve of tangential stress can be obtained according to force balance differential equations on circumferential direction and Trasca rule.Subsequently the real state and virtual state moment equations were established,a new method was presented adopting the virtual principle of deformation system to calculate the x-axis and y-axis displacement of arbitrary point on cross-section.So the major and minor axes of deformed cross-section can be calculated according to the displacements of each point,and the variety value of major and minor axes will be obtained further.Finally the theoretical calculating result is compared with NC tube rotary-bending experiment results to verify the rationality of theoretical analysis,and the cross-section deformation rule of thin-walled tube can be received. | LIU Jingyao TANG Chengtong NING Ruxin | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 5 |
| 16 | Synthesis and facet-dependent photocatalytic activity of strontium titanate polyhedron nanocrystals显示文摘Cubic-perovskite (SrTiO 3) 有一个大潜力在大量应用被利用。然而,当前,很,很少在他们的物理化学的性质上对形状和 SrTiO 3 的方面效果被知道。这大部分由于在在合成期间控制方面的形态学的困难。此处,我们为 singlecrystalline SrTiO 3 的控制方面、控制尺寸的制造描述一条灵巧的线路三角形的棱柱与高度暴露了 { 101 } 方面脸并且 { 111 } 结束脸。他们的 photocatalytic 表演的理论、试验性的研究证明了三角形的棱柱比 nanocubes 展出优异 photocatalytic 活动与暴露( 001 )为器官的沾染物的降级面对,它可以首先被归因于高得多的表面精力{ 101 }方面( 2.97 J/m 2)并且{ 111 }方面( 2.80 J/m 2)比的{ 001 }方面( 0.98 J/m 2)。 | Junfang Li Hua Bai Wencai Yi Jingyao Liu Yahui Li Qing Zhang Haifeng Yang Guangcheng Xi | 2016 | Nano Research2016，9，5： | 4 |
| 17 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 18 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 19 | MoS2 Nanosheets Sensitized with Quantum Dots for Room-Temperature Gas Sensors显示文摘The Internet of things for environment monitoring requires high performance with low power-consumption gas sensors which could be easily integrated into large-scale sensor network.While semiconductor gas sensors have many advantages such as excellent sensitivity and low cost,their application is limited by their high operating temperature.Two-dimensional(2D)layered materials,typically molybdenum disulfide(MoS2)nanosheets,are emerging as promising gas-sensing materials candidates owing to their abundant edge sites and high in-plane carrier mobility.This work aims to overcome the sluggish and weak response as well as incomplete recovery of MoS2 gas sensors at room temperature by sensitizing MoS2 nanosheets with PbS quantum dots(QDs).The huge amount of surface dangling bonds of QDs enables them to be ideal receptors for gas molecules.The sensitized MoS2 gas sensor exhibited fast and recoverable response when operated at room temperature,and the limit of NO2 detection was estimated to be 94 ppb.The strategy of sensitizing 2D nanosheets with sensitive QD receptors may enhance receptor and transducer functions as well as the utility factor that determine the sensor performance,offering a powerful new degree of freedom to the surface and interface engineering of semiconductor gas sensors. | Jingyao Liu Zhixiang Hu Yuzhu Zhang HuaYao Li Naibo Gao Zhilai Tian Licheng Zhou Baohui Zhang Jiang Tang Jianbing Zhang Fei Yi Huan Liu | 2020 | Nano-Micro Letters2020，12，5： | 3 |
| 20 | Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma显示文摘Hypoxia mediates a metabolic switch from oxidative phosphorylation to glycolysis and increases glycogen synthesis.We previously found that glycogen branching enzyme(GBE1)is downstream of the hypoxia-inducible factor-1(HIF1)signaling pathway in lung adenocarcinoma(LUAD)cells;however,the molecular mechanism underlying HIF1 regulation of GBE1 expression remains unknown.Herein,the effect of GBE1 on tumor progression via changes in metabolic signaling under hypoxia in vitro and in vivo was evaluated,and GBE1-related genes from human specimens and data sets were analyzed.Hypoxia induced GBE1 upregulation in LUAD cells.GBE1-knockdown A549 cells showed impaired cell proliferation,clone formation,cell migration and invasion,angiogenesis,tumor growth,and metastasis.GBE1 mediated the metabolic reprogramming of LUAD cells.The expression of gluconeogenesis pathway molecules,especially fructose-1,6-bisphosphatase(FBP1),was markedly higher in shGBE1 A549 cells than it was in the control cells.FBP1 inhibited the tumor progression of LUAD.GBE1-mediated FBP1 suppression via promoter methylation enhanced HIF1αlevels through NF-κB signaling.GBE1 may be a negative prognostic biomarker for LUAD patients.Altogether,hypoxia-induced HIF1αmediated GBE1 upregulation,suppressing FBP1 expression by promoter methylation via NF-κB signaling in LUAD cells.FBP1 blockade upregulated HIF1α,triggered the switch to anaerobic glycolysis,and enhanced glucose uptake.Therefore,targeting HIF1α/GBE1/NF-κB/FBP1 signaling may be a potential therapeutic strategy for LUAD. | Lifeng Li Li Yang Zhirui Fan Wenhua Xue Zhibo Shen Yongliang Yuan Xiangdong Sun Dan Wang Jingyao Lian Liping Wang Jie Zhao Yi Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
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