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| 1 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 2 | Does gastric atrophy exist in children?显示文摘Several clinical reports confirmed that gastric atrophy is a pathology not only limited to adult patients. In pediatrics, it is most often described in association with a H pylori infection but this bacteria does not seem to be the only etiological factor of this preneoplastic state in children. The frequency of gastric atrophy and intestinal metaplasia in children are unknown because they are not systematically sought during upper gastrointestinal endoscopy. The lack of specific histological classification of children’s gastropathies makes their diagnosis difficult for pathologists. Based on our knowledge to date, we think that it is necessary to describe, in detail, the natural course of this lesion during childhood. A close and prolonged clinical and endoscopic follow-up is important for children with gastric atrophy. | Georges Dimitrov Frédéric Gottrand | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 3 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 4 | Dual-color deep-tissue three-photon microscopy with a multiband infrared laser显示文摘Multiphoton microscopy combined with genetically encoded fluorescent indicators is a central tool in biology.Threephoton(3P)microscopy with excitation in the short-wavelength infrared(SWIR)water transparency bands at 1.3 and 1.7μm opens up new opportunities for deep-tissue imaging.However,novel strategies are needed to enable in-depth multicolor fluorescence imaging and fully develop such an imaging approach.Here,we report on a novel multiband SWIR source that simultaneously emits ultrashort pulses at 1.3 and 1.7μm that has characteristics optimized for 3P microscopy:sub-70 fs duration,1.25 MHz repetition rate,and μJ-range pulse energy.In turn,we achieve simultaneous 3P excitation of green fluorescent protein(GFP)and red fluorescent proteins(mRFP,mCherry,tdTomato)along with third-harmonic generation.We demonstrate in-depth dual-color 3P imaging in a fixed mouse brain,chick embryo spinal cord,and live adult zebrafish brain,with an improved signal-to-background ratio compared to multicolor twophoton imaging.This development opens the way towards multiparametric imaging deep within scattering tissues. | Khmaies Guesmi Lamiae Abdeladim Samuel Tozer Pierre Mahou Takuma Kumamoto Karolis Jurkus Philippe Rigaud Karine Loulier Nicolas Dray Patrick Georges Marc Hanna Jean Livet Willy Supatto Emmanuel Beaurepaire Frédéric Druon | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 5 | Olfactory Responses to Aphid and Host Plant Volatile Releases: (E)-β-Farnesene an Effective Kairomone for the Predator Adalia bipunctata显示文摘 | Frédéric Francis Georges Lognay Eric Haubruge | 2004 | Journal of Chemical Ecology2004，，4： | 2 |
| 6 | STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo显示文摘 | Melanie Spitzner Birte Roesler Christian Bielfeld Georg Emons Jochen Gaedcke Hendrik A. Wolff Margret Rave‐Fr?nk Frank Kramer Tim Beissbarth Julia Kitz Jürgen Wienands B. Michael Ghadimi Reinhard Ebner Thomas Ried Marian Grade | 2014 | Int J Cancer2014，，4： | 2 |
| 7 | The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control显示文摘 | Jean-Philippe Guégan Christophe Frémin Georges Baffet Chantal Desdouets | 2012 | International Journal of Hepatology2012，，： | 2 |
| 8 | Isoflurane pretreatment has immediatde and delayed protective effects against cytokine-induced injury in endothelial and vascular smooth muscle cells显示文摘 | De Klaver MJM Mary-Gordon B George FR | 2003 | Anesthesiology2003，99，4： | 1 |
| 9 | Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors for Which FISH Analysis Does Not Detect an Increase in EGFR Gene Copy Number显示文摘 | Antoine Italiano MD Philippe Follana MD Fran?ois-Xavier Caroli MD Jean-Luc Badetti MD Daniel Benchimol MD Georges Garnier MD Jean Gugenheim MD Juliette Haudebourg MD Frédérique Keslair MS Gérard Lesbats MD Gérard Lledo MD Jean-Francois Roussel MD Florence | 2008 | Annals of Surgical Oncology2008，，2： | 1 |
| 10 | Activating mutations in ALK provide a therapeutictarget in neuroblastom显示文摘 | George RE Sanda T Hanna M Frhling S Luther W 2nd Zhang J | 2008 | Nature2008，455，7215： | 1 |
| 11 | The functional significance of E-β-Farnesene: Does it influence the populations of aphid natural enemies in the fields?显示文摘 | Liang-Liang Cui Frédéric Francis Stéphanie Heuskin Georges Lognay Ying-Jie Liu Jie Dong Ju-Lian Chen Xu-Ming Song Yong Liu | 2011 | Biological Control2011，，2： | 1 |
| 12 | Electrophysiological and Behavioral Responses of the Multicolored Asian Lady Beetle, Harmonia axyridis Pallas, to Sesquiterpene Semiochemicals显示文摘 | Fran?ois J. Verheggen Quentin Fagel Stéphanie Heuskin Georges Lognay Frédéric Francis Eric Haubruge | 2007 | Journal of Chemical Ecology2007，，11： | 1 |
| 13 | Orientation dependent modulation of apparent speed:psychophysical evidence显示文摘 | Georges S Seriès P Frégnac Y | 2002 | Vision Research2002，42，25： | 1 |
| 14 | Improved hemodynamics with a novel miniaturized intra- aortic axial flow pump in a porcine model of acute left ventricular dysfunction 显示文摘 | Shabari FR George J Cuchiara MP | 2013 | ASAIO J2013，59，3： | 1 |
| 15 | Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity显示文摘 | Kevin M. Foote Andrew A. Mortlock Nicola M. Heron Frédéric H. Jung George B. Hill Georges Pasquet Madeleine C. Brady Stephen Green Simon P. Heaton Sarah Kearney Nicholas J. Keen Rajesh Odedra Stephen R. Wedge Robert W. Wilkinson | 2008 | Bioorganic & Medicinal Chemistry Letters2008，，6： | 1 |
| 16 | Isolation and characterization of Photosystem I from two strains of the marine oxychlorobacterium Prochlorococcus显示文摘 | Laurence Garczarek Georg W. M. van der Staay Jean Claude Thomas Frédéric Partensky | 1998 | Photosynthesis Research1998，，2： | 1 |
| 17 | Geometric morphometrics on Greek house mouse populations (Mus musculus domesticus) with Robertsonian and aU-acrocentric chromosomal arrangements 显示文摘 | Maria K George T Stella Fr | 2013 | Mamm Biol2013，78，： | 1 |
| 18 | Improved hemodynamicswith a novel miniaturized intra - aortic axial flow pump in a porcinemodel of acute left ventricular dysfunction 显示文摘 | Shabari FR George J Cuchiara MP | 2013 | ASAIO J2013，59，3： | 1 |
| 19 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 1 |
| 20 | Super Extended Versus Extended Pelvic Lymph Node Dissection in Patients Undergoing Radical Cystectomy for Bladder Cancer: A Comparative Study显示文摘 | Pascal Zehnder Urs E. Studer Eila C. Skinner Ryan P. Dorin Jie Cai Beat Roth Gus Miranda Frédéric Birkh?user John Stein Fiona C. Burkhard Sia Daneshmand George N. Thalmann Inderbir S. Gill Donald G. Skinner | 2011 | The Journal of Urology2011，，4： | 1 |
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