| 1 | Binding Reaction of Hemin with Chloroquine, Quinine and Quinidine in Water-propylene Glycol Mixture显示文摘The interaction of hemin with chloroquine, quinine and quinidine was investigated in 50% water propylene glycol mixture at pH=9, 8 1, 7 4 and 6 8 using a spectrophotometric method. The data could be well fitted into a model consistent with the formation of a 1∶1 complex between the reacting partners. In addition, the results indicated that hemin complexed more strongly with quinidine than with chloroquine and quinine, and the binding constants were pH dependent. Moreover, it was proved that the water propylene glycol mixture is well suitable to the study of the systems containing hemin and quinoline based drugs. | MAVAKALA B. K. NLANDU B. B. MPIANA P. T. GUSHIMANA Z. Y. 尉志武 | 2003 | Chinese Journal of Chemistry2003，21，8： | 0 |
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