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| 1 | OsPRP3, a flower specific proline-rich protein of rice, determines extracellular matrix structure of floral organs and its overexpression confers cold-tolerance显示文摘 | Gothandam K M Nalini E Karthikeyan S | 2010 | Plant Molecular Biology2010，72，： | 1 |
| 2 | OsPPR1, a pentatricopeptide repeat protein of rice is essential for the chloroplast biogenesis显示文摘 | Gothandam K M Kim E S Cho H | 2005 | Plant Molecular Biology2005，58，： | 1 |
| 3 | Ultrastructural study of rice tapetum under low - temperature stress 显示文摘 | Gothandam K M Kim E S Chung Y Y | 2007 | Journal of Plant Biology2007，50，4： | 1 |
| 4 | OsPPR1, a pentatricopeptiderepeat protein of rice is essential for the chloroplast biogenesis 显示文摘 | Gothandam K M Kim E S Cho H J | 2005 | Plant Mol Biol2005，58，3： | 1 |
| 5 | BcXTH1, a Brassica campestris homologue of Arabidopsis XTH9, is associated with cell expansion显示文摘 | Yoon-Kyung Shin Hyunsik Yum Eun-Sook Kim Hongju Cho Kodiveri M. Gothandam Jiyoung Hyun Yong-Yoon Chung | 2006 | Planta2006，，1： | 1 |
| 6 | OsPRP3, a flower specific proline-rich protein of rice, determines extracellular matrix structure of floral organs and its over- expression confers cold-tolerance显示文摘 | Gothandam K M Nalini E Karthikeyan S | 2010 | Plant Molecular Bi- ology2010，72，12： | 1 |
| 7 | OsPPRl,apentatrico- peptide repeat protein of rice is essential for theehloroplast bio- genesis显示文摘 | Gothandam K M Kim E S Cho H J | 2005 | Plant Mol Biol2005，58，3： | 1 |
| 8 | OsPRP3, a flower specific proline-rich protein of rice, de- termines extracellular matrix structure of floral organs and its overexpression confers cold-tolerance 显示文摘 | GOTHANDAM K M NALINI E KARTHIKEYAN S | 2010 | Plant Molecular Biology2010，72，1： | 1 |
| 9 | OsPPR1 a pentatricopeptide repeat protein of rice is essential for the chloroplast biogenesis 显示文摘 | KODIVERI M GOTHANDAM E S K HONGIOO C | 2005 | Plant Molecular Biology2005，58，： | 1 |
| 10 | OsPPR1, a pentatricopeptide repeat protein of rice is essential for the chloroplast biogenesis 显示文摘 | Gothandam K M Kim E S Cho H | 2005 | Plant Molecular Biology2005，58，3： | 1 |
| 11 | Ospprl ,a pentatricopeptide re- peat protein of rice is essential for the chloroplast biogenesis显示文摘 | GOTHANDAM K M KIM E CHO H | 2005 | Plant Molecular Biology2005，58，3： | 1 |
| 12 | OsPPR1,apentatricopeptide repeat protein of rice is essential for the chloroplastbiogenesis显示文摘 | Kodiveri M Gothandam Eun-Sook kim | 2005 | Plant Molecular Biology2005，28，： | 1 |
| 13 | Combinatorial effect of diclofenac with piperine and D-limonene on inducing apoptosis and cell cycle arrest of breast cancer cells显示文摘Objective:To investigate the potential synergistic activity of diclofenac with piperine and D-limonene in inducing apoptosis and cell cycle arrest in breast cancer MCF-7 cells.Methods:Molecular docking study was conducted to evaluate the binding affinity of diclofenac with piperine and D-limonene against p53,Bax,and Bcl-2.The MTT assay was used to determine IC50,and the Chou-Talay method was used to determine the synergistic concentration of the combination treatment of diclofenac plus piperine and diclofenac plus D-limonene.Apoptosis detection,cell cycle arrest,reactive oxygen species production,and mitochondrial membrane potential were also investigated.Results:Diclofenac,piperine,and D-limonene showed potent binding affinity for p53,Bax,and Bcl-2.Diclofenac plus piperine and diclofenac plus D-limonene enhanced the formation of reactive oxygen species,which also had an effect on the mitochondrial membrane’s integrity and caused DNA fragmentation.Diclofenac plus piperine and diclofenac plus D-limonene arrested the cells in the sub-G0phase while drastically lowering the percentage of cells in the G2/M phase.Furthermore,the elevated apoptosis in the combined therapy was confirmed by annexin V/propidium iodide staining.Conclusions:The combined therapy prominently enhanced the antiproliferative and apoptotic effects on MCF-7 cells compared with treatment with diclofenac,piperine,and D-limonene alone. | Srivarshini Sankar Gothandam Kodiveri Muthukaliannan | 2023 | Asian Pacific Journal of Tropical Biomedicine2023，13，2： | 0 |
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