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| 1 | Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner显示文摘Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner. | Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 2 | Standardization of Surgeon-Controlled Variables: Impact on Outcome in Patients With Acute Cholecystitis显示文摘 | Joshua A. Greenwald Heather F. McMullen Gene F. Coppa Richard M. Newman | 2000 | Annals of Surgery2000，，3： | 1 |
| 3 | WNT AGONIST ATTENUATES LIVER INJURY AND IMPROVES SURVIVAL AFTER HEPATIC ISCHEMIA/REPERFUSION显示文摘 | Michael Kuncewitch Weng-Lang Yang Ernesto Molmenti Jeffrey Nicastro Gene F. Coppa Ping Wang | 2013 | Shock2013，，1： | 1 |
| 4 | Alcohol and hepatocyte-Kupffer cell interaction (Review)显示文摘 | Michael Ajakaiye Asha Jacob Rongqian Wu Jeffrey Nicastro Gene Coppa Ping Wang | 2011 | Molecular Medicine Reports2011，，4： | 1 |
| 5 | Human ghrelin protects animals from renal ischemia-reperfusion injury through the vagus nerve显示文摘 | Derry Rajan Rongqian Wu Kavin G. Shah Asha Jacob Gene F. Coppa Ping Wang | 2012 | Surgery2012，，1： | 1 |
| 6 | Standardization of Surgeon-Controlled Variables: Impact on Outcome in Patients With Acute Cholecystitis显示文摘 | Joshua A. Greenwald Heather F. McMullen Gene F. Coppa Richard M. Newman | 2000 | Annals of Surgery2000，，3： | 1 |
| 7 | Adenocarcinoma arising at ileostomy sites:Two cases and a review of the literature显示文摘Total colectomy with ileostomy placement is a treatment for patients with inflammatory bowel disease or familial adenomatous polyposis(FAP). A rare and late complication of this treatment is carcinoma arising at the ileostomy site. We describe two such cases: a 78-year-old male 30 years after subtotal colectomy and ileostomy for FAP, and an 85-year-old male 50 years after colectomy and ileostomy for ulcerative colitis. The long latency period between creation of the ileostomies and development of carcinoma suggests a chronic metaplasia due to an irritating/inflammatory causative factor. Surgical excision of the mass and relocation of the stoma is the mainstay of therapy, with possible benefits from adjuvant chemotherapy. Newly developed lesions at stoma sites should be biopsied to rule out the possibility of this rare ileostomy complication. | Lauren Procaccino Sameer Rehman Alexander Abdurakhmanov Peter McWhorter Nicholas La Gamma Madhu C Bhaskaran James Maurer Gregory M Grimaldi Horacio Rilo Jeffrey Nicastro Gene Coppa Ernesto P Molmenti John Procaccino | 2015 | World Journal of Gastrointestinal Surgery2015，7，6： | 0 |
| 8 | Monoclonal antibodies that target the immunogenic proteins expressed in colorectal cancer显示文摘In an attempt to improve upon the end results obtained in treating colorectal cancer it was apparent that the earlier the diagnosis that could be obtained, the better the chance for obtaining desired results. In the case of more advanced tumors typified by later stage colorectal cancer, surgical debulking is an important part of the treatment strategy. Here the use of additional therapeu-tic modalities including chemotherapy and present day immunotherapy has failed to accomplish the desired im-provements that have been sought after. Adjuvant ther-apy, has offered little to the overall survival. The concept of early detection is now recognized as the initial step in reaching proper end results and can readily be demon-strated from colorectal cancer studies. Here survival has been found to be a reflection of the stage at which the tumor is first identified and treated. When specific mono-clonals targeting colorectal cancer are employed diagnos-tically, we have been able to demonstrate detection of colorectal cancer at its inception as a premalignant lesion, such that genotypic features can be identified before the phenotypic appearance of cancer can be noted. | Myron Arlen Philip Arlen Gene Coppa Jim Crawford XuePing Wang Olga Saric Alex Dubeykovskiy Ernesto Molmenti | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 0 |
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