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| 1 | Optical characteristics of Ce,Eu:YAG single crystal grown by Czochralski method显示文摘Eu-doped Ce:YAG single crystal(SC) was fabricated by the Czochralski method. The crystal structure,optical and photoelectric property of the constructed w-LED was investigated. The XRD and HRTEM results show that YAG crystal structure has little change when Eu^(3+), Ce^(3+) are doped. Absorption spectra and photoluminescence spectra show that the Ce,Eu:YAG single crystal can effectively absorb the 460 nm blue light to form a broadband emission center at 530 nm, decay curves of the crystal show that the energy transfer between Ce^(3+) and Eu^(3+) is highly suppressed. Compared with commercial Ce:YAG phosphor, Ce,Eu:YAG exhibits better thermal stability. | Jingfeng Zhang Guorui Gu Xiaoxuan Di Weidong Xiang Xiaojuan Liang | 2019 | Journal of Rare Earths2019，37，2： | 4 |
| 2 | Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling显示文摘The link of hedgehog (Hh) signaling activation to human cancer and synthesis of a variety of Hh signaling inhibitors raise great expectation that inhibiting Hh signaling may be effective in human cancer treatment. Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein. However, its poor solubility, acid sensitivity, and weak potency relative to other Hh antagonists prevent the clinical development of Cyc as a therapeutic agent. Here, we report properties of cyclopamine tartrate salt (CycT) and its activities in Hh signaling-mediated cancer in vitro and in vivo. Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT had a higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC50 = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). We also tested the antitumor effectiveness of these Hh inhibitors using two mouse models of basal cell carcinomas (K14cre:Ptch1neo/neo and K14cre:SmoM2YFP). After topical application of CycT or Cyc daily for 21 days, we found that all CycT-treated mice had tumor shrinkage and decreased expression of Hh target genes. Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis. | Qipeng Fan Dongsheng Gu Miao He Hailan Liu Tao Sheng Guorui Xie Ching-xin Li Xiaoli Zhang Brandon Wainwright Arash Garrossian Massoud Garrossian Dale Gardner Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，7： | 3 |
| 3 | A New Optical Fiber Loop System Used in Measurement of Dispersion Compensation Ability显示文摘ANewOpticalFiberLoopSystemUsedinMeasurementofDispersionCompensationAbilityManuscriptreceivedDec.24,1996.SupportedbyKeyProject... | Sun Jian, Gu Wanyi, Chen Xue, Li Guorui and Xu Daxiong (Telecommunication Engineering Department, Beijing University of Posts and Telecommunications, Beijing 100876, P.R.China) | 1997 | The Journal of China Universities of Posts and Telecommunications1997，4，2： | 1 |
| 4 | Nonlinear Amplifying Loop Mirror for Reducing ASE in Nonsoliton Transmission显示文摘NonlinearAmplifyingLoopMirrorforReducingASEinNonsolitonTransmission￥HeHuajie;GuWanyi;LiGuorui;andXuDaxiong(DepartmentofTeleco... | He Huajie Gu Wanyi Li Guorui and Xu Daxiong(Department of Telecommunication Engineering, Beijing University of Posts and Telecommunications, Beijing 100088, P. R. China) | 1996 | The Journal of China Universities of Posts and Telecommunications1996，3，2： | 0 |
| 5 | Efficient outsourced extraction of histogram features over encrypted images in cloud显示文摘Dear editor,JPEG steganalysis mainly includes feature extraction and classification[1,2],and thus the quality of the extracted features has an important influence on the detection performance of classifiers.With the development of JPEG steganalysis,the dimension of extracted features is greatly increased for improving the detecting performance[3]. | Yanli REN Xinpeng ZHANG Dawu GU Guorui FENG | 2021 | Science China(Information Sciences)2021，64，3： | 0 |
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