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| 1 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol显示文摘OBJECTIVE: To investigate the effect of acupuncture at Neiguan(PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia(MI) induced by isoproterenol(ISO).METHODS: Twenty-seven Sprague-Dawley rats were randomly assigned to normal, model, and acupuncture groups. The model and acupuncture groups were given injections of ISO(85 mg/kg) to establish the MI model. After model establishment,the acupuncture group was treated with acupuncture at Neiguan(PC 6) for 30 min. Echocardiography was used to monitor diastolic and systolic function for 30 min starting from the time after the acupuncture needles were removed. Changes in the length of left ventricular internal diameter at end-diastole(LVIDd), length of left ventricular internal diameter at end-systole(LVIDs), the ratio of mitral peak velocity at early diastole and atrial contraction(E/A), ejection fraction(EF), fractional shortening(FS), and stroke volume(SV) were measured.RESULTS: Compared with the model group at 0and 15 min after needles were removed, the means of LVIDd and LVIDs were significantly lower(P <0.01) and E/A, EF, FS, and SV significantly higher(P < 0.01) in the acupuncture group. In the acupuncture group, the means of LVIDd and LVIDs15 min after the needles were removed were significantly higher(P < 0.01) than those at 0 min. The means of E/A, EF, FS, and SV significantly decreased(P < 0.01) from 0 to 15 min in the acupuncture group.CONCLUSION: These findings indicate that acupuncture at Neiguan(PC 6) can affect cardiac function by increasing left ventricular diastolic and systolic function in MI rat models, but the effect only lasts for 15 min. | Wang Songzi Ren Lu Jia Lianqun Gu Zhongyue Fan Xu Chen Wenna Hou Ping Liang Fanrong Rong Peijing Ma Tieming Liu Xulai Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 12 |
| 2 | Perovskite quantum dot lasers显示文摘Owing to the excellent properties of perovskite quantum dots(QDs),such as an easy synthesis process,high photoluminescence quantum yields,high defect tolerance,and tunable bandgap with different elements,laser actions have been widely conducted.Over the past few years,several approaches have been used for successfully creating perovskite QD lasers.In this review,we summarize the progress of perovskite QD lasers from the aspects of laser theory,characteristics and applications of QD lasers,advantages of perovskite materials for lasers,factors influencing the QD laser threshold,two-photon pumped QD lasers,and perovskite QD laser stability.At the same time,aiming at existing problems,possible solutions and prospects are presented. | Jie Chen Wenna Du Jianwei Shi Meili Li Yue Wang Qing Zhang Xinfeng Liu | 2020 | InfoMat2020，2，1： | 6 |
| 3 | Lichong decoction inhibits micro-angiogenesis by reducing the expressions of hypoxia inducible factor-1αand vascular endothelial growth factor in hysteromyoma mouse model显示文摘OBJECTIVE:To investigate the efficacy of Lichong decoction(LD)from Traditional Chinese Medicine,on micro-angiogenesis in a mouse model of hysteromyoma.METHODS:A mouse model of hysteromyoma was developed by orthotopic intrauterine injection of primary human myoma cells isolated from patients from the Beijing Obstetrics and Gynecology Hospital into CB-17 Scid mice.Mice were administered high-dose LD,low-dose LD,mifepristone or water(control)daily by gavage for 4 weeks.Uterine diameter and coefficient(uterine weight/body weight)were measured.Uterine morphology was assessed by light microscopy(hematoxylin and eosin)and transmission electron microscopy.Serum levels of estradiol,progesterone,follicle-stimulating hormone and luteinizing hormone(LH)were measured by enzyme-linked immunosorbent assay.Uterine protein expression of hypoxia inducible factor(HIF)-1α,CD31 and proliferating cell nuclear antigen(PCNA)was detected by immunohistochemistry.VEGF and HIF-1αm RNAs were quantified by RT-PCR.RESULTS:High-dose LD,low-dose LD and mifepristone reduced uterine diameter and coefficient,and attenuated the morphologic abnormalities associated with hysteromyoma.High-dose LD,low-dose LD and mifepristone inhibited hysteromyoma-induced micro-angiogenesis,as evidenced by a decrease in the number of new microvessels co-immunostaining for CD31 and PCNA(P<0.01).High-dose LD and mifepristone lowered serum levels of estradiol,progesterone and LH(P<0.05).High-dose LD,low-dose LD and mifepristone down-regulated HIF-1αm RNA and protein expressions and VEGF m RNA expression(P<0.01).CONCLUSION:The inhibition of hysteromyoma by LD may involve reductions in HIF-1αand VEGF expression and suppression of micro-angiogenesis. | Wang Wenna Zhang Wufang Li Donghua Qian Ruiya Zhu Lijuan Liu Yu Chen Chao | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 6 |
| 4 | Y_(4)GeO_(8):Er^(3+),Yb^(3+) up-conversion phosphors for optical temperature sensor based on FIR technique显示文摘Herein,we reported novel Y_(4)GeO_(8):Er^(3+),Yb^(3+)phosphors elaborated via conventional solid-state reaction.and we further explored their properties as optical thermometer by using fluorescence intensity ratio(FIR)method complemented by detailed analysis on crystal structure,up-conversion luminescence and energy transfer from Yb^(3+)to Er^(3+).Upon 980 nm laser excitation,Y_(4)GeO_(8):Er^(3+),Yb^(3+)phosphors present525,547 and 659 nm emission bands assigned to the characteristic transitions of Er^(3+).Furthermore,Y_(4)GeO_(8):Er^(3+),Yb^(3+)samples show outstanding temperature sensing performances.To be specific,the minimal temperature resolution is 0.03 K(303 K),and the relative sensitivity of FIR can be up to 1.152%/K(303 K).Hence,Y_(4)GeO_(8):Er^(3+),Yb^(3+)phosphors can be possible candidates for thermometry devices. | Yihang Chen Jing Chen Ye Tong Wenna Zhang Xiusha Peng Hai Guo Daxing Huang | 2021 | Journal of Rare Earths2021，39，12： | 5 |
| 5 | Effect of Chaihushugan San on expression of the Raf/mitogen-activated protein kinase/extracellular signal-regulated kinase pathway in the hippocampi of perimenopausal rats induced by immobilization stress显示文摘OBJECTIVE: We wished to study the impact of Chaihushugan San(CSS) on the behavior of perimenopausal rats with liver-Qi stagnation(LQS) and to investigate the effect of CSS on signal transduction of the Raf/mitogen-activated protein kinase(MEK)/extracellular signal-regulated kinase(ERK) cascade in the hippocampi of rats induced by immobilization.METHODS: Twenty 52-week-old female rats were divided into two groups by the random number table method: model control group(MCG) and CSS group(CSSG), with 10 rats in each group.Ten-week-old female rats were used as the normal control group(NCG). CSS effects were assessed using rats exposed to immobilization stress by measuring body weight and sucrose consumption, serum hormone levels, and observing performance in the open field test(OFT). Molecular mechanisms were examined by measuring the effect of CSS on expression of Raf1, MEK1/2 and ERK1/2 m RNA in hippocampi using quantitative real-time polymerase chain reaction and by measuring levels of these proteins and related phospho-proteins using Western blotting.RESULTS: Perimenopausal rats with LQS had decreased locomotor activity; reduced sucrose consumption; and increased serum levels of corticotropin releasing hormone(CRH) and corticosterone(CORT). Activation of hippocampal Raf/MEK/ERK cascade was suppressed significantly in the MCG,and activation was increased after 21 days of CSS treatment.CONCLUSION: CSS has significant effects upon relief of the symptoms of LQS in immobilization-induced rats. The mechanism underlying this action might(at least in part) be mediated by reversal of disruption of the Raf/MEK/ERK pathway. | Li Shengqiang Liang Wenna Li Yachan Chen Yunlong Chen Shujiao Li Candong | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 3 |
| 6 | Study on Atmospheric Environmental Capacity of Shennongjia显示文摘Through analysis and evaluation on status quo of atmospheric environment in Shennongjia,atmospheric environment capacity in ClassII functional area of Shennongjia was counted by A value method. The results showed that atmospheric environment capacities of SO2,NO2 and PM10in Shennongjia Forest District were respectively 6 268. 8,17 666. 2 and 2 279. 5 t / a,much larger than emissions of air pollutants in Shennongjia in 2012. | Zhang Wenna Cheng Chang Chen Tao Jiang Liping | 2014 | Meteorological and Environmental Research2014，5，9： | 2 |
| 7 | Preparation of Epoxy Resin Based on 1,5-Naphthalenediol and Its Application in Carbon Fiber-Reinforced Composites显示文摘 | Hua Ren Jun Xiao Wenna Chen | 2011 | Polymer-Plastics Technology and Engineering2011，，6： | 1 |
| 8 | Effect of hydrophobic group on flocculation properties and dewatering efficiency of cationic acrylamide copolymers显示文摘 | Haijing Ren Wenna Chen Yunfei Zheng | 2007 | Reactive and Functional Polymers2007，67，7： | 1 |
| 9 | Identification of hub genes and their novel diagnostic and prognostic significance in pancreatic adenocarcinoma显示文摘Objective:The main reasons for the poor prognoses of pancreatic adenocarcinoma(PA)patients are rapid early-stage progression,advanced stage metastasis,and chemotherapy resistance.Identification of novel diagnostic and prognostic biomarkers of PA is therefore urgently needed.Methods:Three mRNA microarray datasets were obtained from the Gene Expression Omnibus database to select differentially expressed genes(DEGs).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses for hub genes were performed using DAVID.Correlations between expression levels of hub genes and cancer-infiltrating immune cells were investigated by TIMER.Cox proportional hazard regression analyses were also performed.Serum hub genes were screened using the HPA platform and verified for diagnostic value using ELISAs.Results:We identified 59 hub genes among 752 DEGs.GO analysis indicated that these 59 hub genes were mainly involved in the defense response to viruses and the type I interferon signaling pathway.We also discovered that RSAD2 and SMC4 were associated with immune cell infiltration in the PA microenvironment.Additionally,DLGAP5 mRNA might be used as an independent risk factor for the prognoses of PA patients.Furthermore,the protein encoded by ISG15,which exists in peripheral blood,was validated as a potential diagnostic biomarker that distinguished PA patients from healthy controls(area under the curve:0.902,95%confidence interval:0.819–0.961).Conclusions:Our study suggested that RSAD2 and SMC4 were associated with immune cell infiltration in the PA microenvironment,while DLGAP5 mRNA expression might be an independent risk factor for the survival prognoses of PA patients.Moreover,ELISAs indicated that serum ISG15 could be a potential novel diagnostic biomarker for PA. | Duo Zuo Yongzi Chen Xinwei Zhang Zhuozhi Wang Wenna Jiang Fan Tang Runfen Cheng Yi Sun Lu Sun Li Ren Rui Liu | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 10 | Synthesis and properties of poly(L-lactide) poly(ethylene glycol)multiblock copolymers by coupling triblock copolymers显示文摘 | Wenna Chen Weijun Luo Shenguo Wang | | 0，，： | 1 |
| 11 | Preparation of epoxy resin based on 1,5-naphthalenediol and its application in carbon fiber- reinforced composites显示文摘 | Ren Hua Xiao Jun Chen Wenna | 2011 | Polymer-Plastics Technology and Engineering2011，50，6： | 1 |
| 12 | Effect of hydrophobic group on flocculation properties and dewatering efficiency of cationic acrylamide copolymers显示文摘 | Ren Haijing Chen Wenna Zheng Yunfei | 2007 | Reactive and Functional Polymers2007，67，7： | 1 |
| 13 | Synthesis and properties of poly(L-lactide) -poly(ethylene glycol)multiblock copolymers by coupling triblock copolymers显示文摘 | Wenna Chen Weijun Luo Shenguo Wang | 2003 | Polymers for Advanced Technologies2003，14，35： | 1 |
| 14 | Prenatal stress cause gender-dependent neuronal loss and oxidative stress in rat hippocampus显示文摘 | Zhu Zhongliang Li Xia Chen Wenna | 2004 | Journal of Neuroscience Research2004，78，： | 1 |
| 15 | Synthesis and Properties of Poly ( L-lactide )-Poly ( ethylene glycol ) Multiblock Copolymers by Coupling Triblock Copolymers 显示文摘 | Chen Wenna Luo Weijun Wang Shenguo | 2003 | Polymers for Advanced Technologies2003，14，35： | 1 |
| 16 | Ecological Carrying Capacity of Shennongjia Based on Sustainable Development显示文摘Ecological carrying capacity is a significant index for measuring sustainability of natural resources in a region. This paper applied ecological footprint counting model to calculate ecological footprint and ecological carrying capacity of the typical resource-based city—Shennongjia from 2008 to 2012. The results showed that(a) ecological footprint and per capita ecological footprint in Shennongjia area increased from 86,464.48 ha and 1.076 ha. in 2008 to 93,13.59 ha. and 1.171 ha. in 2012;(b) total ecological carrying capacity, and per capita ecological carrying capacity fluctuated, and total ecological carrying capacity > total ecological footprint, per capita ecological carrying capacity > total ecological footprint, thus it had ecological surplus;(c) among all land use types, water resources had the largest ecological surplus, construction land and woodland had the second and third largest; waters and fossil energy land showed ecological deficit and needed outer supply. As a whole, Shennongjia area had an excellent ecological environment with less destruction and good sustainability. | ZHAO Liya CHEN Tao CHENG Chang ZHANG Wenna JIANG Liping | 2016 | Journal of Landscape Research2016，8，1： | 1 |
| 17 | Protective effect of Sheng-Nao-Kang decoction on focal cerebral ischemia-reperfusion injury in rats显示文摘 | Lin Chen Ye Zhao Tianlong Zhang Xuan Dang Renming Xie Zhenzhi Li Yang Li Yuli Li Wenna Zhao Hongru Song | 2014 | Journal of Ethnopharmacology2014，，： | 1 |
| 18 | Based on network pharmacology to explore the mechanism of nephrotoxicity of Xanthii Fructus显示文摘Objective:To explore the potential mechanism of nephrotoxicity induced by Xanthii Fructus(XF)through network pharmacology.Methods:The active ingredients and targets of XF were screened through Traditional Chinese Medicine Systems Pharmacology Database,PubChem Database and Swiss Target Prediction Database,and the related pathogenic genes of nephrotoxicity were downloaded from Genecards,pharmGKB and OMIM databases.The potential target is the intersection of XF and the pathogenic gene of nephrotoxicity.Cytoscape software was used to construct a network of“XF-Potential active ingredient-Target-Nephrotoxicity network”.Protein protein interaction(PPI)network was constructed by String database,and the data was analyzed and sorted out to obtain the key active components and core target proteins of XF.GO functional enrichment analysis and KEGG pathway enrichment analysis of key target proteins were performed by R software.Results:11 active components,167 targets,6839 nephrotoxicity related pathogenic genes and 139 intersection target genes were screened from XF.After constructing the network of“XF-Potential active ingredient-target-nephrotoxicity network”and PPI network,the key active ingredients of XF were identified as Moupinamide,Beta-sitosterol and Stigmasterol,and the core target proteins were CASP3,HSP90AA1 and TP53.There were 2072 GO entries(P<0.05),including 1876 Biological Process(BP),64 Cellular Component(CC)and 132 Molecular Function(MF).KEGG enrichment analysis revealed 138 pathways(P<0.05),mainly involving p53 signaling pathway,IL-17 signaling pathway,PI3K-Akt signaling pathway were strongly correlated with the nephrotoxicity of XF.Conclusion:The core target protein of XF HSP90AA1,CASP3 and TP53 participate in p53 signaling Pathway,PI3K-Akt signaling Pathway,IL-17 signaling Pathway and other pathways to regulate apoptosis and induce inflammatory responses,resulting in kidney damage. | Tao Chen Tengda Li Wenna Zhang Yulin Song Yuman Tang Rui Gong Hua Jin | 2022 | Asian Toxicology Tesearch2022，4，1： | 0 |
| 19 | Optimum Anti-erosion Structures and Anti-erosion Mechanism for Rotatory Samples Inspired by Scorpion Armor of Parabuthus transvaalicus显示文摘Solid particle erosion on the material surfaces is a very common phenomenon in the industrial field,which greatly affects the efficiency,service life,and even poses a great threat to life safety.However,current research on erosion resistance is not only inefficient,but also limited to the improvement of hardness and toughness of materials.Inspired by typical scorpion(Parabuthus transvaalicus),biomimetic functional samples with exquisite anti-rosion structures were manufactured.Macroscopic morphology and structure of the biological prototype were analyzed and measured.According to above analysis,combined with response surface methodology,a set of biomimetic samples with different structural parameters were fabricated by using 3D printing technology.The anti-crosion performance of these biomimetic samples was investigated using a blasting jet machine.Based on the results of blasting jet test,as well as regression analysis and fiting,the optimal structural parameters were obtained.In addition to the static test conditions,the optimal biomimetic sample was also eroded in rotating condition and showed excellent erosion resistance property.The presence of bump and groove structures,on the one hand,reduced the croded area of biominetic sample surface.On the other hand,they made the airlow turbulent and consequently reduced the impact cnergy of solid particles,which significantly improved the erosion resistance of biomimetic materials.This study provides a new strategy to improvethe service life of components easily affected by erosion in the aviation,energy and military fields. | Shuaijun Zhang Wenna Chen Bo Li Shichao Niu Haiyue Yu Yahua Liu Xiao Yang Junqiu Zhang Zhiwu Han Luquan Ren | 2021 | Journal of Bionic Engineering2021，18，1： | 0 |
| 20 | Isolation and species diversity of arbuscular mycorrhizal fungi in the rhizosphere of Puccinellia tenuiflora of Songnen saline-alkaline grassland,China显示文摘Salinization has led to the deterioration of the ecological environment,affected the growth of plants,and hindered the development of agriculture and forestry.Arbuscular mycorrhizal(AM)fungi,as important soil microorganisms,play significant physiological and ecological roles in promoting plant nutrient absorption and improving soil structure.Puccinellia tenuiflora(Turcz.)Scribn.et Merr.in Songnen saline-alkaline grassland was selected as the research object to observe AM fungal colonization of the roots and explore the species and diversity of AM fungi in symbiotic association with P.tenuiflora.This study showed that AM fungi colonized in P.tenuiflora roots and formed a typical Arum-type mycorrhizal structure.A significant correlation was observed between vesicular abundance and the colonization intensity of mycorrhiza.Isolation and identification revealed 40 species of AM fungi in the rhizosphere of P.tenuiflora,belonging to 14 genera,of which two species could not be identified.The richness of the genus Glomus was the highest,accounting for 30%of the total species.Funneliformis mosseae and Rhizophagus intraradices were isolated from all the samples and were the species with the widest distribution in the rhizosphere of P.tenuiflora.Correlation analysis showed that pH only had a significant impact on the distribution of a few species,such as Glomus pustulatum,Diversispora spurca,Glomus aggregatum,Rhizophagus clarum,and Acaulospora foveata.The present study provides a theoretical basis for further exploring the resources of AM fungi in saline-alkaline soil. | YUNHUI ZHOU YAJIE LIU WENNA ZHAO FEI CHEN YUDAN WANG CHUNXUE YANG | 2022 | BIOCELL2022，46，11： | 0 |
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