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| 1 | A Kelch Motif-Containing Serine/Threonine Protein Phosphatase Determines the Large Grain QTL Trait in Rice显示文摘A thorough understanding of the genetic basis of rice grain traits is critical for the improvement of rice (Oryza sativa L.) varieties.In this study,we generated an F 2 population by crossing the large-grain japonica cultivar CW23 with Peiai 64 (PA64),an elite indica small-grain cultivar.Using QTL analysis,17 QTLs for five grain traits were detected on four different chromosomes.Eight of the QTLs were newly-identified in this study.In particular,qGL3-1,a newly-identified grain length QTL with the highest LOD value and largest phenotypic variation,was fine-mapped to the 17 kb region of chromosome 3.A serine/threonine protein phosphatase gene encoding a repeat domain containing two Kelch motifs was identified as the unique candidate gene corresponding to this QTL.A comparison of PA64 and CW23 sequences revealed a single nucleotide substitution (C→A) at position 1092 in exon 10,resulting in replacement of Asp (D) in PA64 with Glu (E) in CW23 for the 364th amino acid.This variation is located at the D position of the conserved sequence motif AVLDT of the Kelch repeat.Genetic analysis of a near-isogenic line (NIL) for qGL3-1 revealed that the allele qGL3-1 from CW23 has an additive or partly dominant effect,and is suitable for use in molecular marker-assisted selection. | Zejun Hu Haohua He Shiyong Zhang Fan Sun Xiaoyun Xin Wenxiang Wang Xi Qian Jingshui Yang Xiaojin Luo | 2012 | Journal of Integrative Plant Biology2012，54，12： | 41 |
| 2 | Additive and Over-dominant Effects Resulting from Epistatic Loci Are the Primary Genetic Basis of Heterosis in Rice显示文摘A set of 148 F9 recombinant inbred lines(RILs) was developed from the cross of an indica cultivar 93-11 and japonica cultivar DT713,showing strong F1 heterosis.Subsequently,two backcross F1(BCF1) populations were constructed by backcrossing these 148 RILs to two parents,93-11 and DT713.These three related populations(281BCF1 lines,148 RILs) were phenotyped for six yield-related traits in two locations.Significant inbreeding depression was detected in the population of RILS and a high level of heterosis was observed in the two BCF1 populations.A total of 42 main-effect quantitative trait loci(M-QTLs) and 109 epistatic effect QTL pairs(E-QTLs) were detected in the three related populations using the mixed model approach.By comparing the genetic effects of these QTLs detected in the RILs,BCF1 performance and mid-parental heterosis(HMP),we found that,in both BCF1 populations,the QTLs detected could be classified into two predominant types:additive and over-dominant loci,which indicated that the additive and over-dominant effect were more important than complete or partially dominance for M-QTLs and E-QTLs.Further,we found that the E-QTLs detected collectively explained a larger portion of the total phenotypic variation than the M-QTLs in both RILs and BCF1 populations.All of these results suggest that additive and over-dominance resulting from epistatic loci might be the primary genetic basis of heterosis in rice. | Xiaojin Luo Yongcai Fu Peijiang Zhang Shuang Wu Feng Tian Jiayong Liu Zuofeng Zhu Jinshui Yang Chuanqing Sun | 2009 | Journal of Integrative Plant Biology2009，51，4： | 20 |
| 3 | Genomic Survey and Expression Profiling of the MYB Gene Family in Watermelon显示文摘Myeloblastosis(MYB)proteins constitute one of the largest transcription factor(TF)families in plants.They are functionally diverse in regulating plant development,metabolism,and multiple stress responses.However,the function of watermelon MYB proteins remains elusive to date.Here,a genome-wide identification of watermelon MYB TFs was performed by bioinformatics analysis.A total of 162 MYB genes were identified from watermelon(Cla MYB).A comprehensive overview of the Cla MYB genes was undertaken,including the gene structures,chromosomal distribution,gene duplication,conserved protein motif,and phylogenetic relationship.According to the analyses,the watermelon MYB genes were categorized into three groups(R1R2R3-MYB,R2R3-MYB,and MYB-related).Amino acid alignments for all MYB motifs of Cla MYBs demonstrated high conservation.Investigation of their chromosomal localization revealed that these Cla MYB genes distributed across the 11watermelon chromosomes.Gene duplication analyses showed that tandem duplication events contributed predominantly to the expansion of the MYB gene family in the watermelon genome.Phylogenetic comparison of the Cla MYB proteins with Arabidopsis MYB proteins revealed that watermelon MYB proteins underwent a more diverse evolution after divergence from Arabidopsis.Some watermelon MYBs were found to cluster into the functional clades of Arabidopsis MYB proteins.Expression analysis under different stress conditions identified a group of watermelon MYB proteins implicated in the plant stress responses.The comprehensive investigation of watermelon MYB genes in this study provides a useful reference for future cloning and functional analysis of watermelon MYB proteins. | XU Qing HE Jie DONG Jianhui HOU Xiaojin ZHANG Xian | 2018 | Horticultural Plant Journal2018，4，1： | 14 |
| 4 | Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway显示文摘Glioblastoma 是最好攻击的大脑肿瘤,并且它的预后仍然保持差。因此,新奇治疗学的策略为 glioma 治疗被需要。Polyphyllin 我(PPI ) ,从巴黎 polyphylla 提取的 bioactive 成分,被报导有反肿瘤活动。然而,为这项活动的详细机制仍然保持不清楚。这里,我们在 vitro 在 glioma 房间和它的机制上调查了 PPI 的禁止的效果。U251 房间为 24 ~ 72 h 与 PPI (2-9 M ) 的各种各样的集中被对待。由 PPI 的 U251 房间增长的抑制被 MTT 试金估计。房间周期和 apoptosis 上的效果被流动 cytometry 与 PI 和 annexin V-FITC/PI 检验双染色,并且房间 mitochondrial 膜潜力水平被荧光显微镜学评估, JC-1 染色。apoptosis 相关的蛋白质和 JNK 信号小径蛋白质的表达式层次被西方的污点分析评估。结果证明 PPI 显著地以一种集中依赖者方式禁止了 U251 房间的增长。PPI 导致了 G 2/M 阶段拘捕和 apoptosis,并且它 upregulated Bax,细胞色素 c,和 p-JNK 的表情,而是 downregulated 在 U251 房间的 anti-apoptotic 蛋白质 Bcl-2 的表示。而且, PPI 挑起了 mitochondrial 膜潜力的去极。另外, PPI 导致的 apoptosis 被 JNK 禁止者 SP600125 显著地压制。我们的数据提供 PPI 禁止增长并且在 U251 房间导致 apoptotic 房间死亡的证据。这效果可以与 JNK 小径被联系。这些结果建议 PPI 是与潜在的 anti-glioma 效果表明小径的 JNK 的使活跃之物。 | Jiaxin Liu Yueting Zhang Li Chen Fei Yu Xiaojin Li Dan Tao Jianhua Zhao Shuai Zhou | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 11 |
| 5 | Regional Distribution and Sustainable Development Strategy of Mineral Resources in China显示文摘This paper summarizes the distribution and production layout of the major mineral resources in China,including coal,iron ore,copper and bauxite,from a national perspective.It also identifies the incompatibility between the mineral resources distribution and regional economic development.Significant issues with China's mineral resource industry cause challenges for the sustainable development of both the mining industry and the national socio-economy.The sustainability of regional mineral resources and the environmental pollution by mining in the western China were also analyzed.Results show that the distribution of China's mineral resources is misaligned with its regional layout of economic development.China's mineral resources have been over-exploited,and the mineral resources production in the eastern China is unsustainable.The continuously expanding production of mineral resources in the western China has heavily endangered the ecological environment.We propose strategies to boost the sustainable development of mineral resources,including measures to accelerate economic development and enhance the sustainability of domestic mineral resources.We also offer suggestions for scientifically planning the mineral resource prospecting and exploitation and regional economic layout,as well as for proactively undertaking industry transfer in the eastern China and raising the environmental benchmark requirements for the mineral industry in the central and western China. | LI Chaofeng WANG Anjian CHEN Xiaojin CHEN Qishen ZHANG Yanfei LI Ying | 2013 | Chinese Geographical Science2013，23，4： | 11 |
| 6 | Progress in inhomogeneity of critical current and index n value measurements on HTS tapes using contact-free method显示文摘The development of high temperature superconducting(HTS)tapes has recently made great progress,and Bi-based tapes(1 G) and YBCO coated conductor(2 G)are commercially fabricated with practical length.Application of HTS in electric power apparatuses made important achievement,various superconducting devices were demonstrated in grid,laying solid foundation for their commercialization.However,since their intrinsic microscopic defects such as weak-link,granularity,small second phase likely exist,critical current and index n value of the HTS tapes in practical length are impossible homogeneous,which have significant influences on safety,stability and efficiency of the HTS apparatuses.Therefore,critical current and index n value are two important parameters describing inhomogeneity of HTS tapes,thus two important indices for evaluating quality of practical long HTS tapes.This paper focuses on main progresses in inhomogeneity of critical current and index n value measurements on HTS tapes using contact-free methods.The statistical analytical methods evaluating the inhomogeneity of critical current and index n value are suggested.They can provide essential references for design and operation of HTS apparatuses. | WANG YinShun GUAN XiaoJin ZHANG HuiYuan LIU HongWei | 2010 | Science China(Technological Sciences)2010，53，8： | 8 |
| 7 | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia显示文摘Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014). | Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu Xiaojin He Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao | 2019 | Journal of Genetics and Genomics2019，46，1： | 7 |
| 8 | Spectrum Sensing via Temporal Convolutional Network显示文摘In this paper,we investigate a spectrumsensing system in the presence of a satellite,where the satellite works as a sensing node.Considering the conventional energy detection method is sensitive to the noise uncertainty,thus,a temporal convolutional network(TCN)based spectrum-sensing method is designed to eliminate the effect of the noise uncertainty and improve the performance of spectrum sensing,relying on the offline training and the online detection stages.Specifically,in the offline training stage,spectrum data captured by the satellite is sent to the TCN deployed on the gateway for training purpose.Moreover,in the online detection stage,the well trained TCN is utilized to perform real-time spectrum sensing,which can upgrade spectrum-sensing performance by exploiting the temporal features.Additionally,simulation results demonstrate that the proposed method achieves a higher probability of detection than that of the conventional energy detection(ED),the convolutional neural network(CNN),and deep neural network(DNN).Furthermore,the proposed method outperforms the CNN and the DNN in terms of a lower computational complexity. | Tao Ni Xiaojin Ding Yunfeng Wang Jun Shen Lifeng Jiang Gengxin Zhang | 2021 | China Communications2021，18，9： | 6 |
| 9 | An AIEgens and exonuclease Ⅲ aided quadratic amplification assay for detecting and cellular imaging of telomerase activity显示文摘Monitoring telomerase activity with high sensitive and reliable is of great importance to cancer analysis.In this paper, we report a sensitive and facile method to detect telomerase activity using AIEgens modified probe(TPE-Py-DNA) as a fluorescence reporter and exonuclease Ⅲ(Exo Ⅲ) as a signal amplifier.With the aid of telomerase, repeat units(TTAGGG)n are extended from the end of template substrate oligonucleotides(TS primer) that form duplex DNAs with TPE-Py-DNA. Then, Exo Ⅲ catalyzes the digestion of duplex DNAs, liberating elongation product and releasing hydrophobic TPE-Py. The released hydrophobic TPE-Py aggregate together and produce a telomerase-activity-related fluorescence signal.The liberated product hybridizes with another TPE-Py-DNA probe, starting the second cycle. Finally,we obtain the target-to-signal amplification ratio of 1:N^2. This strategy exhibits good performance for detecting clinical urine samples(distinguishing 15 cancer patients' samples from 8 healthy ones) and checking intracellular telomerase activity(differentiating cell lines including He La, MDA-MB-231,MCF-7, A375, HLF and MRC-5 from the cells pretreated with telomerase-related drug), which shows its potential in clinical diagnosis as well as therapeutic monitoring of cancer. | Xuehong Min Lei Xia Yuan Zhuang Xudong Wang Jie Du Xiaojin Zhang Xiaoding Lou Fan Xia | 2017 | Science Bulletin2017，62，14： | 5 |
| 10 | Tribological Properties and Failure Analysis of PTFE Composites used for Seals in the Transmission Unit显示文摘The sealing rings are one of the most important components as the sealing devices in the wet clutch unit of a heavy vehicle. The sealing ring, made from PTFE composites, was subjected to serious wear on the sealing surface, but the mating metal surface only had slight abrasion. A specialized test rig was designed for wear research and failure analysis of the sealing ring. The composition analyses of the ring material, working conditions and wear surface characteristics by visual inspection and tribological properties as well as microscopic analysis with scanning electron microscope was performed to determine the wear mechanism and failure causes. Results revealed that the wear of PTFE composites was characterized by abrasion and adhesion after a certain duration testing, and the wear mechanism changed to thermal fatigue and abrasive wear in the stage of intense wear. The thermal deformation and fatigue were primarily responsible for the rapid wear of the PTFE composites for the sealing rings. | 宫燃 WAN Xiaojin ZHANG Xuerong | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，1： | 5 |
| 11 | Mid‐infrared all‐fiber gain‐switched pulsed laser at 3μm显示文摘Mid-infrared(MIR)fiber pulsed lasers are of tremendous application interest in eye-safe LIDAR,spectroscopy,chemical detection and medicine.So far,these MIR lasers largely required bulk optical elements,complex free-space light alignment and large footprint,precluding compact all-fiber structure.Here,we proposed and demonstrated an all-fiberized structured gain-switched Ho3+-doped ZBLAN fiber laser operating around 2.9μm.A home-made 1146 nm Raman fiber pulsed laser was utilized to pump highly concentrated single-cladding Ho3+-doped ZBLAN fiber with different lengths of 2 m or 0.25 m.A home-made MIR fiber mirror and a perpendicular-polished ZBLAN fiber end construct the all-fiberized MIR cavity.Stable gain-switched multiple states with a sub-pulse number tuned from 1 to 8 were observed.The effects of gain fiber length,pump power,pump repetition rate and output coupling ratio on performance of gain-switched pulses were further investigated in detail.The shortest pulse duration of 283 ns was attained with 10 kHz repetition rate.The pulsed laser,centered at 2.92μm,had a maximum average output power of 54.2 mW and a slope efficiency of 10.12%.It is,to the best of our knowledge,the first time to demonstrate a mid-infrared gain-switched Ho3+:ZBLAN fiber laser with compact all-fiber structure. | Xiaojin Zhang Weiwei Li Jin Li Huiying Xu Zhiping Cai Zhengqian Luo | 2020 | Opto-Electronic Advances2020，3，5： | 4 |
| 12 | Molecular cloning of human heat shock protein 27 and study of its protective effects on oxidative damage in rat cardiomyocte H9c2显示文摘Objective: To clone human cardiac heat shock protein 27(HSP27) gene and to determine the effects of HSP27 on the oxidative stress in rat cardiomyocyte cell line H9c2. Methods: Full length of HSP27 cDNA which got by RT-PCR was constructed into pCDNA3.1+. The recombinant was transfected into rat cardiomyocyte cell line H9c2 and the stable transfection cell line was selected by G418. Then we observe the effects of HSP27 over-expression on LDH release and apoptosis induced H2O2 in H9c2. Results:①pCDNA3.1+/HSP27 provided a sound expression of HSP27 in both 293T and H9c2. ②LDH releasing induced by 0, 100,250,500,1000 μmol/L H2O2 in HSP27 over-expression group and wild type group were 0.396±0.017 vs. 0.390±0.009 (p>0.05), 0.437±0.014 vs. 0.416±0.015 (P<0.05), 0.471±0.018 vs. 0.417±0.009 (P<0.001), 0.505±0.030 vs. 0.657±0.022(P<0.001),0.547±0.027 and 0.661±0.011(P<0.001),respectively. ③Apoptosis induced by 150 μmol/L H2O2 in HSP27 over-expression group and wild type group were (10.693±1.122)% vs. (4.027±1.628)%(P<0.01). Conclusion: We cloned and constructed human cardiac HSP27 gene successfully, and over-expression of human HSP27 could inhibit oxidative damage significantly in H9c2. | Li Liu Xiaojin Zhang Surong Jiang Xiang Gao Guoxain Ding Yunlin Cheng | 2005 | Journal of Nanjing Medical University2005，19，4： | 3 |
| 13 | Ginsenoside Rb1 relieves glucose fluctuationinduced oxidative stress and apoptosis in Schwann cells显示文摘Cultured Schwann cells were treated with 5.6 mM and 50 mM glucose alternating every 8 hours to simulate intermittent high glucose. The present study analyzed the neuroprotective effects of 1, 10 and 100 μM ginsenoside Rb1 on oxidative damage and apoptosis in Schwann cells induced by intermittent high glucose. Flow cytometry demonstrated that ginsenoside Rb1 reduced intermittent high glucose-mediated reactive oxygen species production. Enzyme linked immunosorbent assay showed that 8-hydroxy-2-deoxy guanosine levels in Schwann cells decreased following ginsenoside Rb1 treatment. Quantitative real-time reverse transcription-PCR and western blot assay results revealed that ginsenoside Rb1 inhibited intermittent high glucose-upregulated Bax expression, but antagonized intermittent high glucose-downregulated Bcl-2 expression in Schwann cells. These effects were most pronounced with 100 μM ginsenoside Rb1. These results indicate that ginsenoside Rb1 inhibits intermittent high glucose-induced oxidative stress and apoptosis in Schwann cells. | Bing Xue Lianqing Sun Xiaojin Li Xuan Wang Ying Zhang Yiming Mu Linlang Liang | 2012 | Neural Regeneration Research2012，7，30： | 2 |
| 14 | Influence of Gas Density on Hydrodynamics in a Bubble Column显示文摘Two kinds of gases were used to investigate the influence of gas density on the hydrodynamic characteristics in a bubble column. It can be found out that higher gas density leads to smaller bubble diameter and the flow patterns are different for the both gases. Energy balance mechanisms are analyzed by considering the gas density difference. Models were developed to predict the average bubble diameter with good accuracy. | Tang Xiaojin Hou Shuandi Zhang Zhanzhu | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 2 |
| 15 | Modeling of Continuous Cross-flow Microfiltration Process in an Airlift External-loop Slurry Reactor显示文摘New modified combination mathematical models including the pores blocking models and the cake layer models were developed to describe the continuous cross-flow microfiltration in an airlift external loop slurry reactor. The pores blocking models were created based on the standard blocking law and the intermediate blocking law, and then the cake layer models were developed based on the hydrodynamic theory in which the calculation method of porosity of cake layer was newly corrected. The Air-Water-FCC equilibrium catalysts cold model experiment was used to verify the relevant models.Results showed that the calculated values fitted well with experimental data with a relative error of less than 10%. | Zheng Bo Tang Xiaojin Zhang Zhanzhu Zong Baoning | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，1： | 2 |
| 16 | Molecular epidemiology of porcine epidemic diarrhea virus in China显示文摘 | Jianfei Chen Chengbao Wang Hongyan Shi Huaji Qiu Shengwang Liu Xiaojin Chen Zhibang Zhang Li Feng | 2010 | Archives of Virology2010，，9： | 2 |
| 17 | Space-Terrestrial Integrated Architecture for Internet of Things显示文摘To realize the ultimate vision of Internet of Things(IoT),only depending on terrestrial network is far from enough.As a supplement and extension of terrestrial network,satellite network can offer powerful support to realize the depth and breadth of the coverage.However,existing satellite networks are usually designed for particular purposes.Moreover,traditional satellite networks and terrestrial networks are developed and operated separately,consequently they cannot meet the need of network flexibility required by IoT.In this paper,a space-terrestrial architecture is conceived for constructing a spaceterrestrial based IoT(ST-IoT) system.Additionally,a reliable identification procedure,an integrated access and communication procedure,as well as a clustering cooperative transmission strategy are also presented. | ZHANG Gengxin DING Xiaojin QU Zhicheng | 2020 | ZTE Communications2020，18，4： | 2 |
| 18 | Spleen-kidney supplementing formula alleviates insulin resistance via regulating AKT/glycogen synthase kinase 3β pathway in rats with type 2 diabetic induced by high-fat diet显示文摘OBJECTIVE: To explore the molecular mechanism underpinning the action by investigating its effect on glycogen content and AKT(also known as protein kinase B)/glycogen synthase kinase 3β(GSK-3β) pathway in the liver of rats with type 2 diabetic induced by high-fat diet.METHODS: The rat model of type 2 diabetes was induced by high-fat diet and multiple low-dose streptozotocin injection. Diabetic rats were divided into five groups: the model control group, the Metformin group, spleen-kidney supplementing formula groups of low, medium and high doses. Fasting blood glucose(FBG) levels were measured before treatment and every two weeks during treatment.After the treatment, oral glucose tolerance test was performed, and hemoglobin A1c (HbA1c) and C-peptide were measured to assess the formula's effect on glucose metabolism and insulin resistance. The protein expression levels of AKT, GSK-3βand their phosphorylated forms in the liver were also measured to study the formula's role in insulin signaling pathway.RESULTS: Spleen-kidney supplementing formula significantly relieved the symptoms of polydipsia,polyuria and weight loss in type 2 diabetic rats, reduced FBG and HbA1c levels, increased glycogen content, and improved insulin sensitivity. The anti-diabetic effects of spleen-kidney supplementing formula are dose dependent. It also increased the total AKT protein level and the GSK-3β phosphorylation in the liver of type 2 diabetic rats.CONCLUSION: Spleen-kidney supplementing formula has hypoglycemic effect and relieves insulin resistance by enhancing AKT/GSK-3β signaling pathway in the liver of type 2 diabetic rats. | Tian Chunyu Wang Ya La Xiaojin Li Ji'an Zhang Biwei | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 2 |
| 19 | Polyps and paralysis phonation classification with nonlinear dynamics model显示文摘In order to provide the basis for parameter selection of vocal diseases classification,a nonlinear dynamic modeling method is proposed.A biomechanical model of vocal cords with polyp or paralysis,which couples to glottal airflow to produce laryngeal sound source,is introduced.And then the fundamental frequency and its perturbation parameters are solved.Poincare section and bifurcation diagram are applied to nonlinear analysis of model vibration.By changing the pathological parameters or subglottal pressure,the changes of fundamental frequency and Lyapunov exponents are analyzed.The simulation results show that,vocal cord paralysis reduces the fundamental frequency,and the chaos occurs only within a certain pressure range;while vocal cord with a polyp don't reduce the fundamental frequency,chaos distributes throughout the entire range of pressure.Therefore this study is helpful for classification of polyp and paralysis by the acoustic diagnoses. | GU Lingling ZHANG Xiaojun HUANG Chengwei WU Di ZHOU Xiaojin TAO Zhi | 2016 | Chinese Journal of Acoustics2016，35，1： | 2 |
| 20 | Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients显示文摘 | Dekai Qiu Qixia Wang Hui Wang Qing Xie Guoqing Zang Hong Jiang Chuantao Tu Jinsheng Guo Shuncai Zhang Jianshe Wang Yi Lu Ying Han Lei Shen Xiaoyu Chen Xiqi Hu Xiaojin Wang Chengwei Chen Qingchun Fu Xiong Ma | 2010 | Journal of Hepatology2010，，： | 2 |
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