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| 1 | Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer显示文摘瞄准:在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ,肿瘤坏死因素高山哈( TNFalpha ), peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma ),细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法:学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行,结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ,和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果:ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77, 95% CI:1.34-2.34;或 = 1.83, 95% CI:1.23-2.72;并且或 = 1.35, 95% CI:1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78, 95% CI:1.25-2.49 ) 。结论:在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些, SNP 可以改进在风险的为亚人口的适当屏蔽。 | George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli | 2006 | World Journal of Gastroenterology2006，12，31： | 16 |
| 2 | A branch and bound method for stochastic global optimization显示文摘 | Vladimir I Norkin Georg Ch Pfiug and Andrzej Ruszczynski | 1998 | Math Prog1998，83，： | 2 |
| 3 | hnaging features of a heterogeneous group of disorders显示文摘 | Georg FE Jean CH Heinz T | 1998 | Pediatr Radiol1998，28，： | 1 |
| 4 | Prevalence in the U- nited States of aac(6')-Ib-cr encoding a ciprofloxacin-modif- ying enzyme 显示文摘 | Park CH Robicsed A George J | 2006 | Antimicrob Agents Chemother2006，50，39： | 1 |
| 5 | SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs 显示文摘 | Thompson CH Kahlig KM George AL | 2011 | Epilepsia2011，52，5： | 1 |
| 6 | Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor显示文摘 | Michael CH Christopher LC George DD | 2003 | J Clin Oncol2003，21，： | 1 |
| 7 | BSA nanoparticle loaded atorvastatin ealcium-a new facet for an old drug 显示文摘 | Sripriyalakshmi S Anjali CH George PD | 2014 | PLoS One2014，9，86： | 1 |
| 8 | Ryanodine re- ceptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies 显示文摘 | George CH Jundi H Thomas NL | 2007 | J Mol Cell Car- diol2007，42，1： | 1 |
| 9 | Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyo- cytes 显示文摘 | George CH Higgs GV Lai FA | 2003 | Circulation Research2003，93，6： | 1 |
| 10 | Configurations of Series-Parallel Networks with Maximum Relia- bility 显示文摘 | Walter Gutiahr Georg Ch Pflug Andrzei Ruszczynski | 1996 | Microelectronics and Reliability1996，36，2： | 1 |
| 11 | Diode-pumped Yb:GGG laser: comparison with Yb:YAG显示文摘 | S. Chénais F. Druon F. Balembois P. Georges A. Brenier G. Boulon | 2002 | Optical Materials2002，，2： | 1 |
| 12 | Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages显示文摘Polyribonucleotide nucleotidyltransferase 1(Pnpt1)plays critical roles in mitochondrial homeostasis by controlling mitochondrial RNA(mt-RNA)processing,trafficking and degradation.Pnpt1 deficiency results in mitochondrial dysfunction that triggers a type I interferon response,suggesting a role in inflammation.However,the role of Pnpt1 in inflammasome activation remains largely unknown.In this study,we generated myeloid-specific Pnpt1-knockout mice and demonstrated that Pnpt1 depletion enhanced interleukin-1 beta(IL-1β)and interleukin-18(IL-18)secretion in a mouse sepsis model.Using cultured peritoneal and bone marrow-derived macrophages,we demonstrated that Pnpt1 regulated NLRP3 inflammasome-dependent IL-1βrelease in response to lipopolysaccharide(LPS),followed by nigericin,ATP or poly(I:C)treatment.Pnpt1 deficiency in macrophages increased glycolysis after LPS administration and mt-reactive oxygen species(mt-ROS)after NLRP3 inflammasome activation.Pnpt1 activation of the inflammasome was dependent on increased glycolysis and the expression of mitochondrial antiviral-signaling protein(MAVS)but not NF-κB signaling.Collectively,these data suggest that Pnpt1 is an important mediator of inflammation,as shown by activation of the NLRP3 inflammasome in murine sepsis and cultured macrophages. | Chia George Hsu Wenjia Li Mark Sowden Camila Lage Chávez Bradford C.Berk | 2023 | Cellular & Molecular Immunology2023，20，2： | 1 |
| 13 | Developing new anti-arrhythmics:clues from the molecular basis of cardiac ryanodine receptor(RyR2) Ca2+-release channel dysfunction显示文摘 | George CH Lai FA | 2007 | Curr Pharm Des2007，13，31： | 1 |
| 14 | Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes显示文摘 | George CH Higgs GV Lai FA | 2003 | Circ Res2003，93，6： | 1 |
| 15 | Arrhythmogenic mutation-linked defects in ryandine receptor autoregulation reveal a novel mechanism of Ca^2+ release channel dysfunction显示文摘 | George CH Jundi H Waiters N et ai | 2006 | Circ Res2006，98，： | 1 |
| 16 | INSPIRE – Co-Simulation von Energie- und IKT-Systemen zur Evaluation von Smart-Grid-Applikationen显示文摘 | Sven Christian Müller Hanno Georg Markus Küch Christian Wietfeld | 2014 | at - Automatisierungstechnik2014，，5： | 1 |
| 17 | BSA nanoparticle loaded atorvastatin calcium-a new facet for an old drug显示文摘 | Sripriyalakshmi S Anjali CH George PDC | 2014 | Plos One2014，9，86： | 1 |
| 18 | Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coil Topoisomerase Ⅳ 显示文摘 | John HT George A J David CH | 2005 | Antimicrob Agents Chemother2005，49，7： | 1 |
| 19 | Vancomycin-resistant enterococci显示文摘 | Uttley AH Collins CH Naidoo J George RC | 1988 | Lancet1988，1，： | 1 |
| 20 | Variation in red cell transfusion practice in the intensive care unit:a multicentre cohort study显示文摘 | PAUL CH GEORGE W CLAUDIO M | 1999 | Critical Care1999，3，： | 1 |
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