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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Wavelet neural network based fault diagnosis in nonlinear analog circuits显示文摘The theories of diagnosing nonlinear analog circuits by means of the transient response testing are studied. Wavelet analysis is made to extract the transient response signature of nonlinear circuits and compress the signature dada. The best wavelet function is selected based on the between-category total scatter of signature. The fault dictionary of nonlinear circuits is constructed based on improved back-propagation(BP) neural network. Experimental results demonstrate that the method proposed has high diagnostic sensitivity and fast fault identification and deducibility. | Yin Shirong Chen Guangju Xie Yongle | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 16 |
| 3 | Feature evaluation and extraction based on neural network in analog circuit fault diagnosis显示文摘Choosing the right characteristic parameter is the key to fault diagnosis in analog circuit. The featureevaluation and extraction methods based on neural network are presented. Parameter evaluation of circuit features is realized by training results from neural network; the superior nonlinear mapping capability is competent for extracting fault features which are normalized and compressed subsequently. The complex classification problem on fault pattern recognition in analog circuit is transferred into feature processing stage by feature extraction based on neural network effectively, which improves the diagnosis efficiency. A fault diagnosis illustration validated this method. | Yuan Haiying Chen Guangju Xie Yongle | 2007 | Journal of Systems Engineering and Electronics2007，18，2： | 16 |
| 4 | Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals显示文摘尽管 myocyte 房间移植研究为心肌的梗塞建议了一个有希望的治疗学的潜力,到为心肌的修理的临床的治疗的发展的一个主要障碍是与为移植获得相对同类的室的 myocytes 联系的困难。人的胚胎的干细胞(hESCs ) 是 cardiomyocytes 的有希望的来源。这里,我们报导发信号的 retinoid 在 hESCs 的心脏的区别期间调整 atrial 对室的 myocytes 的命运说明。我们发现少量和 pan-retinoic 酸受体对手 BMS-189453 (RAi ) 显著地增加了 hESCs 的心脏的区别效率。为了调查 retinoid,工作,我们把对待 Noggin+RAi 的文化与对待 Noggin+RA 的文化作比较。我们的结果证明室特定的基因 IRX-4 的表示层次极端地在对待 Noggin+RAi 的文化被提高。MLC-2V,另一个室特定的标记,在对待 Noggin+RAi 的文化,然而并非在对待 Noggin+RA 的文化的 cardiomyocytes 在 cardiomyocytes 的多数被表示。流动 cytometry 分析和 electrophysiological 研究与 64.7 | Qiangzhe Zhang Junjie Jiang Pengcheng Han Qi Yuan Jing Zhang Xiaoqian Zhang Yanyan Xu Henghua Cao Qingzhang Meng Li Chen Tian Tian Xin Wang Pu Li Jurgen Hescheler Guangju Ji Yue Ma | 2011 | Cell Research2011，21，4： | 10 |
| 5 | Emergency treatment of 16 patients with necrotizing fasciitis caused by Vibrio vulnificus infection complicated with septic shock显示文摘Necrotizing fasciitis (NF) caused by vibrio vulnificus (VV) is a rare but fatal clinical emergency characterized by hemorrhagic bullous skin lesions,septic shock and multiple organ dysfunction syndrome (MODS),commonly occurring in patients with chronic liver disease.1,2 In general,mortality of these patients is higher than 60%,which could approach 100% when complicated with septic shock.Therefore,early diagnosis and effectively surgical intervention in emergency room are the mainstays for better outcomes of these patients.However,many emergency physicians lack experiences in diagnosing and managing vibrio NF.Furthermore,due to the preexisting severe medical complications including hypotension,lactic acidosis,coagulation disorders and thrombocytopenia,the optimal therapeutic strategies for these critical patients should obviously be evaluated on a patient-to-patient basis,which remains largely undefined. | Hong Guangliang Wu Bin Lu Caijiao Li Mengfang Zhao Guangju Lu Zhongqiu | 2014 | Chinese Medical Journal2014，，10： | 8 |
| 6 | Changes in sediment discharge in a sediment-rich region of the Yellow River from 1955 to 2010: implications for further soil erosion control显示文摘The well-documented decrease in the discharge of sediment into the Yellow River has attracted considerable attention in recent years. The present study analyzed the spatial and temporal variation of sediment yield based on data from 46 hydrological stations in the sediment-rich region of the Yellow River from 1955 to 2010. The results showed that since 1970 sediment yield in the region has clearly decreased at different rates in the 45 sub-areas controlled by hydrological stations. The decrease in sediment yield was closely related to the intensity and extent of soil erosion control measures and rainstorms that occurred in different periods and sub-areas. The average sediment delivery modulus(SDM) in the study area decreased from 7,767.4 t/(km2?a) in 1951–1969 to 980.5 t/(km2?a) in 2000–2010. Our study suggested that 65.5% of the study area with the SDM below 1,000 t/(km2?a) is still necessary to control soil deterioration caused by erosion, and soil erosion control measures should be further strengthened in the areas with the SDM above 1,000 t/(km2?a). | JuYing JIAO ZhiJie WANG GuangJu ZHAO WanZhong WANG XingMin MU | 2014 | Journal of Arid Land2014，6，5： | 7 |
| 7 | Anti-aliasing nonstationary signals detecion algorithm based on interpolation in the frequency domain using the short time Fourier transform显示文摘To eliminate the aliasing that appeared during the measurement of multi-components nonstationary signals, a novel kind of anti-aliasing algorithm based on the short time Fourier transform (STFT) is brought forward. First the physical essence of aliasing that occurs is analyzed; second the interpolation algorithm model is setup based on the Hamming window; then the fast implementation of the algorithm using the Newton iteration method is given. Using the numerical simulation the feasibility of algorithm is validated. Finally, the electrical circuit experiment shows the practicality of the algorithm in the electrical engineering. | Bian Hailong Chen Guangju | 2008 | Journal of Systems Engineering and Electronics2008，19，3： | 7 |
| 8 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 9 | Inadvertent insertion of nephrostomy tube into the renal vein following percutaneous nephrolithotomy: A case report and literature review显示文摘Percutaneous nephrolithotomy(PCNL)is an effective and well accepted procedure for the treatment of large and complex renal calculi.We encountered a patient with a mis-placed percutaneous nephrostomy drainage tube(PNDT)into the contralateral renal vein re-sulting thrombus formation after undergoing right side PCNL.We placed a temporary filter to prevent embolism and started anti-coagulation therapy immediately and finally the PNDT was removed without bleeding. | Guangju Ge Zhenghui Wang Mingchao Wang Gonghui Li Zuhao Xu Yukun Wang Shawpong Wan | 2020 | Asian Journal of Urology2020，7，1： | 3 |
| 10 | Low overhead design-for-testability for scan-based delay fault testing显示文摘An efficient design-for-testability (DFT) technique is proposed to achieve low overhead for scan-based delay fault testing. Existing techniques for delay test such as skewed-load or broadside make the test generation process complex and produce lower coverage for scan-based designs as compared with non-scan designs, whereas techniques such as enhanced-scan test can make the test easy but need an extra holding latch to add substantial hardware overhead. A new tri-state holding logic is presented to replace the common holding latch in enhanced-scan test to get a substantial low hardware overhead. This scheme can achieve low delay overhead by avoiding the holding latch on the critical timing scan path. What’s more, this method can also keep the state and signal activity in the combinational circuit from the scan during data scan-in operation to reduce the power dissipation. Experiment results on a set of ISCAS89 benchmarks show the efficiency of the proposed scheme. | Yang Decai Chen Guangju Xie Yongle | 2007 | Journal of Systems Engineering and Electronics2007，18，1： | 3 |
| 11 | GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation显示文摘 | Yuting Guo Huiwen Wang Yinglong Tang Yue Wang Mengqi Zhang Zhiguang Yang Eric Nyirimigabo Bin Wei Zhongbing Lu Guangju Ji | 2018 | Protein & Cell2018，9，11： | 3 |
| 12 | Spatial-temporal Analysis and Prediction of Precipitation Extremes: A Case Study in the Weihe River Basin, China显示文摘Extreme precipitation events bring considerable risks to the natural ecosystem and human life.Investigating the spatial-temporal characteristics of extreme precipitation and predicting it quantitatively are critical for the flood prevention and water resources planning and management.In this study,daily precipitation data(1957–2019)were collected from 24 meteorological stations in the Weihe River Basin(WRB),Northwest China and its surrounding areas.We first analyzed the spatial-temporal change of precipitation extremes in the WRB based on space-time cube(STC),and then predicted precipitation extremes using long short-term memory(LSTM)network,auto-regressive integrated moving average(ARIMA),and hybrid ensemble empirical mode decomposition(EEMD)-LSTM-ARIMA models.The precipitation extremes increased as the spatial variation from northwest to southeast of the WRB.There were two clusters for each extreme precipitation index,which were distributed in the northwestern and southeastern or northern and southern of the WRB.The precipitation extremes in the WRB present a strong clustering pattern.Spatially,the pattern of only high-high cluster and only low-low cluster were primarily located in lower reaches and upper reaches of the WRB,respectively.Hot spots(25.00%–50.00%)were more than cold spots(4.17%–25.00%)in the WRB.Cold spots were mainly concentrated in the northwestern part,while hot spots were mostly located in the eastern and southern parts.For different extreme precipitation indices,the performances of the different models were different.The accuracy ranking was EEMD-LSTM-ARIMA>LSTM>ARIMA in predicting simple daily intensity index(SDII)and consecutive wet days(CWD),while the accuracy ranking was LSTM>EEMD-LSTM-ARIMA>ARIMA in predicting very wet days(R95 P).The hybrid EEMD-LSTM-ARIMA model proposed was generally superior to single models in the prediction of precipitation extremes. | QIU Dexun WU Changxue MU Xingmin ZHAO Guangju GAO Peng | 2022 | Chinese Geographical Science2022，32，2： | 3 |
| 13 | Application of the InVEST model for assessing water yield and its response to precipitation and land use in the Weihe River Basin, China显示文摘With realizing the importance of ecosystem services to society, the efforts to evaluate the ecosystem services have increased. As the largest tributary of the Yellow River, the Weihe River has been endowed with many ecological service functions. Among which, water yield can be a measure of local availability of water and an index for evaluating the conservation function of the region. This study aimed to explore the temporal and spatial variation of water yield and its influencing factors in the Weihe River Basin(WRB), and provide basis for formulating reasonable water resources utilization schemes. Based on the InVEST(integrated valuation of ecosystem services and tradeoffs) model, this study simulated the water yield in the WRB from 1985 to 2019, and discussed the impacts of climatic factors and land use change on water yield by spatial autocorrelation analysis and scenario analysis methods. The results showed that there was a slight increasing trend in water yield in the WRB over the study period with the increasing rate of 4.84 mm/10a and an average depth of 83.14 mm. The main water-producing areas were concentrated along the mainstream of the Weihe River and in the southern basin. Changes in water yield were comprehensively affected by climate and underlying surface factors. Precipitation was the main factor affecting water yield, which was consistent with water yield in time. And there existed significant spatial agglomeration between water yield and precipitation. Land use had little impact on the amount of water yield, but had an impact on its spatial distribution. Water yield was higher in areas with wide distribution of construction land and grassland. Water yield of different land use types were different. Unused land showed the largest water yield capacity, whereas grassland and farmland contributed most to the total water yield. The increasing water yield in the basin indicates an enhanced water supply service function of the ecosystem. These results are of great significance to the water resources management of the WRB. | WU Changxue QIU Dexun GAO Peng MU Xingmin ZHAO Guangju | 2022 | Journal of Arid Land2022，14，4： | 2 |
| 14 | Enhancement effects of flat-mirror reflection on plasma radiation显示文摘 | Chen Jinzhong Bai Jinning Song Guangju | 2013 | Applied Optics2013，52，25： | 1 |
| 15 | Streamflow trends and climate variability impacts in Poyang Lake Basin, China 显示文摘 | ZHAO Guangju HORMANN G FOHRER N | 2010 | Water Resources Management2010，24，4： | 1 |
| 16 | Frequency domain interpolation wavelet transform based algorithm for harmonic analysis of power system communications 显示文摘 | Du Tianjun Chen Guangju Lei Yong | 2004 | Circuits and Systems2004，2，6： | 1 |
| 17 | Quan- tifying the Impact of Climate Variability and Human Activities on Streamflow in the Middle Reaches of the Yellow River Basin, China 显示文摘 | Zhao Guangju Tian Peng Mu Xingmin | 2014 | Journal of Hydrology2014，519，： | 1 |
| 18 | Real-valued Discrete Gabor Transforms for Discrete Signal and Image Representation 显示文摘 | Tao Liang Chen Guangju | 2001 | Chinese Journal of Electronics2001，10，4： | 1 |
| 19 | Thiourea-based coordinating polymers: synthesis and binding to noble metals 显示文摘 | ZUO GUANGJU MAMOUN MUHAMNED | 1995 | Reac Polym1995，24，： | 1 |
| 20 | Thiourea-based coordinating polymers:synthesis and binding to noble metals显示文摘 | Zuo Guangju Muhammed M | 1995 | Reat Polym1995，24，： | 1 |
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