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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Combustion performance of an aluminum meltingfurnace operating with natural gas and liquid fuel显示文摘 | Nieckele AO Naccache MF Gomes MSP | | 0，，： | 1 |
| 3 | Transgenic overexpression ol BMP4 increases astroglial and decreases oligodendroglial lineage commitment显示文摘 | Gomes WA Mehler MF Kessler JA | 2003 | Dev Biol2003，255，1： | 1 |
| 4 | Homo-genous demineralized dentin matrix for applicationin cranioplasty of rabbits with alloxan-induceddiabetes: histomorphometric analysis显示文摘 | Gomes MF Banzi EC Destro MF | 2007 | Int J OralMaxillofac Implants2007，22，6： | 1 |
| 5 | Intravenous immunoglobulin in lupus panniculitis 显示文摘 | Espirito S J Gomes MF Gomes M J | 2010 | Clin Rev Allergy Immunol2010，38，23： | 1 |
| 6 | Molecular Mechanisms Involved in the Angiotensin-(1-7)/Mas Signaling Pathway in Cardiomyocytes显示文摘 | Dias-Peixoto MF Santos RA Gomes ER | 2008 | Hypertension2008，52，3： | 1 |
| 7 | Pre- referral rectal artesunatc to prevent death and disability in severe malaria: a pla- cebo - controlled trial 显示文摘 | Gomes MF Faiz MA Gyapong JO | 2009 | Lancet2009，373，： | 1 |
| 8 | Molecularmechanisms involved in the angiotensin-(1-7)/Mas signalingpathway in cardiomyocytes显示文摘 | Dias-Peixoto MF Santos RA Gomes ER | 2008 | Hypertension2008，52，3： | 1 |
| 9 | Effect of NaF, SnF2, and TiF4 toothpastes on bovine enamel and dentin erosion-abra- sion in vitro显示文摘 | Comar LP Gomes MF Ito N | 2012 | Int J Dent2012，2012，8： | 1 |
| 10 | Calcium signaling in the nucleus显示文摘 | Gomes DA Leite MF Bennett AM | 2006 | Can J Physiol Pharmacol2006，84，34： | 1 |
| 11 | Residual beta-cell function and microvascular complications in type 1 diabeticpatients显示文摘 | Gomes MB Goncalves MF Neves R | 2000 | Braz J Med Biol Res2000，33，2： | 1 |
| 12 | The interference of the cleaning procedure of root walls with two different solvents on the adhesion of fiberglass intraradicular posts显示文摘 | Gomes MF Botta SB Matos AB | | 0，，3： | 1 |
| 13 | Optical density of bone repair after implantation ol homogenous demineral- ized dentin matrix in diabetic rabbits 显示文摘 | Gomes MF Destro MF Banzi EC | 2008 | Braz Oral Res2008，22，3： | 1 |
| 14 | Optical densityof bone repair after implantation of homogenous demineral- ized dentin matrix in diabetic rabbits 显示文摘 | Gomes MF Destro MF Banzi EC | 2008 | Braz Oral Res2008，22，3： | 1 |
| 15 | Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment显示文摘 | Gomes WA Mehler MF Kessler JA | 2003 | Dev Biol2003，255，1： | 1 |
| 16 | Molecular mechanisms involved in the angiotensin - (1 -7 )/Mas signaling pathway in eardiomyocytes 显示文摘 | Dias -Peixoto MF Santos RA Gomes ER | 2008 | Hypertension2008，52，3： | 1 |
| 17 | Intravenous immu- noglobulin in lupus panniculitis 显示文摘 | Espirito Santo J Gomes MF Gomes M J | 2010 | Clin Rev Allergy Immunol2010，38，23： | 1 |
| 18 | Intravenous immunoglobulin in lupus panniculitis 显示文摘 | Espirito S J Gomes MF Gomes M J | 2010 | Clin Rev Allergy Immunol2010，38，23： | 1 |
| 19 | Homogenous demineralized dentin matrix for application in cranioplasty of rabbits with alloxan-induced diabetes: histomorphometric analysis显示文摘 | Gomes MF Banzi EC Destro MF | 2007 | Int J Oral Maxillofac Implants2007，22，6： | 1 |
| 20 | Intravenous im- munoglobulinin lupus panniculitis 显示文摘 | Espirito S J Gomes MF Gomes M J | 2010 | Clin Rev Allergy- Immunol2010，38，23： | 1 |
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