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| 1 | Formation and Water Stability of Aggregates in Red Soils as Affected by Organic Matter显示文摘FormationandWaterStabilityofAggregatesinRedSoilsasAffectedbyOrganicMatter￥ZHANGMINGKUI;HEZHENLI;CHENGUOCHAO;HUANGCHANGYONGIan... | ZHANG MINGKUI HE ZHENLI CHEN GUOCHAO HUANG CHANGYONGI andM. J. WILSON￣2(￣1DePartment of Land Use and Applied Chemistry, Zhejiang Agricultural University, Hangzhou 31O029(China))(￣2Soils and Soil Microbiology Division, Macaulay Land Use Research Inst | 1996 | Pedosphere1996，6，1： | 38 |
| 2 | Metallogenic Epoch and Ore-forming Environment of the Lamasu Skarn-porphyritic Cu-Zn deposit,western Tianshan,Xinjiang,NW China显示文摘花岗石的岩石,广泛地在 Lamasu 铜矿石区域发展了,西方的 Tianshan 在 390.5 | ZHANG Zuoheng WANG Zhiliang WANG Longsheng ZUO Guochao | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 21 |
| 3 | Intercropping with Solanum nigrum and Solanum photeinocarpum from Two Ecoclimatic Regions Promotes Growth and Reduces Cadmium Uptake of Eggplant Seedlings显示文摘Soil contamination by heavy metals is a serious environmental problem worldwide, and reduction of heavy metal accumulation in vegetables grown on contaminated land is a matter of urgency. A pot experiment was conducted to study the effects of intercropping with the Cd hyperaccumulators Solanum nigrum and Solanum photeinocarpum from two ecoclimatic regions, Ya'an and Chengdu,Sichuan Province, China, on the growth and cadmium(Cd) uptake of eggplant(Solanum melongena L.). The biomass, photosynthetic pigment contents, and activities of antioxidant enzymes of eggplant were enhanced by intercropping. The biomass of eggplant was the highest after intercropping with S. photeinocarpum from Ya'an, but did not differ significantly from that after intercropping with S. nigrum from Chengdu. The shoot Cd content of eggplant was significantly reduced by intercropping with the hyperaccumulators,which ranked as follows: S. nigrum from Chengdu > S. nigrum from Ya'an > S. photeinocarpum from Chengdu > S. photeinocarpum from Ya'an, with the decreases being 19.60%, 14.36%, 9.66%, and 6.42%, respectively, as compared with the control. The lowest shoot Cd content and translocation factor of eggplant were attained after intercropping with S. nigrum from Chengdu. Therefore, it was feasible to intercrop eggplant with S. nigrum and S. photeinocarpum on Cd-contaminated soil. | TANG Yi HE Juan YU Xuena XIE Yongdong LIN Lijin SUN Guochao LI Huanxiu LIAO Mingan LIANG Dong XIA Hui WANG Xun ZHANG Jing LIU Zejing TU Lihua LIU Li | 2017 | Pedosphere2017，27，3： | 17 |
| 4 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 5 | Single-zircon dating of Precambrian strata in the west sector of the northern Qilian Mountains and its geological significance显示文摘Single_zircon evaporation method was employed in the present study to determine the age of the iron_bearing rock series in Precambrian strata in the western sector of the northern Qilian Mountains. Three zircon ages from the diabase of the Aoyougou ophiolite previously put into Upper Lithologic Formation of the Zhulongguan Group are (1 840±2), (1 783±2) and (1 784±2) Ma respectively, whereas the zircon ages from the welded breccias in the Zhulongguan Group are (733±7), (738±4) and (604±6) Ma respectively. These results show that they should belong to the bottom of the middle Proterozoic and the upper part of upper Proterozoic respectively. | Jingwen Mao Zhaochong Zhang Jianmin Yang Biao Song Maobing Wu Guochao Zuo | 1998 | Chinese Science Bulletin1998，43，15： | 5 |
| 6 | Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer显示文摘Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity.Dendritic cell(DCs)vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality.Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world.Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years,their efficacy is still unsatisfactory overall.Therefore,there is an urgent unmet clinical need for lung cancer treatment.Here,we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm,2 medical centers,pilot study initiated by the investigator(ChiCTR-ONC 16009100,NCT02956551).The patients enrolled were patients with heavily treated metastatic lung cancer.Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis.A total of 12 patients were enrolled in this study.A total of 85 vaccine treatments were administered with a median value of 5 doses/person(range:3-14 doses/person).In total,12-30 peptide-based neoantigens were selected for each patient.AIl treatment-related adverse events were grade 1-2 and there were no delays in dosing due to toxic effects.The objective effectiveness rate was 25%;the disease control rate was 75%;the median progression-free survival was 5.5 months and the median overall survival was 7.9 months.This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. | Zhenyu Ding Qing Li Rui Zhang Li Xie Yang shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 7 | Toll-like receptor 5 agonist CBLB502 induces radioprotective effects in vitro显示文摘从沙门氏菌 flagellin 导出的 CBLB502 是像使用费的受体的新奇收缩筋 5 (TLR5 ) 。CBLB502 能与低毒性和 immunogenicity 在整个身体的照耀期间从官方补给、造血的症候群在老鼠和首领上施加高避免受辐射影响的功效,这被显示出。然而,没有有效系统被用来在 vitro 对照耀和相关机制调查 CBLB502 的保护的效果。在这研究,我们在组成地表示人的 TLR5 和 NF-B-dependent 酶的 HEK293-N-T 房间调查了 CBLB502 的避免受辐射影响的性质。HEK293-N-T 房间在 60 公司 -- 光线照耀。在照耀以后,房间生存能力是即时的由使用即时房间分析系统为 4 是天。我们发现 CBLB502 能够高效地维持照耀的 HEK293-N-T 房间的幸存率。然后, apoptotic 房间死亡和房间周期被流动 cytometry 检测。结果证明那个 CBLB502 预告的处理能减少 apoptosis 并且以一种剂量依赖者方式从 G2 阶段拘捕支持照耀的 HEK293-N-T 房间的恢复。我们的数据显示 CBLB502 经由 anti-apoptosis 在 vitro 有直接避免受辐射影响的效果并且支持房间周期恢复。这里开发的方法能是一在 vitro 有效屏蔽象 CBLB502 一样的另外的 TLR5 目标 radioprotectants 的系统。 | Tong Shi Liqin Li Guochao Zhou Chen Wang Xuejun Chen Ruihua Zhang Jianfu Xu Xiaojing Lu Hui Jiang Jisheng Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 2 |
| 8 | Detection of UXO magnetic anomaly in Jinshan area显示文摘Magnetic survey is one of the most successful techniques for locating buried unexploded ordnances( UXO). For the location and identification of buried UXO in Jinshan area,a total-field magnetic survey is applied. The analytic signal of magnetic field is widely used to outline the boundaries of geology bodies,slightly dependent on the magnetization direction. In order to locate the UXO position,the analytic signal is applied to process the magnetic UXO data,which performs better than the conventional magnetic data. Then a typical UXO anomaly is extracted from the original data to invert for its depth by an improved Euler method proposed.The calculated depth is close to the real buried depth. | WU Guochao HUANG Danian ZHANG Chong YUAN Yuan | 2015 | Global Geology2015，18，1： | 2 |
| 9 | Temporo-Spatial Distribution and Evolution of Ore Deposits in the West Sector of the Northern Qilian Mountains显示文摘The west sector of the northern Qilian Mountains is well-known for the Jingtieshan-type iron deposits. A new breakthrough has been made in prospecting for gold and copper in recent years. In this paper, the distribution characteristics of ore deposits in the study area are discussed from the viewpoint of tectonic evolution. It is suggested that there are 9 stages of mineralization from the Palaeoproterozoic to Indosinian. Four minerogenetic series and two minerogenetic subseries of ore deposits are recognized. Iron mineralization occurred in several stages, while most of the metals were accumulated in large amounts in the Caledonian. The enrichment and mineralization of gold is related to large-scale shear-strike-slip faults and the ascent and unloading of deep-seated fluids. | MAO Jingwen ZHANG Xiaoyu ZHANG Zhaochong REN Fengshou ZUO Guochao ZHANG Zuoheng YANG Jianmin WANG Zhiliang YE Dejin | 1999 | Acta Geologica Sinica(English Edition)1999，73，2： | 1 |
| 10 | Reactive molecular dynamics smulations of the initial stage of brown coal oxidation at high temperatures显示文摘 | Yan Guochao Zhang Zhiqiang Yan Kefeng | 2013 | Molecular Physics2013，111，1： | 1 |
| 11 | Reactive Molecular Dynamics Simulations of the Initial stage of Brown Coal Oxidation at High Temperatures显示文摘 | YAN Guochao ZHANG Zhiqiang YAN Kefeng | 2013 | Molecular Physics2013，111，1： | 1 |
| 12 | Late Triassic Magma Mixing and Fractional Crystallization in the Qingchengzi Orefield,Eastern Liaoning Province:Regional Petrogenetic and Metallogenic Implications显示文摘The Qingchengzi orefield is an important Pb-Zn-Au-Ag polymetallic orefield in NE Chi-na.The Indosinian magmatism has formed the Shuangdinggou batholith and the Xinling stock,as well as dikes of quartz monzonite porphyry and lamprophyre.According to petrographic characteristics,the Shuangdinggou intrusion can be divided into the main suite and the central suite.Zircon U-Pb dat-ing yielded crystallization ages of 215.0-220.9 Ma for these various Qingchengzi magmatic units,which are within analytical error and represent coeval magmatism.The Shuangdinggou main suite contains abundant mafic microgranular enclaves(MMEs)and shows features of magma mixing.Geochemically,the major oxide contents of the MMEs and their quartz monzonite host show well-defined linear frac-tionation trends.The REE and trace element patterns of the MMEs and their host are similar,which demonstrates certain degree of geochemical homogenization between the two during magma mixing.The Shuangdinggou main suite shares similar geochemical characteristics with typical high Ba-Sr gra-nites(Ba=1082 ppm-2051 ppm,Sr=803 ppm-886 ppm),and was likely originated from the mixing between a melt derived from partial melting of the thickened lower crust and the enriched mantle.The central suite was likely formed by fractional crystallization of the main-suite magma.The Xinling in-trusion may represent a branch of the Shuangdinggou intrusion and has the same genesis as the central suite.The quartz monzonite porphyries geochemically mimic the Shuangdinggou main suite,and may also be an epioic facies of the Shuangdinggou intrusion.The MMEs and lamprophyres may have been derived from incomplete magma mixing.Formation of the Pb-Zn and Au-Ag deposits in the Qing-chengzi orefield may have been related to the granite/quartz monzonite porphyries near the Shuangdinggou intrusion,which were formed by magma mixing and fractional crystallization. | Hongjing Xie Yuwang Wang Dedong Li Guochao Zhou Zhichao Zhang | 2021 | Journal of Earth Science2021，32，1： | 1 |
| 13 | 显示文摘 | Qi Guochao Zhang S Khor K A | 2008 | Applied Surface Science2008，255，2： | 1 |
| 14 | Screening of High Virulent Isolate of Beauveria spp. against Helicoverpa assulta and Changes in Protective Enzymes Activities of Infected Larvae显示文摘Eleven isolates of Beauveria spp., including B. bassiana(Bb062) newly isolated from Helicoverpa assulta, and other seven B. bassiana isolates and three B. brongniartii isolates that were originally isolated from different geographic origins and various hosts, were tested against the 3^(rd) instar larvae of H. assulta. The protective enzyme activity in the 3^(rd) larvae of H. assulta infected by highly virulent isolate was also assayed. The results showed that the isolate Bb062 had the highest virulence to the 3^(rd) instar larvae among eleven isolates of Beauveria spp., with a corrected mortality reaching 91.07% within 10 d post treatment, and the LT_(50) was 4.67 d. After inoculated with three concentrations(1.0 ×10~6, 1.0 ×10~7 and 1.0×10~8 conidia/mL) of Bb062 conidial suspension, the accumulative mortality of H. assulta larvae increased with the increase of concentration and observation time, and the LC_(50) was 1.82×10~7 conidia/mL. Activities of superoxide dismutase(SOD), peroxidase(POD) and catalase(CAT) in H. assulta larvae first increased rapidly then dropped sharply within 72 h. Bb062 showed high virulence to H. assulta and could inhibit activities of protective enzymes. Therefore, it will be a promising biocontrol agent against H. assulta. | Zhang Guochao Liu Mingke Zhou Jianyun Chen Dexin Yan Fangfang Xu Chuangtao Jiang Lianqiang Li Maoye | 2019 | Plant Diseases and Pests2019，10，2： | 0 |
| 15 | Research on the Applications of Big Data on Artistic Designing and Its Infl uences on the Design Behavior显示文摘In this paper, we conduct research on the applications of big data on artistic designing and its infl uences on the design behavior. Modern art design enhance the grade of the product, increase the added value of products, promote the development of the economy, make the product of the aesthetic value and economic value of the perfect unity. In today’s society due to the value of the product are much more than the product itself contains the value of performance, usage, etc. is more of a product in gradually improve the aesthetic value, sometimes even more than the use of the product value and exchange value, therefore the product has become the dominant value. Under this basis, we propose the new idea on the design pattern that will be meaningful. | Guochao Zhang | 2016 | International Journal of Technology Management2016，，6： | 0 |
| 16 | Simultaneous capture of ISG15 conjugating and deconjugating enzymes using a semi-synthetic ISG15-Dha probe显示文摘ISG15 is a ubiquitin-like(Ubl) protein attached to substrate proteins by ISG15 conjugating enzymes whose dysregulation is implicated in a multitude of disease processes, but the probing of these enzymes remains to be accomplished. Here, we describe the development of a new activity-based probe ISG15-Dha(dehydroalanine) through protein semi-synthesis. In vitro crosslinking and cell lysate proteomic profiling experiments showed that this probe can sequentially capture ISG15 conjugating enzymes including E1 enzyme UBA7, E2 enzyme UBE2L6, E3 enzyme HERC5, the previously known ISG15 deconjugating enzyme(USP18), as well as some other enzymes(USP5 and USP14) which we additionally confirmed to impart deISGylation activity. Collectively, ISG15-Dha provides a new tool that can simultaneously capture ISG15 conjugating and deconjugating enzymes for biochemical or pharmacological studies. | Chuntong Li Tian Wang Lujun Liang Guochao Chu Jiachen Zhang Wei He Lei Liu Jinghong Li | 2023 | Science China Chemistry2023，66，3： | 0 |
| 17 | 诱导性多能干细胞的低基因组稳定性使非同源末端连接增加显示文摘背景与目的诱导性多能干细胞(induced pluripotent stem cells,iPSCs)和胚胎干细胞(embryonic stem cells,ESCs)具有许多共同特征,包括相似的形态、基因表达和体外分化谱。然而,iPSCs的基因组稳定性远低于ESCs。在本研究中,我们研究了iPSCs中DNA损伤修复的改变是否为其具有更大诱变倾向的原因。方法将小鼠iPSCs、ESCs和胚胎成纤维细胞暴露于电离辐射(4 Gy),导致双链DNA断裂。照射4 h后使用全基因组重测序评估DNA损伤修复的保真度。我们还分析了分别源自iPSCs或ESCs的小鼠的基因组稳定性。结果照射后,与胚胎干细胞和胚胎成纤维细胞相比,iPSCs具有较低的DNA损伤修复能力,有更多的体细胞突变和短片段插入缺失。iPSCs有更多的非同源末端连接DNA修复和更少的同源重组DNA修复。源自iPSCs的小鼠比ESCs小鼠以及C57对照小鼠的DNA损伤修复能力更低。结论本研究结果部分表明,iPSCs的低基因组稳定性及其在体内的高致瘤性是由DNA损伤修复的低保真度所致。 | Minjie Zhang Liu Wang Ke An Jun Cai Guochao Li Caiyun Yang Huixian Liu Fengxia Du Xiao Han Zilong Zhang Zitong Zhao Duanqing Pei Yuan Long Xin Xie Qi Zhou Yingli Sun | 2019 | 癌症2019，38，8： | 0 |
| 18 | Basophils as a potential therapeutic target in cancer显示文摘Basophils,which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation,have been neglected by researchers in the past decades.Previous studies have revealed their vital roles in allergic diseases and parasitic infections.Intriguingly,recent studies even reported that basophils might be associated with cancer development,as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers.However,it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components;the answer may depend on the tumor biology and the microenvironment.Herein,we reviewed the role of basophils in cancers,and highlighted some potential and promising therapeutic strategies. | Jicheng ZHANG Hanlin YIN Qiangda CHEN Guochao ZHAO Wenhui LOU Wenchuan WU Ning PU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，12： | 0 |
| 19 | Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP-Seq links epigenetic inheritance to metabolism显示文摘Histone methylation is a kind of important epigenetic modification which occurs on the lysine residue or arginine residue of histone tails(Zhang and Reinberg,2001).It takes part in multiple biological processes,including gene expression,genomic stability,stem cell maturity,genetic imprinting,mitosis and development(Fischle et al.,2005).Abnormal histone methylation pattern | Ke An Fengxia Du Hao Meng Guochao Li Minjie Zhang Zongzhi Liu Zitong Zhao Zilong Zhang Di Yu Dong Wang Caiyun Yang Wencui Ma Lin Yuan Meiting Zhou Lili Duan Li Jin Hui Li Yan Zhang Jianzhong Su Jie Qiao Yingli Sun | 2018 | Journal of Genetics and Genomics2018，45，3： | 0 |
| 20 | Deep pedigree analysis reveals family specific ‘‘fingerprint” pattern of DNA methylation for men显示文摘DNA methylation plays an essential role in mammalian development[1].However,how DNA methylation is inherited between generations and if there is family-specific DNA methylation pattern remains to be elucidated[2].In this study,we collect male blood samples including a big pedigree of the descendants of an ancient Chinese empire and samples from different haplogroups to study their whole genome DNA methylation pattern.We find 115 male family-specific methylation sites from three families.The difference of whole genome DNA methylation pattern correlates | Guochao Li Minjie Zhang Hua Chen Ke An Zongzhi Liu Fengxia Du Caiyun Yang Xiao Han Li Jin Hui Li Yan Zhang Jie Qiao Yingli Sun | 2018 | Science Bulletin2018，63，1： | 0 |
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