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| 1 | Determination of quorum-sensing signal substances in water and solid phases of activated sludge systems using liquid chromatography–mass spectrometry显示文摘The detection of acyl homoserine lactones(AHLs) in activated sludge is essential for clarifying their function in wastewater treatment processes. An LC–MS/MS method was developed for the detection of AHLs in both the aqueous and solid phases of activated sludge. In addition, the effects of proteases and extracellular polymeric substances(EPS) on the detection of AHLs were evaluated by adding protease inhibitors and extracting EPS,respectively. Recoveries of each AHL were improved by adding 50 μL of protease inhibitor,and recoveries were also improved from 0 to 56.9% to 24.2%–105.8% by EPS extraction.Applying the developed method to determine the type and concentration of AHLs showed that C4-HSL, C_6-HSL, C_8-HSL and 3-oxo-C_8-HSL were widely detected in a suspended activated sludge system. The dominant AHL was C_8-HSL, with a highest concentration of304.3 ng/L. C_4-HSL was mainly distributed in the aqueous phase, whereas C_6-HSL, C_8-HSL and 3-oxo-C_8-HSL were preferentially distributed in the sludge phase. | Yuepeng Sun Kai He Qidong Yin Shinya Echigo Guangxue Wu Yuntao Guan | 2018 | Journal of Environmental Sciences2018，30，7： | 6 |
| 2 | Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice显示文摘Cre/lox P technology has been widely used to study cell type-specific functions of genes. Proper interpretation of such data critically depends on a clear understanding of the tissue specificity of Cre expression. The Dmp1-Cre mouse, expressing Cre from a 14-kb DNA fragment of the mouse Dmp1 gene, has become a common tool for studying gene function in osteocytes, but the presumed cell specificity is yet to be fully established. By using the Ai9 reporter line that expresses a red fluorescent protein upon Cre recombination, we find that in2-month-old mice, Dmp1-Cre targets not only osteocytes within the bone matrix but also osteoblasts on the bone surface and preosteoblasts at the metaphyseal chondro-osseous junction. In the bone marrow, Cre activity is evident in certain stromal cells adjacent to the blood vessels, but not in adipocytes. Outside the skeleton, Dmp1-Cre marks not only the skeletal muscle fibers, certain cells in the cerebellum and the hindbrain but also gastric and intestinal mesenchymal cells that express Pdgfra. Confirming the utility of Dmp1-Cre in the gastrointestinal mesenchyme, deletion of Bmpr1 a with Dmp1-Cre causes numerous large polyps along the gastrointestinal tract, consistent with prior work involving inhibition of BMP signaling.Thus, caution needs to be exercised when using Dmp1-Cre because it targets not only the osteoblast lineage at an earlier stage than previously appreciated, but also a number of non-skeletal cell types. | Joohyun Lim Joseph Burclaff Guangxu He Jason C Mills Fanxin Long | 2017 | Bone Research2017，5，1： | 4 |
| 3 | Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing显示文摘There remain unmet clinical needs for safe and effective bone anabolic therapies to treat aging-related osteoporosis and to improve fracture healing in cases of nonunion or delayed union. Wnt signaling has emerged as a promising target pathway for developing novel bone anabolic drugs. Although neutralizing antibodies against the Wnt antagonist sclerostin have been tested,Wnt ligands themselves have not been fully explored as a potential therapy. Previous work has demonstrated Wnt7b as an endogenous ligand upregulated during osteoblast differentiation, and that Wnt7b overexpression potently stimulates bone accrual in the mouse. The earlier studies however did not address whether Wnt7b could promote bone formation when specifically applied to aged or fractured bones. Here we have developed a doxycycline-inducible strategy where Wnt7b is temporally induced in the bones of aged mice or during fracture healing. We report that forced expression of Wnt7b for 1 month starting at 15 months of age greatly stimulated trabecular and endosteal bone formation, resulting in a marked increase in bone mass. We further tested the effect of Wnt7b on bone healing in a murine closed femur fracture model. Induced expression of Wnt7b at the onset of fracture did not affect the initial cartilage formation but promoted mineralization of the subsequent bone callus. Thus, targeted delivery of Wnt7b to aged bones or fracture sites may be explored as a potential therapy. | Deye Song Guangxu He Fangfang Song Zhepeng Wang Xiaochen Liu Lele Liao Jiangdong Ni Matthew JSilva Fanxin Long | 2020 | Bone Research2020，8，1： | 3 |
| 4 | Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth显示文摘Bone morphogenetic proteins(Bmp) are well-known to induce bone formation following chondrogenesis,but the direct role of Bmp signaling in the osteoblast lineage is not completely understood. We have recently shown that deletion of the receptor Bmpr1 a in the osteoblast lineage with Dmp1-Cre reduces osteoblast activity in general but stimulates proliferation of preosteoblasts specifically in the cancellous bone region,resulting in diminished periosteal bone growth juxtaposed with excessive cancellous bone formation.Because expression of sclerostin(SOST), a secreted Wnt antagonist, is notably reduced in the Bmpr1 adeficient osteocytes, we have genetically tested the hypothesis that increased Wnt signaling might mediate the increase in cancellous bone formation in response to Bmpr1 a deletion. Forced expression of human SOST from a Dmp1 promoter fragment partially rescues preosteoblast hyperproliferation and cancellous bone overgrowth in the Bmpr1 a mutant mice, demonstrating functional interaction between Bmp and Wnt signaling in the cancellous bone compartment. To test whether increased Wnt signaling can compensate for the defect in periosteal growth caused by Bmpr1 a deletion, we have generated compound mutants harboring a hyperactive mutation(A214 V) in the Wnt receptor Lrp5. However, the mutant Lrp5 does not restore periosteal bone growth in the Bmpr1 a-deficient mice. Thus, Bmp signaling restricts cancellous bone accrual partly through induction of SOST that limits preosteoblast proliferation, but promotes periosteal bone growth apparently independently of Wnt activation. | Guangxu He Yu Shi Joohyun Lim Teresita Bellido Jiangdong Ni Fanxin Long | 2017 | Bone Research2017，5，3： | 3 |
| 5 | Synthesis and electrochemical properties of Zn_3V_3O_8 as novel anode material显示文摘Zn_3V_3O_8 two-dimensional micro sheets are successfully synthesized by combination of solvothermal method and heat treatment. The X-ray diffraction(XRD) and field emission scanning electron microscopy(SEM) are used to characterize the structure and morphology of the samples, and the battery testing system is used to investigate its electrochemical performance. The results show that the Zn_3V_3O_8 is successfully obtained using mix solvent(water:ethylene glycol =1:1), and the sample takes on morphology of two-dimensional sheets. The initial discharge capacity for Zn_3V_3O_8 two-dimensional micro sheets is 752.0 mAh/g at 100 mA/g in the voltage range of 0.01-3 V. After heat treatment in a tube furnace at 550 ℃, the sample had the initial discharge capacity as 1152.0 mAh/g and maintained it at 901.4 mAh/g after 100 cycles. The good electrochemical performance for Zn_3V_3O_8 two-dimensional micro sheets make it possible to be used as novel anode for lithium ion battery application. | Yunxia Jin Junjie He Zaihua Ou Chuanqi Feng Guangxue Zhang | 2019 | Chinese Chemical Letters2019，30，3： | 1 |
| 6 | Controlled synthesis of CeO2 nano particles from the coupling route of homogenous precipitation with mieroemulsion显示文摘 | He Yongjun Yang Bolun Cheng Guangxu | 2003 | Materials letters2003，57，6： | 1 |
| 7 | On the oxidative coupling of methane with carbon dioxide over CeOJZnO nanocatalysts显示文摘 | He Yongjun Yang Bolun Cheng Guangxu | 2004 | Catalysis Today2004，98，4： | 1 |
| 8 | Domino free radical photopolymerization based on phototriggered base proliferation reaction and redox initiation显示文摘 | Minghui He Shun Jiang Ruixin Xu Jianwen Yang Zhaohua Zeng Guangxue Chen | 2014 | J Polym Sci Part A: Polym Chem2014，，11： | 1 |
| 9 | Controlled synthesis of CeO2 nanoparticles from the coupling route of homogeneous precipitation with microemulsion 显示文摘 | HE Yongjun YANG Bolun CHENG Guangxu | 2003 | Mater Lett2003，57，1314： | 1 |
| 10 | Risk of tuberculosis infection and tuberculous meningitis after discontinuation of bacillus calmette-guerin in Beijing显示文摘 | Dehua Tu Guangxue He | 2000 | Am J Respir Crit Care Med2000，162，4： | 1 |
| 11 | Space-Time Clustering Characteristics of Tuberculosis in China, 2005-2011 显示文摘 | Fei Zhao Shiming Cheng Guangxue He | 2013 | Plos2013，8，： | 1 |
| 12 | Triterpene-Enriched Olive Extract as an Immunopotentiator in Black Sea Bream(Acanthopagrus schlegelii)显示文摘Recently,the use of natural immunopotentiators,such as plant extracts,is predicted to offer high disease-prevention potential in aquaculture.However,few reports on the immunomodulatory impacts of olive extract(OE)on teleost are available.Therefore,the effects of dietary intake of triterpene-enriched OE on black sea bream(Acanthopagrus schlegelii)were investigated in this study.Our data showed that total blood cell counts,in vivo content of lysozyme,activities of antiprotease and myeloperoxidase,and contents of IL-4 and IL-6 were significantly up-regulated by dietary intake of triterpene-enriched OE.Additionally,the hampered immune response induced by cadmium exposure was significantly mitigated by the administration of OE as were indicated by partially or completely rescued immune-relating parameters.Furthermore,the expressions of immune-related genes encoding NF-κB inhibitor alpha(IkBα),tumor necrosis factorα(TNFα),cyclooxygenase-2(COX-2),and proto-oncogene protein c-fos(FOS)were found to be significantly up-regulated by the dietary intake of OE.In general,the results suggested that the dietary intake of triterpene-enriched OE has immune enhancing effect in black sea bream.Such effect may be realized by 1)increasing the total counts of diverse blood cells;2)activating nonspecific immune biomolecules;and 3)affecting signaling pathways such as IKK and ERK and subsequently inducing IL-4 and IL-6 biosyntheses. | RONG Jiahuan HAN Yu ZHA Shanjie TANG Yu SHI Wei GUAN Xiaofan DU Xueying HE Maolong LIU Guangxu | 2020 | Journal of Ocean University of China2020，19，2： | 1 |
| 13 | “Three medicines and three formulas”in COVID-19:from bench to bedside显示文摘Chinese guideline has proven effective in the fight against coronavirus disease 2019(COVID-19)during the global spread of the epidemic.Traditional Chinese medicine(TCM)is widely recognized for its effectiveness in alleviating symptoms,inhibiting disease progress,reducing mortality,and improving the cure rate of patients with COVID-19.During the pandemic,“three medicines and three formulas”(TMTFs)stood out from hundreds of others in registered clinical studies,which became highly recommended as TCM for COVID-19 treatment.The TMTFs not only effectively relieve the clinical symptoms of fever,cough,fatigue,and phlegm,but also substantially shorten the time of nucleic acid negative conversion,improve lung computed tomography imaging features and inflammation,ameliorate clinical biochemical indicators,and reduce sequelae.Their potential pharmacological mechanisms are mainly related to the crosstalk between viral toxicity,endothelial damage,cytokine storm,immune response,and microthrombus.In brief,the clinical effects and the potential mechanisms of TMTFs on COVID-19 were systematically analyzed and summarized covering the entirety of disease development,including virus invasion and replication,immune response and cytokine storm,and acute respiratory distress syndrome and multiple organ dysfunction syndrome.This review provides a theoretical basis and reference for the in-depth understanding of the positive role of TMTFs in COVID-19 treatment. | Guangxu Xiao Simeng Wang Ruijiao Wang Li Tan Shibo Ma Shuang He Guanwei Fan Yan Zhu Ming Lyu | 2023 | Acupuncture and Herbal Medicine2023，3，4： | 1 |
| 14 | On the oxidative coupling of methane with carbondioxide over CeO2/ZnO nanocatalysts显示文摘 | YANG BOLUN CHENG GUANGXU | 2004 | Catalysis Today2004，98，： | 1 |
| 15 | 微正压精准送风对车间温度均匀性影响的实验研究显示文摘卷烟厂制造车间需要严格控制温度,一般的空调送风系统很难保证车间内的温度及温度均匀性要求。因此,本文建立微型车间结构,并采用一种新型纤维风管微正压柔性精准送风系统实现定点送风,对风口尺寸、风速、送风温度等参数对制造车间的送风效果进行研究。实验结果表明:2号风管以30℃的送风温度,7.6 m/s孔口风速进行送风效果最优,车间内平均温度维持在25℃左右;在极端天气下车间外温度低至-5℃时,以30℃送风温度进行送风,车间内温度恒定在23.5~25.1℃的可控范围之内,仍可满足卷烟厂制造车间内温度要求。 | 李日南 吴敬华 赵静芬 王正伟 高磊 曹泷 吴学红 ZHOU Guangxu LIU He | 2022 | 制冷2022，41，4： | 0 |
| 16 | 31.38 Gb/s GaN-based LED array visible light communication system enhanced with V-pit and sidewall quantum well structure显示文摘Although the 5G wireless network has made significant advances,it is not enough to accommodate the rapidly rising requirement for broader bandwidth in post-5G and 6G eras.As a result,emerging technologies in higher frequencies including visible light communication(VLC),are becoming a hot topic.In particular,LED-based VLC is foreseen as a key enabler for achieving data rates at the Tb/s level in indoor scenarios using multi-color LED arrays with wavelength division multiplexing(WDM)technology.This paper proposes an optimized multi-color LED array chip for high-speed VLC systems.Its long-wavelength GaN-based LED units are remarkably enhanced by V-pit structure in their efficiency,especially in the“yellow gap”region,and it achieves significant improvement in data rate compared with earlier research.This work investigates the V-pit structure and tries to provide insight by introducing a new equivalent circuit model,which provides an explanation of the simulation and experiment results.In the final test using a laboratory communication system,the data rates of eight channels from short to long wavelength are 3.91 Gb/s,3.77 Gb/s,3.67 Gb/s,4.40 Gb/s,3.78 Gb/s,3.18 Gb/s,4.31 Gb/s,and 4.35 Gb/s(31.38 Gb/s in total),with advanced digital signal processing(DSP)techniques including digital equalization technique and bit-power loading discrete multitone(DMT)modulation format. | Zengyi Xu Wenqing Niu Yu Liu Xianhao Lin Jifan Cai Jianyang Shi Xiaolan Wang Guangxu Wang Jianli Zhang Fengyi Jiang Zhixue He Shaohua Yu Chao Shen Junwen Zhang Nan Chi | 2023 | Opto-Electronic Science2023，2，5： | 0 |
| 17 | Influence of arsanilic acid, Cu2+, PO43- and their interaction on anaerobic digestion of pig manure显示文摘 | Ping He Guangxue Wu Rui Tang Peilun Ji Shoujun Yuan Wei Wang Zhenhu Hu | 2018 | Frontiers of Environmental Science & Engineering2018，12，2： | 0 |
| 18 | Enhanced the photoelectrochemical performance of Bi_(2)XO_6(X = W, Mo) for detecting hexavalent chromium by modification of CuS显示文摘In this work, Bi2XO6(X = W, Mo) are synthesized at different temperatures. The results of tests find the optimal temperatures of Bi_(2)WO_(6) and Bi_(2)MoO_(6) are 180 and 160 °C(BW-180, BM-160). Then, BW-180 and BM-160 are further compounded with different contents of CuS. The results of photoelectrochemical(PEC) tests show that CuS can improve the PEC performance of semiconductor materials, and it has better performance when CuS mass fraction is 5%. These maybe the photoelectron potentials generated by Cu S/Bi_(2)XO_(6)(X = Mo, W) heterojunction reduce the combination of photogenerated electrons and holes. When the PEC sensor based on 5%-CuS/BW-180 detects Cr(VI), it has a linear range of 1–80 μmol/L with detection limit of 0.95 μmol/L, while the PEC sensor based on 5%-CuS/BM-160 detects Cr(VI) has a linear range of 0.5–230 μmol/L and a detection limit of 0.12 μmol/L. Thus, 5%-CuS/Bi_(2)XO_(6) has potential application in hexavalent chromium detection. | Guangxue Zhang Di Cheng Mengying Li Chuanqi Feng Huimin Wu He Mei | 2021 | Journal of Environmental Sciences2021，33，5： | 0 |
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