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| 1 | An M/M/1 Queueing-Inventory System with Geometric Batch Demands and Lost Sales显示文摘 | YUE Dequan ZHAO Guoxi QIN Yaling | 2018 | Journal of Systems Science & Complexity2018，31，4： | 3 |
| 2 | Selective oxidation of cyclopentene with H2O2 by using H3PW12O40 and TBAB as a phase transfer catalyst显示文摘The selective oxidation of cyclopentene by aqueous H2O2 using H3PW12O40 and tetrabutyl ammonium bromide(TBAB) as a phase transfer catalyst has been investigated. The results show that the presence of TBAB significantly improved the oxidation selectivity of cyclopentene. The effects of the reaction conditions on the conversion of cyclopentene were investigated in detail. The optimal reaction conditions are as follows: the H3PW12O40 to TBAB molar ratio, 1:1–1:3;H3PW12O40 to cyclopentene molar ratio,0.54:100–0.64:100;and molar ratio of H2O2 to cyclopentene, 1.6:1. The conversion reached to 59.8% in 4h at 35.0 ℃, while the selectivity of glutaraldehyde was 38.0% and the selectivity of 1,2-cyclopentanediol was 55.6%. In addition, a route for oxidation of cyclopentene by aqueous H2O2 using a heteropoly acid and quaternary ammonium salt as a phase transfer catalyst was proposed. | Yaling Luo Changjun Liu Hairong Yue Siyang Tang Yingming Zhu Bin Liang | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 3 |
| 3 | A Production Inventory System w让h Service Time and Production Vacations显示文摘In this paper, we consider a production inventory system with service time and production vacations. Customers arrive in the system according to a Poisson process requiring service from a single server. The single production facility produces items according to an (s, S) policy, and 让 takes a vacation of random duration once the inventory level becomes S. It is assumed that all arriving customers are lost during the stock out period. We first derive the stationary joint distribution of the queue length and the on-hand inventory level in product form. Then, we compute explicitly some performance measures, and develop a cost function based on these performance measures. Finally;some numerical results are presented. | Dequan Yue Yaling Qin | 2019 | Journal of Systems Science and Systems Engineering2019，28，2： | 2 |
| 4 | Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells显示文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction'(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4 | Jie Liang Keman Cheng Yao Li Jiaqi Xu Yiwei Chen Nana Ma Qingqing Feng Fei Zhu Xiaotu Ma Tianjiao Zhang Yale Yue Guangna Liu Xinjing Guo Zhiqiang Chen Xinwei Wang Ruifang Zhao Ying Zhao Jian Shi Xiao Zhao Guangjun Nie | 2022 | Fundamental Research2022，2，1： | 2 |
| 5 | Floralozone protects endothelial function in atherosclerosis by ameliorating NHE1显示文摘Endothelial dysfunction is the pathological basis of atherosclerosis.Incomplete understanding of endothelial dysfunction etiology has impeded drug development for this devastating disease despite the currently available therapies.Floralozone,an aroma flavor,specifically exists in rabbit ear grass.Recently,floralozone has been demonstrated to inhibit atherosclerosis,but the underlying mechanisms are undefined.The present study was undertaken to explore whether floralozone pharmacologically targets endothelial dysfunction and therefore exerts therapeutic effects on atherosclerosis.The Na+/H+exchanger 1(NHE1),a channel protein,plays a vital role in atherosclerosis.Whether NHE1 is involved in the therapeutic effects of floralozone on endothelial dysfunction has yet to be further answered.By performing oil red staining and hematoxylin–eosin staining,vascular functional study,and oxidative stress monitoring,we found that floralozone not only reduced the size of carotid atherosclerotic plaque but also prevented endothelial dysfunction in atherosclerotic rats.NHE1 expression was upregulated in the inner membrane of carotid arteries and H2O2-induced primary rat aortic endothelial cells.Inspiringly,floralozone prevented the upregulation of NHE1 in vivo and in vitro.Notably,the administration of NHE1 activator LiCl significantly weakened the protective effect of floralozone on endothelial dysfunction in vivo and in vitro.Our study demonstrated that floralozone exerted its protective effect on endothelial dysfunction in atherosclerosis by ameliorating NHE1.NHE1 maybe a drug target for the treatment of atherosclerosis,and floralozone may be an effective drug to meet the urgent needs of atherosclerosis patients by dampening NHE1. | Ning Huang Yue Qiu Yanhua Liu Tianheng Liu Xianjun Xue Ping Song Jian Xu Yutian Fu Ruili Sun Yaling Yin Peng Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 2 |
| 6 | Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease显示文摘 | J.‐F. Yale G. Bakris B. Cariou D. Yue E. David‐Neto L. Xi K. Figueroa E. Wajs K. Usiskin G. Meininger | 2013 | Diabetes Obes Metab2013，，： | 1 |
| 7 | A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global pandemic of novel coronavirus disease(COVID-19).The neutralizing monoclonal antibodies(mAbs)targeting the receptor-binding domain(RBD)of SARS-CoV-2 are among the most promising strategies to prevent and treat COVID-19.However,SARS-CoV-2 variants of concern(VOCs)profoundly reduced the efficacies of most of mAbs and vaccines approved for clinical use.Herein,we demonstrated mAb 35B5 efficiently neutralizes both wild-type(WT)SARS-CoV-2 and VOCs. | Xiaofei Wang Ao Hu Xiangyu Chen Yixin Zhang Fei Yu Shuai Yue Arong Li Junsong Zhang Zhiwei Pan Yang Yang Yao Lin Leiqiong Gao Jing Zhou Jing Zhao Fang Li Yaling Shi Feng Huang Xiaofan Yang Yi Peng Luoyang Tu Huan Zhang Huanying Zheng Jun He Hui Zhang Lifan Xu Qizhao Huang Yongqun Zhu Kai Deng Lilin Ye | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 8 | SJWD14090900000506显示文摘 | J.‐F. Yale G. Bakris B. Cariou J. Nieto E. David‐Neto D. Yue E. Wajs K. Figueroa J. Jiang G. Law K. Usiskin G. Meininger | 2014 | Diabetes Obes Metab2014，，10： | 1 |
| 9 | First Discovery of Dicerorhinus sumatrensis from Yanjinggou Provides Insights into the Pleistocene Rhinocerotidae of South China显示文摘The Rhinocerotidae is one of the most common and important families in the Pleistocene mammalian fauna of South China.Since the last century,most of the Pleistocene rhinocerotid fossils were prematurely assigned to Rhinoceros sinensis,which has resulted in confusion of taxonomy for decades,especially in South China.The Yanjinggou area in Chongqing Municipality of China,where the neotype of R.sinensis came from,has yielded abundant rhinocerotid fossils and is a key area to solve this problem.A recently discovered juvenile skull from a karstic fissure in this area can be referred to Dicerorhinus sumatrensis(Fischer,1814),which is the first confirmed non-Rhinoceros rhinocerotid from the area.This new finding indicates that non-Rhinoceros fossils might have been mixed in AMNH collection from Yanjinggou and thus the diagnosis of Rhinoceros sinensis needs reformation.On the other hand,Stephanorhinus?kirchbergensis is also detected in Granger’s collection based on our reobservation.The coexistence of Rhinoceros,Dicerorhinus and Stephanorhinus shows the higher diversity of Pleistocene rhinocerotids in South China. | CHEN Shaokun PANG Libo YAN Yaling WEI Guangbiao YUE Zongying | 2021 | Acta Geologica Sinica(English Edition)2021，95，4： | 1 |
| 10 | Feature Extraction by Using Attention Mechanism in Text Classification显示文摘In recent years,machine learning technology has made great success in fields of computer vision,natural language processing,speech recognition and so on.And machine learning model has been widely used in face recognition,automatic driving,malware detection,intelligent medical analysis and other practical tasks.In this paper,attention mechanism is proposed to combine with LSTM model to extract features in text classification.The results show that,on the one hand,LSTM+Attention can improve classification performance;on the other hand,by sorting by word weights generated by the attention layer,we find some meaningful word features,however,its recognition performance is not good.Some possible reasons were analyzed and it was found that attention mechanism sometimes misjudges wrong word features,resulting from these wrong words often appearing at the same time with meaningful word features. | Yaling Wang Yue Wang | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 11 | Performance Analyses of Production Inventory Systems Considering Service Time and Product Returns of Online Shopping显示文摘This paper considers a production inventory system with service time and product returns, dependent on the characteristics of online shopping beliaviors. The customers arrive according to a Poisson process, in which the arriving customer requires an item in the inventory, as well as a server service that the service time is exponentially distributed. Moreover, there is one production facility to produce items according to (s, S) policy, and the production time also follows an exponential (listribution. In the beginning, the stationary joint distribution is obtained in the product form for the queue length and the on-hand inventory level. Additionally, the resulting distribution is applied to derive some performance measures, which can be adopted to numerically calculate the optimal (s, S) policy. Finally, numerical analyses are processed to investigate the effects of some system parameters on the performance measures. The numerical results clearly indicate that the product return rate has a significantly monotonic effect on the optimal policy and optimal cost. | QIN Yaling YUE Dequan | 2019 | Journal of Systems Science & Complexity2019，32，3： | 0 |
| 12 | Sources of cumulus expansion enabling factor (CEEF) in porcine follicles显示文摘It was shown that expansion of porcine cumulus did not depend on oocyte-secreted factor(s), and it is therefore presumed that porcine CEEF may not be produced exclusively by the oocyte. In this experiment, we used mouse oocytectomized complexes (OOX), which were incapable of CEEF production, to assess the secretion of CEEF by evacuated zona, oocytes of different quality and somatic cells in the porcine follicles. The results showed that: (i) Evacuated zonae from both porcine and mouse oocytes did not produce CEEF. (ii) Porcine oocytes of A, B and C types from 3-6 mm follicles were not significantly different in both production and activity of CEEF. (iii) Both porcine OOX from 3-6 mm follicles and granulose cells from < 1 mm follicles secreted CEEF in a large quantity, independent of gonadotro-pins; mural granulose cells from 3-6 mm follicles, however, produced neglectable amount of CEEF. (iv) The follicular fluid from 3-6 mm porcine follicles contained CEEF activity that was concentration-dependent, | SUN Xingshen YUE Kuizhong MA Suofeng YI Yaling ZOU Yi TAN Jinghe | 2002 | Chinese Science Bulletin2002，47，19： | 0 |
| 13 | Rare tumors: a blue ocean of investigation显示文摘Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible number,the practice of precision medicine and development of novel therapies are largely hampered by many obstacles.Their low incidence and drastic regional disparities result in the difficulty of informative evidence-based diagnosis and subtyping.Sample exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinical guidelines,insufficient biomarkers for prognosis/efficacy,and inability to identify potential novel therapies in clinical trials.Herein,by reviewing the epidemiological data of Chinese solid tumors and publications defining rare tumors in other areas,we proposed a definition of rare tumor in China,including 515 tumor types with incidences of less than 2.5/100000 per year.We also summarized the current diagnosis process,treatment recommendations,and global developmental progress of targeted drugs and immunotherapy agents on the status quo.Lastly,we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical trial by NCCN.With this informative report,we aimed to raise awareness on the importance of rare tumor investigations and guarantee a bright future for rare tumor patients. | Shuhang Wang Peiwen Ma Ning Jiang Yale Jiang Yue Yu Yuan Fang Huilei Miao Huiyao Huang Qiyu Tang Dandan Cui Hong Fang Huishan Zhang Qi Fan Yuning Wang Gang Liu Zicheng Yu Qi Lei Ning Li | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 14 | Modularly designed peptide-based nanomedicine inhibits angiogenesis to enhance chemotherapy for post-surgical recurrence of esophageal squamous cell carcinomas显示文摘Traditional surgical treatment is difficult to thoroughly remove esophageal squamous cell carcinomas(ESCC),postoperative recurrence caused by residual tumor cells is a critical factor in the poor prognosis.Since surgical resection promotes the local angiogenesis at the tumor site,further exacerbating the proliferation and invasion of residual tumor cells,it is urgent to inhibit angiogenesis after surgery.Here,a functional peptide-based nanomedicine was obtained from peptide–drug conjugates,which are composed of a hydrophilic targeting motif(vascular endothelial growth factor family and their receptors(VEGFR)targeting peptide for anti-angiogenesis),an ester-linked hydrophobic oridonin(ORI).The nanomedicine exhibits esterase-catalyzed disassembly and drug release,significantly enhanced the anti-tumor efficacy of chemotherapeutics in a postoperative tumor recurrence model through synergistic anti-angiogenic strategies.This study provides an integrated solution for anti-angiogenesisaugmented chemotherapy and demonstrates the encouraging potential for postoperative treatment. | Yingqiu Qi Jinxiu Shen Chen Liu Anni Du Mengdie Chen Xiaocao Meng Hui Wang Saiyang Zhang Lirong Zhang Zhongjun Li Yike Li Yale Yue Huan Min | 2023 | Nano Research2023，16，5： | 0 |
| 15 | The novel function of citronellal for antidiabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM),a leading cause of morbidity and mortality,is a diabetes-related complication characterized by myocardial fibrosis,left ventricular(LV)hypertrophy,and compromised cardiac function[1].Citronellal(CT;Fig.1A)is a monoter-pene aldehyde primarily produced by the secondary metabolism of plants.It is a non-racemic mixture of R and S enantiomers obtained from bergamot and citronella oil[2]. | Yue Qiu Liuwei Meng Chunyan Chao Ling Wang Yang Wang Tianheng Liu Yutian Fu Yue Li Yuting Song Yaqi Guo Qianqian Niu Jie Zhang Yaling Yin Peng Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 0 |
| 16 | Immunogenic cell death effects induced by doxorubicin improved chemo-immunotherapy via restoration of granzyme B activity显示文摘Chemotherapy remains one of the irreplaceable treatments for cancer therapy.The use of immunogenic cell death(ICD)-inducing chemotherapeutic drugs offers a practical strategy for killing cancer cells,simultaneously eliciting an antitumor immune response by promoting the recruitment of cytotoxic immune cells and production of granzyme B(GrB).However,numerous malignant cancers adaptively acquired the capacity of secreting serpinb9(Sb9),a physiological inhibitor of GrB,which can reversibly inhibit the biological activity of GrB.To circumvent this dilemma,in this study,an integrated tailor-made nanomedicine composed of tumor-targeting peptide(Arg-Gly-Asp,RGD)decorated liposome,doxorubicin(DOX,an effective ICD inducer),and the compound 3034(an inhibitor of Sb9),is developed(termed as D3RL)for breast cancer chemo-immunotherapy.In vitro and in vivo studies show that D3RL can directly kill tumor cells and trigger the host immune response by inducing ICD.Meanwhile,D3RL can competitively relieve the inhibition of Sb9 to GrB.The restored GrB can not only effectively induce tumor immunotherapy,but also degrade matrix components in the tumor microenvironment,consequently improving the infiltration of immune cells and the penetration of nanomedicines,which in return enhance the combined antitumor effect.Taken together,this work develops an integrated therapeutic solution for targeted production and restoration of GrB to achieve a combined chemo-immunotherapy for breast cancer. | Tao Huang Xiaofan Sun Yingqiu Qi Xi Yang Linyao Fan Mengdie Chen Yale Yue Hong Ge Yiye Li Guangjun Nie Huan Min Xianfu Sun | 2023 | Nano Research2023，16，12： | 0 |
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