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351篇 您的检索式:作者名="Qinghua Chen"
    题名 作者 年代 出处 被引量
1A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen 2017Molecular Plant2017,10,3:39
2Constructal entransy dissipation rate minimization for 'disc-to-point' heat conduction显示文摘Based on constructal theory,'disc-to-point' heat conduction is optimized by minimizing the entransy dissipation rate whereby a critical point is determined that distributes the high-conductivity material according to optimized radial or branch patterns.The results show that the critical point is determined by the product of the thermal conductivity ratio of the two materials and the volume fraction of the high-conductivity material allocated to the entire volume.The notion of optimal heat transfer performance can be attributed to the disc based on the entransy dissipation extremum principle.Comparing the results based on EDR minimization (entransy dissipation rate minimization) with those based on MTD minimization (maximum temperature difference minimization),one finds that the performance derived from the two optimization procedures are different.When the product of the thermal conductivity ratio and volume fraction is 30,the critical point of the former procedure is that for which the nondimensional radius of the disc equals 1.75,while that of the latter procedure is that for which this radius of the disc equals 2.18.Comparing heat transfer performances from the two procedures,the mean heat transfer temperature difference is decreased more for the former procedure thereby receiving an improved performance quota.XIAO QingHua CHEN LinGen SUN FengRui 2011Chinese Science Bulletin2011,56,1:31
3Constructal entransy dissipation rate and flow-resistance minimizations for cooling channels显示文摘Based on constructal theory,a construct of a volume that generates heat at every point and is cooled by the coolant in the constant or tapered channel is optimized by minimizing entransy dissipation rate and flow resistance.The optimal constructs of the rectangular elements with dimensionless mean thermal resistance minimization as well as the first-,secondand thirdorder assemblies with dimensionless global flow resistance minimizations are obtained respectively.The results show that both the mean temperature difference and the limiting temperature difference of rectangular elements based on EDR (entransy dissipation rate) and MTD (maximum temperature difference) minimizations respectively are almost equal.Comparing heat transfer performances from the two optimization procedures,the dimensionless global flow resistance is decreased more for the former procedure when the assembly’s order is high.It may create great superiority for constructal optimization to combine the entransy dissipation extreme principle with heat convection.XIAO QingHua,CHEN LinGen & SUN FengRui Postgraduate School,Naval University of Engineering,Wuhan 430033,China 2010Science China(Technological Sciences)2010,53,9:27
4Constructal entransy dissipation rate minimization for umbrella-shaped assembly of cylindrical fins显示文摘Umbrella-shaped assembly of cylindrical fins is optimized by adopting analytical method and taking dimensionless mean thermal resistance (MTR) as performance index. The optimal construct of umbrella-shaped assembly is obtained. The results show that the heat conductance performance of the assembly becomes ever worse with ever greater number of elemental cylindrical fins,the umbrella-shaped assembly reduces to cylindrical fin in some values of design parameters,and the diameters’ dependence on design parameters is weak for the optimized assembly. An equivalent thermal resistance defined based on entransy dissipation rate (EDR) reflects an average heat transfer effect of the assembly. The constructal design corresponding to the minimum EDR (or MTR) should be adopted for designing an assembly of fins in engineering at the limit safe condition.XIAO QingHua CHEN LinGen SUN FengRui 2011Science China(Technological Sciences)2011,54,1:24
5Geospatial-temporal analysis of land-use changes in the Yellow River Delta during the last 40 years显示文摘Comprehensive study on land-use change of spatial pattern and temporal process is the key component in land use/land cover changes (LUCC) study nowadays. According to the theories and methods of Geo-information Tupu (Carto-methodology in Geo-information, CMGI) for geospatial and temporal analysis and integration models of spatial pattern and temporal processes in GIS, the paper puts forward Tupu methodology of land-use change and names the basic synthetic unit of spatial-temporal information Tupu unit. Tupu unit is the synthetic unit for geospatial-temporal analysis, which is synthesized by “space·attribute·process”features and composed of relatively homogeneous geographic unit and temporal unit. Based on the spatial features of 4 stages of land-use change in 1956, 1984, 1991, and 1996, a series of Tupu on land-use change in the Yellow River Delta (YRD) are created and studied in the paper, which includes 3 temporal units of spatial-temporal Tupu, process Tupu of land-use changes during the last 40 years, and reconstructions of a series of “arisen”Tupu, “arisen”process Tupu and pattern Tupu on land-use changes in the last 40 years by remapping tables of a reclassifying system. There are 3 methods of Tupu analysis on land-use change that are used to disclose change processes of land-use spatial conversion in YRD, such as spatial query and statistics, order of Tupu units by area and land-use conversion matrixes. In order to reveal the spatial pattern of land-use change processes, we analyze spatial-temporal changes of each Tupu above in various temporal units and spatial difference of pattern Tupu in the last 40 years by dynamic Tupu units. Tupu analysis on regional land-use is a promising trial on the comprehensive research of “spatial pattern of dynamic process”and “temporal process of spatial pattern”in LUCC research. The geo-information Tupu methodology would be a powerful and efficient tool on integrated studies of spatial pattern and temporal process in geoscience.YE Qinghua1,3,4,LIU Gaohuan2,TIAN Guoliang1,CHEN Shenliang3,HUANG Chong2,CHEN Shupeng1,2,LIU Qingshen2,CHANG Jun2 & SHI Yanan2 1.State Key Laboratory of Remote Sensing Science,Institute of Remote Sensing Applications(IRSA),Chinese Academy of Science(CAS),Beijing 100101,China 2.Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing 100101,China 3.State Key Laboratory of Estuarine and Coastal Research,East China Normal University,Shanghai 200062,China 4.Institute of Tibetan Plateau Research(ITPR),CAS,Beijing 100085,China Correspondence should be addressed to Ye Qinghua(email: yeqh@itpcas.ac.cn) 2004Science China Earth Sciences2004,47,11:22
6Endothelial Nitric Oxide Synthase Gene Intron 4, 27 bp Repeat Polymorphism and Essential Hypertension in the Kazakh Chinese Population显示文摘为了调查在 27 bp 之间的关系,在内含子 4in 重复多型性 endothelial 在 KazakhChinese 人口的氮的氧化物合酶( eNOS4 )基因和必要高血压,有必要高血压和 138 个健康的人的 151 个病人在 Xinjiang uygur 从 Shawan 区域的 Boertonggu 农村被选择中国 in2006 的自治区域。在二个组的 eNOS 的多型性与聚合酶链反应试金被检测,在每个组的遗传型频率是计算的跟随 Hardy-Weinberg 法律。Fourand 27 bp 重复的五辆双人脚踏车是被指明一 and “ b' 分别地。b/b, b/a 和 eNOS4 基因的 a/a 遗传型的频率在控制组是 84.06% , 15.22% 和 0.72% ,这被发现,并且 81.46% , 15.89% 和 2.65% 分别地在高血压组织。基因的频率一 and “ b' 在控制组是 91.67% 和 8.33% , 89.40% 和 10.60% 分别地在高血压组织。血浆 eNOS 活动没与 eNOS 基因的遗传型和等位基因被联系,这被发现。在高血压组的血浆 eNOS 活动显著地与控制组(P<0.01 ) 相比被减少。结果建议 eNOS4 基因多型性是不大可能的是为在 Xinjiang 哈萨克人口的必要高血压的主要基因危险性因素。然而,在血浆 eNOS 活动之间的一个积极协会和必要高血压被揭示了。Fengmei DENG Qinghua HU Bin TANG Fang HE Shuxia GUO Jiang CHEN Feng LI Xuehua WU Jun ZHANG Huimin ZHANG Juan ZHAO Hua ZHONG Ling HE Jun LI Le ZHANG Shuren WANG 2007Acta Biochimica et Biophysica Sinica2007,39,5:18
7Constructal entransy dissipation rate minimization for heat conduction based on a tapered element显示文摘Based on constructal theory,the structure of a tapered element and high-conductivity link is optimized by taking the minimization of the entransy dissipation rate as the optimization objective.The results show that the mean temperature difference of the heat transfer cannot always decrease when the internal complexity of the control-volume increases.There exists an optimal constructal order leading to the minimum mean temperature difference for heat transfer.The thermal current density in high-conductivity links with variable shapes does not linearly depend on the length.Therefore,the optimized constructs based on the minimization of the entransy dissipation rate are different from those based on the minimization of the maximum temperature difference.Compared with the construct based on the minimization of the maximum temperature difference,the construct based on the minimization of the entransy dissipation rate can reduce the mean temperature difference,and improve the heat transfer performance significantly.Because entransy describes the heat transfer ability more suitably,various constructal problems in heat conduction may be addressed more effectively using this basis.XIAO QingHua CHEN LinGen SUN FengRui 2011Chinese Science Bulletin2011,56,22:17
8Identification of the novel recessive gene pi55(t) conferring resistance to Magnaporthe oryzae显示文摘The elite rice cultivar Yuejingsimiao 2 (YJ2) is characterized by a high level of grain quality and yield, and resistance against Magnaporthe oryzae. YJ2 showed 100% resistance to four fungal populations collected from Guangdong, Sichuan, Liaoning, and Heilongjiang Provinces, which is a higher frequency than that shown by the well-known resistance (R) gene donor cultivars such as Sanhuangzhan 2 and 28zhan. Segregation analysis for resistance with F 2 and F 4 populations indicated the resistance of YJ2 was controlled by multiple genes that are dominant or recessive. The putative R genes of YJ2 were roughly tagged by SSR markers, located on chromosomes 2, 6, 8, and 12, in a bulked-segregant analysis using genome-wide selected SSR markers with F 4 lines that segregated into 3 resistant (R):1 susceptible (S) or 1R:3S. The recessive R gene on chromosome 8 was further mapped to an interval 1.9 cM/152 kb in length by linkage analysis with genomic position-ready markers in the mapping population derived from an F 4 line that segregated into 1R:3S. Given that no major R gene was mapped to this interval, the novel R gene was designated as pi55(t). Out of 26 candidate genes predicted in the region based on the reference genomic sequence of the cultivar Nipponbare, two genes that encode a leucine-rich repeat-containing protein and heavy-metalassociated domain-containing protein, respectively, were suggested as the most likely candidates for pi55(t).HE XiuYing LIU XinQiong WANG Li WANGLing LIN Fei CHENG YongSheng CHEN ZhaoMing LIAO YaoPing PAN QingHua 2012Science China(Life Sciences)2012,55,2:15
9Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang 2015Cellular & Molecular Immunology2015,12,3:15
10Crop 3D a LiDAR based platform for 3D high-throughput crop phenotyping显示文摘With the growing population and the reducing arable land, breeding has been considered as an effective way to solve the food crisis.As an important part in breeding, high-throughput phenotyping can accelerate the breeding process effectively. Light detection and ranging(LiDAR) is an active remote sensing technology that is capable of acquiring three-dimensional(3 D) data accurately,and has a great potential in crop phenotyping. Given that crop phenotyping based on LiDAR technology is not common in China,we developed a high-throughput crop phenotyping platform, named Crop 3 D, which integrated LiDAR sensor, high-resolution camera, thermal camera and hyperspectral imager. Compared with traditional crop phenotyping techniques, Crop 3 D can acquire multi-source phenotypic data in the whole crop growing period and extract plant height, plant width, leaf length, leaf width, leaf area, leaf inclination angle and other parameters for plant biology and genomics analysis. In this paper, we described the designs,functions and testing results of the Crop 3 D platform, and briefly discussed the potential applications and future development of the platform in phenotyping. We concluded that platforms integrating LiDAR and traditional remote sensing techniques might be the future trend of crop high-throughput phenotyping.Qinghua Guo Fangfang Wu Shuxin Pang Xiaoqian Zhao Linhai Chen Jin Liu Baolin Xue Guangcai Xu Le Li Haichun Jing Chengcai Chu 2018Science China(Life Sciences)2018,61,3:14
11Research Progress on Heat Stress of Rice at Flowering Stage显示文摘Global warming has caused frequent occurrence of heat stress at the flowering stage of single-season rice in the Yangtze River region of China, which results in declines of spikelet fertility and yield in rice. Rice flowering stage is the most sensitive period to high temperatures, and therefore, the key for heat stress happening is the flowering stage coinciding with high temperature, which causes spikelet fertility decreasing in heat-sensitive varieties, and is the major factor for heat injury differences among various rice planting regions. With the development of rice breeding, temperature indexes for heat stress has been converted from daily maximum temperature of 35 oC to 38 oC with the stress duration of more than 3 d. During the flowering stage, anther dehiscence inhibition and low pollen shedding onto the stigma are two main reasons for spikelet fertility reduction under high temperatures. At panicle initiation stage, high temperatures aggravate spikelet degeneration, and destroy floral organ development. Various types of rice varieties coexist in production, and indica-japonica hybrid rice demonstrates the highest heat resistance in general, followed by indica and japonica rice varieties. In production, avoiding high temperature is the main strategy of preventing heat stress, and planting suitable cultivars and adjustment of sowing date are the most effective measures. Irrigation is an effective real-time cultivation measure to decline the canopy temperature during the rice flowering stage. We suggested that further study should be focused on exploring heat injury differences among different rice variety types, and innovating rice-planting methods according to planting system changes in rice planting regions with extreme heat stress. Meanwhile, high temperature monitor and warning systems should be improved to achieve optimal heat stress management efficiencies.WANG Yaliang WANG Lei ZHOU Jianxia HU Shengbo CHEN Huizhe XIANG Jing ZHANG Yikai ZENG Yongjun SHI Qinghua ZHU Defeng ZHANG Yuping 2019Rice science2019,26,1:13
12Distant eQTLs and Non-coding Sequences Play Critical Roles in Regulating Gene Expression and Quantitative Trait Variation in Maize显示文摘Haijun Liu Xin Luo Luyao Niu Yingjie Xiao Lu Chen Jie Liu Xiaqing Wang Minliang Jin Wenqiang Li Qinghua Zhang Jianbing Yan 2017Molecular Plant2017,10,3:13
13Constructal design for a steam generator based on entransy dissipation extremum principle显示文摘Steam generator is optimized by applying entransy dissipation extremum principle and constructal theory and adopting analyti-cal method.The obtained results show that the optimal spacing between adjacent tubes,the mass flow rate of gas and the maximum entransy dissipation rate all depend on the dimensionless diameter of one tube,the dimensionless pressure difference number and the dimensionless length of flow channel of gas.Besides the three dimensionless groups,the optimal numbers of riser tubes and downcomer tubes and their summation all depend on the dimensionless height of one tube.The maximum entransy dissipation rate increases as the pressure difference that drives the gas flowing increases,and as the diameter of one tube and the length of flow channel both decrease.The mean heat flux in the heat transfer process of hot gas grows greatly,and the performance of the system is improved.Compared with the optimal construct with heat transfer rate maximization,the optimal construct with entransy dissipation rate maximization can improved the heat transfer effect of the steam generator more.XIAO QingHua CHEN LinGen SUN FengRui 2011Science China(Technological Sciences)2011,54,6:12
14Constructal entransy dissipation rate minimization for a heat generating volume cooled by forced convection显示文摘The geometry of a heat generating volume cooled by forced convection is optimized by applying the entransy dissipation extremum principle and constructal theory, while the optimal spacing between the adjacent tubes and the optimal diameter of each tube are obtained based on entransy dissipation rate minimization. The results of this work show that the optimal constructs based on entransy dissipation rate minimization and maximum temperature difference minimization, respectively, are clearly different. For the former, the porosity of the volume of channels allocated to the heat generating volume is 1/2; while for the latter, the larger the porosity is, the better the performance will be. The optimal construct of the former greatly decreases the mean thermal resistance and improves the global heat transfer performance of the system compared with the optimal construct of the latter. This is identical to the essential requirement of the entransy dissipation extremum principle that the required heat transfer temperature difference is minimal with the same heat transfer rate (the given amount of heat generated in the heat generating volume) based on the entransy dissipation extremum principle.XIAO QingHua CHEN LinGen SUN FengRui 2011Chinese Science Bulletin2011,56,27:12
15Use of a multi-temporal grid method to analyze changes in glacier coverage in the Tibetan Plateau显示文摘This paper describes a multi-temporal grid method for quantifying changes in glacier coverage. A multi-temporal grid synthesizes spatial, attribute and process components of glacier information by sequentially combining spatial data from satellite images or maps. It enables us to identify glacier retreat and advance areas in individual grid cells for three or more periods of data sets. Discrepancies among the sequential data sets were detected graphically and numerically, including noise from geo-location error, misclassification, or different interpretation results in various pixel resolutions. Noise was detected and corrected to a large extent by visualization of the synthetic grid. The paper compares the results with that from a common method based on individual data sets, focusing on the Mt. Naimona’Nyi and Mt. Qomolangma regions at the northern slopes of the Himalayas. Results show that the identified noise (e.g. by 2.5 km2 in the Mt. Naimona’Nyi region) is much larger than measurement uncertainty calculated by sensor resolution and coregistration error (e.g. by 0.015 km2 in the Mt. Naimona’Nyi region). After noise removal, we notice that glacier recession clearly accelerates. The multi-temporal grid method results in a better quantification of glacier variation. It shows that glaciers in the Himalayas have both retreated and advanced during the last several decades, with retreat dominating and accelerating. Glaciers on the northern slope of Mt. Qomolangma in the middle Himalayas retreat more extensively and faster than those in the Mt. Naimona’Nyi region in the western Himalayas.Qinghua Ye Feng Chen Alfred Stein Zhenwei Zhong 2009Progress in Natural Science:Materials International2009,19,7:11
16Towards reliable Arctic sea ice prediction using multivariate data assimilation显示文摘Rapid declines in Arctic sea ice have captured attention and pose significant challenges to a variety of stakeholders. There is a rising demand for Arctic sea ice prediction at daily to seasonal time scales, which is partly a sea ice initial condition problem. Thus, a multivariate data assimilation that integrates sea ice observations to generate realistic and skillful model initialization is needed to improve predictive skill of Arctic sea ice. Sea ice data assimilation is a relatively new research area. In this review paper, we focus on two challenges for implementing multivariate data assimilation systems for sea ice forecast. First, to address the challenge of limited spatiotemporal coverage and large uncertainties of observations, we discuss sea ice parameters derived from satellite remote sensing that(1) have been utilized for improved model initialization, including concentration, thickness and drift, and(2) are currently under development with the potential for enhancing the predictability of Arctic sea ice, including melt ponds and sea ice leads. Second, to strive to generate the ‘‘best' estimate of sea ice initial conditions by combining model simulations/forecasts and observations, we review capabilities and limitations of different data assimilation techniques that have been developed and used to assimilate observed sea ice parameters in dynamical models.Jiping Liu Zhiqiang Chen Yongyun Hu Yuanyuan Zhang Yifan Ding Xiao Cheng Qinghua Yang Lars Nerger Gunnar Spreen Radley Horton Jun Inoue Chaoyuan Yang Ming Li Mirong Song 2019Science Bulletin2019,64,1:10
17Performance of pond–wetland complexes as a preliminary processor of drinking water sources显示文摘Shijiuyang Constructed Wetland(110 hm^2) is a drinking water source treatment wetland with primary structural units of ponds and plant-bed/ditch systems. The wetland can process about 250,000 tonnes of source water in the Xincheng River every day and supplies raw water for Shijiuyang Drinking Water Plant. Daily data for 28 months indicated that the major water quality indexes of source water had been improved by one grade. The percentage increase for dissolved oxygen and the removal rates of ammonia nitrogen, iron and manganese were 73.63%, 38.86%, 35.64%, and 22.14% respectively. The treatment performance weight of ponds and plant-bed/ditch systems was roughly equal but they treated different pollutants preferentially. Most water quality indexes had better treatment efficacy with increasing temperature and inlet concentrations. These results revealed that the pond–wetland complexes exhibited strong buffering capacity for source water quality improvement. The treatment cost of Shijiuyang Drinking Water Plant was reduced by about 30.3%. Regional rainfall significantly determined the external river water levels and adversely deteriorated the inlet water quality, thus suggesting that the 'hidden' diffuse pollution in the multitudinous stream branches as well as their catchments should be the controlling emphases for river source water protection in the future. The combination of pond and plant-bed/ditch systems provides a successful paradigm for drinking water source pretreatment. Three other drinking water source treatment wetlands with ponds and plant-bed/ditch systems are in operation or construction in the stream networks of the Yangtze River Delta and more people will be benefited.Weidong Wang Jun Zheng Zhongqiong Wang Rongbin Zhang Qinghua Chen Xinfeng Yu Chengqing Yin 2016Journal of Environmental Sciences2016,28,1:10
18A new numerical technique for simulating the coupled seismic and electromagnetic waves in layered porous media显示文摘Chen's technique of computing synthetic seismograms,which decomposes every vector with a set of basis of orthogonality and completeness before applying the Luco-Apsel-Chen(LAC)generalized reflection and transmission coefficients method,is confirmed to be efficient in dealing with elastic waves in multi-layered media and accurate in any frequency range.In this article,we extend Chen's technique to the computation of coupled seismic and electromagnetic(EM)waves in layered porous media.Expanding the involved mechanical and electromagnetic fields by a set of scalar and vector wave-function basis,we obtain the fundamental equations which are subsequently solved by using a recently developed version of the LAC generalized reflection and transmission coefficients method.Our approach and corresponding program is validated by reciprocity tests.We also show a numerical example of a two-layer model with an explosion source.The P-to-EM conversion waves radiated from the interface may have potential application.Hengxin Ren Qinghua Huang Xiaofei Chen 2010Earthquake Science2010,23,2:10
19Short-term local prediction of wind speed and wind power based on singular spectrum analysis and locality-sensitive hashing显示文摘With the growing penetration of wind power in power systems, more accurate prediction of wind speed and wind power is required for real-time scheduling and operation. In this paper, a novel forecast model for shortterm prediction of wind speed and wind power is proposed,which is based on singular spectrum analysis(SSA) and locality-sensitive hashing(LSH). To deal with the impact of high volatility of the original time series, SSA is applied to decompose it into two components: the mean trend,which represents the mean tendency of the original time series, and the fluctuation component, which reveals the stochastic characteristics. Both components are reconstructed in a phase space to obtain mean trend segments and fluctuation component segments. After that, LSH is utilized to select similar segments of the mean trend segments, which are then employed in local forecasting, so that the accuracy and efficiency of prediction can be enhanced. Finally, support vector regression is adopted forprediction, where the training input is the synthesis of the similar mean trend segments and the corresponding fluctuation component segments. Simulation studies are conducted on wind speed and wind power time series from four databases, and the final results demonstrate that the proposed model is more accurate and stable in comparison with other models.Ling LIU Tianyao JI Mengshi LI Ziming CHEN Qinghua WU 2018Journal of Modern Power Systems and Clean Energy2018,6,2:10
20MTERF1 regulates the oxidative phosphorylation activity and cell proliferation in HeLa cells显示文摘mitochondrial 抄写结束因素(MTERF ) 家庭是一组高度保存的 DNA 有约束力的蛋白质 composedof 四个关键成员, MTERF14。迄今为止,几研究在 mitochondrial genomeand 上调查了 MTERF1 的有约束力的地点 mitochondrial 基因抄写的规定,而是在 mitochondrial 基因 transcriptionregulation 之间的更复杂的连接, mitochondrial 氧化 phosphorylation (OXPHOS ) ,和房间增长仍然糟糕被理解。在这研究,我们构造了在表示上和是进 HeLa 房间的 transfected 调查 MTERF1 的功能的 MTERF1 的击倒的向量。结果证明尽管 MTERF1 是 mitochondrial 基因抄写的一个 positiveregulatory 因素,它没在 MTERF1 的 mitochondrial DNA.Over表示的复制上有重要效果增加的 mitochondrial 氧化 phosphorylation 活动和支持的 ATP 合成, cyclin D1expression ,和房间增长它的击倒的禁止的 ATP 合成,减少的 cyclin D1 表示,并且 slowedthe 房间生长。这些结果建议 MTERF1 可以由在 HeLa 房间调整氧化 phosphorylationactivity 支持房间增长。最终,这些调查结果由提供新奇卓见进位于房间增长下面的潜在的机制在 MTERF 家庭的 physiologicalfunctions 上为进一步、更最后的研究创造一个基础规定。Guiyuan Chen Jie Dai Shirui Tan Shengke Meng Zhongjian Liu Meizhang Li Qinghua Cui Min Yu 2014Acta Biochimica et Biophysica Sinica2014,46,6:10
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