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| 1 | Fatigue reliability assessment for bridge welded details using long-term monitoring data显示文摘A reliability assessment method of fatigue life based on the long-term monitoring data is developed for welded details in steel box girder,and the application research is presented with examples of welded rib-to-deck details in Runyang Bridges. Firstly the fatigue damage limit-state function is established based on S-N curves and Miner's rule,and the probability distribution characteristics of the coefficients in the function are discussed in detail. The uncertainties in fatigue loading effects are mainly studied based on long-term monitoring data. In the traditional studies,only the uncertainty of equivalent stress range is considered in fatigue reliability assessment. However,stress cycle number is also treated as a random variable in this paper because we know traffic flow every day differs in a thousand ways. Then the optimization method is employed to calculate the fatigue reliability. After studying the changing law of the reliability indices with time and the effect of the randomness of stress cycle number on reliability,the effect of the traffic growth on the reliability is studied. This study shows that the uncertainty in the fatigue life of the welded details can be well studied based on structural health monitoring,so it is necessary to carry out long-term strain monitoring of the welded details for accurate fatigue reliability assessment during the whole service period. | DENG Yang DING YouLiang LI AiQun ZHOU GuangDong | 2011 | Science China(Technological Sciences)2011，54，12： | 24 |
| 2 | Efficacy of intramuscular matrine in the treatment of chronic hepatitis B显示文摘BACKGROUND: Hepatitis B virus (HBV) infection, a glo- bal public health problem, is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. There are more than 350 million HBV carriers in the world and up to one million die annually due to hepatitis B associated liv- er disease. So far no optimal treatment is available for pa- tients with chronic hepatitis B. In the paper we investigated the efficacy of intramuscular matrine in the treatment of chronic hepatitis B. METHODS: One hundred and twenty patients with chronic hepatitis B were randomly divided into matrine treatment group (n =60) and control group (n =60). The patients of the matrine group were given intramuscularly with matrine (an alkaloid extracted from a traditional Chinese herb Radix Sophorae Flavescentis by Guangzhou Ming Xing Pharmaceu cal Factory, Guangzhou, China) of 100 mg daily for 90 days in addition to conventional liver-protective drugs in- cluding glucurone, inosine, compound vitamin B and caryophyllin. The control group received conventional liv- er-protective drugs alone. Clinical manifestations and labo- ratory parameters including liver biochemistry and serum hepatitis B virus markers were monitored before and after treatment in the two groups. RESULTS: Significant differences were seen between the two groups in terms of improvement of clinical symptoms and signs, recovery of liver functions, and serum conver- sion from hepatitis Be antigen to HBe antibody and from positive to negative serum HBV DNA (P <0.05-0.01). The result of the matrine group was more marked than that of the control group. Serious side-effects were not observed except mild pain at the site of injection of matrine in a few patients. CONCLUSION: These results indicate that intramuscular matrine may be an economical, efficacious, safe drug for the treatment of chronic hepatitis B. | Yao Long, Xiao-Tian Lin, Kun-Lun Zeng and Lian Zhang Zhanjiang, China Department of Infectious Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China Haibin Centre Hospital, Zhanjiang 524005, China Centre of Hepatology of Nanfang Hospital, First Military Medical University, Guang- zhou 510515, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 21 |
| 3 | Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer显示文摘AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer. | Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South China, Department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key Laboratory of Oncology in South China, Department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China | 2010 | World Journal of Gastroenterology2010，16，19： | 16 |
| 4 | Influence of whole peptidoglycan of bifidobacterium on cytotoxic effectors produced by mouse peritoneal macrophages显示文摘INTRODUCTIONBifidobacteria are physiologically beneficial bacteria which are perdominant in human intestine ,and possess the most important functions .They play an important role in maintaining microbial balance of the intestine .Furthermore , their presence is thought to be an important indication of health of the body [1-4].Whole peptidoglycan ( WPG) is the major component in the cell wall of bifidobacterium ,which is also a biological responsemodifier with nontoxic side dffcets. | Li Sheng Wang~1 Hui Ming Zhu~1 Dian Yuan Zhou~2 Yu Lin Wang~1 Wan Dai Zhang~2 ~1Departrnent of Gastroenterology,Shenzhen Municipal People’s Hospital,Jinan University of Medical Sciences,Shenzhen 518020,Guangdong Province,China ~2Chinese PLA Institute of Digestion,the First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaLi Sheng Wang graduated and obtained Ph.D,from the First Military Medical University in 1998,now working at Department of Gastroenterology,Shenzhen Municipal People’s Hospital.Jinan University of Medical Sciences.having 35 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 15 |
| 5 | Effect of Protein Kinase C on Proliferation and Apoptosis of T Lymphocytes in Idiopathic Thrombocytopenic Purpura Children显示文摘It is well-documented that T lymphocyte proliferation and apoptosis are abnormal in idiopathic thrombocytopenic purpura (ITP) children. However, the underlying regulation mechanisms especially in terms of signal transduction remain unknown. In this paper, we reported the changes of protein kinase C (PKC) activity in peripheral blood T lymphocytes and the effect of PKC on T lymphocyte proliferation and apoptosis. We demonstrated that in ITP children, the activator (PMA) and inhibitor (H-7) of PKC affected on T lymphocyte proliferation and apoptosis dramatically, but they altered little in healthy children. PKC activity was significantly enhanced in ITP children together with an increased expression of FasL on CD3+ T, CD4+ T and CD8+T cells, resulting in a positive correlation between PKC activity and the expression of FasL on T cells. While the PKC activity and the platelet count were negatively correlated. Taken together, our findings suggest that the PKC activation may enhance T lymphocytes activity, suppress T cell apoptosis and be involve in thrombocytes damage as a mechanism related to immune pathogenesis of ITP. | Changlin Wu~(1,2) Fang Liu~1 Xuemin Zhou~1 Zhengwei Cheng~1 Xiaomeng Yang~1 Hong Xiao~1 Qun Chen~1 Kangrong Cai~1 ~1Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang,Guangdong,524023,China ~2Corresponding to:Dr.Changlin Wu,Department of Microbiology and Immunology,Guangdong Medical College,2 Wen-Ming East Road,Zhanjiang,Guangdong,524023,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 12 |
| 6 | Estimation of the Effects of Maize Straw Return on Soil Carbon and Nutrients Using Response Surface Methodology显示文摘Straw incorporation is generally considered an effective agricultural management practice that improves nutrient cycling and maintains soil fertility. To study the interactive effects of straw returning factors on soil organic carbon and available nutrients, a17-month(May 6, 2016 to October 6, 2017) experiment was conducted on straw incorporation by using response surface methodology under a three-factor(straw length, amount, and burying depth), five-level quadratic orthogonal rotation experimental design. Weight was assigned to each indicator for soil carbon and nutrients and then a comprehensive indicator was established. Then, a second-order polynomial model of the three straw returning factors was established using response surface methodology. Results indicated that17 months after straw incorporation, straw amount and burying depth had significant effects on the comprehensive indicator of soil carbon and nutrients. Straw length and the interactions of straw amount and burying depth showed no significant effects on the comprehensive indicator of soil carbon and nutrients. It was concluded that 17 months after straw incorporation, the highest value of the comprehensive indicator of soil carbon and nutrients was achieved when the straw length, amount, and burying depth were approximately 17–20 cm, 740–840 g m^(-2), and 9–13 cm, respectively, which can be recommended as the most suitable parameters for use in straw returning in the study area. | ZHOU Dongxing SU Ye NING Yucui RONG Guohua WANG Guangdong LIU Di LIU Liyan | 2018 | Pedosphere2018，28，3： | 12 |
| 7 | Nitrogen Deposition and Its Spatial Pattern in Main Forest Ecosystems along North-South Transect of Eastern China显示文摘A continuous three-year observation(from May 2008 to April 2011)was conducted to characterize the spatial variation of dissolved inorganic nitrogen(DIN)deposition at eight main forest ecosystems along the north-south transect of eastern China(NSTEC).The results show that both throughfall DIN deposition and bulk DIN deposition increase from north to south along the NSTEC.Throughfall DIN deposition varies greatly from 2.7 kg N/(ha·yr)to 33.0 kg N/(ha·yr),with an average of 10.6 kg N/(ha·yr),and bulk DIN deposition ranges from 4.1 kg N/(ha·yr)to 25.4 kg N/(ha·yr),with an average of 9.8 kg N/(ha·yr).NH4+-N is the dominant form of DIN deposition at most sampling sites.Additionally,the spatial variation of DIN deposition is controlled mainly by precipitation.Moreover,in the northern part of the NSTEC,bulk DIN deposition is 17%higher than throughfall DIN deposition,whereas the trend is opposite in the southern part of the NSTEC.The results demonstrate that DIN deposition would likely threaten the forest ecosystems along the NSTEC,compared with the critical loads(CL)of N deposition,and DIN deposition in this region is mostly controlled by agricultural activities rather than industrial activities or transportation. | ZHAN Xiaoyun YU Guirui HE Nianpeng FANG Huajun JIA Bingrui ZHOU Mei WANG Chuankuan ZHANG Junhui ZHAO Guangdong WANG Silong LIU Yunfen YAN Junhua | 2014 | Chinese Geographical Science2014，24，2： | 10 |
| 8 | Recent Progress in Cartilage Tissue Engineering--Our Experience and Future Directions显示文摘软骨缺损难以自行修复,组织工程是实现软骨再生的理想途径。目前,组织工程软骨主要有两类用途:一是用于骨科或关节外科,修复关节表面或半月板部位的软骨缺损,实现关节运动功能的重建;二是用于整形或头颈外科,修复耳廓、气管、睑板、鼻、喉等具有特殊形态及功能的软骨缺损。不同应用目标的组织工程软骨,其构建方法和所面临的挑战,以及临床转化进程均会有很大差别。本文旨在针对上述两大应用目标,结合我们团队在研究过程中所建立的观点及积累的经验,对组织工程软骨目前的主要研究进展和所面临的挑战,以及未来的发展方向做一简要总结。 | Yu Liu Guangdong Zhou Yilin Cao | 2017 | Engineering2017，3，1： | 9 |
| 9 | Construction and selection of the natural immune Fab antibody phage display library from patients with colorectal cancer显示文摘AIM: To construct the natural immune Fab antibody phage display libraries of colorectal cancer and to select antibodies related with colorectal cancer.METHODS: Extract total RNA from tissue of local cancer metastasis lymph nodes of patients with colorectal cancer.RT-PCR was used to amplify the heavy chain Fd and light chain к and the amplification products were inserted successively into the vector pComb3 to construct the human libraries of Fab antibodies. They were then panned by phage display technology. By means of Dot immunoblotting and ELISA, the libraries were identified and the Fab phage antibodies binding with antigens of colorectal cancer were selected.RESULTS: The amplified fragments of Fd and к gained by RT-PCR were about 650bp. Fd and к PCR products were subsequently inserted into the vector pComb3, resulting in a recombination rate of 40% and the volume of Fab phage display library reached 1.48 x 106. The libraries were enriched about 120-fold by 3 cycles of adsorption-elution- multiplication (panning). Dot immunoblotting showed Fab expressions on the phage libraries and ELISA showed 5clones of Fab phage antibodies which had binding activities with antigens of colorectal cancer.CONCLUSION: The natural immune Fab antibody phage display libraries of colorectal cancer were constructed. They could be used to select the relative antibodies of colorectal cancer. | Bao-Ping Wu~1 Bing Xiao~1 Tian-Mo Wan~1 Ya-Li Zhang~1 Zhen-Shu Zhang~1 Dian-Yuan Zhou~1 Zhuo-Sheng Lai~1 Chun-Fang Gao~2 1 Institute for Digestive Diseases,Nanfang Hospital,Guangzhou 510515,Guangdong Province,China2 Surgical Department of Colon and Rectum,150 Central Hospital,Luoyang 471031,Henan Province,China | 2001 | World Journal of Gastroenterology2001，7，6： | 9 |
| 10 | Energy distributions of the large-scale horizontal currents caused by wind in the baroclinic ocean显示文摘Ocean current data for nearly 3 months in the South China Sea (SCS), combined with the NCEP/NCAR reanalysis wind data, are analyzed. The results indicate that the wind en-ergy enters the upper mixed layer in a wide continuous frequency band. In addition, the interac-tion between the low-frequency wind anomaly and the low-frequency current anomaly is the most ‘effective’ way for the energy input from the wind to the upper ocean. However, only the inertial and the near inertial energy propagate downwards through the upper mixed layer. The down-ward-propagating energy is distributed into the barotropic currents, the baroclinic currents and each mode of the baroclinic currents following the normal distributions. The energy change ratios between the barotropic motion to the baroclinic motion induced by the wind present a normal distribution of N (0.0242, 0.3947). The energy change ratios of the first 4 baroclinic modes to the whole baroclinic currents also follow the normal distributions. The first baroclinic mode follows N (0.2628, 0.1872), the second N (0.1979, 0.1504), the third N (0.1331, 0.1633), and the fourth N (0.0650, 0.1540), respectively. | ZHOU Lei1, TIAN Jiwei1 & WANG Dongxiao2 1. Physical Oceanography Laboratory, Ocean University of China, Qingdao 266003, China 2. Key Laboratory of Tropical Marine Environmental Dynamics, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangdong 510301, China | 2005 | Science China Earth Sciences2005，48，12： | 6 |
| 11 | Assessment on the Eco-environment and the Land Use Based on the Ecosystem Service Value——A Case of Guangdong Province,China显示文摘Based on the previous research and the 1996 and 2008 land use change survey,land use type of Guangdong Province is divided into 10 types of farmland,garden plot,woodland,grassland,residential points and other construction sites,traffic and transmission land,land for water conservancy facilities,wetland,water area,and land hard to be utilized. Then,area change and annual changing rate of land use type in Guangdong Province are calculated by the analysis method of land use change. Based on this,ecosystem service value assessment method is used to discuss the variation of ecosystem service value in Guangdong Province. Result shows that ecosystem service value of land use shows a decreasing trend in Guangdong Province,having reduced from from 635 036 billion yuan in the year 1996 to 632 394 billion yuan in the year 2008. Ecosystem service value has reduced by 2 642 billion yuan,a reduction rate of only 0.416 1%. Farmland,woodland,grassland,wetland,land for water conservancy facilities,and unused land have all reduced. But garden plot,traffic and transmission land,water area,and residential point and other construction site have increased. The major characteristics of land use change the years 1996-2008 in Guangdong Province are the internal adjustment of agricultural structure and the increase of construction land. Land use change and adjustment direction are basically rational and the ecological environment is stable. | ZHOU Chang-ping Guangdong Institute of Land Surveying & Planning,Guangzhou 510075,China | 2010 | Asian Agricultural Research2010，2，4： | 6 |
| 12 | The relationship between HBV lamivudine resistance and HBV genotypes or basic core promoter mutations显示文摘OBJECTIVE: To investigate the relationship between HBV Iamivudine resistance and HBV genotypes orbasic core promoter (BCP) mutations.METHODS: The common coated probes were synthesized according to the conserved regions of the preCgene of hepatitis B virus (HBV). Different colorized probes were chosen from the sequences of differentgenotypes of HBV (A to F), BCP and YMDD wild types and mutants, respectively. HBV DNA levels,HBV genotypes, BCP and YMDD resistants were analyzed by PCR microplate hybridization ELISA at thezero and 6th month after the patients were treated with lamivudine.RESULTS: HBV genotyping results showed that HBV types B, C, D accounted for about 30%, 36%and 23% patients respectively. Thirteen BCP mutations (type B in 1 patient, type C in 8 and type D in4) were found before treatment with lamivudine. HBV DNA levels were lower than 100 pg/ml in 2patients anti higher than 100 pg/ml in 11. 9.4% of the HBV patients (5/43; type C in 3 and type D in2) showed YMDD resistants and 4 BCP mutations at the same time.CONCLUSION: Oral treatment of lamivudine decreases the level of serum HBV DNA. The appearanceof HBV YMDD resistants is related to certain HBV genotypes, and most of them are BCP mutations. | Dong-Yao Zhou Lian-Ying Lin Hong Wang Jian-Sheng Huang the Department of Clinical Laboratory Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China Molecular Biology Diagnostic Center, First Military Medical University, Guangzhou 510515, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，1： | 5 |
| 13 | In Vivo Chondrogenesis of Bmscs at Non-Chondrogenesis Site by Co-Transplantation of BMSCs and Chondrocytes with Pluronic as Biomaterial显示文摘 | Guangdong Zhou Wei Liu Lei Cui Yilin Cao | 2005 | 中国生物学文摘2005，19，10： | 5 |
| 14 | Significance of MD-2 and MD-2B expression in rat liver during acute cholangitis显示文摘AIM: To investigate the expression of myeloid differentiation protein-2 (MD-2), MD-2B (a splicing isoform of MD-2 that can block Toll-like receptor 4 (TLR4)/MD-2 LPS-mediated signal transduction) and TLR4 in the liver of acute cholangitis rats. METHODS: Male Sprague-Dawley rats (SPF level) were randomly divided into four groups: (A) sham-operated group; (B) simple common bile duct ligation group; (C)acute cholangitis group; and (D) acute cholangitis anti- TLR4 intervention group (n = 25 per group). Rat liver tissue samples were used to detect TLR4, MD-2 and MD-2B mRNA expression by fluorescence quantitative PCR in parallel with pathological changes. RESULTS: In acute cholangitis, liver TLR4 and MD-2 mRNA expression levels at 6, 12, 24, 48 and 72 h were gradually up-regulated but MD-2B mRNA expression gradually down-regulated (P < 0.05). After TLR4 antibody treatment, TLR4 and MD-2 mRNA expression were lower compared with the acute cholangitis group (P < 0.05). However, MD-2B mRNA expression was higher than in the acute cholangitis group (P < 0.05). MD-2 and TLR4 mRNA expressions were positively correlated (r = 0.94981, P < 0.05) and MD-2B mRNA expression was negatively correlated with MD-2 and TLR4 mRNA (r = -0.89031, -0.88997, P< 0.05). CONCLUSION: In acute cholangitis, MD-2 plays an important role in the process of TLR4- mediated in? am- matory response to liver injury while MD-2B plays a negative regulatory role. | Hui-Lai Miao, Zhi-Dong Qiu, Fu-Long Hao, Yong-Hui Bi, Ming-Yi Li, Ming Chen, Nian-Ping Chen, Fei Zhou, Department of Hepatobiliary Surgery, the Affiliated Hospital of Guangdong Medical College, Zhanjing 524001, Guangdong Province, China Hepatobiliary Surgery, Research Institute of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China | 2010 | World Journal of Hepatology2010，2，6： | 3 |
| 15 | HBV resistant to lamivudine: experimental and clinical studies显示文摘Objective: To identify the impact of lamivudine onHBV e antigen (HBeAg) seroconversion and HBVDNA level, and the appearance of Tyr-Met-Asn-Asp(YMDD) resistants.Methods: Forty-seven hepatitis B patients were trea-ted with oral lamivudine. ALT level and HBeAgwere detected in the treatment on the zero, 3rd, 6thand 9th month respectively. The levels of HBV DNAand YMDD resistants were analyzed with PCR mi-croplate hybridization-ELISA.Results: After 9 months of treatment, HBV DNA be-came negative and ALT level was normal in 74% pa-tients. Among these patients, 17% patients hadHBeAg converted to negative and anti-HBe antibodypositive, whereas another 15% patients showedHBeAg negative. YMDD resistants appeared in 19 %patients (9/47). One, three and five resistants weredetected in the treatment on the 3rd, 6th and 9thmonth respectively.Conclusions: Most HBV DNA in serum became nega-tive after 9 months of treatment, and the rate ofHBeAg seroconversion was 17% (HBV DNA levelwas lower than 100 pg/ml before treatment). YMDDresistants appeared in 19% patients. | Dong-Yao Zhou Yong-Jian Cao Lian-Ying Lin Hong Wang Jian-Sheng Huang the Department of Clinical Laboratory Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China Institution of Molecular Biology Diagnostic Center, First Military Medical University, Guangzhou 510515, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，4： | 3 |
| 16 | Reaction mechanism of arsenic capture by a calcium-based sorbent during the combustion of arsenic-contaminated biomass: A pilot-scale experience显示文摘Large quantities of contaminated biomass due to phytoremediation were disposed through combustion in low-income rural regions of China.This process provided a solution to reduce waste volume and disposal cost.Pilot-scale combustion trials were conducted for in site disposal at phytoremediation sites.The reaction mechanism of arsenic capture during pilot-scale combustion should be determined to control the arsenic emission in flue gas.This study investigated three Pteris vittata L.biomass with a disposal capacity of 600 kg/d and different arsenic concentrations from three sites in China.The arsenic concentration in flue gas was greater than that of the national standard in the trial with no emission control,and the arsenic concentration in biomass was 486 mg/kg.CaO addition notably reduced arsenic emission in flue gas,and absorption was efficient when CaO was mixed with biomass at 10% of the total weight.For the trial with 10% CaO addition,arsenic recovery from ash reached 76%,which is an ~8-fold increase compared with the control.Synchrotron radiation analysis confirmed that calcium arsenate is the dominant reaction product. | Mei Lei Ziping Dong Ying Jiang Philip Longhurst Xiaoming Wan Guangdong Zhou | 2019 | Frontiers of Environmental Science & Engineering2019，13，2： | 2 |
| 17 | Structure and composition-dependent optical properties of(Pb_xSr_(1-x))TiO_3(x=0.4,0.6) nanotube arrays | Yan-ping JIANG~(1,2),Xin-gui TANG~(1,2),Yi-chun ZHOU~1,Qiu-xiang LIU~2 1.Key Laboratory of Low Dimensional Materials and Application Technology, Xiangtan University,Xiangtan 411105,China 2.School of Physics and Optoelectronic Engineering,Guangdong University of Technology, Guangzhou 510006,China | 2011 | Progress in Natural Science:Materials International2011，21，3： | 2 |
| 18 | Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels显示文摘Physiological repair of large-sized bone defects is great challenging in clinic due to a lack of ideal grafts suitable for bone regeneration.Decalcified bone matrix(DBM)is considered as an ideal bone regeneration scaffold,but low cell seeding efficiency and a poor osteoinductive microenvironment greatly restrict its application in large-sized bone regeneration.To address these problems,we proposed a novel strategy of bone regeneration units(BRUs)based on microgels produced by photo-crosslinkable and microfluidic techniques,containing both the osteogenic ingredient DBM and vascular endothelial growth factor(VEGF)for accurate biomimic of an osteoinductive microenvironment.The physicochemical properties of microgels could be precisely controlled and the microgels effectively promoted adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.BRUs were successfully constructed by seeding BMSCs onto microgels,which achieved reliable bone regeneration in vivo.Finally,by integrating the advantages of BRUs in bone regeneration and the advantages of DBM scaffolds in 3D morphology and mechanical strength,a BRU-loaded DBM framework successfully regenerated bone tissue with the desired 3D morphology and effectively repaired a large-sized bone defect of rabbit tibia.The current study developed an ideal bone biomimetic microcarrier and provided a novel strategy for bone regeneration and large-sized bone defect repair. | Junxiang Hao Baoshuai Bai Zheng Ci Jincheng Tang Guanhuai Hu Chengxiang Dai Mengyuan Yu Meng Li Wei Zhang Yixin Zhang Wenjie Ren Yujie Hua Guangdong Zhou | 2022 | Bioactive Materials2022，7，8： | 2 |
| 19 | The band structures of BSb and B_xGa_(1-x)Sb alloys显示文摘The band structures of BSb and BxGa1-xSb alloys are studied using first-principles calculations in the generalized gradient approximation. By SQS-8 supercells to model a random alloy, the direct transition energy-gap (Γ15v- Γ1c) bowing of 3.0 eV is obtained for BxGa1-xSb alloys in x = 0-50%, in x = 0-11% the energy-gap is the band-gap and increases by 7 meV/%B with boron composition increasing; by SQS-16 supercells the bowing parameter is about 1.9 eV in x = 0-12.5%. The formation enthalpies of mixing, ΔH, are calculated for BxGa1-xAs and BxGa1-xSb alloys. A comparison of enthalpies indicates that BxGa1-xSb films with boron composition of 7% may be possible. | XIONG DePing1, ZHOU ShouLi2, WANG Qi3, LUO Li1, HUANG YongQing3 & REN XiaoMin3 1 School of Physics and Optoelectronic Engineering, Guangdong University of Technology, Guangzhou 510006, China 2 College of Information Engineering, Zhejiang University of Technology, Hangzhou 310032, China 3 Key Laboratory of Optical Communication and Lightwave Technologies Ministry of Education, Beijing University of Posts and Telecommunications, Beijing 100876, China | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，6： | 2 |
| 20 | Bioprinting and regeneration of auricular cartilage using a bioactive bioink based on microporous photocrosslinkable acellular cartilage matrix显示文摘Tissue engineering provides a promising strategy for auricular reconstruction.Although the first international clinical breakthrough of tissue-engineered auricular reconstruction has been realized based on polymer scaffolds,this approach has not been recognized as a clinically available treatment because of its unsatisfactory clinical efficacy.This is mainly since reconstruction constructs easily cause inflammation and deformation.In this study,we present a novel strategy for the development of biological auricle equivalents with precise shapes,low immunogenicity,and excellent mechanics using auricular chondrocytes and a bioactive bioink based on biomimetic microporous methacrylate-modified acellular cartilage matrix(ACMMA)with the assistance of gelatin methacrylate(GelMA),poly(ethylene oxide)(PEO),and polycaprolactone(PCL)by integrating multi-nozzle bioprinting technology.Photocrosslinkable ACMMA is used to emulate the intricacy of the cartilage-specific microenvironment for active cellular behavior,while GelMA,PEO,and PCL are used to balance printability and physical properties for precise structural stability,form the microporous structure for unhindered nutrient exchange,and provide mechanical support for higher shape fidelity,respectively.Finally,mature auricular cartilage-like tissues with high morphological fidelity,excellent elasticity,abundant cartilage lacunae,and cartilage-specific ECM deposition are successfully regenerated in vivo,which provides new opportunities and novel strategies for the fabrication and regeneration of patient-specific auricular cartilage. | Litao Jia Yujie Hua Jinshi Zeng Wenshuai Liu Di Wang Guangdong Zhou Xia Liu Haiyue Jiang | 2022 | Bioactive Materials2022，7，10： | 2 |
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