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| 1 | Genomic Survey and Expression Profiling of the MYB Gene Family in Watermelon显示文摘Myeloblastosis(MYB)proteins constitute one of the largest transcription factor(TF)families in plants.They are functionally diverse in regulating plant development,metabolism,and multiple stress responses.However,the function of watermelon MYB proteins remains elusive to date.Here,a genome-wide identification of watermelon MYB TFs was performed by bioinformatics analysis.A total of 162 MYB genes were identified from watermelon(Cla MYB).A comprehensive overview of the Cla MYB genes was undertaken,including the gene structures,chromosomal distribution,gene duplication,conserved protein motif,and phylogenetic relationship.According to the analyses,the watermelon MYB genes were categorized into three groups(R1R2R3-MYB,R2R3-MYB,and MYB-related).Amino acid alignments for all MYB motifs of Cla MYBs demonstrated high conservation.Investigation of their chromosomal localization revealed that these Cla MYB genes distributed across the 11watermelon chromosomes.Gene duplication analyses showed that tandem duplication events contributed predominantly to the expansion of the MYB gene family in the watermelon genome.Phylogenetic comparison of the Cla MYB proteins with Arabidopsis MYB proteins revealed that watermelon MYB proteins underwent a more diverse evolution after divergence from Arabidopsis.Some watermelon MYBs were found to cluster into the functional clades of Arabidopsis MYB proteins.Expression analysis under different stress conditions identified a group of watermelon MYB proteins implicated in the plant stress responses.The comprehensive investigation of watermelon MYB genes in this study provides a useful reference for future cloning and functional analysis of watermelon MYB proteins. | XU Qing HE Jie DONG Jianhui HOU Xiaojin ZHANG Xian | 2018 | Horticultural Plant Journal2018，4，1： | 14 |
| 2 | Modeling of Isobutane/Butene Alkylation Using Solid Acid Catalysts in a Fixed Bed Reactor显示文摘A dynamic mass transfer model of isobutane/butene alkylation over solid acid catalysts in a fixed bed reactor was established. In the model, a modified equation for the relationship between point activity and effective diffusion coefficient was proposed. It is found that the simulation results fit the experimental data well and the breakthrough time of the bed layer is predicted accurately. By modeling the alkylation process, the time-space distribution of butene and point activity profiles of catalysts can be obtained. Furthermore, the reasons for the deactivation of solid acid catalysts were investigated. It indicates that the main reason for the deactivation of catalysts is the site coverage near the inlet of the reactor, while it is ascribed to the steric effect in the region far away from the inlet. | Liu Zheng Tang Xiaojin Hu Lifeng Hou Shuandi | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，2： | 3 |
| 3 | Influence of Gas Density on Hydrodynamics in a Bubble Column显示文摘Two kinds of gases were used to investigate the influence of gas density on the hydrodynamic characteristics in a bubble column. It can be found out that higher gas density leads to smaller bubble diameter and the flow patterns are different for the both gases. Energy balance mechanisms are analyzed by considering the gas density difference. Models were developed to predict the average bubble diameter with good accuracy. | Tang Xiaojin Hou Shuandi Zhang Zhanzhu | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 2 |
| 4 | New techniques and strategies in drug discovery显示文摘Great success has been witnessed in last decades,some new techniques and strategies have been widely used in drug discovery.In this roadmap,several representative techniques and strategies are highlighted to show recent advances in this filed.(A)A DOX protocol has been developed for accurate protein-ligand binding structure prediction,in which first principle method was used to rank the binding poses.Validation against crystal structures have found that DOX prediction achieved an impressive success rate of 99%,indicating significant improvement over molecular docking method.(B)Virtual target profiling is a compound-centric strategy enabling a parallel implementation of interrogating compounds against various targets in a single screen,which has been used in hit/lead identification,drug repositioning,and mechanism-of-action studies.Current and emerging methods for virtual target profiling are briefly summarized herein.(C)Research on targeted autophagy to treat diseases has received encouraging progress.However,due to the complexity of autophagy and disease,experimental and in silico methods should be performed synergistically for the entire process.This part focuses on in silico methods in autophagy research to promote their use in medicinal research.(D)Histone deacetylases(HDACs)play important roles in various biological functions through the deacetylation of lysine residues.Recent studies demonstrated that HDACs,which possess low deacetylase activities,exhibited more efficient defatty-acylase activities.Here,we review the defatty-acylase activity of HDACs and describe examples for the design of isoform selective HDAC inhibitor.(E)The FDA approval of three kinase allosteric inhibitors and some others entering clinical study has spurred considerable interests in this targeted drug discovery area.(F)Recent advances are reviewed in structure-based design of novel antiviral agents to combat drug resistance.(G)Since nitric oxide(NO)exerts anticancer activity depending on its concentration,optimal levels of NO in cancer cells is desirable.In this minireview,we briefly describe recent advances in the research of NO-based anticancer agents by our group and present some opinions on the future development of these agents.(H)The field of photoactivation strategies have been extensively developed for controlling chemical and biological processes with light.This review will summarize and provide insight into recent research advances in the understanding of photoactivatable molecules including photoactivatable caged prodrugs and photoswitchable molecules. | Jintong Du Jing Guo Dongwei Kang Zhihong Li Guan Wang Jianbing Wu Zhen Zhang Hao Fang Xuben Hou Zhangjian Huang Guobo Li Xiaoyun Lu Xinyong Liu Liang Ouyang Li Rao Peng Zhan Xiaojin Zhang Yihua Zhang | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 5 | Study on Separation of Water and Alumina Fine Particles by Cross-Flow Microfiltration显示文摘A cross-flow microfiltration process had been developed to separate alumina fine particles from the suspension using a stainless steel membrane tube with a pore size of 10 μm. The influence of cross-flow velocity and trans-membrane pressure on the permeate flux and the solid holdup in permeate had been investigated. It was found that both the permeate flux and the solid holdup in permeate decreased with time. Moreover, the permeate flux increased with an increasing transmembrane pressure but the influence of cross-flow velocity on the permeate flux was quite complex. Both the permeate flux and the solid holdup in permeate in long term filtration had been studied. The operation of cross-flow microfiltration could be carried out stably for 10 hours with the permeate flux values ranging from 520.5 to 936 L/(m^2·h) at rs=1%, while it could continue in 10 hours with the permeate flux values ranging from 226 to 432 L/(m^2·h) at rs=5%. The solid holdup in permeate had been less than 10 mg/L during the whole operating cycle. | Zheng Bo Tang Xiaojin Hou Shuandi Zong Baoning | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 1 |
| 6 | Genome-Wide Classification and Evolutionary and Expression Analyses of Citrus MYB Transcription Factor Families in Sweet Orange 显示文摘 | Hou Xiaojin Li Sibei Liu Shengrui | 2014 | Ploe One2014，9，11： | 1 |
| 7 | Phase Behaviors of Multi-tailed B_(2)AB_(2)-Type Regio-isomeric Giant Surfactants at the Columnar-Spherical Boundary显示文摘We report herein the precision synthesis and phase behaviors of multi-tailed B_(2)AB_(2)-type regio-isomeric giant surfactants consisting of a hydrophilic polyhedral oligomeric silsesquioxane(POSS)head tethered with four hydrophobic polystyrene(PS)tails.The synthesis was accomplished through two sequential'click'reactions to give a series of regio-isomeric giant surfactants S2DS2(where S is short for PS tails and D for hydroxyl-functionalized POSS)in para-,meta-,and ortho-configurations.Their phase structures and phase be-haviors at the columnar-spherical boundary were investigated with a single PS tail molecular weight of 1.4 kDa.Specifically,the para-and meta-isomers show hexagonally packed cylinders phases with slightly different order-disorder transition temperatures(~120℃ and~130℃)and the ortho-isomer exhibits an order-order transition from a kinetically favored,metastable dodecagonal quasi-crystal phase to a thermodynamically stable sigma phase at~120℃,as well as a further transition into the disordered state at~140℃.The phase diagram was constructed and their differences were rationalized based on the calculated interfacial area per molecule.This work demonstrates that tiny structural disparity could not only lead to unconventional phase formation in single-component macro-molecules,but also render dynamic and rich phase behaviors in these macromolecular assemblies. | Yu Shao Di Han Xiaojin Yan Bo Hou Yiwen Li Jinlin He Qiang Fu Wen-Bin Zhang | 2021 | Chinese Journal of Chemistry2021，39，12： | 0 |
| 8 | Study of Macro-Mixing in a Microreactor显示文摘The transfer rate between fluids in a microreactor is directly influenced by the mixing within the reactor, which subsequently impacts the reaction rate. This paper investigates the flow behavior and macro-mixing performance in a microreactor. First, the flow performance of the Ehrfeld Miprowa microreactor is studied. Cold experiments are conducted to examine fundamental flow laws and verify the accuracy of the chosen computational fluid dynamics simulation model.Subsequently, macro-mixing performance in the microreactor, both with and without internal components, is investigated through both experiment and simulation. A bromocresol violet–NaOH–H2SO4 system is utilized in the macro-mixing experiments, which explore the effects of flow rate and internal components on macro-mixing. The Navier–Stokes equation is adopted as the computational model for macro-mixing simulations, which also consider the mass transfer and diffusion of tracer. The simulation results are in good agreement with the experimental results. Both experimental and simulation results demonstrate that the presence of internal components in the microreactor enhance its macro-mixing performance. | Cao Huili Tang Xiaojin Bao Di Hou Shuandi | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，4： | 0 |
| 9 | Microchannel reactors for Fischer-Tropsch synthesis:Experimental investigation and mathematical modeling显示文摘The Fischer-Tropsch synthesis is a significant technology for converting coal,natural gas,and biomass into synthetic fuels.In recent years,the use of microchannel reactors for the Fischer-Tropsch synthesis has attracted significant attention.Fischer-Tropsch synthesis experiments were carried out in a microchannel reactor and the influences of reaction conditions on the experimental results were investigated in this study.Based on the experimental data,a dynamic multi-component pseudo-homogeneous variable-volume flow model of microchannel reactors for the Fischer-Tropsch synthesis was built to determine the pressure-,velocity-,conversion-and(component-wise)concentration-distributions in reaction channels.The model takes into account the combined effects of gas volume expansion caused by the frictional pressure drop and gas volume contraction caused by reaction consumption.A novel effective method for calculating the pressure and superficial gas velocity values in microchannel reactors was proposed in the model.Besides that,two sets of experimental data were selected from references to evaluate the validity and accuracy of the model.The reaction performances in the microchannels were analyzed carefully based on the calculated results. | Huili Cao Run Xu Xiaojin Tang Tao Yang Shuandi Hou Chaopeng Hou | 2023 | Chinese Journal of Chemical Engineering2023，64，12： | 0 |
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