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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | The first pulsar discovered by FAST显示文摘To assist with the commissioning [1] of the Five-hundredmeter Aperture Spherical radio Telescope (FAST), we performed a pulsar search, with the primary goal of developing and testing the pulsar data acquisition and processing pipelines. We tested and used three pipelines, two (Pl and P2 hereafter) searched for the periodic signature of pulsars whereas the other one was used to search for bright single pulses (P3 hereafter). | Lei Qian ZhiChen Pan Di Li George Hobbs WeiWei Zhu Pei Wang ZhiJie Liu YouLing Yue Yan Zhu HongFei Liu DongJun Yu JingHai Sun Peng Jiang GaoFeng Pan Hui Li HengQian Gan Rui Yao XiaoYao Xie Fernando Camilo Andrew Cameron Lei Zhang Shen Wang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 3 |
| 3 | The role of FAST in pulsar timing arrays显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) will become one of the world-leading telescopes for pulsar timing array(PTA) research. The primary goals for PTAs are to detect(and subsequently study) ultra-low-frequency gravitational waves, to develop a pulsar-based time standard and to improve solar system planetary ephemerides. FAST will have the sensitivity to observe known pulsars with significantly improved signal-to-noise ratios and will discover a large number of currently unknown pulsars. We describe how FAST will contribute to PTA research and show that jitter-and timing-noise will be the limiting noise processes for FAST data sets. Jitter noise will limit the timing precision achievable over data spans of a few years while timing noise will limit the precision achievable over many years. | George Hobbs Shi Dai Richard N.Manchester Ryan M.Shannon Matthew Kerr Ke-Jia Lee Ren-Xin Xu | 2019 | Research in Astronomy and Astrophysics2019，19，2： | 2 |
| 4 | A sustainable agricultural landscape for Australia: A review of interlacing carbon sequestration, biodiversity and salinity management in agroforestry systems显示文摘 | George S J Harper R J Hobbs R J | 2012 | Agriculture Ecosystems and Environment2012，，： | 1 |
| 5 | A sus- tainable agricultural landscape for Australia: A review of interlacing carbon sequestration, bio- diversity and salinity management in agro- forestry systems显示文摘 | George S J Harper R J Hobbs R J | 2012 | Agriculture Ecosystems and Environment2012，163，： | 1 |
| 6 | Flux density measurements for 32 pulsars in the 20 cm observing band显示文摘Flux densities are fundamental observational parameters that describe a pulsar.In the current pulsar catalogue,27% of the listed radio pulsars have no flux density measurement in the 20 cm observing band.Here,we present the first such measurements for 32 pulsars observed employing the Parkes radio telescope.We have used both archival and new observations to make these measurements.Various schemes exist for measuring flux densities and we show how the measured flux densities vary between these methods and how the presence of radio-frequency interference will bias the flux density measurements. | Yan-Wei Xie Jing-Bo Wang George Hobbs Jane Kaczmarek Di Li Jie Zhang Shi Dai Andrew Cameron Lei Zhang Chen-Chen Miao Mao Yuan Shen Wang Song-Bo Zhang Heng Xui Ren-Xin Xu | 2019 | Research in Astronomy and Astrophysics2019，19，7： | 1 |
| 7 | The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies显示文摘 | Hobbs DA George TW Lovegrove JA | 2013 | Nutr Res Rev2013，26，2： | 1 |
| 8 | Gravitational wave astronomy: the current status显示文摘In the centenary year of Einstein's General Theory of Relativity, this paper reviews the current status of gravitational wave astronomy across a spectrum which stretches from attohertz to kilohertz frequencies. Sect. 1 of this paper reviews the historical development of gravitational wave astronomy from Einstein's first prediction to our current understanding the spectrum. It is shown that detection of signals in the audio frequency spectrum can be expected very soon, and that a north-south pair of next generation detectors would provide large scientific benefits. Sect. 2 reviews the theory of gravitational waves and the principles of detection using laser interferometry. The state of the art Advanced LIGO detectors are then described. These detectors have a high chance of detecting the first events in the near future. Sect. 3 reviews the KAGRA detector currently under development in Japan,which will be the first laser interferometer detector to use cryogenic test masses. Sect. 4 of this paper reviews gravitational wave detection in the nanohertz frequency band using the technique of pulsar timing. Sect. 5 reviews the status of gravitational wave detection in the attohertz frequency band, detectable in the polarisation of the cosmic microwave background, and discusses the prospects for detection of primordial waves from the big bang. The techniques described in sects. 1–5 have already placed significant limits on the strength of gravitational wave sources. Sects. 6 and 7 review ambitious plans for future space based gravitational wave detectors in the millihertz frequency band. Sect. 6 presents a roadmap for development of space based gravitational wave detectors by China while sect. 7 discusses a key enabling technology for space interferometry known as time delay interferometry. | BLAIR David JU Li ZHAO ChunNong WEN LinQing CHU Qi FANG Qi CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong REITZE David H. ARAI Koji ZHANG Fan FLAMINIO Raffaele ZHU XingJiang HOBBS George MANCHESTER Richard N. SHANNON Ryan M. BACCIGALUPI Carlo GAO Wei XU Peng BIAN Xing CAO ZhouJian CHANG ZiJing DONG Peng GONG XueFei HUANG ShuangLin JU Peng LUO ZiRen QIANG Li'E TANG WenLin WAN XiaoYun WANG Yue XU ShengNian ZANG YunLong ZHANG HaiPeng LAU Yun-Kau NI Wei-Tou | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 1 |
| 9 | Clinical pharmacology of an atrasentan and docetaxel regimen in men with hormone-refractory prostate cancer显示文摘 | Islam R. Younis Daniel J. George Terence J. McManus Herbert Hurwitz Patricia Creel Andrew J. Armstrong Jing Jie Yu Kristina Bacon Gerald Hobbs Cody J. Peer William P. Petros | 2014 | Cancer Chemotherapy and Pharmacology2014，，5： | 1 |
| 10 | Gravitational wave research using pulsar timing arrays显示文摘A pulsar timing array(PTA) refers to a program of regular, high-precision timing observations of a widely distributed array of millisecond pulsars. Here we review the status of the three primary PTA projects and the joint International Pulsar Timing Array project. We discuss current results related to ultra-low-frequency gravitational wave searches and highlight opportunities for the near future. | George Hobbs Shi Dai | 2017 | National Science Review2017，4，5： | 1 |
| 11 | Correcting for the solar wind in pulsar timing observations: the role of simultaneous and low-frequency observations显示文摘The primary goal of pulsar timing array projects is to detect ultra-low-frequency gravitational waves. Pulsar data sets are affected by numerous noise processes including varying dispersive delays in the interstellar medium and from the solar wind. The solar wind can lead to rapidly changing variations that, with existing telescopes, can be hard to measure and then remove. In this paper we study the possibility of using a low frequency telescope to aid in such correction for the Parkes Pulsar Timing Array(PPTA) and also discuss whether the ultra-wide-bandwidth receiver for the FAST telescope is sufficient to model solar wind variations. Our key result is that a single wide-bandwidth receiver can be used to model and remove the effect of the solar wind. However, for pulsars that pass close to the Sun such as PSR J1022+1022, the solar wind is so variable that observations at two telescopes separated by a day are insufficient to correct the solar wind effect. | Ze-Xi Niu George Hobbs Jing-Bo Wang Shi Dai | 2017 | Research in Astronomy and Astrophysics2017，17，10： | 0 |
| 12 | Wide-bandwidth drift-scan pulsar surveys of globular clusters:application to early science observations with FAST显示文摘The Five-hundred-meter Aperture Spherical Telescope(FAST) will begin its early-science operations during 2016.Drift-scan pulsar surveys will be carried out during this period using an ultra-wide-band receiver system(covering ~ 270 to 1620 MHz).We describe a method for accounting for the changes in the telescope beam shape and the pulsar parameters when searching for pulsars over such a wide bandwidth.We applied this method to simulated data sets of pulsars in globular clusters that are visible to FAST and found that a representative observation would have a sensitivity of ~40 μJy.Our results showed that a single drift-scan(lasting less than a minute) is likely to find at least one pulsar for observations of four globular clusters.Repeated observations will increase the likely number of detections.We found that pulsars in ~16clusters are likely to be found if the data from 100 drift-scan observations of each cluster are incoherently combined. | Lei Zhang George Hobbs Di Li Duncan Lorimer Jie Zhang Meng Yu You-Ling Yue Pei Wang Zhi-Chen Pan Shi Dai | 2016 | Research in Astronomy and Astrophysics2016，16，10： | 0 |
| 13 | Ultra-wide Bandwidth Observations of 19 Pulsars with Parkes Telescope显示文摘Flux densities are basic observation parameters to describe pulsars.In the most updated pulsar catalog,24%of the listed radio pulsars have no flux density measurement at any frequency.Here,we report the first flux density measurements,spectral indices,pulse profiles,and correlations of the spectral index with pulsar parameters for 19 pulsars employing the Ultra-Wideband Low receiver system installed on the Parkes radio telescope.The results for spectral indices of 17 pulsars are in the range between-0.6 and-3.10.The polarization profiles of thirteen pulsars are shown.There is a moderate correlation between the spectral index and spin frequency.For most pulsars detected,the signal-to-noise ratio of pulse profile is not high,so DM,Faraday rotation measure,and polarization cannot be determined precisely.Twenty-nine pulsars were not detected in our observations.We discuss the possible explanations for why these pulsars were not detected. | Zu-Rong Zhou Jing-Bo Wang Na Wang George Hobbs Shuang-Qiang Wang | 2022 | Research in Astronomy and Astrophysics2022，22，8： | 0 |
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