|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 2 | Progress in the biological function of alpha-enolase显示文摘Alpha-enolase(ENO1), also known as 2-phospho-D-glycerate hydrolase, is a metalloenzyme that catalyzes the conversion of 2-phosphoglyceric acid to phosphoenolpyruvic acid in the glycolytic pathway. It is a multifunctional glycolytic enzyme involved in cellular stress, bacterial and fungal infections, autoantigen activities, the occurrence and metastasis of cancer, parasitic infections, and the growth, development and reproduction of organisms. This article mainly reviews the basic characteristics and biological functions of ENO1. | Hong Ji Jianfa Wang Jingru Guo Yue Li Shuai Lian Wenjin Guo Huanmin Yang Fanzhi Kong Li Zhen Li Guo Yanzhi Liu | 2016 | Animal Nutrition2016，，1： | 9 |
| 3 | Correlation between BRAF^(V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma显示文摘In adults, the presence of the BRAF^(V600E) mutation in papillary thyroid cancer(PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF^(V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF^(V600E) mutation in48 pediatric patients with PTC, aged 3–13 years. Of these patients, 41 were diagnosed with classic PTC, five were found to have a follicular variant of PTC, and two to exhibit a diffuse sclerosing PTC variant. The BRAF^(V600E) mutation was identified to be present in 35.4% of the 48 analyzed patients, and in 41.5% of the patients diagnosed with classical PTC. Furthermore, the presence of the BRAF^(V600E) mutation was found to be associated with a patient age at diagnosis of less than ten years(P=0.011), the performance of a thyroidectomy(P=0.03), exhibited tumor multifocality(P=0.02) and/or extra-thyroidal invasion(P=0.003), and both a low MACIS(Metastases, Age, Completeness of resection, Invasion, Size)(P=0.036) and AMES(Age, Metastasis, Extent of tumor,Size)(P=0.001)score. Together, these data suggest that the presence of the BRAF^(V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric PTC. | Jiangqiao Geng Huanmin Wang Yuanhu Liu Jun Tai Yaqiong Jin Jie Zhang Lejian He Libing Fu Hong Qin Yingluan Song Jinzhu Su Aiying Zhang Xin Wen Yongli Guo Xin Ni | 2017 | Science China(Life Sciences)2017，60，7： | 9 |
| 4 | Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion显示文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy. | Huanmin Niu Lilin Qian Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 4 |
| 5 | Correlation between TERT C228T and clinic-pathological features in pediatric papillary thyroid carcinoma显示文摘The aims of the present study were to reveal the prevalence of the TERT C228 T mutation in pediatric papillary thyroid carcinoma(PPTC) and to further investigate the role of the TERT C228 T mutation in PPTC. We also tested another TERT mutation, TERT C250 T, although this was not detected in PPTC patients. In this study, 48 patients with PPTC(41 with classic PPTC) were enrolled. DNA was extracted from PPTC tissues and TERT C228 T mutation analysis was performed. Chi-squared analysis,Fisher’s exact test, and a t-test were applied to test the significance of differences. The TERT C228 T mutation presented in 13(27.1%) of the 48 PPTC patients and 10(24.4%) of the 41 classical PPTC patients. There were significant differences between PPTC patients with the TERT C228 T mutation and those without in terms of modified radical neck dissection, multifocality,capsular invasion, extrathyroidal invasion, and American Joint Committee on Cancer(AJCC) tumor stage(P<0.05). In classical PPTC, there were additional significant differences in other clinic-pathological features, such as AJCC nodal stage(P=0.009)and American Thyroid Association(ATA) PPTC stage(P=0.021) between patients with and without the TERT C228 T mutation.These findings indicate that the TERT C228 T mutation is significantly correlated with certain aggressive clinic-pathological features of PPTC. | Jiangqiao Geng Yuanhu Liu Yongli Guo Huanmin Wang Jun Tai Yaqiong Jin Jie Zhang Yongbo Yu Shengcai Wang Yingluan Song Xin Ni | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 6 | Diagnosis and treatment of infantile malignant solid tumors in Beijing,China:A multicenter 10-year retrospective study显示文摘Importance:Cancer is the main cause of death by disease in children.Children experience the highest incidence of cancer in the first year of life.However,there is no comprehensive registration system for children with tumors in China.Objective:To summarize the diagnosis and treatment of infant cancer and analyze the status of standardized diagnosis and management among several treatment centers in Beijing,China,thereby providing evidence to guide further clinical research.Methods:From January 1,2010 to December 31,2019,patients with newly diagnosed infantile malignant solid tumors were admitted to six large tertiary pediatric solid tumor diagnosis and treatment centers in Beijing.The epidemiology,clinical features,and therapeutic effects of tumors in these patients were analyzed retrospectively.All patients were followed up until March 31,2020.Results:In total,938 patients were enrolled in this study.There were 530 boys(56.5%)and 408 girls(43.5%);the median age was 6.0 months(range,0-12.0 months).The three most common tumors were retinoblastoma in 366 patients(39.0%),neuroblastoma in 266 patients(28.4%),hepatoblastoma in 133 patients(14.2%),and central nervous system tumors in 52 patients(5.5%).The estimated 5-year overall survival rate was 81.3%±1.8%,and the 5-year event-free survival rate was 71.8%±2.9%.The 5-year overall survival rates of non-rhabdomyosarcoma soft tissue sarcoma,neuroblastoma,and retinoblastoma were 100%,88%±2.2%,and 86.9%±2.1%,respectively.The 5-year event-free survival rates were 81.1%±2.7%for neuroblastoma,81.6%±9.8%for non-rhabdomyosarcoma soft tissue sarcoma,and 72.7%±14.1%for extracranial malignant germ cell tumors.Interpretation:The three most common infantile malignant solid tumors were retinoblastoma,neuroblastoma,and hepatoblastoma.Multidisciplinary combined diagnosis and treatment is needed for infantile tumors. | Mei Jin Zhi Tian Yao Xie Zhaoxia Zhang Miao Li YaxiongYu Weiling Zhang Junyang Zhao Huanmin Wang Qi Zeng Long Li Ming Ge Ning Sun Xiaolun Zhang Jian Gong Wanshui Wu Rong Liu Weihong Zhao Dongsheng Huang Xiaoli Ma | 2020 | Pediatric Investigation2020，4，3： | 3 |
| 7 | A mesh simplification algorithm with area-weighted half edge collapse and progressive mesh construct 显示文摘 | Liu Huanmin Yang Kejian Wang Yuhua | 2005 | Journal of Wuhan University of Technology2005，29，1： | 1 |
| 8 | Analysis of diagnosis and treatment of lipoblastomatosis显示文摘Dear Editor,Lipoblastomatosis is a rare benign soft tissue tumor arising from the white fetal-embryonal adipose tissue(Choi et al.,2013).Since the distinction of lipoblastomatosis from lipoblastma was reported by Vellios et al.,there are only a few studies,and the incidence rate is approximately3.5/1,000,000.To analyze the diagnosis and treatment of lipoblastomatosis,10 diagnosed cases,from January 2006 to December 2015 in Beijing Children’s Hospital,are discussed in the present study. | Zhiqiang Mo Xianghui Xie Huanmin Wang Hong Qin Wei Han Xiaosong Li | 2017 | Science China(Life Sciences)2017，60，7： | 1 |
| 9 | Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress显示文摘The negative effects of low temperature can readily induce a variety of diseases.We sought to understand the reasons why cold stress induces disease by studying the mechanisms of fine-tuning in macrophages following cold exposure.We found that cold stress triggers increased macrophage activation accompanied by metabolic reprogramming of aerobic glycolysis.The discovery,by genome-wide RNA sequencing,of defective mitochondria in mice macrophages following cold exposure indicated that mitochondrial defects may contribute to this process.In addition,changes in metabolism drive the differentiation of macrophages by affecting histone modifications.Finally,we showed that histone acetylation and lactylation are modulators of macrophage differentiation following cold exposure.Collectively,metabolism-related epigenetic modifications are essential for the differentiation of macrophages in cold-stressed mice,and the regulation of metabolism may be crucial for alleviating the harm induced by cold stress. | Jingjing LU Shoupeng FU Jie DAI Jianwen HU Shize LI Hong JI Zhiquan WANG Jiahong YU Jiming BAO Bin XU Jingru GUO Huanmin YANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，6： | 0 |
| 10 | Electroacupuncture-attenuated ischemic brain injury increases insulin-like growth factor-1 expression in a rat model of focal cerebral ischemia显示文摘Acupuncture has recently gained popularity in many countries as an alternative and complementary therapeutic intervention.Previous studies have shown that changes in genes,proteins,and their metabolites were measureable during acupuncture for treatment of cerebral ischemia.Through the use of in situ hybridization and immunohistochemistry,the present study confirmed that electroacupuncture increased insulin-like growth factor-1 mRNA and protein expression in the corpus striatum following cerebral ischemia,reduced brain edema following middle cerebral artery occlusion reperfusion,and decreased infarct volume.Results suggested that electroacupuncture is effective in the relief of cerebral ischemia by increasing endogenous insulin-like growth factor-1 expression. | Huanmin Gao Ling Wang Yunliang Guo | 2010 | Neural Regeneration Research2010，5，18： | 0 |
| 11 | Investigation of dementia awareness among stroke patients in China:A cross-sectional study显示文摘Objective:To provide guidelines for the prevention of post-stroke dementia,we investigated whether stroke patients were aware of post-stroke dementia and their level of dementia-related knowledge.Methods:Five dementia-related questions were designed.A field survey was conducted in a questionand-answer method using the designed questions.The surveys assessed 3000 stroke patients(2 weekse6 months after stroke attacks)from 14 hospitals/clinical centers in 7 provinces and cities across China.Results:Among 3000 stroke patients,80.5%had heard of dementia,39.1%knew that stroke can lead to dementia,55.7%believed dementia can be prevented,50.8%thought dementia can be cured,and only 8.8%had ever seen a doctor because of memory deterioration.Then,patients were classified into three groups,including a no cognitive impairment(NCI)group,a mild cognitive impairment(MCI)group,and a mild dementia(MD)group.Among the MCI and MD groups,only 8.7%(75/861)and 9.9%(64/649)of patients,respectively,had ever seen a doctor because of memory deterioration.According to our results,patients with a higher level of cognitive impairment had a lower awareness of dementia(P<.001).Conclusion:The awareness of dementia in stroke patients in China is low,and the consultation rate is even lower.Moreover,patients with a higher level of cognitive impairment have a lower awareness of dementia.To improve public awareness and improve prevention,more emphasis should be put on education regarding post-stroke dementia.Routine cognitive function screening should be conducted on stroke patients as an effective way to assess dementia. | Jing Zhou Ying Wang Jiayi Zhao Baoxin Chen Xuemei Liu Chen Fu Xiaobing Hou Huanmin Niu Yunling Zhang Xianglan Jin | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，2： | 0 |
| 12 | MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma显示文摘Neuroblastoma(NB)is one of the most common malignant tumors in children,with variable clinical behaviors and a 15%death rate of all malignancies in childhood.However,genetic susceptibility to sporadic NB in Han Chinese patients is largely unknown.To identify genetic risk factors for NB,we performed an association study on 357 NB patients and 738 control subjects among Han Chinese children.We focused on DEAD box 1(DDX1),a putative RNA helicase,which is involved in NB carcinogenesis.The potential association of DDX1 polymorphisms with NB has not been discovered.Our results demonstrate that rs72780850(NM_004939.2:c.-1555 T>C)located in the DDX1 promoter region is significantly associated with higher expression of DDX1 transcript and increased NB risk(odds ratio=1.64,95%confidence interval=1.03%–2.60%,P=0.004),especially in aggressive NB compared with ganglioneuroma and ganglioneuroblastoma in a dominant model(TC+CC vs.TT).Furthermore,the MYC-associated protein X(MAX)transcription factor showed stronger binding affinity to the DDX1 rs72780850 CC allele compared with the TT allele,explaining the molecular mechanism of the increased NB risk caused by the rs72780850 polymorphism.Our results highlight the involvement of regulatory genetic variants of DDX1 in NB. | Yaqiong Jin Jin Shi Huanmin Wang Jie Lu Chenghao Chen Yongbo Yu Yaru Wang Yeran Yang Dong Ren Qi Zeng Xin Ni Yongli Guo | 2021 | Science China(Life Sciences)2021，64，6： | 0 |
| 13 | Hepatoblastoma with neonatal necrotizing enterocolitis:Two case reports显示文摘We report two children with hepatoblastoma(HB)with a history of neonatal necrotizing enterocolitis(NEC).Case 1 was diagnosed with HB at 5 months of age.Liver enlargement was found during the NEC operation at 3 months of age and then was clinically diagnosed by imaging.After six chemotherapy courses,a partial hepatectomy was performed.Three months after ceasing the chemotherapy,a chest computed tomography scan suggested that distant metastasis of the tumor should be considered,and the lesion was removed.However,9 months after the operation,alpha-fetoprotein concentrations were increased,and abdominal imaging showed a recurrence of the tumor in situ,resulting in a hepatectomy.Case 2 was diagnosed with NEC shortly after birth and underwent an intestinal resection and anastomosis 1 month later.He was diagnosed with HB at 3 years of age.Hepatectomy was performed after five courses of chemotherapy.Chemotherapy was stopped after 10 courses,and alpha-fetoprotein concentrations were normal.At present,both children have survived and are in a healthy condition.Physicians should be aware of the possibility of HB and a history of NEC in children.Premature birth and low birth weight are common factors leading to the pathogenesis of HB and NEC.The association between these two diseases requires further study。 | Sidou He Xisi Wang Chao Duan Wen Zhao Chiyi Jiang Shihan Zhang Binglin Jian Wei Yang Tong Yu Libing Fu Huanmin Wang Xiaoli Ma | 2023 | Cancer Innovation2023，2，6： | 0 |
| 14 | Effects of Seasons on Embryo Transfer of Cattle in Different Climatic Zones显示文摘The paper was to evaluate the efficient seasons for embryo transfer of cattle in different climatic zones in China. Three climatic zones(mid-temperate zone,warm temperate zone,subtropical zone) were designed,and embryo transfers had been carried out in spring,summer,autumn and winter from 2009 to 2011,respectively. The total number of transplant recipient cattle was 22 208. The results showed that the best seasons for embryo transfers varied with different climatic zones. In mid-temperate zone,summer and autumn were better while summer was the best,and the rate of pregnant was 50. 67%(the number of pregnant cattle was 8 005). In warm temperate zone,spring and autumn were better while autumn was the best,and the rate of pregnant was 54. 99 %(the number of pregnant cattle was 551). In subtropical zone,spring and winter were better while winter was the best,and the rate of pregnant was 56. 94 %(the number of pregnant cattle was 328). The seasonal average temperatures and relative humidity of the best seasons in different climatic zones were concentrated on the same region. In mid-temperate zone,the mean temperature ranged between 22. 4 ℃ and 24. 2 ℃,and the mean relative humidity ranged from 44% to 55. 3%. In warm zone,the mean temperature ranges were between 14. 2 ℃ and 16. 2 ℃,and the mean relative humidity ranges were from 59. 3% to 71. 6%. In sub-tropical zone,the mean temperature ranges were between 3. 26 ℃ and 7. 73 ℃,and the mean relative humidity ranges were from 72% to 80. 6%. Therefore,the optimized conditions of temperature and humidity of season in different zones could be simulated. It is possible that we apply the program to bovine production in the similar agroecological zones,which is of great significance for improving the embryo transfer efficiency of livestock in production. | Wang Feng Wang Shenyuan Zhang Dong Han Lidong Li Lu Huang Chunhua Zhong Gang Han Jinlong Wang Bingping Liu Yiyi Liu Caiyun Pan Jing Zhao Zhichao Zhou Huanmin Zhang Li | 2014 | Animal Husbandry and Feed Science2014，6，4： | 0 |
| 15 | Targeting of VPS 18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance显示文摘Dear Editor,Multidrug resistance(MDR)is still a major challenge for successful cancer treatments.Numerous mechanisms that confer therapy-induced drug resistance have been extensively investigated to explore how to combat the MDR.In this regard,lysosomal sequestration has demonstrated to be a mechanism contributing to drug resistance via an/,off-target,/effect in which hydrophobic and weakly basic chemotherapeutic agents are trapped in lysosomes,sequestering them from their targets. | Huanmin Niu Lilin Qian Yanhai Luo Fang Wang Hongbo Zheng Yanhui Gao Hanbo Wang Xuelei Hu Huiqing Yuan Hongxiang Lou | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员