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| 1 | B7-H3:Another Molecule Marker for Mo-DCs?显示文摘Using a newly generated monoclonal antibody (2E6) against human B7-H3, we explored the expression of the molecule on dendritic cells derived from monocytes (Mo-DCs). Its expression was examined by means of immunostaining and flow cytometric (FCM) analysis. The results showed that B7-H3 was expressed in the course of Mo-DC maturation induced with interleukin 4 (IL-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF). The expression could be detected at all the stages of Mo-DC differentiation, and remained at a quite stable level. Interestingly, B7-H3 was not expressed by T cells and B cells, even these cells were activated respectively by PHA or PWM. A weak expression could be detected on resting monocytes. These data showed that constitutive expression of B7-H3 at a high level was found on imDCs and mDCs derived from monocytes. Due to no expression on T cells and B cells, we speculate that B7-H3 might be another valuable molecule marker for Mo-DCs. | Guangbo Zhang Qiuming Dong Ying Xu Gehua Yu Xueguang Zhang | 2005 | Cellular & Molecular Immunology2005，2，4： | 7 |
| 2 | Low-temperature NH_(3)-SCR of NO_(x) over MnCeO_(x)/TiO_(2) catalyst:Enhanced activity and SO_(2) tolerance by modifying TiO_(2) with Al_(2)O_(3)显示文摘A series of TiO_(2)-Al_(2)O_(3) composites with Al/Ti molar ratios of 0.1,0.2,and 0.4 were synthesized by a coprecipitation method and used as supports to prepare supported MnCeO_(x) catalysts by an impregnation method.The physico-chemical properties of the samples were extensively characterized by N_(2) physisorption,X-ray diffraction,Raman spectroscopy,scanning electron micro scopy and energy-dispersive Xray spectroscopy element mapping,X-ray photoelectron spectroscopy,H_(2)-temperature programmed reduction,ammonia temperature programmed desorption,and in-situ diffuse reflectance infrared Fourier transform spectroscopy.The catalytic activity and resistance to water vapor and SO_(2) of the asprepared catalysts for the SCR of NO_(x) with NH_(3) were evaluated at 50-250℃ and GHSV of 80000 mL/(gcat·h).The results reveal that MnCeO_(x)/TiO_(2)-Al_(2)O_(3) exhibits higher activity and better SO_(2) tolerance than MnCeO_(x)/TiO_(2).Combining with the characterization results,the enhanced activity and SO_(2) tolerance of MnCeO_(x)/TiO_(2)-Al_(2)O_(3) can be mainly attributed to higher relative concentrations of Mn4+and chemisorbed oxygen species,stronger reducibility,and larger adsorption capacity for NH_(3) and NO,which originate from the larger specific surface area and pore volume,higher dispersion of Mn and Ce species compared with MnCeO_(x)/TiO_(2).Moreover,in situ DRIFTS was used to investigate the reaction mechanism,and the results indicate that the NH_(3)-SCR reaction over MnCeO_(x)/TiO_(2) and MnCeO_(x)/TiO_(2)-Al_(2)O_(3) takes place by both the E-R and L-H mechanisms. | Gang Li Dongsen Mao Mengxi Chao Gehua Li Jun Yu Xiaoming Guo | 2021 | Journal of Rare Earths2021，39，7： | 6 |
| 3 | Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis显示文摘Osteoarthritis(OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective diseasemodifying therapy. Here, we report that elevated cyclooxygenase-2(COX-2) expression in the osteocytes of subchondral bone causes both spontaneous OA and rheumatoid arthritis(RA). The knockout of COX-2 in osteocytes or treatment with a COX-2 inhibitor effectively rescues the structure of subchondral bone and attenuates cartilage degeneration in spontaneous OA(STR/Ort)mice and tumor necrosis factor-α transgenic RA mice. Thus, elevated COX-2 expression in subchondral bone induces both OAassociated and RA-associated joint cartilage degeneration. The inhibition of COX-2 expression can potentially modify joint destruction in patients with arthritis. | Manli Tu Mi Yang Nanxi Yu Gehua Zhen Mei Wan Wenlong Liu Baochao Ji Hairong Ma Qiaoyue Guo Peijian Tong Li Cao Xianghang Luo Xu Cao | 2019 | Bone Research2019，7，3： | 5 |
| 4 | Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune Response显示文摘During maturation,murine myeloid dendritic cells (DCs) upregulated the expressions of CD11c,CD25,CD40,CD80,CD86,MHC Ⅱ and programmed death 1 ligands 1 and 2 (PD-L1 and PD-L2). Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-α. PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40-ligated DCs,whereas TNF-α stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs. Proliferations of T lymphocytes stimulated by immature DCs were enhanced by blockade of the PD-1 and PD-1 ligand interaction. But inhibitive effects were found in T lymphocytes stimulated by CD40-ligated DCs. With the fine-tuned expressions of PD-L1 and PD-L2,CD40-ligated DCs could sustain a longer activation period and elicit a more efficient T lymphocyte activation. | Tao Gu Yibei Zhu Cheng Chen Min Li Yongjing Chen Gehua Yu Yan Ge Shiyong Zhou Huan Zhou Yong Huang Yuhua Qiu Xueguang Zhang | 2008 | Cellular & Molecular Immunology2008，5，1： | 3 |
| 5 | A Novel Anti-Human Syndecan-1 (CD138) Monoclonal Antibody 4B3: Characterization and Application显示文摘Syndecan-1 (CD138), a member of integral membrane heparin sulfate proteoglycans, is an essential matrix receptor for maintaining the normal morphological phenotypes. In this study, we generated a specific mouse anti-human syndecan-1 monoclonal antibody (mAb) 4B3 and identified it by competition assay with the available syndecan-1 mAb (BB4). Stained by 4B3, the expression of syndecan-1 was detected on tumor cell lines, such as 8226, U266, XG-1, XG-2, Daudi and Jurkat. The expression was also found on neuron stem cells. It was established that 4B3 mAb could inhibit XG-1 and XG-2 proliferation. The data not only determined that 4B3 mAb was a functional anti-human syndecan-1 mAb, but also indicated that syndecan-1 might be a valuable surface antigen and play an important role in regulation of tumor pathology and differentiation of neural stem cells. This novel antibody 4B3 may be value of study of tumor proliferation/survival mechanism and contributes to diagnosis and treatment of diverse diseases. | Wanping Sun Fengming Wang Fang Xie Guoqing Wang Jin Sun Gehua Yu Yuhua Qiu Xueguang Zhang | 2007 | Cellular & Molecular Immunology2007，4，3： | 1 |
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