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| 1 | Correlation between BRAF^(V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma显示文摘In adults, the presence of the BRAF^(V600E) mutation in papillary thyroid cancer(PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF^(V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF^(V600E) mutation in48 pediatric patients with PTC, aged 3–13 years. Of these patients, 41 were diagnosed with classic PTC, five were found to have a follicular variant of PTC, and two to exhibit a diffuse sclerosing PTC variant. The BRAF^(V600E) mutation was identified to be present in 35.4% of the 48 analyzed patients, and in 41.5% of the patients diagnosed with classical PTC. Furthermore, the presence of the BRAF^(V600E) mutation was found to be associated with a patient age at diagnosis of less than ten years(P=0.011), the performance of a thyroidectomy(P=0.03), exhibited tumor multifocality(P=0.02) and/or extra-thyroidal invasion(P=0.003), and both a low MACIS(Metastases, Age, Completeness of resection, Invasion, Size)(P=0.036) and AMES(Age, Metastasis, Extent of tumor,Size)(P=0.001)score. Together, these data suggest that the presence of the BRAF^(V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric PTC. | Jiangqiao Geng Huanmin Wang Yuanhu Liu Jun Tai Yaqiong Jin Jie Zhang Lejian He Libing Fu Hong Qin Yingluan Song Jinzhu Su Aiying Zhang Xin Wen Yongli Guo Xin Ni | 2017 | Science China(Life Sciences)2017，60，7： | 9 |
| 2 | Liquid-Solid Phase Equilibria of Nb-Si-Ti Ternary Alloys显示文摘To determine the liquid-solid phase equilibria of the Nb-Si-Ti ternary system,Nb-Si-Ti alloys of different compositions are pre-pared. By means of scanning electron microscopy (SEM),X-ray diffraction (XRD) and electron probe microanalysis (EPMA),the phases in the alloys,such as Si-based solutions,Ti(Nb)Si,Ti(Nb)Si2,Nb(Ti)Si2,Ti(Nb)5Si4,Nb(Ti)5Si3,Ti(Nb)5Si3,Nb(Ti)3Si and Nb-based solutions are identified,and the phase evolution is analyzed. As a result,the microstructural and microchemical evidence pro-vides a clear definition of the Nb-Si-Ti liquidus surface projection and indicates that the ternary phase diagram has seven transition reac-tions. | Bao Jing Huang Qiang Tang Liang Geng Tai Zhao Xinqing Ma Chaoli | 2008 | Chinese Journal of Aeronautics2008，21，3： | 5 |
| 3 | Correlation between TERT C228T and clinic-pathological features in pediatric papillary thyroid carcinoma显示文摘The aims of the present study were to reveal the prevalence of the TERT C228 T mutation in pediatric papillary thyroid carcinoma(PPTC) and to further investigate the role of the TERT C228 T mutation in PPTC. We also tested another TERT mutation, TERT C250 T, although this was not detected in PPTC patients. In this study, 48 patients with PPTC(41 with classic PPTC) were enrolled. DNA was extracted from PPTC tissues and TERT C228 T mutation analysis was performed. Chi-squared analysis,Fisher’s exact test, and a t-test were applied to test the significance of differences. The TERT C228 T mutation presented in 13(27.1%) of the 48 PPTC patients and 10(24.4%) of the 41 classical PPTC patients. There were significant differences between PPTC patients with the TERT C228 T mutation and those without in terms of modified radical neck dissection, multifocality,capsular invasion, extrathyroidal invasion, and American Joint Committee on Cancer(AJCC) tumor stage(P<0.05). In classical PPTC, there were additional significant differences in other clinic-pathological features, such as AJCC nodal stage(P=0.009)and American Thyroid Association(ATA) PPTC stage(P=0.021) between patients with and without the TERT C228 T mutation.These findings indicate that the TERT C228 T mutation is significantly correlated with certain aggressive clinic-pathological features of PPTC. | Jiangqiao Geng Yuanhu Liu Yongli Guo Huanmin Wang Jun Tai Yaqiong Jin Jie Zhang Yongbo Yu Shengcai Wang Yingluan Song Xin Ni | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 4 | Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging显示文摘 | Kalra S Tai P Genge A | 2006 | J Neurol2006，253，8： | 1 |
| 5 | Isolation of a Variant of Subtilosin A with Hemolytic Activity显示文摘 | Tai Huang Hao Geng Venugopal R Miyyapuram | 2009 | Journal of Bacteriology2009，91，18： | 1 |
| 6 | Thermodynamic assessment of the Nb-Si-Mo system显示文摘 | Tai Geng Changrong Li Xinqing Zhao | 2010 | CALPHAD: Computer Coupling of Phase Diagrams and Thermochemistry2010，34，： | 1 |
| 7 | Rapid improvement incortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging 显示文摘 | Kalra S Tai P Genge A | 2006 | J Neurol2006，253，： | 1 |
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