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| 1 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 2 | Evaluation of the potential risks of heavy metal contamination in rice paddy soils around an abandoned Hg mine area in Southwest China显示文摘To assess the potential ecological and health risks of trace elements(Hg,Cd,As,Mn,Sb,Pb,Cu,Ni,Cr,and Zn),a total of 138 soil samples from rice paddies were collected during the rice harvest season in the Wanshan mining area,Guizhou Province,Southwest China.Factors of the pollution load index(PLI),geo-accumulation index(I-Geo),enrichment factor(EF),and risk index(RI)were determined.High concentrations of Hg,Sb,As,Zn,Cd,Cu,and Mn were observed in the soils.The PLI,I-Geo,and EF results all showed high levels of contamination by Hg and Sb and moderate levels of contamination by As,Pb,Zn,Cu,Cd,and Mn.There was no significant contamination from Ni and Cr.The RI was very high,with Hg as the dominant pollutant,as expected,indicating that the historical large-scale Hg mining,as well as artisanal mining,has had a significant impact on the Wanshan area.Moreover,coal combustion,manganese factories,and the use of agrochemicals by the local population could also have an impact on the soil through the introduction of heavy metal loads.To address the current state of contamination,pollutant remediation and the regulation control of the anthropogenic activities in Wanshan are urgently needed. | Bayou Adlane Zhidong Xu Xiaohang Xu Longchao Liang Jialiang Han Guangle Qiu | 2020 | Acta Geochimica2020，39，1： | 5 |
| 3 | Chemical characterization and sources of PM2.5 at 12-h resolution in Guiyang, China显示文摘The increasing emission of primary and gaseous precursors of secondarily formed atmospheric particulate matter due to continuing industrial development and urbanization are leading to an increased public awareness of environmental issues and human health risks in China.As part of a pilot study, 12-h integrated fine fraction particulate matter(PM_(2.5) filter samples were collected to chemically characterize and investigate the sources of ambient particulate matter in Guiyang City, Guizhou Province, southwestern China. Results showed that the 12-h integrated PM_(2.5) concentrations exhibited a daytime average of 51 ± 22 lg m^(-3)(mean ± standard deviation) with a range of 17–128 lg m^(-3) and a nighttime average of55 ± 32 lg m~(^(-3)) with a range of 4–186 lg m^(-3). The 24-h integrated PM_(2.5) concentrations varied from 15 to157 lg m~(^(-3)), with a mean value of 53 ± 25 lg m^(-3), which exceeded the 24-h PM_(2.5) standard of 35 lg m^(-3) set by USEPA, but was below the standard of 75 lg m^(-3), set by China Ministry of Environmental Protection. Energy-dispersive X-ray fluorescence spectrometry(XRF) was applied to determine PM_(2.5) chemical element concentrations. The order of concentrations of heavy metals in PM_(2.5) were iron(Fe) [ zinc(Zn) [ manganese(Mn) [ lead(Pb) [ arsenic(As) [ chromium(Cr). The total concentration of 18 chemical elements was 13 ± 2 lg m^(-3),accounting for 25% in PM_(2.5), which is comparable to other major cities in China, but much higher than cities outside of China. | Longchao Liang Na Liu Matthew S. Landis Xiaohang Xu Xinbin Feng Zhuo Chen Lihai Shang Guangle Qiu | 2018 | Acta Geochimica2018，37，2： | 4 |
| 4 | Investigation of microbial corrosion inhibition of Cu-bearing 316L stainless steel in the presence of acid producing bacterium Acidithiobacillus caldus SM-1显示文摘Stainless steel(SS)has unsatisfied corrosion resistance in many aggressive environments,particularly under a low p H condition in the bioleaching industry.In this study,through surface analyses and electrochemical measurements,the corrosion resistance of a novel Cu-bearing 316L SS was evaluated in the presence of an acid-producing bacterium,Acidithiobacillus caldus SM-1 that was able to create an extremely acidic corrosive environment.The significantly enhanced anti-microbiologically-inducedcorrosion performance could be explained by the intracellular reactive oxygen species(ROS)and Fenton reaction on the Cu-bearing 316L SS. | Yuqiao Dong Jiaqi Li Dake Xu Guangling Song Dan Liu Haipeng Wang M.Saleem Khan Ke Yang Fuhui Wang | 2021 | Journal of Materials Science & Technology2021，，5： | 1 |
| 5 | Characteristics and distributions of atmospheric mercury emitted from anthropogenic sources in Guiyang,southwestern China显示文摘Continuous measurements of speciated atmospheric mercury(Hg), including gaseous elemental mercury(GEM), particulate mercury(PHg), and reactive gaseous mercury(RGM) were conducted in Guizhou Province, southwestern China. Guiyang Power Plant(GPP),Guiyang Wujiang Cement Plant, Guizhou Aluminum Plant(GAP), and Guiyang Forest Park(GFP) in Guiyang were selected as study sites. Automatic Atmospheric Mercury Speciation Analyzers(Tekran 2537A) were used for GEM analysis. PHg and RGM were simultaneously collected by a manual sampling system, including elutriator, coupler/impactor, KCl-coated annular denuder, and a ?lter holder.Results show that different emission sources dominate different species of Hg. The highest average GEM value was 22.2 ± 28.3 ngám^(-3)and the lowest 6.1 ± 3.9 ngám^(-3),from samples collected at GPP and GAP, respectively. The maximum average PHg was 1984.9 pgám^(-3)and the minimum average 55.9 pgám^(-3), also from GPP and GAP,respectively. Similarly, the highest average RGM of 68.8pgám^(-3)was measured at GPP, and the lowest level of20.5 pgám^(-3)was found at GAP. We conclude that coal combustion sources are still playing a key role in GEM;traf?c contributes signi?cantly to PHg; and domestic pollution dominates RGM. | Xiaohang Xu Na Liu Matthew S.Landis Xinbin Feng Guangle Qiu | 2016 | Acta Geochimica2016，35，3： | 1 |
| 6 | Mercury accumulation,distribution,and isotopic composition in tissues of the Collared Scops Owl(Otus lettia)显示文摘Mercury is a ubiquitous contaminant known to accumulate in wildlife,particularly bird species at higher trophic levels.Knowledge of tissue-specific Hg distributions aids our understanding of Hg bioaccumulation in organisms.In this study,one adult and three juvenile Collared Scops Owls(Otus lettia)were studied to elucidate the bioaccumulation of Hg in body tissues.Six tissues and organs(feathers,nails,heart,liver,gizzard,and muscle),as well as gastric contents,were examined for total Hg(THg)and methylmercury(MeHg)contents,Hg isotopic compositions including mass-dependent fractionation(MDF;δ202Hg)and mass-independent fractionation(MIF;Δ199Hg andΔ201Hg),and C(δ13C)and N(δ15N)isotopic compositions.Tissue-specific THg and MeHg concentrations in the adult were in the ranges of 150–1360 ng/g and17–1060 ng/g,and lower in the juveniles at 91–419 ng/g and 67–350 ng/g,respectively.Theδ^(202)Hg values in the adult were strongly negative at-1.75‰±0.17‰compared with the juveniles at-0.99‰±0.25‰.The adult exhibited lower MIF values than the juveniles,at0.23‰±0.07‰forΔ^(199)Hg and 0.2‰±0.11‰forΔ^(201)Hg,comparedwith0.81‰±0.09‰and0.66‰±0.07‰,respectively.The lower adult MDF and MIF values suggest that the adult tended to accumulate negative Hg isotopes but the juvenile's positive Hg isotopes.Differences between adult and juvenile tissue Hg concentrations indicate that metabolic processes play an important role in Hg accumulation. | Dongya Jia Kang Luo Zhidong Xu Xiaohang Xu Chan Li Hongmei Wu Dawei Wang Hui Ye Gaoen Wu Zhuo Chen Guangle Qiu | 2023 | Acta Geochimica2023，42，4： | 0 |
| 7 | Tightly coupled INS/CNS/spectral redshift integrated navigation system with the aid of redshift error measurement显示文摘The integration of an inertial navigation system(INS) and a celestial navigation system(CNS) has the superiority of high autonomy. However, its reliability and accuracy are permanently impaired under poor observation conditions. To address this issue, the present paper proposes a tightly coupled INS/CNS/spectral redshift(SRS) integration framework based on the spectral redshift error measurement. In the proposed method, a spectral redshift error measurement equation is investigated and embedded in the traditional tightly coupled INS/CNS integrated navigation system to achieve better anti-interference under complicated circumstances. Subsequently, the inaccurate redshift estimation from the low signal-to-noise ratio spectrum is considered in the integrated system, and an improved chi-square test-based covariance estimation method is incorporated in the federated Kalman filter, allowing to deal with measurement outliers caused by the inaccurate redshift estimation but not influencing the effect of other correct redshift measurements in suppressing the error of the navigation parameter on the filtering solution. Simulations and comprehensive analyses demonstrate that the proposed tightly coupled INS/CNS/SRS integrated navigation system can effectively handle outliers and outages under hostile observation conditions, resulting in improved performance. | GAO GuangLe GAO SheSheng HU GaoGe ZHONG YongMin PENG Xu | 2023 | Science China(Technological Sciences)2023，66，9： | 0 |
| 8 | CircR-ZC3HC1 mediates MiR-384-5p/SIRT1 axis to promote neuronal autophagy and relieves ischemic stroke显示文摘Objective:Circular RNAs(circRNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including autophagy.This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms.Methods:Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected.Hippocampal neurons were treated with oxygen and glucose deprivation(OGD)to establish IS in vitro model.The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope.Cell apoptosis rate and the expression of cleaved caspase-3,Bax,and Bcl-2 were assessed byflow cytometry and western blotting.The binding relationships among circR-ZC3HC1,miR-384-5p,and SIRT1 were predicted and verified.Results:Low expression of circR-ZC3HC1 was found in blood samples of IS patients and OGD-treated neurons.Overexpressed circR-ZC3HC1 or inhibited miR-384-5p expression promoted autophagy and inhibited apoptosis of OGD-treated neurons,which could be reversed by further 3-MA treatment.Mechanistically,circR-ZC3HC1 targeted miR-384-5p to mediate SIRT1 expression.miR-384-5p overexpression or SIRT1 knockdown in the presence of circR-ZC3HC1 overexpression in OGD-treated neurons lead to reduced autophagy and enhanced apoptosis.Conclusion:Collectively,circR-ZC3HC1 promoted neuronal autophagy to attenuate IS via miR-384-5p/SIRT1 axis. | MIN SHEN XIAOMAN XU GUANGLING SUN LIANGZHU WANG TAO YING HANG SU WEI WANG QINGHUA CAO ZHEZHE SUN | 2024 | BIOCELL2024，48，3： | 0 |
| 9 | A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine显示文摘Self-assembly is a powerful approach in molecular engineering for biomedical applications,in particu-lar for creating self-assembling prodrugs.Here,we report a self-assembling prodrug of the anticancer drug gemcitabine(Gem)based on amphiphilic dendrimer approach.The prodrug reported in this study demonstrates high drug loading(40%)and robust ability to self-assemble into small nanomicelles,which increase the metabolic stability of Gem and enable entry into cells via endocytosis,hence bypassing transport-mediated uptake.In addition,this prodrug nanosystem exhibited an effective pH-and enzyme-responsive release of Gem,resulting in enhanced anticancer activity and reduced toxicity.Harboring ad-vantageous features of both prodrug-and nanotechnology-based drug delivery,this self-assembling Gem prodrug nanosystem constitutes a promising anticancer candidate.This study also offers new perspectives of the amphiphilic dendrimer nanoplatforms for the development of self-assembling prodrugs. | Mei Cong Guangling Xu Shaoyou Yang Jing Zhang Wenzheng Zhang Dinesh Dhumal Erik Laurini Kaiyue Zhang Yi Xia Sabrina Pricl Ling Peng Weidong Zhao | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
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