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| 1 | A NEURAL-BASED NONLINEAR L_1-NORM OPTIMIZATION ALGORITHM FOR DIAGNOSIS OF NETWORKS*显示文摘Based on exact penalty function, a new neural network for solving the L1-norm optimization problem is proposed. In comparison with Kennedy and Chua’s network(1988), it has better properties.Based on Bandler’s fault location method(1982), a new nonlinearly constrained L1-norm problem is developed. It can be solved with less computing time through only one optimization processing. The proposed neural network can be used to solve the analog diagnosis L1 problem. The validity of the proposed neural networks and the fault location L1 method are illustrated by extensive computer simulations. | He Yigang (Department of Electrical Engineering, Hunan University, Changsha 410082)Luo Xianjue Qiu Guanyuan(School of Electrical Engineering, Xi’an Jiaotong University, Xi’an 710049) | 1998 | Journal of Electronics(China)1998，15，4： | 8 |
| 2 | Human BDCA2^+CD123^+CD56^+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset显示文摘树枝状的房间(DC ) 包括二个机能上地不同的子集:plasmacytoid DC (pDCs ) 和 myeloid DC (mDCs ) 。pDCs 被专攻类型的快速、巨大的分泌物我响应通过使用费的 nucleic 酸的干扰素(IFN-I ) 相似受体(TLR )-7 或 TLR-9。在这份报告,我们描绘了 CD56 < 啜 class= “ a-plus-plus ” >+ DC 人口包括 CD123 和 BDCA2 表示典型 pDC 标记,但是生产与 pDCs 作比较的少得多 IFN-I。另外, CD56 < 啜 class= “ a-plus-plus ” > 和由介绍的染色体宽的 transcriptional 的 mDCs 然而并非 pDCs 的 + DC 簇。因此, CD56 < 啜 class= “ a-plus-plus ” >+ DC 机能上地由在 TLR4 刺激和 priming na 之上生产 IL-12 类似于 mDCs ? 没有优先的激活的 ve T 房间。这些数据建议 CD56 < 啜 class= “ a-plus-plus ” >+ DC 代表与一些 pDC 特征混合的一个新奇 mDC 子集。CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ hematological 恶意作为 blastic plasmacytoid 被分类树枝状的房间瘤(BPDCN ) 由于它 pDCs 的典型分子的表示。然而,我们证明 BPDCN 接近 CD56 < 啜 class= “ a-plus-plus ” >+ DC 比由介绍的全球基因表示的 pDCs。因此,我们建议 CD4 < 啜 class= “ a-plus-plus ” >+ CD56 < 啜 class= “ a-plus-plus ” >+ 瘤可以是 CD56 的一个肿瘤对应物 < 啜 class= “ a-plus-plus ” >+ mDCs 然而并非 pDCs。 | Haisheng Yu Peng Zhang Xiangyun Yin Zhao Yin QuanxinG Shi Ya Cui Guanyuan Liu Shouli Wang Pier Paolo Piccaluga Taijiao Jiang Liguo Zhang | 2015 | Protein & Cell2015，6，4： | 6 |
| 3 | Construction of a small-caliber tissue-engineered blood vessel using icariin-loaded β-cyclodextrin sulfate for in situ anticoagulation and endothelialization显示文摘The rapid endothelialization of tissue-engineered blood vessels(TEBVs) can effectively prevent thrombosis and inhibit intimal hyperplasia. The traditional Chinese medicine ingredient icariin is highly promising for the treatment of cardiovascular diseases.β-cyclodextrin sulfate is a type of hollow molecule that has good biocompatibility and anticoagulation properties and exhibits a sustained release of icariin. We studied whether icariin-loaded β-cyclodextrin sulfate can promote the endothelialization of TEBVs. The experimental results showed that icariin could significantly promote the proliferation and migration of endothelial progenitor cells; at the same time, icariin could promote the migration of rat vascular endothelial cells(RAVECs). Subsequently,we used an electrostatic force to modify the surface of the TEBVs with icariin-loaded β-cyclodextrin sulfate, and these vessels were implanted into the rat common carotid artery. After 3 months, micro-CT results showed that the TEBVs modified using icariin-loaded β-cyclodextrin sulfate had a greater patency rate. Scanning electron microscopy(SEM) and CD31 immunofluorescence results showed a better degree of endothelialization. Taken together, icariin-loaded β-cyclodextrin sulfate can achieve anticoagulation and rapid endothelialization of TEBVs to ensure their long-term patency. | Jingyuan Yang Keyu Wei Yeqin Wang Yanzhao Li Ning Ding Da Huo Tianran Wang Guanyuan Yang Mingcan Yang Tan Ju Wen Zeng Chuhong Zhu | 2018 | Science China(Life Sciences)2018，61，10： | 5 |
| 4 | Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart显示文摘Cell therapy has been a promising strategy for cardiac repair after myocardial infarction(MI),but a poor ischemic environment and low cell delivery efficiency remain significant challenges.The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI,but it is unclear whether it could be used for human pluripotent stem cell(hiPSC)cultivation and provide a proper microenvironment for cell grafts against the ischemic environment.Herein,we developed a splenic extracellular matrix derived thermoresponsive hydrogel(SpGel).Proteomics analysis indicated that SpGel is enriched with proteins known to modulate the Wnt signaling pathway,cell-substrate adhesion,cardiac muscle contraction and oxidation-reduction processes.In vitro studies demonstrated that hiPSCs could be efficiently induced into endothelial cells(iECs)and cardiomyocytes(iCMs)with enhanced function on SpGel.The cytoprotective effect of SpGel on iECs/iCMs against oxidative stress damage was also proven.Furthermore,in vivo studies revealed that iEC/iCM-laden SpGel improved cardiac function and inhibited cardiac fibrosis of infarcted hearts by improving cell survival,revascularization and remuscularization.In conclusion,we successfully established a novel platform for the efficient generation and delivery of autologous cell grafts,which could be a promising clinical therapeutic strategy for cardiac repair and regeneration after MI. | Ge Guan Da Huo Yanzhao Li Xiaolin Zhao Yinghao Li Zhongliang Qin Dayu Sun Guanyuan Yang Mingcan Yang Ju Tan Wen Zeng Chuhong Zhu | 2021 | Bioactive Materials2021，6，12： | 2 |
| 5 | 中药抗疫四大治则及其合理性的系统医学解读显示文摘随着新型冠状病毒病(COVID-19)全球大流行的第二年,其众多变种继续肆虐,中国和世界其他地区不断涌现出许多应用中药(CHM)治疗COVID-19患者的成功案例。在此,作者从系统医学的角度总结了这些经验,将其归纳为四大治疗原则:(1)早期治疗,注重排毒;(2)扶正补虚,贯穿始终;(3)肺肠同治,脏腑并调;(4)后期抗疫,凉血化瘀。并且解释了这些原则的合理性。这不仅有利于减少推广中药应用的复杂性,进一步提高抗疫疗效,而且有助于加快中医药与现代医疗实践相结合的进程。 | Guanyuan Jin Louis Lei Jin Bonnie Xia Jin | 2021 | Acupuncture and Herbal Medicine2021，1，2： | 2 |
| 6 | Model ing the occupant evacuation of the mass rapid transit station using the control volume model显示文摘 | Wu Guanyuan Chien Shenwen Huang Yuanting | 2010 | Building and Environ- ment2010，45，10： | 1 |
| 7 | Establishment of Paclitaxel-Resistant Cell Line and the Underlying Mechanism on Drug Resistance显示文摘 | Jingjing Zhang Jin Zhao Wenjing Zhang Guanyuan Liu Dongmei Yin Jian Li Sumei Zhang Hongxia Li | 2012 | International Journal of Gynecological Cancer2012，，9： | 1 |
| 8 | Susceptibility behaviour and specific heat anomaly in single crystals of alanine and valine显示文摘 | Wenqing Wang Xiangrong Sheng Haofang Jin Jilan Wu Bo Yin Jingwei Li Zhongxian Zhao Hongshun Yang Fengming Lou Zhizhong Zhuang Guanyuan Yu Lei Shi Zhaojia Chen | 1996 | Journal of Biological Physics1996，，2： | 1 |
| 9 | A novel superposition RBF collocation method to solvemoving conductor eddy current problems显示文摘 | Yang Guanyuan Zhang Yong Lei Gang | | 0，，10： | 1 |
| 10 | Modeling the occupant evacuation of the mass rapid transit station using the control volume model显示文摘 | WU Guanyuan CHIEN Shenwen HUANG Yuanting | 2010 | Building and Environment2010，45，10： | 1 |
| 11 | Two-stage comprehensive evaluation of intensity and its application显示文摘 | Wang Guanyuan | 1985 | Earthquake Engineering1985，13，1： | 1 |
| 12 | TRANSIENT ANALYSIS OF NONUNIFORM TRANSMISSION LINES WITH NONLINEAR TERMINAL NETWORKS显示文摘A semi-analytical method in time domain is presented for analysis of the transient response of nonuniform transmission lines. In this method, the telegraph equations in time domain is differenced in space domain first, and is transformed into a set of first-order differential equations of voltage and current with respect to time. By integrating these differential equations with respect to time, and precise computation, the solution of these differential equations can be obtained. This method can solve the transient response of various kinds of transmission lines with arbitrary terminal networks. Particularly, it can analyze the nonuniform lines with initial conditions, for which there is no existing effective method to analyze the time response so far. The results obtained with this method are stable and accurate. Two examples are given to illustrate the application of this method. | Zhao Jinquan Ma Xikui Xue Jing Qiu Guanyuan | 2006 | Journal of Electronics(China)2006，23，3： | 0 |
| 13 | Characterization of dendritic cell subtypes in human cord blood by single-cell sequencing显示文摘Dendritic cells(DCs)are professional antigen-presenting cells(APCs).The key functions of DCs include engulfing,processing and presenting antigens to T cells and regulating the activation of T cells.There are two major DC subtypes in human blood:plasmacytoid DCs(pDCs)and conventional DCs.To define the differences between the adult and infant immune systems,especially in terms of DC const让ution,we enriched DCs from human cord blood and generated single-cell RNA sequencing data from about 7000 cells using the lOx Genomics Single Cell 3'Solution.After incorporating the differential expression analysis method in our clustering process,we identified all the known dendritic cell subsets.Interestingly,we also found a group of DCs with gene expression that was a mix of megakaryocytes and pDCs.Further;we verified the expression of selected genes at both the RNA level by PCR and the protein level by flow cytometry.This study further demonstrates the power of single-cell RNA sequencing in dendritic cell research. | Xiaoyang Jin Lingyuan Meng Zhao Yin Haisheng Yu Linnan Zhang Weifeng Liang Shouli Wang Guanyuan Liu Liguo Zhang | 2019 | Biophysics Reports2019，5，4： | 0 |
| 14 | Programmable dual responsive system reconstructing nerve interaction with small-diameter tissue-engineered vascular grafts and inhibiting intimal hyperplasia in diabetes显示文摘Small-diameter tissue-engineered vascular grafts(sdTEVGs)with hyperglycemia resistance have not been constructed.The intimal hyperplasia caused by hyperglycemia remains problem to hinder the patency of sdTEVGs.Here,inspired by bionic regulation of nerve on vascular,we found the released neural exosomes could inhibit the abnormal phenotype transformation of vascular smooth muscle cells(VSMCs).The transformation was a prime culprit causing the intimal hyperplasia of sdTEVGs.To address this concern,sdTEVGs were modified with an on-demand programmable dual-responsive system of ultrathin hydrogels.An external primary Reactive Oxygen Species(ROS)-responsive Netrin-1 system was initially triggered by local inflammation to induce nerve remolding of the sdTEVGs overcoming the difficulty of nerve regeneration under hyperglycemia.Then,the internal secondary ATP-responsive DENND1A(guanine nucleotide exchange factor)system was turned on by the neurotransmitter ATP from the immigrated nerve fibers to stimulate effective release of neural exosomes.The results showed nerve fibers grow into the sdTEVGs in diabetic rats 30 days after transplantation.At day 90,the abnormal VSMCs phenotype was not detected in the sdTEVGs,which maintained long-time patency without intima hyperplasia.Our study provides new insights to construct vascular grafts resisting hyperglycemia damage. | Yanzhao Li Yeqin Wang Fangchao Xue Xuli Feng Zhaojing Ba Junjie Chen Zhenhua Zhou Yanhong Wang Ge Guan Guanyuan Yang Ziwei Xi Hao Tian Yong Liu Ju Tan Gang Li Xiewan Chen Mingcan Yang Wen Chen Chuhong Zhu Wen Zeng | 2022 | Bioactive Materials2022，7，1： | 0 |
| 15 | A selective inhibitor of OMA1 and targeted delivery system for the treatment of acute myocardial infarction显示文摘The rescue of dying cardiomyocytes in penumbra within 4 hours is the best way to preserve cardiac function in acute myocardial infarction(AMI).Mitochondrial fission contributes to mitochondrial energy supply deficiency and cardiomyocytes death,and OMA1 promotes mitochondrial fission.Accurate targeting of OMA1 inhibition is important for the treatment of myocardial infarction.Here,a selective inhibitor of OMA1,UNC-R,was firstly described,which could protect the cardiomyocytes through mitochondrial fission inhibition.Moreover,the accurately targeted microsphere was designed,and loaded the UNC-R to form the POMU,which could avoid the phagocytosis of phagocytes in blood,precisely accumulated in the ischemic area,further target the dying cardiomyocytes. | Cheng Panke Yang Guanyuan Zeng Wen Zhu Chuhong | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 16 | Discussion on the Integrated Communication System of Local Electric Power Network in China显示文摘This paper describes current situation and special requirements of local electric power communication network in China. The paper discusses the disadvantages of SDH and fiber loop carrier system applied to electric power communication network. It presents a new Communication System-IDS-2000 integrated digital communication system. The paper introduces the characteristics and application of IDS-2000 system in the local electric power communication network. | Zhang Guanyuan Gao Yun (Communication Department of Nanjing Automation Research Institute) | 1998 | Electricity1998，，4： | 0 |
| 17 | Renewable Energy Seawater Desalination Technology and Application Analysis显示文摘This paper proposed a new technology way for seawater desalination which used renewable energy(wind energy and solar energy).The effects of practical application showed that remote islands and cage culture zones in the bay that lack electricity and water are very suitable for using small seawater desalination devices that do not require consumption of conventional energy. | Guifang HUANG Guanyuan WEI Lan DING | 2023 | Agricultural Biotechnology2023，12，4： | 0 |
| 18 | Optical engineering of infrared PbS CQD photovoltaic cells for wireless optical power transfer systems显示文摘Infrared photovoltaic cells(IRPCs)have attracted considerable attention for potential applications in wireless optical power transfer(WOPT)systems.As an efcient fber-integrated WOPT system typically uses a 1550 nm laser beam,it is essential to tune the peak conversion efciency of IRPCs to this wavelength.However,IRPCs based on lead sulfde(PbS)colloidal quantum dots(CQDs)with an excitonic peak of 1550 nm exhibit low short circuit current(Jsc)due to insufcient absorption under monochromatic light illumination.Here,we propose comprehensive optical engineering to optimize the device structure of IRPCs based on PbS CQDs,for 1550 nm WOPT systems.The absorption by the device is enhanced by improving the transmittance of tin-doped indium oxide(ITO)in the infrared region and by utilizing the optical resonance efect in the device.Therefore,the optimized device exhibited a high short circuit current density of 37.65 mA/cm^(2)under 1 sun(AM 1.5G)solar illumination and 11.91 mA/cm^(2)under 1550 nm illumination 17.3 mW/cm^(2).Furthermore,the champion device achieved a record high power conversion efciency(PCE)of 7.17%under 1 sun illumination and 10.29%under 1550 nm illumination.The PbS CQDs IRPCs under 1550 nm illumination can even light up a liquid crystal display(LCD),demonstrating application prospects in the future. | Mengqiong Zhu Yuanbo Zhang Shuaicheng Lu Zijun Wang Junbing Zhou Wenkai Ma Ruinan Zhu Guanyuan Chen Jianbing Zhang Liang Gao Jiancan Yu Pingqi Gao Jiang Tang | 2023 | Frontiers of Optoelectronics2023，16，2： | 0 |
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