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| 1 | Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer显示文摘The successes achieved by chimeric antigen receptor-modified T(CAR-T) cells in hematological malignancies raised the possibility of their use in non-small lung cancer(NSCLC). In this phase I clinical study(NCT01869166), patients with epidermal growth factor receptor(EGFR)-positive(>50% expression), relapsed/refractory NSCLC received escalating doses of EGFR-targeted CAR-T cell infusions. The EGFR-targeted CAR-T cells were generated from peripheral blood after a 10 to 13-day in vitro expansion. Serum cytokines in peripheral blood and copy numbers of CAR-EGFR transgene in peripheral blood and in tissue biopsy were monitored periodically. Clinical responses were evaluated with RECIST1.1 and immune-related response criteria, and adverse events were graded with CTCAE 4.0. The EGFR-targeted CAR-T cell infusions were well-tolerated without severe toxicity. Of 11 evaluable patients, two patients obtained partial response and five had stable disease for two to eight months. The median dose of transfused CAR+ T cells was 0.97×10~7 cells kg^(-1)(interquartile range(IQR), 0.45 to 1.09×10~7 cells kg^(-1)). Pathological eradication of EGFR positive tumor cells after EGFR-targeted CAR-T cell treatment can be observed in tumor biopsies, along with the CAR-EGFR gene detected in tumor-infiltrating T cells in all four biopsied patients. The EGFR-targeted CAR-T cell therapy is safe and feasible for EGFR-positive advanced relapsed/refractory NSCLC. | Kaichao Feng Yelei Guo Hanren Dai Yao Wang Xiang Li Hejin Jia Weidong Han | 2016 | Science China(Life Sciences)2016，59，5： | 62 |
| 2 | DNA methylation-mediated repression of miR-181a/135a/302c expression promotes the microsatellite-unstable colorectal cancer development and 5-FU resistance via targeting PLAG1显示文摘Micro sate Hite instability(MSI) defines a subtype of colorectal cancer(CRC) with typical clinicopathologic characteristics. CRCs with MSI(MSI CRCs) frequently acquire accelerated carcinogenesis and 5-FU resistance, and the exact underlying mechanism remains incompletely understood. Our previous study has identified the microRNA(miRNA) expression profile in MSI CRCs. In this study, three miRNAs(miR-181 a, miR-135 a and miR-302 c) were validated by qRT-PCR to be dramatically decreased in 67 CRC samples. Proliferation and apoptosis assays demonstrated that miR-181 a/135 a/302 c function as tumor suppressors via repressing PLAG1/IGF2 signaling. Moreover, we presented compelling evidence that restoration of miR-181 a/135 a/302 c expression promoted sensitivity of MSI CRC cells to 5-FU treatment. miR-181 a/135 a/302 c exerted their effect on chemoresistance through attenuating PLAG1 expression. Notably, the hypermethylation status of MSI CRC accounts for the decrements of miR-181 a/135 a/302 c. Our results contribute to a better understanding of the mechanism of chemo?resistance in MSI CRCs, and provide a clue for digging the bio markers and therapeutic targets for CRC patients. | Lu Shi Xiang Li Zhiqiang Wu Xiaolei Li Jing Nie Mingzhou Guo Qian Mei Weidong Han | 2018 | Journal of Genetics and Genomics2018，45，4： | 9 |
| 3 | Uranium Provinces in China显示文摘Three uranium provinces are recognized in China, the Southeast China uranium province, the Northeast China-Inner Mongolia uranium province and the Northwest China (Xinjiang) uranium province. The latter two promise good potential for uranium resources and are major exploration target areas in recent years. There are two major types of uranium deposits: the Phanerozoic hydrothermal type (vein type) and the Meso-Cenozoic sandstone type in different proportions in the three uranium provinces. The most important reason or prerequisite for the formation of these uranium provinces is that Precambrian uranium-enriched old basement or its broken parts (median massifs) exists or once existed in these regions, and underwent strong tectonomagmatic activation during Phanerozoic time. Uranium was mobilized from the old basement and migrated upwards to the upper structural level together with the acidic magma originating from anatexis and the primary fluids, which were then mixed with meteoric water and resulted in | CHEN Zhaobo ZHAO Fengmin XIANG Weidong CHEN Yuehui | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 7 |
| 4 | Features of physical oceanography in the oceans near the Prydz Bay during the 1998/1999 austral summer显示文摘南极的 Thermohaline 特征,空间延期,和深度围绕天极的深水,南极底部水,和上面的间层水接近 Prydz 海湾(包括 Prydz 海湾夏天表水,南极冬季水,并且 Prydz 海湾架流水)被在南部的 Oceannear 获得的完整的深度 CTD 数据的使用分析并且学习 Prydz 海湾在 1998/1999 期间南的夏天。向北方,架水,逆温层的厚度,在垂直温度侧面的最小和温度垂直梯度的扩展被解释。根据重力势地的分析,地转风气流和因地球自转而引起的体积运输被计算在 Prydz 海湾附近在纬向环流决定最强壮的水流的地点并且在 64 °~发现体积运输的空间可变性 66.5 ° S 地区。另外,大陆人水边界(CWB ) 的中央地点,正面的力量,垂直深度和厚度从 CTD 数据被估计在学习区域详细说明 CWB 的空间可变性(64 °~ 66。5 ° S, 70 °~ 75 ° E ) 。 | PU Shuzhen HU Xiaomin DONG Zhaoqian XIANG Baoqiang YU Weidong | 2006 | Acta Oceanologica Sinica2006，25，6： | 5 |
| 5 | Robust YAG:Ce single crystal for ultra-high efficiency laser lighting显示文摘At present,solid-state laser-driven lighting fabricated with blue laser diode(LD)and phosphor has been greatly developed in high-power lighting applications.The major obstacle is the luminescence saturation threshold of the fluorescence conversion material(YAG:Ce).In this work,we successfully prepared a series of high-quality and robust YAG:Ce single crystals.With high quantum efficiency(QE=92%),regular crystal structure and high thermal conductivity,the single-crystal has excellent ability to deal with high radiation flux and thermal accumulation generated by high power.Matching the single-crystal with the laser,the luminous efficiency up to 274 lm/W and saturation threshold of 12 W/mm^(2) were obtained.In addition,the influence of Ce doping concentration and sample processing conditions on the indicators in laser-driven white lighting was systematically studied.The results are of great significance and are believed to promote the development of solid-state laser-driven lighting. | Yaqian Zhang Jianming Liu Yujie Zhang Haisheng Yang Yanxia Yu Qingyun He Xiaojuan Liang Yongfu Liu Weidong Xiang | 2022 | Journal of Rare Earths2022，40，5： | 5 |
| 6 | A new method of micro-motion parameters estimation based on cyclic autocorrelation function显示文摘Signals with sinusoidal frequency modulation(FM)are the general form of micro-Doppler signals in radar echoes from targets with micro-motions.This paper derives the cyclic autocorrelation function of a sinusoidal FM signal using its cyclostationary characteristics,and estimates the parameters of amplitude,modulation index,micro-motion period and noise power based on cyclic autocorrelation function.The estimation method is robust in noise environment when compared with conventional time-frequency analysis methods.Finally,the performances of estimation by utilizing the simulation data and darkroom measurement are shown in tables.The Monte-Carlo simulation results show that the estimator is asymptotically optimal at SNR above6 dB. | NIU Jie LI KangLe JIANG WeiDong LI Xiang KUANG GangYao ZHU HongYu | 2013 | Science China(Information Sciences)2013，56，10： | 4 |
| 7 | Optical characteristics of Ce,Eu:YAG single crystal grown by Czochralski method显示文摘Eu-doped Ce:YAG single crystal(SC) was fabricated by the Czochralski method. The crystal structure,optical and photoelectric property of the constructed w-LED was investigated. The XRD and HRTEM results show that YAG crystal structure has little change when Eu^(3+), Ce^(3+) are doped. Absorption spectra and photoluminescence spectra show that the Ce,Eu:YAG single crystal can effectively absorb the 460 nm blue light to form a broadband emission center at 530 nm, decay curves of the crystal show that the energy transfer between Ce^(3+) and Eu^(3+) is highly suppressed. Compared with commercial Ce:YAG phosphor, Ce,Eu:YAG exhibits better thermal stability. | Jingfeng Zhang Guorui Gu Xiaoxuan Di Weidong Xiang Xiaojuan Liang | 2019 | Journal of Rare Earths2019，37，2： | 4 |
| 8 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 9 | Nonuniform stretch processing for the range profile of a target with micro-motion显示文摘Complex motions such as micro-motions induce complex range-Doppler coupling effect in radar imaging. Hence, it is a challenge to reconstruct a clear range profile of a target with micro-motion. Stretch processing with fine motion compensation cannot perform well while it ties to eliminate the distortion of range profile caused by Doppler effect, because it is difficult to accurately estimate each scattering center velocity during coherent processing interval. Based on nonuniform stretch processing (NSP), a new technology is proposed to decouple range, time and Doppler and then achieve range profile of target with micro-motion. The new technology uses a new synthetic wide-band waveform and has an innovative mathematic interpretation. Statistical properties of the new approach are primarily examined. Typical models of target with micro-motion for high resolution radar are presented. Monte Carlo simulations demonstrate the performance of the new technology and the simulation results confirm our expectations. | CHEN Hangyong JIANG Weidong LIU Yongxiang LI Xiang GUO Guirong | 2006 | Progress in Natural Science:Materials International2006，16，11： | 4 |
| 10 | Deeply learned broadband encoding stochastic hyperspectral imaging显示文摘Many applications requiring both spectral and spatial information at high resolution benefit from spectral imaging.Although different technical methods have been developed and commercially available,computational spectral cameras represent a compact,lightweight,and inexpensive solution.However,the tradeoff between spatial and spectral resolutions,dominated by the limited data volume and environmental noise,limits the potential of these cameras.In this study,we developed a deeply learned broadband encoding stochastic hyperspectral camera.In particular,using advanced artificial intelligenee in filter design and spectrum reconstruction,we achieved 7000-11,000 times faster signal processing and〜10 times improvement regarding noise toleranee.These improvements enabled us to precisely and dynamically reconstruct the spectra of the entire field of view,previously unreachable with compact computational spectral cameras. | Wenyi Zhang Hongya Song Xin He Longqian Huang Xiyue Zhang Junyan Zheng Weidong Shen Xiang Hao Xu Liu | 2021 | Light(Science & Applications)2021，10，6： | 4 |
| 11 | Ultra-stable Eu^(3+)-doped CsPbCl_(2)Br_(1) perovskite quantum dots glass for optical temperature sensing显示文摘In this work,Eu^(3+)-doped CsPbCl_(2)Br_(1) in borosilicate glass was successfully synthesized by the melt quenching annealing technique and crystallization method.This work reports a novel Eu^(3+)-doped CsPbCl_(2)Br_(1) perovskite quantum dots(QDs)glass with high sensitivity for optical temperature sensing.The relation of fluorescence intensity ratio(FIR)with the temperature was studied in the temperature range of 80-440 K.Notably,the maximum absolute temperature sensitivity(Sa)and relative temperature sensitivity(Sr)of Eu^(3+)-doped CsPbCl_(2)Br_(1) perovskite QDs glass can reach as high as 0.0315 K-1 and3.097%/K,respectively.Meanwhile,Eu^(3+)-doped CsPbCl_(2)Br_(1) QDs glass demonstrates good water resistance,excellent thermal and cold cycling stability performance,The Eu^(3+)-doped QDs glass materials can bring inspiration to the future exploration of rare earth ion-doped QDs glass material on the application of optical temperature sensing in the future. | Yanxia Yu Guangzhan Shao Ling Ding Huiling Zhang Xiaojuan Liang Jianping Liu Weidong Xiang | 2021 | Journal of Rare Earths2021，39，12： | 4 |
| 12 | Few-shot text classification by leveraging bi-directional attention and cross-class knowledge显示文摘Few-shot text classification targets at the situation where a model is developed to classify newly incoming query instances after acquiring knowledge from a few support instances.In this paper,we investigate few-shot text classification under a metric-based meta-learning framework.While the representations of the query and support instances are the key to the classification,existing study handles them independently in the text encoding stage.To better describe the classification features,we propose to exploit their interaction with adapted bi-directional attention mechanism.Moreover,distinct from previous approaches that encode different classes individually,we leverage the underlying cross-class knowledge for classification.To this end,we conceive the learning target by incorporating the large margin loss,which is expected to shorten the intra-class distances while enlarging the inter-class distances.To validate the design,we conduct extensive experiments on three datasets,and the experimental results demonstrate that our solution outperforms its state-of-the-art competitors.Detailed analyses also reveal that the bi-directional attention and the cross-class knowledge both contribute to the overall performance. | Ning PANG Xiang ZHAO Wei WANG Weidong XIAO Deke GUO | 2021 | Science China(Information Sciences)2021，64，3： | 3 |
| 13 | Successful operation of a cooperative SLR station of China and Argentina in San Juan显示文摘We introduced the observations and researches using a Satellite Laser Ranging (SLR) system with high precision, which was designed and made in China and installed in the Observatory of San Juan Uni- versity, Argentina, the capability of the system and the achievement of the cooperative procedure be- tween China and Argentina. The SLR station in San Juan, set up by China and Argentina, is quite sig- nificant for improving the distribution of SLR stations and enhancing the orbital coverage of the whole earth. Since the SLR system started to work in the Observatory of San Juan University in the beginning of 2006, the operation is rather good, and rich data with high precision have been obtained. Further plan of the cooperation for the near future is also presented. | HAN YanBen LIU WeiDong E ACTIS R PODESTA WANG TanQiang GUO TangYong QU Feng A M PACHECO A A GONZALEZ E ALONSO XIANG QingGe HUANG DongPing YIN ZhiQiang | 2008 | Chinese Science Bulletin2008，53，16： | 2 |
| 14 | Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells显示文摘Akt 在反肿瘤代理人的发展正在成为一个吸引人的目标。在现在的学习,我们试图对恶意的 glioma 发现新奇否定 Akt 管理者。屏蔽站台在一根 Akt-GFP overexpression 房间线执行了的一个 Akt 管理者被开发,并且自然产品图书馆被屏蔽并且评估了使用这个平台。另外,管理者的细胞毒素的效果被 MTT 试金检测。房间 apoptosis 是由 Hoechst 33342 染色和流动 cytometry 分析的 assayed。以后,表明小径的 apoptotic 被西方的污点分析调查。Glaucocalyxin A,从 Rabdosia 孤立装饰用的梨树,作为一个有势力被识别 Akt 的否定管理者。在导出人的恶意的 glioma U87MG 房间, glaucocalyxin A 禁止了 Akt phosphorylation,压制了增长,并且支持了以一种剂量依赖者方式,然而并非在正常 glial 房间的 apoptosis。而且, glaucocalyxin A 激活 caspase-3,减少的坏 phosphorylation,并且减少了 apoptosis 的 X 连接禁止者的表示蛋白质。一起拿,这些结果显示 glaucocalyxin A 可以在恶意的 glioma 的处理成为一个有希望的候选人。 | Xian Xiao Weidong Cao Xiaofan Jiang Wei Zhang Yongqiang Zhang Bolin Liu Jinxiang Cheng Huiyong Huang Junli Huo Xiang Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 2 |
| 15 | Enhanced multimodal luminescence and ultrahigh stability Eu^(3+)-doped CsPbBr_(3) glasses for X-ray detection and imaging显示文摘As an emerging scintillation material,metal halide perovskite(CsPbX3)has been deemed the most potentially valuable candidate in X-ray detection and medical imaging.Nevertheless,it is a continuing challenge to implement efficient radioluminescence(RL)with high radiation stability and moisture resistance.Moreover,the optimized luminescence properties and excellent uniformity of CsPbX3 glass are also key points for obtaining perfect X-ray images.Herein,we have successfully precipitated Eu^(3+)-doped CsPbBr_(3)nanocrystals(NCs)with improved photoluminescence quantum yield(≈58.6%)because partial Eu^(3+)entered the perovskite lattice in a robust borosilicate glass matrix by in situ crystallization.The small amount of Eu addition made the lattice of NCs shrink and promoted uniform distribution of CsPbBr_(3)NCs in the glass,which effectively reduced the light scattering of the sample.Subsequently,multimodal RL intensity of the CsPbBr_(3)/CsPbBr_(3):xEu NCs glasses(CPB-0Eu/CPB-xEu)as a function of X-ray dose rate showed a superlinear relationship to the benefit of obtaining satisfactory X-ray images.Also,the outstanding radiation stability and water resistance of CPB-xEu were confirmed due to the protection of the robust glass matrix.Finally,an X-ray imaging system using a CPB-xEu scintillator was constructed,and the spring in the opaque sample was legibly detected under the motivation of X-rays,indicating that CsPbX3 glasses possess extensive application prospects in terms of X-ray detection and medical imaging. | YAO TONG QIN WANG HENG YANG XIAOTING LIU ENROU MEI XIAOJUAN LIANG ZHIJUN ZHANG WEIDONG XIANG | 2021 | Photonics Research2021，9，12： | 2 |
| 16 | Preparation and Characterization of Flower-like Cu_2SnS_3 Nanostructures by Solvothermal Route显示文摘Flower-like Cu2SnS3 nanostructures composed of nano-flakes were successfully synthesized by solvothermal technique at 180℃for 16 h.In the preparation process,CuCI2·2H2O,SnCl2·2H2O and thiourea were used as raw materials,and ethylene glycol were used as solvent.The results showed that the obtained product was pure phase Cu2SnS3.The average diameter of Cu2SnS3 flowers and the thickness of the nano-flakes were about 1—1.5μm and 10 nm,respectively.The influence of reaction time and solvents on the morphology,size and structure of the products was investigated by powder X-ray diffraction and fieldemission scan electron microscopy(FESEM).The ultraviolet-visible absorption spectrum measurement indicated that the band gap of the sample was about 1.26 eV and could be applied to the absorbing layer of thin solar cell.The possible formation mechanism of flower-like Cu2SnS3 was also proposed and discussed. | Xiaojuan Liang Qian Cai Weidong Xiang Zhaopin Chen Jiasong Zhong Yun Wang Mingguo Shao Zhenrong Li | 2013 | Journal of Materials Science & Technology2013，29，3： | 2 |
| 17 | Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method显示文摘 | Peng Jiang Weixing Dai Shikai Yan Zhongliang Chen Ruilin Xu Jianmi Ding Li Xiang Shuping Wang Runhui Liu Weidong Zhang | 2011 | Journal of Ethnopharmacology2011，，2： | 2 |
| 18 | Plasma pharmacochemistry based approach to screening potential bioactive components in Huang-Lian-Jie-Du-Tang using high performance liquid chromatography coupled with mass spectrometric detection显示文摘 | Yaohua Hu Peng Jiang Shuping Wang Shikai Yan Li Xiang Weidong Zhang Runhui Liu | 2011 | Journal of Ethnopharmacology2011，，2： | 1 |
| 19 | Reinforce networking theory with OPNET simulation显示文摘 | Guo Jinhua Xiang Weidong Wang Shengquan | | 0，，06： | 1 |
| 20 | Growth and characterization of air annealing Mn- doped YAG:Ce single erystalfor LED显示文摘 | Xiang Weidong Zhong Jiasong Zhao Yinsheng | 2012 | Journal of Alloys and Compounds2012，542，11： | 1 |
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