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| 1 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 2 | Embedding lead halide perovskite quantum dots in carboxybenzene microcrystals improves stability显示文摘铅卤化物 perovskite 量点(PQD ) 的稳定性被在 carboxybenzene microcrystals 嵌入他们改进。结果塑造针的混合 microcrystals 保存了 PQD 的强壮的光致发光。与以前报导的包含聚苯乙烯的 PQD 相比, carboxybenzene 晶体是柔韧的并且保护了点免受潮湿和 photodegradation 的伤害。提高的稳定性被归因于 carboxybenzene microcrystals 的紧密的矩阵,它保护了 PQD 免受潮湿的伤害。这万用的策略保护了各种各样的 QD,包括所有无机的 PQD 和 chalcogenide QD (例如, CdSe/ZnS QD 和 CuInS/ZnS QD ) 。它提供保护 PQD 的一个灵巧、万用的方法并且可以启用应用在固态有象显示,激光,和轻射出二极管那样的高颜色质量要求的系统。 | Wei Xu Zhixiong Cai Feiming Li Jing Dong Yiru Wang Yaqi Jiang Xi Chen | 2017 | Nano Research2017，10，8： | 4 |
| 3 | Scalable and facile synthesis of V_(2)O_(5) nanoparticles via ball milling for improved aerobic oxidative desulfurization显示文摘In recent years, transition-metal oxides(TMOs) have been long employed for aerobic oxidative desulfurization. However, the inherent bottlenecks, such as the low explosion of active sites, limit the application of bulk TMOs catalyst. In this study, V_(2)O_(5) nanoparticles with oxygen vacancies were prepared in large-scale via facile ball milling strategy with adding oxalic acid as a reducing agent. The as-prepared catalysts exhibit remarkable sulfur removal for oils with different initial S-concentrations and different substrates. Sulfur removal could reach up to 99.7%(< 2 ppm) under the optimized reaction conditions. This work provides a feasible desulfurization strategy for fuel oils. | Yiru Zou Chao Wang Hanxiang Chen Haiyan Ji Qian Zhu Wenshu Yang Linlin Chen Zhigang Chen Wenshuai Zhu | 2021 | Green Energy & Environment2021，6，2： | 4 |
| 4 | MICROSTRUCTURE OF INTERFACE BETWEEN HVOF SPRAYED WC-Co COATING AND SPRING STEEL SUBSTRATE显示文摘MICROSTRUCTUREOFINTERFACEBETWEENHVOFSPRAYEDWC-CoCOATINGANDSPRINGSTEELSUBSTRATE￥ShaoBeiling;LiuAnsheng;WangXiaohua;LiYonghong;... | Shao Beiling Liu Ansheng Wang Xiaohua Li Yonghong Zou Linying Wang Jing Zhang Jianguo Shi Changyong Zhou Yiru(General Research institute For Nonferrous Metals,Beijing 100088) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 3 |
| 5 | Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder显示文摘Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological changes.Glucocorticoid,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion disorders.In this review,we summarize the independent and interactive functions of these three axes in female MDD patients.The similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA. | Yuncheng Zhu Xiaohui Wu Rubai Zhou Oliver Sie Zhiang Niu Fang Wang Yiru Fang | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 6 | Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery显示文摘尽管有高 echogenicity 的充满气体的 microbubbles 是广泛地应用的 inclinical ultrasonography,微米规模粒子尺寸在稳固的肿瘤的处理阻碍他们的使用,它对目标可存取不到几百纳米。我们此处建议包含导致 apH 的核心壳 micelle-to-vesicle 转变准备拥有多重特征的超声敏感的聚合 nanospheres (在结构的 polymersomes ) 的一条不平常的途径,包括进水的腔的一个阶段过渡的成像代理人的 nanosize, monodispersity,和加入。这些特征不经由为 polymersome 准备的常规双乳剂方法是可完成的。nanospheres 与双 pH 敏感基于新奇 triblock 共聚物被构造。外部低频率的超声导致的成像代理人的 liquid-to-gas 阶段转变可以为一个快速的药版本破坏 nanospheres,与在一个肿瘤内的同时的渗透织物的药交货。这些效果可以为有效癌症治疗的发展向新机会提供很少不利效果。 | Yiru Wang Tinghui Yin Zhenwei Su Chen Qiu Yong Wang Rongqin Zheng Meiwan Chen Xintao Shuai | 2018 | Nano Research2018，11，7： | 3 |
| 7 | Fabrication of Non-woven Fabric-Based SERS Substrate for Direct Detection of Pesticide Residues in Fruits显示文摘In surface-enhanced Raman scattering(SERS),flexible substrate plays an important role in target molecular collection from various shape surfaces and increases the analytical sensitivity.In this study,silver nanoparticles(Ag NPs)were deposited on a non-woven fabric used as an SERS substrate by self-assembly,in situ growing or the self-assembly/in situ growing combination method.4-Aminothiophenol was selected as a model molecular for the evaluation of the SERS performance using the substrates.The Ag NPs substrate prepared by self-assembly/in situ growing method presented the best Raman enhancement effect and its enhancement factor was estimated as high as 3.59106.The substrate was applied to the determination of four pesticide residues on the surfaces of fruit samples through wipe sampling,and the results revealed the good reproducibility of SERS responses and high detection sensitivity.The prepared flexible substrate was simple to fabricate and environmentally friendly.It could be expected to be a useful tool in rapid on-site test of pesticide residues on fruit surfaces because of its high sensitivity,convenience and non-destructive characteristics. | Lemei Cai Zhuo Deng Jing Dong Shidong Song Yiru Wang Xi Chen | 2017 | Journal of Analysis and Testing2017，1，4： | 3 |
| 8 | GhKT2: a novel K^+ transporter gene in cotton(Gossypium hirsutum)显示文摘Potassium is an essential nutrient for plant growth and productivity of crops. K+transporters are important for K+uptake and transport in plants. However,information on the function of K+transporters and K+channels in cotton is limited. The KT/KUP/HAK protein family is essential for a variety of physiological processes in plants, including nutrient acquisition and regulation of development. This study, identified a K+transporter gene,Gh KT2, expressed in the roots of cotton(Gossypium hirsutum) cv. Liaomian17. The deduced transcript of Gh KT2 is highly homologous to Cluster II of KUP/HAK/KT K+transporters and is predicted to contain 11 transmembrane domains. Gh KT2 has been localized to the plasma membrane, and its transcripts were detected in roots, stems, leaves and shoot apices of cotton seedlings.Consistently, b-glucuronidase(GUS) expression driven by the Gh KT2 promoter could be detected in roots, mesophyll cells, and leaf veins in transgenic Arabidopsis. In addition,the expression of Gh KT2 was induced by low K+stress in cotton roots and p Gh KT2::GUS-transgenic Arabidopsis seedlings. The Gh KT2-overexpression Arabidopsis lines plants were larger and showed greater K+accumulation than the wild type(WT) regardless of K+concentration supplied. The net K+influx rate, measured by the noninvasive micro-test technique, in root meristem zone of Gh KT2-transgenic Arabidopsis lines was significantly greater than that of WT. Taken together, this evidence indicates that Gh KT2 may participate in K+acquisition from low or high external K+, as well as K+transport and distribution in plants. | Yiru WANG Juan XU Mingcai ZHANG Xiaoli TIAN Zhaohu LI | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 2 |
| 9 | A Hybrid Conjugate Gradient Algorithm for Solving Relative Orientation of Big Rotation Angle Stereo Pair显示文摘The fast convergence without initial value dependence is the key to solving large angle relative orientation.Therefore,a hybrid conjugate gradient algorithm is proposed in this paper.The concrete process is:①stochastic hill climbing(SHC)algorithm is used to make a random disturbance to the given initial value of the relative orientation element,and the new value to guarantee the optimization direction is generated.②In local optimization,a super-linear convergent conjugate gradient method is used to replace the steepest descent method in relative orientation to improve its convergence rate.③The global convergence condition is that the calculation error is less than the prescribed limit error.The comparison experiment shows that the method proposed in this paper is independent of the initial value,and has higher accuracy and fewer iterations. | Jiatian LI Congcong WANG Chenglin JIA Yiru NIU Yu WANG Wenjing ZHANG Huajing WU Jian LI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，2： | 2 |
| 10 | Perspective on Etiology and Treatment of Bipolar Disorders in China: Clinical Implications and Future Directions显示文摘Bipolar disorder (BD) is a chronic, recurrent, disabling disease, even when given currently-available pharmacological and psychological treatments. Currently, the etiology and pathogenesis of BD remain unclear. As a consequence, patients with BD are frequently unrecognized, misdiagnosed, and inappropriately treated, which often yields a low treatment response and poor outcome. | Zuowei Wang Chen Jun Kerning Gao Haichen Yang Yiru Fang | 2019 | Neuroscience Bulletin2019，35，4： | 2 |
| 11 | Numerical Simulation to Evaluate the Effects of Upward Lightning Discharges on Thunderstorm Electrical Parameters显示文摘A theoretical discussion of the discharge effects of upward lightning simulated with a fine-resolution 2D thunderstorm model is performed in this paper,and the results reveal that the estimates of the total induced charge on the upward lightning discharge channels range from 0.67 to 118.8 C,and the average value is 19.0 C,while the ratio of the induced charge on the leader channels to the total opposite-polarity charge in the discharge region ranges from 5.9%to 47.3%,with an average value of 14.7%.Moreover,the average value of the space electrostatic energy consumed by upward lightning is 1.06×10^9 J.The above values are lower than those related to intracloud lightning discharges.The density of the deposited opposite-polarity charge is comparable in magnitude to that of the preexisting charge in the discharge area,and the deposition of these opposite-polarity charges rapidly destroys the original space potential well in the discharge area and greatly reduces the space electric field strength.In addition,these opposite-polarity charges are redistributed with the development of thunderstorms.The space charge redistribution caused by lightning discharges partly accounts for the complexity of the charge structures in a thunderstorm,and the complexity gradually decreases with the charge neutralization process. | Tianxue ZHENG Yongbo TAN Yiru WANG | 2021 | Advances in Atmospheric Sciences2021，38，3： | 2 |
| 12 | Cost-effectiveness analysis on COVID-19 surveillance strategy of large-scale sports competition显示文摘Background:Nucleic acid test(NAT)could effectively control the spread of COVID-19 caused by large-scale sports competitions.However,quantitative analysis on the appropriate frequency of NAT is scarce,and the cost-effectiveness and necessity of high-frequency NAT remain to be fully explored and validated.This study aims to optimize the COVID-19 surveillance strategies through cost-effectiveness analysis for the Tokyo 2020 Olympic Games and the upcoming Beijing 2022 Olympic Winter Games.Methods:A total of 18 scenarios were designed regarding the NAT frequency,symptom monitoring,and strengthening close-contact control.An agent-based stochastic dynamic model was used to compare the cost-effectiveness of different NAT scenarios and optimize the surveillance strategies.The dynamics of the proposed model included the arrival and departure of agents,transmission of the disease according to Poisson processes,and quarantine of agents based on regular NATs and symptom onset.Accumulative infections,cost,and incremental cost-effectiveness ratio(ICER)were simulated in the frame of the model.ICER was used to compare the cost-effectiveness of different scenarios.Univariate sensitivity analysis was performed to test the robustness of the results.Results:In Scenario 16,where the competition-related personnel(CRP)received NAT daily and national sports delegation(NSD)with quarantined infections accepted an additional NAT daily,accumulative infection was 320.90(90 initial infections),the total cost was(United States Dollar)USD 8920000,and the cost of detecting out each infection was USD 27800.Scenario 16 would reduce the total cost by USD 22570000(avoid 569.61 infections),USD 1420000(avoid 47.2 infections)compared with Scenario 10(weekly NAT,strengthened close contact control)and Scenario 7(daily NAT,no strengthened close contact control),respectively.Sensitivity analysis showed that the result was most sensitive to the change in basic reproductive number.Conclusions:High-frequency NATs such as bidaily,daily,and twice a day were cost-effective.NAT daily for CRP with strengthening close-contact control could be prioritized in defense against COVID-19 at large-scale sports competitions.This study could assist policymakers by assessing the cost-effectiveness of NAT scenarios and provide the host country with an optimal COVID-19 surveillance strategy. | Xuechun Wang Yiru Cai Bo Zhang Xiangyu Zhang Lianhao Wang Xiangyu Yan Mingchen Zhao Yuan Zhang Zhongwei Jia | 2022 | Infectious Diseases of Poverty2022，11，2： | 2 |
| 13 | Luminescent graphene quantum dots as new fluorescent materials for environmental and biological applications显示文摘 | Liping Lin Mingcong Rong Feng Luo Dongmei Chen Yiru Wang Xi Chen | 2014 | Trends in Analytical Chemistry2014，，： | 1 |
| 14 | An Investigation of a Confirmed Imported Case of COVID-19 Infected Abroad—Qingpu District,Shanghai Municipality,China,November 15,2020显示文摘Summary What is already known about this topic?A passenger who was from the United States was taken to the hotel for the required isolation on November 13,2020.During the quarantine she was diagnosed as the COVID-19 patient on November 15,2020.Controlling the importation of COVID-19 remains a major challenge.What is added by this report? | Hongrang Zhou Xiaoling Wang Qiufang Xu Xiaoming Wang Yadong Ma Yiru Shi Zhouli Wu Peifeng Zhu Jinjiang Zhao Ruifang Xu Changpo Lin Ning Xiao | 2021 | China CDC weekly2021，3，10： | 1 |
| 15 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 16 | Determination of nerolidol in teas using headspace solid phase microextraction–gas chromatography显示文摘 | Chunhua Ma Yanqin Qu Yingxue Zhang Bin Qiu Yiru Wang Xi Chen | 2014 | Food Chemistry2014，，： | 1 |
| 17 | Increased FoxM1 expression is a target for metformin in the suppressionof EMT in prostate cancer显示文摘 | Yiru Wang Binwei Yao Yu Wang Mingbo Zhang Shuai Fu Hanjing Gao Ruiyun Peng Lingqiang Zhang Jie Tang | 2014 | International Journal of Molecular Medicine2014，，6： | 1 |
| 18 | Improvement of mieroalgae harvesting by magnetic nanocomposites coated with polyethylenimine 显示文摘 | Hu YiRu Guo Chen Wang Feng | 2014 | Chemical Engineering Journal2014，242，11： | 1 |
| 19 | Topology optimization design of micro-mass sensors for maximizing detection sensitivity显示文摘Micro-mass sensors have attracted increasing attention in the fiel of biomolecular and chemical detection. It has been found that the size, shape, and geometry of the structure may affect the performance of the sensor. As a result, a topology optimization methodology is proposed in this paper for the design of micro-mass sensors. A phasefiel function controlled by nodal variables and finit element shape functions is used to describe the configuratio of a sensor in the constructed optimization problem. The design goal is to maximize the mass detection sensitivity. On the basis of these formulations, an optimization algorithm is constructed using the finit element method and the method of moving asymptotes. Numerical examples are presented to demonstrate the validity of the proposed problem formulation. The results suggest that the performance of the micro-mass sensor can be improved by using the proposed approach. | Zheqi Lin Xuansheng Wang Yiru Ren | 2015 | Acta Mechanica Sinica2015，31，4： | 1 |
| 20 | Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium显示文摘 | Adam B. Stein Roberto Bolli Buddhadeb Dawn Santosh K. Sanganalmath Yanqing Zhu Ou-Li Wang Yiru Guo Roberto Motterlini Yu-Ting Xuan | 2011 | Journal of Molecular and Cellular Cardiology2011，，1： | 1 |
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