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| 1 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Insight into the critical factors determining the particle number concentrations during summer at a megacity in China显示文摘To identify the critical factors impacting the number concentration of particles with the aerodynamic diameters less than 2.5 μm(PNC_(2.5)), the continuous measurement of PNC_(2.5),chemical components in PM_(2.5), gaseous pollutants and meteorological conditions were conducted at an urban site in Tianjin in June 2015. Results indicated that the average PNC_(2.5) was 2839 ± 2430 d N/dlog Dp 1/cm^3 during the campaign. Compared to other meteorological parameters, the relative humidity(RH) had the strongest relationship with PNC_(2.5), with a Pearson's correlation coefficient of 0.53, and RH larger than 30% influenced strongly PNC_(2.5).The important influence of secondary reactions on PNC_(2.5) was inferred due to higher correlation coefficients between PNC_(2.5) and SO_4^(2-), NO_3^-, NH_4^+(r = 0.78–0.89; p < 0.01) and between PNC_(2.5) and ratios that represent the conversion of nitrogen and sulfur oxides to particulate matter(r = 0.42–0.49; p < 0.01). Under specific RH conditions, there were even stronger correlations between PNC_(2.5) and NO_3^-, SO_4^(2-), NH_4^+, while those between PNC_(2.5) and EC, OC were relatively weak, especially when RH exceeded 50%. Principal component analysis(PCA) and Pearson's correlation analysis indicated that secondary sources, vehicle emission and coal combustion might be major contributors to PNC_(2.5). Backward trajectory and potential source contribution function(PSCF) analysis suggested that the transport of air masses originated from these regions around Tianjin(Liaoning, Hebei, Shandong and Jiangsu) influenced critically PNC_(2.5). The north of Jiangsu, the west of Shandong, and the east of Hebei were distinguished as major potential source-areas of PNC_(2.5) by PSCF model. | Baoshuang Liu Xiaohui Bi Jiaying Zhang Jie Yuan Zhimei Xiao Qili Dai Yinchang Feng Yufen Zhang | 2019 | Journal of Environmental Sciences2019，31，1： | 1 |
| 3 | Exploitation of Malus EST-SSRs and the utility in evaluation of genetic diversity in Malus and Pyrus显示文摘 | Lihua Yao Xiaoyan Zheng Danying Cai Yuan Gao Kun Wang Yufen Cao Yuanwen Teng | 2010 | Genetic Resources and Crop Evolution2010，，6： | 1 |
| 4 | Overexpression of CaWRKY27 , a subgroup IIe WRKY transcription factor of Capsicum annuum , positively regulates tobacco resistance to Ralstonia solanacearum infection显示文摘 | Fengfeng Dang Yuna Wang Jianju She Yufen Lei Zhiqin Liu Thomas Eulgem Yan Lai Jing Lin Lu Yu Dan Lei Deyi Guan Xia Li Qian Yuan Shuilin He | 2014 | Physiol Plantarum2014，，3： | 1 |
| 5 | Penta-coordinated phosphorus structure analysis on kinases显示文摘In this paper, based on the known crystal structures of Square Pyramid (SP) and Trigonal Bipyramid (TBP) penta-coordinated phosphorus compounds containing amino acid side chains, such as amino, carboxyl, hydroxyl or thiol, a software designed to survey the P(5)-Structure of phosphorylated proteins. By this software, it was found that 382 of 398 phos- phorus-related kinases (96%) from current PDB could go through the penta-coordinated phos- phorus transition state or intermediate. For example, in protein 1HE8, amino group in Lysine16 was within 3.58 ?from the phosphorus atom, and a potential TBP structure consisting GNP2 and NZ could be overlapped with an authentic TBP with an RMSD value of 0.71 ?. | LI Wu MA Yuan ZHAO Yufen | 2004 | Science China Chemistry2004，47，5： | 0 |
| 6 | Power Dependence of the Recombination Processes in the In_(x)Ga_(1-x)As/GaAs Single Quantum Well显示文摘We have measured the power dependence of the photoluminesence spectra from a set of strained In_(x)Ga_(1-x)As/GaAs single quantum wells.The result shows that the excitation power has important effect on the carrier recombination processes.When the power increases from 0.5 to 14mW,the photoluminescence from the barrier becomes more intense than that from the well and the trapping efficiency decreases.At high excitation level,the ratio of the radiative recombination rate to the nonradiative recombination rate of the barrier increases ten times than that at lower excitation level,while it only doubles for the well. | QIAN Shixiong WU Jianyao YUAN Shu LI Yufen Thorwald G.Andersson CHEN Zonggui PENG Wenji SHE Weilong YU Zhenxin | 1991 | Chinese Physics Letters1991，8，8： | 0 |
| 7 | Appraisal of an oligomerization behavior of unprotected carbohydrates induced by phosphorus reagent显示文摘In this article, a novel oligomerization behavior of unprotected monosaccharides was discovered in a one-pot reaction induced by phosphorus reagent at room temperature. The inherent characteristics of the oligomerization reaction were dissected in detail by mass spectrometry based method combined with NMR technology. It was found that the main glycosidic bonding pattern is (1→6) linkage with 66% regioselectivity for each step. The ratio of α-(1→6) and β-(1→6) glycosidic bonds formed is around 1:1. The reactivity of 1-OH group from aldoses and the driving force from penta-coordinated phosphorus intermediates are the two critical factors for the oligomerization, according to the monitoring experiments by ESI-MS and NMR. Besides, the oligomerization reaction has good compatibility for various aldoses and could expand to O-glycosylated modification of peptides in vitro. The above results will provide a novel enlightenment to develop more convenient and higher-efficient methods for the synthesis of oligosaccharide library. | Hang Yuan Xu Yang Peng Chen Yan Liu Guo Tang Yufen Zhao | 2018 | Science China Chemistry2018，61，2： | 0 |
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