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| 1 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol显示文摘OBJECTIVE: To investigate the effect of acupuncture at Neiguan(PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia(MI) induced by isoproterenol(ISO).METHODS: Twenty-seven Sprague-Dawley rats were randomly assigned to normal, model, and acupuncture groups. The model and acupuncture groups were given injections of ISO(85 mg/kg) to establish the MI model. After model establishment,the acupuncture group was treated with acupuncture at Neiguan(PC 6) for 30 min. Echocardiography was used to monitor diastolic and systolic function for 30 min starting from the time after the acupuncture needles were removed. Changes in the length of left ventricular internal diameter at end-diastole(LVIDd), length of left ventricular internal diameter at end-systole(LVIDs), the ratio of mitral peak velocity at early diastole and atrial contraction(E/A), ejection fraction(EF), fractional shortening(FS), and stroke volume(SV) were measured.RESULTS: Compared with the model group at 0and 15 min after needles were removed, the means of LVIDd and LVIDs were significantly lower(P <0.01) and E/A, EF, FS, and SV significantly higher(P < 0.01) in the acupuncture group. In the acupuncture group, the means of LVIDd and LVIDs15 min after the needles were removed were significantly higher(P < 0.01) than those at 0 min. The means of E/A, EF, FS, and SV significantly decreased(P < 0.01) from 0 to 15 min in the acupuncture group.CONCLUSION: These findings indicate that acupuncture at Neiguan(PC 6) can affect cardiac function by increasing left ventricular diastolic and systolic function in MI rat models, but the effect only lasts for 15 min. | Wang Songzi Ren Lu Jia Lianqun Gu Zhongyue Fan Xu Chen Wenna Hou Ping Liang Fanrong Rong Peijing Ma Tieming Liu Xulai Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 12 |
| 2 | Inhibiting collagen Ⅰ production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles显示文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells. | Yan Yan Cancan Du Xixi Duan Xiaohan Yao Jiajia Wan Ziming Jiang Zhongyu Qin Wenqing Li Longze Pan Zhuoyu Gu Fazhan Wang Ming Wang Zhihai Qin | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 3 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(https://covid19.who.int).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 4 | Study design,general characteristics of participants,and preliminary findings from the metabolome,microbiome,and dietary salt intervention study(MetaSalt)显示文摘Background:High sodium intake is an important risk factor for hypertension and cardiovascular disease.However,the association between gut microbiota composition and metabolomic profiles with dietary sodium intake and blood pressure(BP)is not well-understood.The metabolome,microbiome,and dietary salt intervention(MetaSalt)study aimed to investigate microbial and metabolomic profiles related to dietary sodium intake and BP regulation.Methods:This family-based intervention study was conducted in four communities across three provinces in rural northern China in 2019.Probands with untreated prehypertension or stage-1 hypertension were identified through community-based BP screening,and family members including siblings,offspring,spouses,and parents were subsequently included.All participants participated in a 3-day baseline examination with usual diet consumption,followed by a 10-day low-salt diet(3 g/d of salt or 51.3 mmol/d of sodium)and a 10-day high-salt diet(18 g/d of salt or 307.8 mmol/d of sodium).Differences in mean BP levels were compared according to the intervention phases using a paired Student’s t-test.Results:A total of 528 participants were included in this study,with a mean age of 48.1 years,36.7%of whom were male,76.8%had a middle school(69.7%)or higher(7.1%)diploma,23.4%had a history of smoking,and 24.4%were current drinkers.The mean arterial pressure at baseline was 97.2±10.5 mm Hg for all participants,and significantly decreased during the low-salt intervention(93.8±9.3,P<0.0001)and subsequently increased during the high-salt intervention(96.4±10.0,P<0.0001).Conclusions:Our dietary salt intervention study has successfully recruited participants and will facilitate to evaluate the effects of gut microbiota and metabolites on BP regulation in response to sodium burden,which will provide important evidence for investigating the underlying mechanisms in the development of hypertension and subsequent cardiovascular diseases.Trial registration:The study was registered in the Chinese Clinical Trial Registry database(ChiCTR1900025171). | Zengliang Ruan Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Zhongyu Xue Laiyuan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu | 2021 | Chronic Diseases and Translational Medicine2021，7，4： | 1 |
| 5 | Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats显示文摘The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be solved.In this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed genes.De-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was verified.De-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in vivo.The reprogramming mechanism of hSDF-1a participated in the dedifferentiation process.By successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt pathway.De-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats. | Zhou Xiaoqin Liu Jia Dai Mengjie Gu Jialu Bi Yang Wang Yuting Hu Huajian Liu Bo Zhang Xiaojun Li Zhongyue Chen Jie Li Tingyu Zhan Xue | 2021 | Genes & Diseases2021，8，3： | 1 |
| 6 | Visualizing Material Processing via Photoexcitation-ControlledOrganic-Phase Aggregation-Induced Emission显示文摘Aggregation-induced emission(AIE)has been much employed for visualizing material aggregation and self-assembly.However,water is generally required for the preparation of the AIE aggregates,the operation of which limits numerous material processing behaviors.Employing hexathiobenzene-based small molecules,monopolymers,and block copolymers as different material prototypes,we herein achieve AIE in pure organic phases by applying a nonequilibrium strategy,photoexcitationcontrolled aggregation.This strategy enabled a dynamic change of molecular conformation rather than chemical structure upon irradiation,leading to a continuous aggregation-dependent luminescent enhancement(up to~200-fold increase of the luminescent quantum yield)in organic solvents.Accompanied by the materialization of the nonequilibrium strategy,photoconvertible self-assemblies with a steady-state characteristic can be achieved upon organic solvent processing.The visual monitoring with the luminescence change covered the whole solution-to-film transition,as well as the in situ photoprocessing of the solid-state materials. | Jian Gu Bingbing Yue Glib V.Baryshnikov Zhongyu Li Man Zhang Shen Shen HansÅgren Liangliang Zhu | 2021 | Research2021，，1： | 1 |
| 7 | Galangin mitigates glucocorticoid-induced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway显示文摘Glucocorticoid-induced osteoporosis(GIOP),one of the most common and serious adverse effects associated with glucocorticoid administration,manifests as decreased bone formation and increased bone resorption,eventually culminating in bone loss.Galangin(GAL)is a flavonoid extracted from the medicinal herbal galangal that possesses a variety of pharmacological activities and can inhibit osteoclastogenesis.However,the effects of GAL on GIOP remain unclear.Our study aims to explore the effects of GAL on GIOP in mice and the underlying mechanism.Our results show that GAL markedly mitigates the severity of dexamethasone(Dex)-induced osteoporosis in mice and potentiates osteogenic differentiation in mouse bone marrow-derived mesenchymal stem cells(BMSCs).Furthermore,GAL also significantly counteracts Dex-mediated suppression of osteogenic differentiation and autophagy in human BMSCs.GAL augments PKA/CREB-mediated autophagic flux in BMSCs and the bones of osteoporotic mice.GAL-mediated osteogenic differentiation in Dex-treated BMSCs is significantly decreased by the PKA inhibitor H89 and autophagy inhibitor 3-methyladenine.Collectively,our data indicate that GAL can ameliorate GIOP,partly by augmenting the mineralization of BMSCs by potentiating PKA/CREB-mediated autophagic flux,highlighting its potential therapeutic use in treating glucocorticoid-related osteoporosis. | Chenying Zeng Shan Wang Huimin Gu Fenglei Chen Ziming Wang Jinteng Li Zhongyu Xie Pei Feng Huiyong Shen Yanfeng Wu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 8 | ZTE's Solution to China Next Generation Internet (CNGI)显示文摘Today IPv6 is the hottest topic worldwide. Many countries are positively impelling the research and application of the Next Generation Internet (NGI). China launched a large scale IPv6 backbone network project: China Next Generation Internet (CNGI). This article introduces the birth of IPv6 and CNGI, then discusses ZTE’s solution to CNGI in detail. | Gu Zhongyu, Liu Jumei (Data Division of ZTE Corporation, Nanjing 210012, China) | 2005 | ZTE Communications2005，3，3： | 0 |
| 9 | A novel optical high-pressure apparatus for studying the combustion of solid propellant under periodic strain显示文摘The combustion of solid propellants can provide tremendous thrust to drive solid rocket motors.Solid propellant grains are subjected to mechanical loads during practical combustion applications.The causes of mechanical loads include,but are not limited to,impulsive loads during ignition and periodic loads(>5 Hz)due to mechanical oscillation[1,2]. | OUYANG JianFeng GU MingMing WANG ShaoJie CUI CunHao SHI XiaoMing HOU KaiYu ZHOU ZhongYue QI Fei | 2023 | Science China(Technological Sciences)2023，66，3： | 0 |
| 10 | Strategies of Transition to IPv6显示文摘The paper briefly describes the necessity of introducing IPv6 into networks and the fact that IPv4 and IPv6 will coexist in operators’ networks for a long time. It also introduces Dual Stack, Tunneling and Translation technologies for the transition from IPv4 to IPv6 and their coexistence. Moreover, it makes a brief analysis of transition strategies of operators’ networks to IPv6 networks. | Gu Zhongyu (Data Division of ZTE Corporation, Nanjing 210012, China) | 2005 | ZTE Communications2005，3，2： | 0 |
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