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| 1 | Plant Programmed Cell Death Caused by an Autoactive Form of Prf Is Suppressed by Co-Expression of the Prf LRR Domain显示文摘在西红柿, NBARC-LRR 抵抗(R) 蛋白质 Prf 与 Pto 或分 kinase 在音乐会行动对 Pseudomonas syringae pv 决定免疫。西红柿(Pst ) 。发信号的调停 Prf 的防卫被二顺序无关的藏匿 Pst 的受动器蛋白质, AvrPto 和 AvrPtoB 的识别开始,由西红柿 Pto 或分。Prf 检测这些相互作用并且激活发信号包括与 Pst 生长的拘捕被联系的局部性的规划细胞死亡(PCD ) 导致宿主防卫回答。当短暂地在 Nicotiana benthamiana 的叶子表示了时,我们发现有在在在 NBARC 领域的 IHD 主题(isoleucine-histidine-aspartic 酸) 的 D1416 的单个氨基酸替换的 Prf 变体引起受动器无关的 PCD,建议 D1416 起在 Prf 的激活的一个重要作用。Prf (NPrf ) 和 LRR 领域的 N 终端区域为发信号的这 autoactive Prf 房间死亡被要求但是为 PrfD1416V 蛋白质的累积非必需。显著地, Prf LRR 然而并非 NPrf 的合作表示与 PrfD1416V, AvrPto/Pto, AvrPtoB/Pto, Pto (PtoY207D ) 的一种 autoactive 形式,或分完全压制 PCD。然而, Prf LRR 不防碍 PCD 由 Rpi-blb1D475V 引起了,表明事件的不同 R 调停蛋白质的 PCD,或由 MAPKKK 的 overexpression 引起了, Prf 下游地行动的蛋白质。而且,我们发现当与 Prf LRR 领域共同表示时, PrfD1416V 蛋白质是不能的在植物房间积累,多半向房间死亡解释抑制。为 PrfD1416V 的导致 LRR 的降级的机制是未知的,但是可以在 Prf 或到独立 LRR 的绑定的 intramolecular 相互作用包含干扰到为 Prf 稳定性被需要的另外的主机蛋白质。 | Xinran Du Min Miao Xinrong Ma Yongsheng Liu Joseph C. Kuhl Gregory B. Martin Fangming Xiao | 2012 | Molecular Plant2012，5，5： | 4 |
| 2 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 3 | Tetracyclines inhibit activated B cell function显示文摘 | Kuzin Ⅱ Jennifer ES Gregory DU | 2001 | Int Immunol2001，13，： | 1 |
| 4 | Genome sequence of the palaeopolyp|oid soybean 显示文摘 | Jeremy S Steven B C Jessica S Ma J X Therese M William N David L H Qijian S Jay J T Cheng J L Xu D Uffe H Gregory D M Yeisoo Y Tetsuya S Taishi U Madan K B Devinder S Babu V Erika L Myron P David G Shu S Q David G Kerrie B Montona F Brian A Du J C Tian Z Zhu L Navdeep G Trupti J Marc L Anand S Zhang X C Kazuo S Henry T N Rod A Perry C James S Jane G Dan R Gary S Randy C S Scott A J | 2010 | Nature2010，463，： | 1 |
| 5 | 肺癌细胞中甲基化转移酶METTL3能够促进促癌基因翻译显示文摘美国哈佛医学院的Richard I.Gregory教授和其研究团队发现,在肺癌细胞中甲基化转移酶METTL3能够促进促癌基因翻译,从而促进了肿瘤细胞的生存、增殖和侵袭。相关论文发表在2016年5月5日的Molecular Cell杂志上。促癌基因的异常活化是导致肿瘤发生的最主要原因之一,常见的促癌基因有Myc,Src,EGFR等。然而是什么因素导致了促癌基因激活仍然并不清楚, | 王华敏 S Lin J Choe P Du R Triboulet R Gregory | 2016 | 中国肿瘤生物治疗杂志2016，23，4： | 1 |
| 6 | Cloud-based storage and computing for remote sensing big data:a technical review显示文摘The rapid growth of remote sensing big data(RSBD)has attracted considerable attention from both academia and industry.Despite the progress of computer technologies,conventional computing implementations have become technically inefficient for processing RSBD.Cloud computing is effective in activating and mining large-scale heterogeneous data and has been widely applied to RSBD over the past years.This study performs a technical review of cloud-based RSBD storage and computing from an interdisciplinary viewpoint of remote sensing and computer science.First,we elaborate on four critical technical challenges resulting from the scale expansion of RSBD applications,i.e.raster storage,metadata management,data homogeneity,and computing paradigms.Second,we introduce state-of-the-art cloud-based data management technologies for RSBD storage.The unit for manipulating remote sensing data has evolved due to the scale expansion and use of novel technologies,which we name the RSBD data model.Four data models are suggested,i.e.scenes,ARD,data cubes,and composite layers.Third,we summarize recent research on the application of various cloud-based parallel computing technologies to RSBD computing implementations.Finally,we categorize the architectures of mainstream RSBD platforms.This research provides a comprehensive review of the fundamental issues of RSBD for computing experts and remote sensing researchers. | Chen Xu Xiaoping Du Xiangtao Fan Gregory Giuliani Zhongyang Hu Wei Wang Jie Liu Teng Wang Zhenzhen Yan Junjie Zhu Tianyang Jiang Huadong Guo | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 7 | Electrically injected GeSn lasers with peak wavelength up to 2.7 μm显示文摘GeSn lasers enable the monolithic integration of lasers on the Si platform using all-group-Ⅳ direct-bandgap material.The GeSn laser study recently moved from optical pumping into electrical injection.In this work,we present explorative investigations of GeSn heterostructure laser diodes with various layer thicknesses and material compositions.Cap layer material was studied by using Si_(0.03)Ge_(0.89)Sn_(0.08) and Ge_(0.95)Sn_(0.05),and cap layer total thickness was also compared.The 190 nm SiGeSn-cap device had threshold of 0.6 kA/cm^(2) at 10 K and a maximum operating temperature(T_(max)) of 100 K,compared to 1.4 kA/cm^(2) and 50 K from 150 nm SiGeSn-cap device,respectively.Furthermore,the 220 nm GeSn-cap device had 10 K threshold at 2.4 kA/cm^(2) and T_(max) at 90 K,i.e.,higher threshold and lower maximal operation temperature compared to the SiGeSn cap layer,indicating that enhanced electron confinement using SiGeSn can reduce the threshold considerably.The study of the active region material showed that device gain region using Ge_(0.87)Sn_(0.13) had a higher threshold and lower T_(max),compared to Ge_(0.89)Sn_(0.11).The performance was affected by the metal absorption,free carrier absorption,and possibly defect density level.The maximum peak wavelength was measured as 2682 nm at 90 K by using Ge_(0.87)Sn_(0.13) in gain regions.The investigations provide directions to the future GeSn laser diode designs toward the full integration of group-Ⅳ photonics on a Si platform. | YIYIN ZHOU SOLOMON OJO CHEN-WEI WU YUANHAO MIAO HUONG TRAN JOSHUA MGRANT GREY ABERNATHY SYLVESTER AMOAH JAKE BASS GREGORY SALAMO WEI DU GUO-EN CHANG JIFENG LIU JOE MARGETIS JOHN TOLLE YONG-HANG ZHANG GREG SUN RICHARD ASOREF BAOHUA LI SHUI-QING YU | 2022 | Photonics Research2022，10，1： | 0 |
| 8 | Elucidation of thermally induced internal porosity in zinc oxide nanorods显示文摘 | Albertus D. Handoko Laura-Lynn Liew Ming Lin Gopinathan Sankar Yonghua Du Haibin Su Zhili Dong Gregory K. L. Goh | 2018 | Nano Research2018，11，5： | 0 |
| 9 | Frailty and Anticoagulant Therapy in Patients Aged 65 Years or Older with Atrial Fibrillation显示文摘Background:Elderly adults with atrial fi brillation(AF)are at increased risk of frailty and thromboembolic complications.However,studies on the prevalence of frailty in AF patients and data on the relationship between frailty and the use of anticoagulants are limited.Methods:We conducted a cross-sectional study involving 500 participants.Patients aged 65 years or older were consecutively selected from the Chinese Atrial Fibrillation Registry study.The patient’s frailty status was assessed with use of the Canadian Study of Health and Aging Clinical Frailty Scale.We assessed the prevalence of and factors associated with frailty,and how frailty affects anticoagulant therapy.Results:In 500 elderly adults with AF(age 75.2±6.7 years;51.6%female),201 patients(40.2%)were frail.The prevalence of frailty was higher in females(P=0.002)and increased with age and CHA 2 DS 2-VASc score(P for trend less than 0.001 for both).The factors associated with frailty were a history of heart failure(odds ratio[OR]2.40,95%confi dence interval[CI]1.39–4.14),female sex(OR 2.09,95%CI 1.27–3.43),and advanced age(OR 1.13,95%CI 1.09–1.17).Frail patients were signifi cantly less likely to have ever been prescribed anticoagulants compared with nonfrail patients(81.7 vs.54.9%,P<0.001).Conclusions:Frailty is prevalent in elderly adults with AF,especially in females,those of advanced age,and those with heart failure.Frailty status has a signifi cant impact on prescription of anticoagulants for high-risk AF patients. | Jiapeng Liu Xin Du Mengmeng Li Zhaoxu Jia Shangxin Lu Sanshuai Chang Ribo Tang Rong Bai Jianzeng Dong Gregory Y.H.Lip Changsheng Ma | 2020 | Cardiovascular Innovations and Applications2020，，1： | 0 |
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