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| 1 | Endocrine role of bone in the regulation of energy metabolism显示文摘Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function.Recently,an increasing number of studies have characterized the significance of bone as an endocrine organ,suggesting that bone-derived factors regulate local bone metabolism and metabolic functions.In addition,these factors can regulate global energy homeostasis by altering insulin sensitivity,feeding behavior,and adipocyte commitment.These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis,treatment,and prevention of metabolic diseases such as osteoporosis,obesity,and diabetes mellitus.In this review,we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research. | Ruoyu Zhou Qiaoyue Guo Ye Xiao Qi Guo Yan Huang Changjun Li Xianghang Luo | 2021 | Bone Research2021，9，4： | 11 |
| 2 | Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis显示文摘Osteoarthritis(OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective diseasemodifying therapy. Here, we report that elevated cyclooxygenase-2(COX-2) expression in the osteocytes of subchondral bone causes both spontaneous OA and rheumatoid arthritis(RA). The knockout of COX-2 in osteocytes or treatment with a COX-2 inhibitor effectively rescues the structure of subchondral bone and attenuates cartilage degeneration in spontaneous OA(STR/Ort)mice and tumor necrosis factor-α transgenic RA mice. Thus, elevated COX-2 expression in subchondral bone induces both OAassociated and RA-associated joint cartilage degeneration. The inhibition of COX-2 expression can potentially modify joint destruction in patients with arthritis. | Manli Tu Mi Yang Nanxi Yu Gehua Zhen Mei Wan Wenlong Liu Baochao Ji Hairong Ma Qiaoyue Guo Peijian Tong Li Cao Xianghang Luo Xu Cao | 2019 | Bone Research2019，7，3： | 5 |
| 3 | New practice in semaglutide on type-2 diabetes and obesity:clinical evidence and expectation显示文摘Obesity is an important risk factor of type 2 diabetes(T2D),which has become an important factor threatening human health.However,no perfect drug choice for obesity exists.Semaglutide is a kind of human glucagon-like peptide-1(GLP-1)analog that promotes insulin secretion while inhibiting glucagon secretion through a glucose concentration-dependent mechanism.GLP-1 can also delay stomach emptying and suppress appetite to help lose weight.This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes expectations on future clinical trials for obesity treatment. | Yalin Liu Xianghang Luo | 2022 | Frontiers of Medicine2022，16，1： | 2 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | MicroRNAs and their roles in osteoclast differentiation显示文摘Osteoclasts,which are derived from monocyte-macrophage precursors,are exclusive bone resorption cells.Limited evidence indicates that a class of small non-coding single-stranded RNAs known as“microRNAs”(miRNAs)is also involved in bone resorption.Although various miRNAs regulate cell proliferation and differentiation,few miRNAs have been reported to play a key role in the regulation of osteoclast differentiation.In this short review,the biology and functional mechanisms of miRNAs in osteoclastogenesis are summarized.The profiling,function,and target prediction of miRNAs are discussed as well. | Zhuying Xia Chao Chen Peng Chen Hui Xie Xianghang Luo | 2011 | Frontiers of Medicine2011，5，4： | 2 |
| 6 | Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway显示文摘 | Luo Xianghang Guo Lijuan Yuan Lingqing | 2005 | Exp Cell Res2005，309，1： | 1 |
| 7 | Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts via the MAPK signaling pathway显示文摘 | Luo Xianghang Guo Lijuan Xie Hui | 2006 | J Bone M iner Res2006，21，10： | 1 |
| 8 | The role of microRNAs in adipocyte differentiation显示文摘Adipocytes differentiate from mesenchymal stem cells(MSCs)in a process known as adipogenesis.The programme of adipogenesis is regulated by the sequential activation of transcription factors and several signaling pathways.There is growing evidence indicating that a class of small non-coding single-stranded RNAs known as“microRNAs(miRNAs)”also are involved in this process.In this review,we summarize the biology and functional mechanisms of miRNAs in adipocyte differentiation.In addition,we further discuss the miRNAs profiling,the miRNAs function and miRNAs target prediction in the adipogenesis. | Rong Zhang Di Wang Zhuying Xia Chao Chen Peng Cheng Hui Xie Xianghang Luo | 2013 | Frontiers of Medicine2013，7，2： | 0 |
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