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| 1 | The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line显示文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. | Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 26 |
| 2 | Effect of elevated total cholesterol level and hypertension on the risk of fatal cardiovascular disease: a cohort study of Chinese steelworkers显示文摘增加的血压和提高的全部的胆固醇( TC )铺平的背景在 world.Hypertension 和血胆脂醇过多是心血管的疾病( CVD )的二个很重要的可修改的风险因素比的更经常共存将被期望并且是否在提高的 TC 和高血压需要之间的致命的 CVD 上有 synergistic 影响是进一步在我们进行了的中国 population.Methods 检验了招募了男 steelworkers 变老的 5092 中国人的队研究在 1974-1980 的 18-74 | YANG Ying LI Jian-xin CHEN Ji-chun CAO Jie LU Xiang-feng CHEN Shu-feng WU Xi-gui DUAN Xiu-fang MO Xing-bo GU Dong-feng | 2011 | Chinese Medical Journal2011，，22： | 8 |
| 3 | miR-30b and miR-30c expression predicted response to tyrosine kinase inhibitors as first line treatment in non-small cell lung cancer显示文摘 | GU Yan-fei ZHANG Hui SU Dan MO Min-li SONG Pan ZHANG Fang ZHANG Shu-cai | 2013 | Chinese Medical Journal2013，，23： | 8 |
| 4 | Endovascular treatment of blood blister-like aneurysms in the internal carotid artery using a Willis covered stent显示文摘Background Despite the current availability of flow diverter devices(FDD), problems remains regarding optimal endovascular treatment(EVT) for blood blister-like aneurysms(BBAs) of the internal carotid artery(ICA). Objective To evaluate the safety and efficacy of EVT of BBAs in the ICA with a Willis covered stent. Methods 20 consecutive patients(5 men and 15 women) with ruptured BBAs underwent EVT using a Willis covered stent in two institutions from March 2013 to March 2018. Clinical observations, angiographic characteristics, and procedural and follow-up outcomes were retrospectively evaluated. Results 20 consecutive patients(5 men and 15 women) with ruptured BBAs underwent EVT using a Willis covered stent in two institutions from March 2013 to March 2018. Clinical observations, angiographic characteristics, and procedural and follow-up outcomes were retrospectively evaluated. Conclusion Our initial results demonstrate that reconstructive EVT using a Willis covered stent provides a viable approach to treat ICA BBAs. However, an expanded clinical evaluation and larger cohort are needed to confirm the results. | Yi Gu Binxian Gu Yongdong Li Yueqi Zhu Haitao Lu Liming Wei Mo Chen Minhua Li Jieqing Wan Wu Wang | 2018 | Journal of Interventional Medicine2018，1，3： | 8 |
| 5 | Non-buckled vitrectomy for retinal detachment with inferior breaks and proliferative vitreoretinophathy显示文摘AIM: To investigate the efficacy of non-buckled vitrectomy with classical endotamponade agents in the treatment of primary retinal detachment (RD) complicated by inferior breaks and proliferative vitreoretinophathy (PVR).METHODS: A retrospective, consecutive and case series study of 40 patients with inferior break RD and PVR≥C1 was conducted. All patients underwent a standard 3-port 20-gauge pars plana vitrectomy (PPV) with gas or silicone oil tamponade without supplementary scleral buckling. The vitreous and all proliferative membrane were completely removed, and retinectomy was performed when necessary. The mean follow-up was 12.5 months. The primary and final anatomic success rate, visual acuity and complications were recorded and analyzed. RESULTS: Primary anatomic success rate was achieved in 35 of 40 eyes (87.5%) and the final anatomic success rate was 100%. The most common cause of redetachment was recurrent PVR. The best-corrected visual acuity (BCVA) at final follow-up was improved in 34 eyes (85%), remained stable in 1 eye (2.5%), and worsened in 5 eyes (12.5%). The mean visual acuity at final follow-up was improved significantly (P=0.000).CONCLUSION: This retrospective study provides evidence that vitrectomy without scleral buckling seemed to be an effective treatment for inferior break RD with PVR. With complete removal of vitreous and proliferative membranes and timing of retinectomy, the inferior breaks which complicated with PVR could be closed successfully without additional scleral buckling. | Yan Sheng, Wu Liu | 2012 | International Journal of Ophthalmology(English edition)2012，5，5： | 8 |
| 6 | Phylogenetic diversity of bacteria in an earth-cave in Guizhou Province, Southwest of China显示文摘 | Zhou JR Gu YQ Zou CS Mo MH | 2007 | 中国生物学文摘2007，21，9： | 6 |
| 7 | Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation. | GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 8 | Adsorption of platinum(Ⅳ)onto D301R resin显示文摘磅(IV ) 是 D301R 树脂在 pH = 的媒介吸附的份量上 3.47。静态地浸透的吸附能力是 410 mg/g。在 D301R 树脂上吸附的磅(IV ) 能是由 1.0-2.0 mol/L NaOH 的 eluted。率常数是 k298 = 5. | MO Jianjun SHI Linmei GU Yongbing YAN Guobing | 2008 | Rare Metals2008，27，3： | 6 |
| 9 | OsAM1 is required for leptotene-zygotene transition in rice显示文摘发生在成熟分裂的发作的事件充分没被阐明。在现在的学习, OsAM1 被基于地图的克隆在米饭(Oryza sativa L.) 识别。OsAM1, Arabidopsis SWI1 的一个相当或相同的事物和玉米 AM1,与一个卷卷领域把蛋白质编码为它的中央区域。在 Osam1 异种,花粉母亲房间在 leptotene 被逮捕,证明 OsAM1 为 leptotene-zygotene 转变被要求。Immunocytological 分析表明 OsAM1 在早前期作为 foci 存在我 meiocytes。很微弱的 OsREC8 foci 在 Osam1 异种坚持了,显示 OsAM1 没为 OsREC8 的起始的 meiotic 招募被要求。当 OsAM1 不在时,包括 PAIR2, ZEP1 和 OsMER3,许多另外的批评 meiotic 部件不能正确地被安装到染色体上。在 pair2, Osmer3 和 zep1 异种,相反, OsAM1 能通常被装载,建议 OsAM1 起造在成熟分裂的开始的合适的染色体结构里的一个基本作用。 | Lixiao Che Ding Tang Kejian Wang Mo Wang Keming Zhu Hengxiu Yu Minghong Gu Zhukuan Cheng | 2011 | Cell Research2011，21，4： | 4 |
| 10 | Performance improvement of solution-processed CdS/CdTe solar cells with a thin compact TiO_2 buffer layer显示文摘The device performance of CdS/CdTe solar cells largely depends on not only the back ohmic contact, but also the conformality of Cd S window layer coating. In order to reduce the light absorption loss in Cd S, the Cd S thickness is usually less than 100 nm. However, pinholes in Cd S and non-conformal coverage of Cd S on transparent conducting oxide layer will cause shunting thus leading to device performance degradation and failure. In this paper, low-temperature and low-cost fabrication methods, i.e., chemical bath deposition and electrochemical deposition, were used to deposit Cd S and Cd Te, respectively. It was found that the yield of device was around 20 % due to shunting. In order to alleviate this problem, a compact layer of TiO2 was inserted between the fluorine-doped tin oxide and Cd S as a buffer layer. The thickness effect of TiO2 was studied and showed that devices with thin(20 nm thickness) TiO2 performed better than the counterparts with thick layers. It was discovered that device yield improved to 80 % and stability in air substantially improved with TiO2 layer. | Aashir Waleed Qianpeng Zhang Mohammad Mahdi Tavakoli Siu-Fung Leung Leilei Gu Jin He Xiaoliang Mo Zhiyong Fan | 2016 | Science Bulletin2016，61，1： | 4 |
| 11 | A soft tissue adhesive based on aldehyde-sodium alginate and amino-carboxymethyl chitosan preparation through the Schiff reaction显示文摘 | Yu WU Liu YUAN Nai-an SHENG Zi-qi GU Wen-hao FENG Hai-yue YIN Yosry MORSI Xiu-mei MO | 2017 | Frontiers of Materials Science2017，11，3： | 4 |
| 12 | 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling显示文摘AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in rats.METHODS:Chronic colitis was induced in rats by repeated administration of increasing dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg)by rectal injection for 6 wk(from day0 to day 35),while control rats received the vehicle.TNBS+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg/kg,whereas the control and TNBS groups received the same amount of the vehicle.Histologic scoring of inflammation and fibrosis was performed.Colonic production of transforming growth factor(TGF)-βwas measured by ELISA.Colon fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western blot.Expression of the tight junction proteins,occludin and claudin-1,were assessed by Western blot.Colon proteasome activities(chymotrypsin-like and trypsinlike activities)were assessed.RESULTS:TNBS-treated rats had a higher colon weight/length ratio compared to control rats(P<0.01).Furthermore,fibrosis and inflammation scores were higher in TNBS-treated rats compared to control rats(P<0.01 for both).Colonic production of TGF-βproduction tended to be higher in TNBS-treated rats(P<0.06).Fibrosis-related proteins such as phospho-p38,phospho-SMAD2/3,and PPARγwere significantly higher in TNBS-treated rats compared to control rats(all P<0.05).TNBS rats had a higher expression of Akt compared to control rats(P<0.01).Tight junction proteins were modified by repeated TNBS challenge:colon occludin expression rose significantly(P<0.01),whereas claudin-1 expression fell(P<0.01).Bortezomib inhibition significantly decreased chymotrypsin-like activity(P<0.05),but had no significant effect on trypsin-like activity(P>0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,TGF-βsignaling,or tight junction expression(P>0.05 for all).CONCLUSION:Rats with TNBS-induced chronic colitis exhibited colon fibrosis associated with higher TGF-βsignaling.Proteasome inhibition by bortezomib had no effect on fibrosis in our experimental conditions. | Emilien Loeuillard Julien Bertrand Anni Herranen Chloé Melchior Charlène Guérin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte Guillaume Savoye Rachel Marion-Letellier | 2014 | World Journal of Gastroenterology2014，20，48： | 4 |
| 13 | Recovery of saturated signal waveform acquired from high-energy particles with artificial neural networks显示文摘Artificial neural networks(ANNs)are a core component of artificial intelligence and are frequently used in machine learning.In this report,we investigate the use of ANNs to recover the saturated signals acquired in highenergy particle and nuclear physics experiments.The inherent properties of the detector and hardware imply that particles with relatively high energies probably often generate saturated signals.Usually,these saturated signals are discarded during data processing,and therefore,some useful information is lost.Thus,it is worth restoring the saturated signals to their normal form.The mapping from a saturated signal waveform to a normal signal waveform constitutes a regression problem.Given that the scintillator and collection usually do not form a linear system,typical regression methods such as multi-parameter fitting are not immediately applicable.One important advantage of ANNs is their capability to process nonlinear regression problems.To recover the saturated signal,three typical ANNs were tested including backpropagation(BP),simple recurrent(Elman),and generalized radial basis function(GRBF)neural networks(NNs).They represent a basic network structure,a network structure with feedback,and a network structure with a kernel function,respectively.The saturated waveforms were produced mainly by the environmental gamma in a liquid scintillation detector for the China Dark Matter Detection Experiment(CDEX).The training and test data sets consisted of 6000 and 3000 recordings of background radiation,respectively,in which saturation was simulated by truncating each waveform at 40%of the maximum signal.The results show that the GBRF-NN performed best as measured using a Chi-squared test to compare the original and reconstructed signals in the region in which saturation was simulated.A comparison of the original and reconstructed signals in this region shows that the GBRF neural network produced the best performance.This ANN demonstrates a powerful efficacy in terms of solving the saturation recovery problem.The proposed method outlines new ideas and possibilities for the recovery of saturated signals in high-energy particle and nuclear physics experiments.This study also illustrates an innovative application of machine learning in the analysis of experimental data in particle physics. | Yu Liu Jing-Jun Zhu Neil Roberts Ke-Ming Chen Yu-Lu Yan Shuang-Rong Mo Peng Gu Hao-Yang Xing | 2019 | Nuclear Science and Techniques2019，30，10： | 3 |
| 14 | Inhibition of KU70 and KU80 by CRISPR interference,not NgAgo interference,increases the efficiency of homologous recombination in pig fetal fibroblasts显示文摘Non-homologous end-joining(NHEJ) is a predominant pathway for the repair of DNA double-strand breaks(DSB). It inhibits the efficiency of homologous recombination(HR) by competing for DSB targets. To improve the efficiency of HR, multiple CRISPR interference(CRISPRi) and Natronobacterium gregoryi Argonaute(NgAgo) interference(NgAgoi) systems have been designed for the knockdown of NHEJ key molecules, KU70, KU80, polynucleotide kinase/phosphatase(PNKP), DNA ligase IV(LIG4), and NHEJ1. Suppression of KU70 and KU80 by CRISPRi dramatically promoted(P<0.05) the efficiency of HR to 1.85-and 1.58-fold, respectively, whereas knockdown of PNKP, LIG4, and NHEJ1 repair factors did not significantly increase(P>0.05) HR efficiency. Interestingly, although the NgAgoi system significantly suppressed(P<0.05) KU70, KU80, PNKP, LIG4, and NHEJ1 expression, it did not improve(P>0.05) HR efficiency in primary fetal fibroblasts. Our result showed that both NgAgo and catalytically inactive Cas9(dCas9) could interfere with the expression of target genes, but the downstream factors appear to be more active following CRISPR-mediated interference than that of NgAgo. | LI Guo-ling QUAN Rong WANG Hao-qiang RUAN Xiao-fang MO Jian-xin ZHONG Cui-li YANG Huaqiang LI Zi-cong GU Ting LIU De-wu WU Zhen-fang CAI Geng-yuan ZHANG Xian-wei | 2019 | Journal of Integrative Agriculture2019，18，2： | 2 |
| 15 | Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA)显示文摘 | D. Gu K. Reynolds X. Duan X. Xin J. Chen X. Wu J. Mo P. K. Whelton J. He | 2003 | Diabetologia2003，，9： | 2 |
| 16 | D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration显示文摘Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium(RPE)cell death,which is considered to be the primary cause of dry age-related macular degeneration(AMD),leading to blindness in the elderly.However,an effective therapy for this disease is lacking.Here,we described a robust high-content screening procedure with a library of 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate(SI)-induced oxidative cell death and prolonged their healthy survival.D609 effectively attenuated excessive reactive oxygen species(ROS)and prevented severe mitochondrial loss due to oxidative stress in the RPE cells.Surprisingly,the potent antioxidative effects of D609 were not achieved through its own reducibility but were primarily dependent on its ability to increase the expression of metallothionein.The injection of this small water-soluble molecule also showed an explicit protective effect of the RPE layer in an SI-induced AMD mouse model.These findings suggested that D609 could serve as a novel antioxidative protector of RPE cells both in vitro and in vivo and unveiled a novel antioxidative mechanism of D609,which may ultimately have clinical applications for the treatment of AMD. | Bowen Wang Li Wang Sijie Gu Yankun Yu Huaxing Huang Kunlun Mo He Xu Fanzhu Zeng Yichen Xiao Lulu Peng Chunqiao Liu Nan Cao Yizhi Liu Jin Yuan Hong Ouyang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 17 | Acid modified carrier on catalytic oxidation of dichloromethane over CeO_(2)/HZSM-5 catalysts显示文摘In this study,a series of Hydrogen-Zeolite Socony Mobil-5-X(HZSM-5-X) catalysts were prepared by acid modification,then Ce/HZSM-5-X(X=0,0.2,0.4,1.0,2.0) catalysts were prepared by impregnation method.The catalytic performance of the catalysts on dichloromethane(DCM) oxidation was investigated.Through different characterizations,HZSM-5-X exhibit high specific surface area,good redox ability,rich acidity and much suitable acidic site distribution after acid treatment.Among them,Ce/HZSM-5-0.4 shows better catalytic activity with the lowest by-product and the best CO_(2) yield.Its T_(90) is 302℃ and the CO_(2) yield of T_(90) is more than 80 wt%,which demonstrates that the acid modification of carrier plays the positive effect on the catalytic capacity for DCM oxidation. | Mengxiang Li Jing Mo Xuanyu Gu Yue Zhou Mengjie Fan Shubao Shen Yingwen Chen | 2022 | Journal of Rare Earths2022，40，10： | 2 |
| 18 | Reduction in Intrahepatic cccDNA and Integration of HBV in Chronic Hepatitis B Patients with a Functional Cure显示文摘Background and Aims:Functional cure(FC)is characterized by the clearance of the hepatitis B surface antigen from the serum of patients with chronic hepatitis B(CHB).However,the level of intrahepatic covalently closed circular DNA(cccDNA)and hepatitis B virus(HBV)integration remains unclear.We conducted this study to determine them and reveal their value in the treatment of CHB.Methods:There were two sessions to elucidate the changes in intrahepatic cccDNA and HBV integration after antiviral therapy.In the first session,116 patients were enrolled and divided into FC,non-functional cure(NFC),and CHB groups,including 48 patients with functionally cured CHB,27 with CHB without functional cure after antiviral treatment,and 41 with treatment-naïve CHB.Patients were tested for both intrahepatic cccDNA and other viral markers.All patients in the FC group were followed up for at least 24 weeks to observe relapse.In the second session,another ten patients were included for in-depth whole-genome sequencing to analyze HBV integration.Results:Thirteen patients in the FC group were negative for intrahepatic cccDNA.Intrahepatic cccDNA was much higher in the CHB group compared with the FC group.Seven patients had HBsAg seroreversion,including two with virological relapse.Integration of HBV was detected in one(33.3%)functionally cured patients and in seven(100%)with CHB.28.0%of the HBV breakpoints were assigned in the 1,500 nt to 1,900 nt range of the HBV genome.Conclusions:After achieving an FC,the rate of intrahepatic cccDNA and HBV integration was significantly reduced in patients with CHB.For those patients who cleared intrahepatic cccDNA,the chances of developing virological relapse were even lower. | Weiqiang Gan Na Gao Lin Gu Zhishuo Mo Xiuqing Pang Ziying Lei Zhiliang Gao | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 2 |
| 19 | Development and Effects of a Motivation- al Interviewing Self - management Program for Elderly Pa- tients with Diabetes Mellitus 显示文摘 | Kang HY Gu MO | 2015 | J Korean Aead Nuts2015，45，4： | 1 |
| 20 | A review of exercise inter- ventions for fall prevention in the elderly显示文摘 | Gu MO Jeon MY Kim HJ Eun J | 2005 | Journal of Korean Academy of Nursing2005，35，6： | 1 |
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