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| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | Chinese and Uighur medicine diagnostic criteria of the evaluation of the Modern drug treatment side-effects in bronchial asthma patients显示文摘We studied Chinese and Uighur medicines and create an automated computer diagnostics system according to principals of Uighur medicine for evaluation of bronchial asthma patient′s state.498 patients with bronchial asthma were enrolled the automated computer diagnostic program.304 patients were evaluated in the process of drug and non-drug treatment.Savda asthma type of Uighur medicine do not corresponds with any of the defined clinico-pathogenetic variants of the disease.Thus,prevailing of atopic bronchial asthma with probability of 0.7 is defined with Savda categories with such as 'Lungs energy deficiency','Spleen energy deficiency' and 'Kidneys Yin deficiency'(P<0.01) variants in Chinese Medicine.The combination of infectious-dependent variant of bronchial asthma Abnormal Savda syndrome with atopy with a probability of 0.8 is accompanied by the categories of 'Hot and Full' asthma with such variants as 'Lungs energy deficiency' 'Spleen energy deficiency','Kidneys Yin deficiency'(P<0.01).Patients with an easier case of Abnormal Savda syndrome bronchial asthma in 71% of cases have prevailing diagnostic categories of 'External,Full and Cold' asthma.Patients with a harder case of Abnormal Savda in 74% of cases belongs to the categories of 'Internal,Empty and Hot' asthma.So,hormone dependency of the disease in 69% of cases is accompanied by the 'Kidneys Yin deficiency' variant and,if there is an aspirin component in the pathogenesis of mixed asthma,in 83% of cases 'Kidneys Yin deficiency' and 'Kidneys Yang deficiency' variants are defined. | Dubrovin Denis Igor Gogol Mikhail Baranov Nurmuhammat Amat Halmurat Upur | 2013 | 新疆医科大学学报2013，36，4： | 2 |
| 3 | 饲料中添加干水果蔬菜渣对育肥猪生产参数和肉品质的影响显示文摘试验讨论了饲料中添加生物活性物质对动物健康和动物产品的影响。试验通过风干的苹果、野樱桃、黑加仑和胡萝卜果渣确定膳食补充剂对育肥猪生产参数和肉品质的影响。野樱桃干果渣的添加,使育肥猪采食量有增加的趋势,育肥期有减少的趋势。干果渣对猪肉中饱和、不饱和脂肪酸含量无显著影响,但对某些n-3家族高水平的多不饱和脂肪酸含量和总胆固醇含量有显著降低的趋势(P≤0.05)。饲料中添加黑加仑干果渣可显著提高猪肉氧化稳定性和维生素E含量(P≤0.05)。因此,饲料中添加干果渣可改善部分与肉品质相关的生产参数,可能有利于消费者的健康。 | Pieszka M Szczurek P Bederska-?ojewska D Migda W Gogol P Jagusiak W | 2017 | 饲料博览2017，0，7： | 2 |
| 4 | Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs显示文摘Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic tests.Often,high-throughput approaches are applied to discover biomarker signatures.These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches.Previously,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and Germany.Here,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by RT-qPCR.We computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from controls.Further,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and B-cells.Our study represents the next important step in translational research for a miRNA-based AD test. | Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 2 |
| 5 | Structure of the ATP synthase complex of EscheHchia coli from cryoelectron microscopy显示文摘 | Leuchen U Gogol E P Capaldi R A | 1990 | Biocllemistry1990，29，22： | 1 |
| 6 | An Efficient and One-pot Synthesis of Imidazolines and Benzimidazoles via An- aerobic Oxidation of Carbon-nitrogen Bonds in Water 显示文摘 | GOGOL P KONWAR D | 2006 | Tetrahedron Lett2006，47，1： | 1 |
| 7 | Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin显示文摘 | GOGOL M CAREY M | 2007 | Science2007，316，： | 1 |
| 8 | Development and characterization of pseudolatex based transdermal drug delivery system of diclofenac 显示文摘 | Vyas SP Jyoti Gogol P Jain SK | 1991 | Drug Dev and Ind Pharm1991，17，8： | 1 |
| 9 | Determ ination of residual pesticide in plant materials using planarcholinesterase Sensors modified with Nation显示文摘 | Gogol E V Evtyugin G A Suprun E V | 2001 | Joural of analytical chemisty2001，，10： | 1 |
| 10 | Effects of aluminumtreatment on phosphorus, carbon, and nitrogen distribution in lakesediment A 31P NMR study 显示文摘 | REITZEL K AHLGREN J GOGOLL A | 2006 | Water Research2006，40，： | 1 |
| 11 | Sediment depth attenuation of biogenic phosphorus compounds measured by 31p NMR显示文摘 | Ahlgren J Tranvik L Gogoll A | | 0，，03： | 1 |
| 12 | Some notes on malignancies of the hearts 显示文摘 | Polhm JA Gogol LJ | 1996 | AmJ Cancer1996，27，3： | 1 |
| 13 | Some notes on malignancies of the heart显示文摘 | Pollia JA Gogol LJ | 1996 | Am J Cancer1996，27，3： | 1 |
| 14 | Sediment depth attenuation of biogenic phosphorus compounds measured by 31P NMR 显示文摘 | Ahlgren J Tranvik L Gogoll A | 2005 | Environmental Science & Technology2005，39，3： | 1 |
| 15 | Sediment depth attenuation of biogenic phosphorus compounds measured by 31P NMR显示文摘 | Joakim Ahlgren Lars Tranvik Adolf Gogoll | 2005 | Environ Sci Technol2005，39，3： | 1 |
| 16 | Effects of aluminum treatment on phosphorus,carbon,and nitrogen distribution in lake sediment:A 31p NMR study显示文摘 | Reitzel K Ahlgren J Gogoll A | | 0，，04： | 1 |
| 17 | Associations of a polymorphic AP-2 binding site in the 5'-flanking region of the bovine beta-lactoglobulin gene with milk proteins显示文摘 | Kuss A W Gogol J Geldermann H | 2003 | J Dairy Sci2003，86，6： | 1 |
| 18 | Degradation rates of organic phosphorus in lake sediment显示文摘 | Kasper Reitzel Joakim Ahlgren Heidi DeBrabandere Monica Waldeb?ck Adolf Gogoll Lars Tranvik Emil Rydin | 2007 | Biogeochemistry2007，，1： | 1 |
| 19 | Ampeno metric biosensors based on coated screen-printed electrodes for the determination of cholinesterase inhibitors显示文摘 | Gogol E V Evtugyn G A Marty J L | 2000 | Talanta2000，53，2： | 1 |
| 20 | Advances in par tial-pressure control applied to reactive sputtering显示文摘 | Sproul W D Rudnik P J Gogol C A | 1989 | Surface and Coatings Technology1989，3940，： | 1 |
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