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| 1 | Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment显示文摘Chimeric antigen receptor(CAR)-T cell therapy has achieved successful outcomes against hematological malignancies and provided a new impetus for treating solid tumors.However,the efficacy of CAR-T cells for solid tumors remains unsatisfactory.The tumor microenvironment has an important role in interfering with and inhibiting the effector function of immune cells,among which upregulated inhibitory checkpoint receptors,soluble suppressive cytokines,altered chemokine expression profiles,aberrant vasculature,complicated stromal composition,hypoxia and abnormal tumor metabolism are major immunosuppressive mechanisms.In this review,we summarize the inhibitory factors that affect the function of CAR-T cells in tumor microenvironment and discuss approaches to improve CAR-T cell efficacy for solid tumor treatment by targeting those barriers. | Guangna Liu Wei Rui Xueqiang Zhao Xin Lin | 2021 | Cellular & Molecular Immunology2021，18，5： | 7 |
| 2 | Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy显示文摘Platelets have long been known to play critical roles in hemostasis by clumping and clotting blood vessel injuries.Recent experimental evidence strongly indicates that platelets can also interact with tumor cells by direct binding or secreting cytokines.For example,platelets have been shown to protect circulating cancer cells in blood circulation and to promote tumor metastasis.In-depth understanding of the role of platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatment.This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated platelets for cancer therapy. The paper also discusses future development opportunities and challenges encountered for clinical translation. | Yinlong Zhang Guangna Liu Jingyan Wei Guangjun Nie | 2018 | Frontiers of Medicine2018，12，6： | 4 |
| 3 | Converting industrial waste contact masses into effective multicomponent copper-based catalysts for the Rochow process显示文摘 | Hezhi Liu Yongjun Ji Yongxia Zhu Guangna Wang Xueguang Wang Ziyi Zhong Fabing Su | 2018 | Particuology2018，16，2： | 2 |
| 4 | Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells显示文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction'(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4 | Jie Liang Keman Cheng Yao Li Jiaqi Xu Yiwei Chen Nana Ma Qingqing Feng Fei Zhu Xiaotu Ma Tianjiao Zhang Yale Yue Guangna Liu Xinjing Guo Zhiqiang Chen Xinwei Wang Ruifang Zhao Ying Zhao Jian Shi Xiao Zhao Guangjun Nie | 2022 | Fundamental Research2022，2，1： | 2 |
| 5 | The effects of cold region meteorology and specific environment on the number of hospital admissions for chronic kidney disease:An investigate with a distributed lag nonlinear model显示文摘Objective:To explore the effects of daily mean temperature(°C),average daily air pressure(hPa),humidity(%),wind speed(m/s),particulate matter(PM)2.5(μg/m3)and PM10(μg/m3)on the admission rate of chronic kidney disease(CKD)patients admitted to the Second Affiliated Hospital of Harbin Medical University in Harbin and to identify the indexes and lag days that impose the most critical influence.Methods:The R language Distributed Lag Nonlinear Model(DLNM),Excel,and SPSS were used to analyze the disease and meteorological data of Harbin from 01 January 2010 to 31 December 2019 according to the inclusion and exclusion criteria.Results:Meteorological factors and air pollution influence the number of hospitalizations of CKD to vary degrees in cold regions,and differ in persistence or delay.Non-optimal temperature increases the risk of admission of CKD,high temperature increases the risk of obstructive kidney disease,and low temperature increases the risk of other major types of chronic kidney disease.The greater the temperature difference is,the higher its contribution is to the risk.The non-optimal wind speed and non-optimal atmospheric pressure are associated with increased hospital admissions.PM2.5 concentrations above 40μg/m3 have a negative impact on the results.Conclusion:Cold region meteorology and specific environment do have an impact on the number of hospital admissions for chronic kidney disease,and we can apply DLMN to describe the analysis. | Xinrui Wei Rui Jiang Yue Liu Guangna Zhao Youyuan Li Yongchen Wang | 2023 | Frigid Zone Medicine2023，3，2： | 0 |
| 6 | Low ambient temperature and air pollution are associated with hospitalization incidence of coronary artery disease:Insights from a cross-sectional study in Northeast China显示文摘Background:Previous studies have established a link between fluctuations in climate and increased mortality due to coronary artery disease(CAD).However,there remains a need to explore and clarify the evidence for associations between meteorological changes and hospitalization incidences related to CAD and its subtypes,especially in cold regions.This study aimed to systematically investigate the relationship between exposure to meteorological changes,air pollutants,and hospitalization for CAD in cold regions.Methods:We conducted a cross-sectional study using hospitalization records of 86,483 CAD patients between January 1,2009,and December 31,2019.Poisson regression analysis,based on generalized additive models,was applied to estimating the influence of hospitalization for CAD.Results:Significant associations were found between low ambient temperature[-10℃,RR=1.65;95%CI:(1.28-2.13)]and the incidence of hospitalization for CAD within a lag of 0-14 days.Furthermore,O_(3)[95.50μg/m^(3),RR=12;95%CI:(1.03-1.21)]and NO_(2)[48.70μg/m^(3),RR=1.0895%CI:(1.01-1.15)]levels were identified as primary air pollutants affecting the incidence of CAD,ST-segment-elevation myocardial infarction(STEMI),and non-STEMI(NSTEMI)within the same lag period.Furthermore,O_(3)[95.50μg/m^(3),RR=1.12;95%CI:(1.03-1.21)]and NO_(2)[48.70μg/m^(3),RR=1.0895%CI:(1.01-1.15)]levels were identified as primary air pollutants affecting the incidence of CAD,ST-segment-elevation myocardial infarction(STEMI),and non-STEMI(NSTEMI)within the same lag period.The effect curve of CAD hospitalization incidence significantly increased at lag days 2 and 4 when NO_(2)and O_(3)concentrations were higher,with a pronounced effect at 7 days,dissipating by lag 14 days.No significant associations were observed between exposure to PM,SO_(2),air pressure,humidity,or wind speed and hospitalization incidences due to CAD and its subtypes.Conclusion:Our findings suggest a positive correlation between short-term exposure to low ambient temperatures or air pollutants(O_(3)and NO_(2))and hospitalizations for CAD,STEMI,and NSTEMI.These results could aid the development of effective preparedness strategies for frequent extreme weather events and support clinical and public health practices aimed at reducing the disease burden associated with current and future abnormal weather events. | Rui Jiang Lingling Xu Yue Liu Guangna Zhao Chun Xing Youyuan Li Yongchen Wang | 2023 | Frigid Zone Medicine2023，3，4： | 0 |
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