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| 1 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 2 | Preparation of Laminin-apatite-polymer Composites Using Metastable Calcium Phosphate Solutions显示文摘A synthetic polymer with a laminin-apatite composite layer on its surface would be useful as a percutaneous device. The preparation of such a composite was attempted in the present study using poly(ethylene terephthalate) (PET) and polyethylene (PE) as the synthetic polymer. PET and PE plates and those pretreated with an oxygen plasma were alternately dipped in calcium and phosphate ion solutions, and then immersed in a metastable calcium phosphate solution supplemented with laminin (LCP solution). The PET and PE plates pretreated with an oxygen plasma formed a uniform and continuous layer of a laminin-apatite composite on their surfaces. In contrast, the PET and PE plates that had not been pretreated with an oxygen plasma did not form a continuous layer of a laminin-apatite composite on their surfaces. The hydrophilic functional groups on the PET and PE surfaces introduced by the plasma treatment were responsible for the successful laminin-apatite composite coating. | A Oyane M Kasahara N Ichinose Y Yokoyama M Uchida A Ito | 2005 | Journal of Wuhan University of Technology(Materials Science)2005，20，B12： | 3 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma 显示文摘 | Itoh N Semba S Ito M | 2002 | Cancer2002，94，12： | 2 |
| 6 | Magnifying video endoscopy is useful to diagnose histologicai gastritis--applicable to the estimation of Helicobacter pylori(HP) eradication显示文摘 | Sunjin K Haruma K Ito N | 2001 | Gastrointest Endosc2001，53，： | 2 |
| 7 | Allocation of photosymthetic products in soybean during the early stages of nodule formation 显示文摘 | Ito S Ohtake N Sueyoshi K | 2006 | Soil Science Plant Nutrition2006，52，： | 1 |
| 8 | Diagnosis of esophageal carcinoma using digital radiography 显示文摘 | Ito B Niwa Y Ando N | 2005 | Eur J Radiol2005，54，3： | 1 |
| 9 | Acute pancreatitis in the early stages of pregnancy associated with a PSTI gene mutation 显示文摘 | Inoue N Ito T Akashi T | 2004 | Pancreaes2004，29，3： | 1 |
| 10 | Human Urine Dnase Ⅰ :Immunological Identity with Human Pancreatic DNase Ⅰ , and Enzymic and Proteochemical Properties of the Enzyme显示文摘 | Ito K Minamiura N Yamamoto T | 1984 | J Biochem1984，95，： | 1 |
| 11 | Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension显示文摘 | Ishikura K Yamada N Ito M | 2006 | Circ J2006，70，2： | 1 |
| 12 | Molecular basis for the generation in pigs of influenza A viruses with pandemic potential显示文摘 | Ito T Coueeiro J N Kelm S | 1998 | J Virol1998，72，： | 1 |
| 13 | Fabrication of thin fihn dye sensitized solar cells with solar to electric power conversion efficiency over 10% 显示文摘 | Ito S Murakami T N Comte P | 2008 | Thin Solid Films2008，516，14： | 1 |
| 14 | A case of Castieman/sdisease complicated with nephritic syndrome due toglomerulopathymimickingmembranoproliferativeglomerulonephritis显示文摘 | Sugimoto T Ito J Takeda N | 2008 | Am J Med Sci2008，335，6： | 1 |
| 15 | Computer generated holography using a graphics processing unit显示文摘 | N Masuda T Ito T Tanaka | 2006 | Opt Express2006，14，2： | 1 |
| 16 | Dielectric Properties of the Pb(Inl/2 Nbl/2 )O3-PbTiO3 Single Crystal显示文摘 | Yasuda N Ohwa H Ito K | 1999 | Ferroelectric1999，230，： | 1 |
| 17 | Types of lumbar herniated disc and clinical course显示文摘 | Ito T Takano Y Yuasa N | | 0，，06： | 1 |
| 18 | Diagnosis of gastric cancer with MDCT using the water-filling method and multiplanar reconstruction:CT-histologic correlation显示文摘 | Shimizu K Ito K Matsunaga N | | 0，，： | 1 |
| 19 | Effect of acute changes of serum phosphate on fibroblast growth factor(FGF)23 levels in humans显示文摘 | Ito N Fukumoto S Takeuchi Y | | 0，，： | 1 |
| 20 | Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell-derived dendritic cells 显示文摘 | Ito T Inoue K Nishimura N | 2012 | J Appl Toxicol2012，32，2： | 1 |
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