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| 1 | C/EBPα regulates SIRT1 expression during adipogenesis显示文摘SIRT1 在 adipogenesis 起一个重要作用,但是 SIRT1 怎么在 adipogenesis 被调整,大部分是未知的。在这研究,我们证明 SIRT1 蛋白质和 mRNA 层次与 CCAAT/enhancer-binding 蛋白质伪一起被增加(C/EBP 伪) 在 adipocyte 区别期间。C/EBP 伪,然而并非 C/EBP 伪 p 30,在 HeLa 房间和 3T3-L1 的激活的 SIRT1 倡导者 preadipocytes。而且, C/EBP 伪 upregulated SIRT1 mRNA 和蛋白质在 Soas2 房间以一种 p53 独立的方式在 HeLa 铺平房间和增加的 SIRT1 表示。在 preadipocytes, C/EBP 伪 upregulated SIRT1 蛋白质水平的宫外的表示并且导致的 C/EBP 伪击倒 SIRT1 的减少蛋白质水平。而且由倡导者删除分析,胶化移动试金和染色质 immunoprecipitation,我们发现了那 C/EBP,伪在一个一致 C/EBP 伪绑定地点跳了到 SIRT1 倡导者。这些数据证明那 C/EBP 伪在 adipogenesis 期间调整 SIRT1 表示由对 SIRT1 倡导者直接有约束力。 | Qihuang Jin Fang Zhang Tingting Yan Zhen Liu Chunxi Wang Xinjian Ge Qiwei Zhai | 2010 | Cell Research2010，20，4： | 8 |
| 2 | The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)显示文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST's special design allows both a large aperture (effective aperture of 3.6 m-4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror's surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects. | Xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu Guo-Ping Li Qi Li Li-Ping Zhang Hong-Jun Su Zheng-Qiu Yao Ya-Nan Wang Xiao-Zheng Xing Xin-Nan Li Yong-Tian Zhu Gang Wang Bo-Zhong Gu A-Li Luo Xin-Qi Xu Zhen-Chao Zhang Gen-Rong Liu Hao-Tong Zhang De-Hua Yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Yan Li Ye-Ping Li Guan-QunLiu Zhi-Gang Liu Huo-Ming Shi Zheng-Hong Tang Qing-Sheng Tao Xiang-Yan Yuan Chao Zhai Jing Zhang Yan-Xia Zhang Yong Zhang Ming Zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou | 2012 | Research in Astronomy and Astrophysics2012，12，9： | 8 |
| 3 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 4 | Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training显示文摘AIM:To evaluate the efficacy of botulinum toxin type A injection to the puborectalis and external sphincter muscle in the treatment of patients with anismus unresponsive to simple biofeedback training.METHODS:This retrospective study included 31 patients suffering from anismus who were unresponsive to simple biofeedback training.Diagnosis was made by anorectal manometry,balloon expulsion test,surface electromyography of the pelvic floor muscle,and defecography.Patients were given botulinum toxin type A(BTX-A) injection and pelvic floor biofeedback training.Follow-up was conducted before the paper was written.Improvement was evaluated using the chronic constipation scoring system.RESULTS:BTX-A injection combined with pelvic floor biofeedback training achieved success in 24 patients,with 23 maintaining persistent satisfaction during a mean period of 8.4 mo.CONCLUSION:BTX-A injection combined with pelvic floor biofeedback training seems to be successful for intractable anismus. | Yong Zhang Zhen-Ning Wang Lei He Ge Gao Qing Zhai Zhi-Tao Yin Xian-Dong Zeng | 2014 | World Journal of Gastroenterology2014，20，35： | 7 |
| 5 | An overview of the resources and environment conditions and major geological problems in the Yangtze River economic zone, China显示文摘Focusing on the Yangtze River economic zone,the previous geological researches are systematically summarized,resources and environment conditions and major geological problems which are needing to be concerned in land planning and construction are studied.The results show that the resource conditions of cultivated land,shale gas,geotherm,lithium and so on are superior in the Yangtze River economic zone,and the resources and environment conditions are conducive to develop the modern agriculture,clean energy industry and strategic emerging industries.3×1013 m^2 farmlands without heavy metal pollution are concentrated;there are three national level shale gas exploration and development bases with explored reserves of 5.441×1011 m^3;geothermal availability is 2.4×109 t of standard coal each year,equivalent to 19% of the amount of coal in 2014;Asia's largest energy lithium metal ore deposit is found.In some parts of Yangtze River economic zone,there are some major geological problems such as active faults,karst collapse,ground subsidence,landslide-collapse-debris flow,affecting the river-crossing channels,high-speed railway,urban agglomeration and green ecological corridor planning and construction.Those problems should be concerned,and the relevant suggestions and countermeasures are put forward.Meanwhile,the ideas to further support the development of the Yangtze River economic zone are put forward. | Yue-hua Jiang Liang-jun Lin Li-de Chen Hua-yong Ni Wei-ya Ge Hang-xin Cheng Gang-yi Zhai Gui-ling Wang Yi-zhong Ban Yuan Li Ming-tang Lei Cheng-xuan Tan Jing-wen Su Quan-ping Zhou Tai-li Zhang Yun Li Hong-ying Liu Ke Peng Han-mei Wang | 2018 | China Geology2018，1，3： | 6 |
| 6 | Brief Introduction to the 'Catalogue of Recent Chinese Earthquakes (1912~1990, M_S≥4.7)显示文摘This paper briefly introduces the principles and methods for compiling the 'Catalog of Recent Chinese Earthquakes (1912 ~ 1990, MS≥4.7).' This new catalog is compiled by revising and supplementing the 1983 version of the Catalog of Chinese Earthquakes. | Wang Suyun, Wu Ge, Shi Zhenliang, Li Qun, Zhai Wenjie, Gao Ajia, Wu Huanying, Guo Ying, and Zhang XiaodongInstitute of Geophysics, CSB, Beijing 100081, ChinaSeismological Bureau of Liaoning Province, Shenyang 110031, China | 1999 | Earthquake Research in China1999，13，1： | 4 |
| 7 | Detecting the storage and change on topsoil organic carbon in grasslands of Inner Mongolia from 1980s to 2010s显示文摘土壤碳隐遁和潜力是在全球碳研究的一个焦点的问题。在全球变化,尺寸的评价以及它土壤的变化的背景下面,器官的碳(SOC ) 存储是很重要的。在 20112012 期间从第二国家土壤调查和地调查把数据基于土壤,由使用在采样土壤数据和遥感数据之间的回归方法,这篇论文试图调查表层土( 020 厘米)的空间分发和变化在在1980年代和2010年代之间的内部蒙古的草地的器官的碳存储。结果显示出那:(1 ) 在在 1980 年代和 2010 年代之间的内部蒙古的草地的 SOC 存储被估计是 2.05 和 2.17 Pg C,与 3.48 和 3.69 kg C | DAI Erfu ZHAI Ruixue GE Quansheng WU Xiuqin | 2014 | Journal of Geographical Sciences2014，24，6： | 4 |
| 8 | Comparison of Clinical and Epidemiological Characteristics of Asymptomatic and Symptomatic SARS-CoV-2 Infection in Children显示文摘To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5±5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4%)domestic cases and 38(77.6%)imported cases.Nine(81.8%)local cases and 12(31.6%)imported cases had a definitive epidemiological exposure.Twenty-eight(57.1%)were symptomatic and 21(42.9%)were asymptomatic.Neither asymptomatic nor symptomatic cases progressed to severe diseases.The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1±6.4 days in asymptomatic cases and 14.8±8.4 days in symptomatic cases(P>0.05).Forty-five(91.8%)cases had viral RNA detected in stool.The mean duration of viral shedding in stool was 28.1±13.3 days in asymptomatic cases and 30.8±18.6 days in symptomatic participants(P>0.05).Children<7 years shed viral RNA in stool for a longer duration than school-aged children(P<0.05).Forty-three(87.8%)cases had seropositivity for antibodies against SARS-CoV-2 within 1–3 weeks after confirmation with infection.In conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic wave.Asymptomatic cases shed viral RNA in a similar pattern as symptomatic cases do.It is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control. | Jiehao Cai Xiangshi Wang Jun Zhao Yanling Ge Jin Xu He Tian Hailing Chang Aimei Xia Jiali Wang Jinqiang Zhang Zhongqiu Wei Jingjing Li Chuning Wang Jianshe Wang Qirong Zhu Xiaowen Zhai Mei Zeng | 2020 | Virologica Sinica2020，35，6： | 4 |
| 9 | Measles Outbreak in Pediatric Hematology and Oncology Patients in Shanghai, 2015显示文摘 | Yan-Ling Ge Xiao-Wen Zhai Yan-Feng Zhu Xiang-Shi Wang Ai-Mei Xia Yue-Fang Li Mei Zeng | 2017 | Chinese Medical Journal2017，，11： | 4 |
| 10 | Synthesis and in vitro antitumor activity of novel diaryl urea derivatives显示文摘A series of novel diaryl ureas containing 4-[(2-amino-6-trifluromethyl)pyrimidine-4-yl]piperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib,some compounds showed more potent and a broader spectrum of anti-cancer activities.Among them,compound 2p demonstrated significant inhibitory activities against MDA-MB-231,HT-29 and MCF-7 cell lines with IC_(50) values of 0.016,0.63,0.001μmol/L, respectively. | Yan-Fang Zhao Zi-Jian Liu Xin Zhai Dan-Dan Ge Qiang Huang Ping Gong | 2013 | Chinese Chemical Letters2013，24，5： | 3 |
| 11 | SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B显示文摘 | Cheng Sun Fang Zhang Xinjian Ge Tingting Yan Xingmiao Chen Xianglin Shi Qiwei Zhai | 2007 | Cell Metabolism2007，，4： | 3 |
| 12 | Whether Syndrome Differentiation Affects Treatment Result:Study Protocol of MaZiRenWan(麻子仁丸)for Functional Constipation in A Randomized Controlled Trial显示文摘Background: Syndrome is one of the most important concepts in Chinese medicine(CM) theory. However, it was not well accounted in most of randomized controlled trials(RCTs). Objective: To determine whether CM syndrome differentiation affects the treatment results, functional constipation(FC) was selected as a target disease, and MaZiRenWan(麻子仁丸, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. Methods: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up. A total of 120 FC patients diagnosed as excessive heat syndrome will be recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Patients will be randomly allocated into fixed MZRW(f_MZRW) granule group, modified MZRW(m_MZRW) granule group or bisacodyl group. For m_MZRW group, no more than two herbal granules can be added according to the syndrome differentiation for individual participants. The primary end point is the mean of complete spontaneous bowel movements(CSBMs) per week during the treatment period. Secondary end points include mean of CSBMs per week during follow-up, stool form, global symptom improvement, constipation and constipation-related symptoms assessment, CM syndrome change, and reported adverse events. Discussion: This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease. | CHENG Chung-wah ZHANG Li ZHAO Chen ZHONG Linda LD SHI Li-jie DAI Liang ZHENG Rui CHEN Jing LI Ge ZHAI Jing-bo KUN Wai LU Ai-ping SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 3 |
| 13 | The first data release(DR1) of the LAMOST regular survey显示文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio(SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra(1 061 918 entries), A-type stars(100 073 entries), and M-type stars(121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided. | A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 2 |
| 14 | RGB WGM lasing woven in fiber braiding cavity显示文摘It is critical to realize woven and wearable red-green-blue(RGB) whispering gallery mode(WGM)lasing that is tunable and flexible in the fiber braiding cavity. However, it is still a challenge to achieve tunable full-color lasing with the large color gamut by a facile approach. Here, we design the braiding cavity to realize RGB WGM lasing with high performance. The braiding cavity consists of three optical fibers coated with dye-doped polymer. Each fiber therein serves as a resonant cavity to support multiple lasing modes. There is no interference owing to the air gap between them;therefore, we can achieve full-color WGM lasing. The lasing emission in our fiber braiding cavity covers a color gamut of 86.7% larger than standard RGB space.Our work may provide a platform for potential applications in white laser and integrated optoelectronic devices. | Kun GE Zhiyang XU Dan GUO Ben NIU Jun RUAN Libin CUI Tianrui ZHAI | 2022 | Science China(Information Sciences)2022，65，8： | 2 |
| 15 | Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling显示文摘The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression.In this study,we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status.Experiments were conducted using 3D collagen,fibrinogen. | Cong Li Shi Qiu Xiaohan Liu Fengzhu Guo Jingtong Zhai Zhijun Li Linghui Deng Liming Ge Haili Qian Lu Yang Binghe Xu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 2 |
| 16 | Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling显示文摘Osmotic stress caused by drought and high salinity is a significant environmental threat that limits plant growth and agricultural yield. Redox regulation plays an important role in plant stress responses, but the mechanisms by which plants perceive and transduce redox signals are still underexplored. Here, we report a critical function for the thiol peroxidase GPX1 in osmotic stress response in rice, where it serves as a redox sensor and transducer. GPX1 is quickly oxidized upon exposure to osmotic stress and forms an intramolecular disulfide bond, which is required for the activation of bZIP68, a VRE-like basic leucine zipper (bZIP) transcription factor involved in the ABA-independent osmotic stress response pathway. The disulfide exchange between GPX1 and bZIP68 induces homo-tetramerization of bZIP68 and thus positively regulates osmotic stress response by regulating osmotic-responsive gene expression. Furthermore, we discovered that the nuclear translocation of GPX1 is regulated by its acetylation under osmotic stress. Taken together, our findings not only uncover the redox regulation of the GPX1-bZIP68 module during osmotic stress but also highlight the coordination of protein acetylation and redox signaling in plant osmotic stress responses. | Heng Zhou Feng Zhang Fengchao Zhai Ye Su Ying Zhou Zhenglin Ge Priyadarshini Tilak Jürgen Eirich Iris Finkemeier Ling Fu Zongmin Li Jing Yang Wenbiao Shen Xingxing Yuan Yanjie Xie | 2022 | Molecular Plant2022，15，4： | 2 |
| 17 | Serum levels of tumor necrosis factor-alpha (TNF-alpha) ,interleukin 6 (IL-6), and their soluble receptors in coal workers' pneumoconiosis 显示文摘 | ZHAI R LIU G GE X | 2002 | Respir Med2002，96，10： | 1 |
| 18 | Differences in cellular and inflammatory cytokine profiles in the bronchial veolar lavage fluid in bagassosis and silicosis 显示文摘 | Zhai R Ge X Li H | 2004 | Am JIndMed2004，46，： | 1 |
| 19 | An approach for simulating the air brake system of long freight trains based on fluid dynamics显示文摘Air brake systems are critical equipment for railway trains, which affects the running safety of the trains significantly. To study air braking characteristics of long freight trains, an approach for simulating air brake systems based on fuid dynamics theory was proposed. The structures and working mechanisms of locomotive and wagon air brakes are introduced, and mathematical models of the pipes, brake valves, reservoirs or chambers, cylinders, etc., are presented.Besides, the dynamic motions of parts in the main valve are considered. The simulation model of the whole air brake system is then formulated, and the solving method based on the finite-difference method is used. New efficient pipe boundary conditions without iterations are developed for brake pipes and branch pipes, which can achieve higher computational efficiency. The proposed approach for simulating the air brake system is validated by comparing with published measured data. Simulation results of different train formations indicate that models that consider the dynamic behavior of brake pipes are recommended for predicting the characteristics of long trains under service braking conditions. | Xin Ge Qinghua Chen Liang Ling Wanming Zhai Kaiyun Wang | 2023 | Railway Engineering Science2023，31，2： | 1 |
| 20 | Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagas sosis and silicosis 显示文摘 | Zhai R Ge X Li H | 2004 | Am J Ind Med2004，46，33： | 1 |
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