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| 1 | Community structure and composition of the Cambrian Chengjiang biota显示文摘Based on previously published species data(228 species in over 18 phyla) and field sampling(114 species and 18406 individuals) in the Chengjiang-Haikou-Anning area,we analyzed quantitatively the paleocommunity composition and structure of the Cambrian Chengjiang biota(Cambrian Series 2,eastern Yunnan,China).Arthropods dominate the community both in species diversity(species:37%) and in abundance(individuals:51.8%).Priapulids(individuals:22.6%) and brachiopods(individuals:16.3%) follow in abundance rank.The arthropod Kunmingella douvillei(26.2%),the priapulid Cricocosmia jinning-ensis(15.4%),and the brachiopod Diandongia pista(11%) are the three most abundant species.Ecological analyses show that the community was dominated by epifaunal organisms(species:63%,individuals:68.4%) followed by infaunal organisms(species:11.9%,individuals:25.9%),nektobenthic organisms(species:11.5%,individuals:2.6%),and pelagic organisms(species:5.3%,individuals:3.1%).The diverse feeding strategies,dominated by suspension feeders(species:35.6%,individuals:26.1%) and hunter/scavengers(species:31.1%,individuals:40.4%),indicate the former existence of a complex food chain and intense competition.Epifaunal vagrant omnivores(28.2%),infaunal vagrant hunter/scavengers(19.8%),epifaunal sessile suspension feeders(17.7%),and epifaunal vagrant hunter/scavengers(15.3%) were the most abundant ecological groups,represented primarily by arthropods,poriferans,priapulids,and brachiopods.Ecological group analyses reveal that the early Cambrian Chengjiang biota is similar in community patterns and functional relations to modern biotas in shallow marine settings. | ZHAO FangChen ZHU MaoYan HU ShiXue | 2010 | Science China Earth Sciences2010，53，12： | 14 |
| 2 | Eocrinoid echinoderms from the Lower Cambrian Guanshan Fauna in Wuding,Yunnan,China显示文摘This is a brief report of a new occurrence of eocrinoids from the Early Cambrian Wulongqing Formation in Yunnan, China. The eocrinoids from the Guanshan fauna are among the earliest known eocrinoids. Different from many other Early and Middle Cambrian eocrinoids, the Guanshan eocrinoids are char-acterized by the absence of sutural pores and epispires, the long and spiral brachioles, the extremely long stalk, and the ratio of the length of the stalk versus that of the calyx. The discovery of the eocri-noids from the Guanshan fauna not only provides new information to the investigation of the early evolution of this animal group, but also shed new light on the occurrence and migration of early eocrinoids. | HU ShiXue LUO HuiLin HOU ShuGuang Bernd-Dietrich ERDTMANN | 2007 | Chinese Science Bulletin2007，52，5： | 13 |
| 3 | New Early Cambrian Chordates from Haikou, Kunming显示文摘Two new chordates, Cathaymyrus haikouensis Luo et Hu sp. nov. andZhongxiniscus intermedius Luo et Hu gen. et sp. nov. are studied in this paper. Both display numerous S-shaped myomeres on their trunk. C. haikouensis shows a long and slim body similar to that of Cathaymyrus diadexus Shu et al., Zhongxiniscus approaches to Myllokunmingia and Haikouichthvs in the dorsal fin, but differs in the myomeres. Zhongxiniscus may be the intermediate form between Ca thaymyrus and Myllokunmingia and Haikouichthys. | LUO Huilin, HU Shixue and CHEN Liangzhong Yunnan Institute of Geological Sciences, 131 Baita Road, Kunming 650011, Yunnan | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 12 |
| 4 | New Record of Palaeoscolecids from the Early Cambrian of Yunnan,China显示文摘摘要:新 palaeoscolecid, Guanduscolex 次要的胡,罗 et Fu 情报。et sp。nov,与内向的人和肠的保存软部分来自云南的更低的寒武纪的 Guanshan 动物志,华南。扫描电子显微镜学(SEM ) 揭示的表皮的微结构细节证明每个环忍受三排盘子,每个盘子忍受 910 边缘并且 45 个中央节点。这发现在关系和 palaeoscolecids 和另外的早 priapulids 的进化小径上打开新灯。 | HU Shixue LI Yong LUO Huilin FU Xiaoping YOU Ting PANG Jiyuan LIU Qi Michael STEINER | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 6 |
| 5 | New observations of the lobopod-like worm Facivermis from the Early Cambrian Chengjiang Lagerstatte显示文摘Facivermis yunnanicus (Hou & Chen, 1989), from the Early Cambrian Chengjiang Lager- st?tte, a worm-like fossil with 5 pairs of tentacles and a perceived shrunken end, has been regarded as related to polychaetes, later it has been variously interpreted as lobopods, Pentastoma and lopho- phorates. Newly discovered complete specimens by the ELI field team show that the taxon has, in addition to the 5 pairs of appendages, a pear-shaped trunk end bearing two or three circles of hooks. Accordingly, based on these important morphological characters, reconsideration of its affinities is provided and the taxonomy is remedied herein. Because the five pairs of appendages of Facivermis yunnanicus resemble the appendages of the fore-trunk of lobopod Mi- raluolishania (Liu & Shu, 2004), it seems that they are homologous structures. Therefore, the affinities of Facivermis are regarded here as being close to the lobopods, in addition, the lobe-like appendages of Facivermis are very crucial to exploring the origin of the appendages of lobopods and arthropods. | LIU Jianni HAN Jian SIMONETTAA. M. HU Shixue ZHANG Zhifei YAO Yang SHU Degan | 2006 | Chinese Science Bulletin2006，51，3： | 5 |
| 6 | A New Arthropod,Guangweicaris Luo,Fu et Hu gen. nov. from the Early Cambrian Guanshan Fauna,Kunming,China显示文摘The Guanshan Fauna is a soft-bodied fauna dominated by arthropods (including trilobites, trilobitoides, Tuzoia, Isoxys, and bradorids) in association with priapulids, brachiopods, anomalocaridids, vetulicoliids, sponges, chancellorids, and echinoderms. This paper reports and describes a new arthropod from the yellowish green mudstone at the lower part of the Wulongqing Formation, Canglangpuan Stage, Lower Cambrian in Kunming, Yunnan, China. The stratigraphic and geographic distribution, classification, fossil preservation, life style of this new arthropod and comparisons with other fossil arthropods are also discussed in details. The discovery and research of the non-mineralized arthropod, Guangweicaris Luo, Fu et Hu gen. nov. from the Guanshan Fauna adds new members to the taxonomic list and provides new information to the evolution of early arthropods. Furthermore, this study would shed new light into the “Cambrian Explosion” and the evolution of early life. | LUO Huilin FU Xiaoping HU Shixue LI Yong HOU Shuguang YOU Ting PANG Jiyuan LIU Qi | 2007 | Acta Geologica Sinica(English Edition)2007，81，1： | 5 |
| 7 | Palaeoecological Analysis of Trace Fossil Sinusichnus sinuosus from the Middle Triassic Guanling Formationin Southwestern China显示文摘The Luoping Biota discovered from the early Middle Triassic(Anisian) Guanling Formation of southwestern China represents a fully recovered shallow marine ecosystem, marking the end point of Early Triassic biotic recovery following the end-Permian mass extinction. Contemporaneously preserved are prolific trace fossils, which offer good opportunities to understand the palaeoecology of marine invertebrates from a fully recovered shallow marine ecosystem. Here we present a newly discovered sinuous branching burrow from the fossil-bearing unit in Member II of the Guanling Formation. Several features, including the horizontal regular sinuous nature, the branching pattern, typical H-junction, and the small wavelength/amplitude ratio of these sinuous structures within the burrow systems justify assignment of these traces as Sinusichnus sinuosus, a trace possibly produced by decapod crustaceans. Close association of S. sinuosus with Rhizocorallium commune suggests a deposit-feeding strategy of these trace makers. The newly reported Anisian material from the Guanling Formation in Luoping represents first report of Sinusichnus from South China. The global record of Sinusichnus occurrence suggests that these burrows might have an older history than Early Middle Triassic. | Mao Luo Yi-Ming Gong G. R. Shi Zhong-Qiang Chen Jinyuan Huang Shixue Hu Xueqian Feng Qiyue Zhang Changyong Zhou Wen Wen | 2018 | Journal of Earth Science2018，29，4： | 4 |
| 8 | New anomalocaridid frontal appendages from the Guanshan biota,eastern Yunnan显示文摘Anomalocaridids were large predators of the Cambrian seas at the top of the trophic pyramid.Complete anomalocaridid specimens have been rarely discovered and the rigid isolated frontal appendages and mouthparts are more commonly preserved.Here we study new material of the frontal appendages from the Wulongqing Formation,Cambrian Stage 4,Series 2 near Kunming,eastern Yunnan.Two new forms of anomalocaridid frontal appendages are described,namely Anomalocaris kunmingensis sp.nov.and Paranomalocaris multisegmentalis gen.nov.,sp.nov.The frontal appendage of A.kunmingensis sp.nov.probably comprises15 podomeres of which the first one has a weakened skeletoned,the second one is armed with small spines,and the third one is armed with remarkably robust proximal ventral spines with 6 anisomerous auxiliary spines;paired auxiliary spines are associated with podomeres 4–14;podomeres 12–14 are armed with paired dorsal spines,and the last podomere bears 2 distal spines,one spine distinctly larger than the other.The frontal appendage of P.multisegmentalis tapered backwards,consisting of 22 visible podomeres;the most ventral spine is armed with 5 pairs of auxiliary spines,and podomeres 12–21 bear dorsal spines,the last podomere with 2 small distal spines.The new material provides additional evidence for our understanding of the diversity of anomalocaridids in the Cambrian.The morphology of these new finds may indicate the importance of different feeding strategies of anomalocaridids in the Cambrian ecosystem. | WANG YuanYuan HUANG DiYing HU ShiXue | 2013 | Chinese Science Bulletin2013，58，32： | 2 |
| 9 | New Occurrence of the Early Cambrian Chengjiang Fauna in Haikou, Kunming, Yunnan Province,and Study on Trilobitoidea显示文摘This paper gives a brief report on the new occurrence of the Early CambrianQiongzhusi’ an Chengjiang fauna in the Haikou area, Kunming and its assemblage feature andthe stratigraphic section of the horizon yielding these fossils. Eight genera and 8 species ofTrilobitoidea are described here, embracing Leanchoilia asiatica Luo et Hu (sp. nov.), Yohoiasinensis Luo et Hu (sp. nov.), Zhongxinia speciosa Luo et Hu (gen. et sp. nov.), Xandarellaspectuculum Hou et al., Dianchia mirabilis Luo et Hu (gen. et sp. nov.), Kuamaia lata Hou,Retifacies longispinus Luo et Hu (sp. nov.) and Sinoburius lunaris Hou et al. | Luo Huilin Hu Shixue Zhang Shishan and Tao Yonghe Yunnan Institute of Geological Sciences, Kunming Yunnan Kunyang Phosphorite Mine, Jinning, Yunnan | 1997 | Acta Geologica Sinica(English Edition)1997，71，2： | 2 |
| 10 | Soil microbial activity measured by microcalorimetry in response to long-term fertilization regimes and available phosphorous on heat evolution显示文摘 | Shixue Zheng Junli Hu Ke Chen Jun Yao Ziniu Yu Xiangui Lin | 2009 | Soil Biology and Biochemistry2009，，： | 1 |
| 11 | Peduncular attached secondary tiering acrotretoid brachiopods from the Chengjiang fauna: Implications for the ecological expansion of brachiopods during the Cambrian explosion显示文摘 | Haizhou Wang Zhifei Zhang Lars E. Holmer Shixue Hu Xiangren Wang Guoxiang Li | 2012 | Palaeogeography Palaeoclimatology Palaeoecology2012，，： | 1 |
| 12 | First record of repaired durophagous shell damages in Early Cambrian lingulate brachiopods with preserved pedicles显示文摘 | Zhifei Zhang Lars E. Holmer Sean P. Robson Shixue Hu Xiangren Wang Haizhou Wang | 2011 | Palaeogeography Palaeoclimatology Palaeoecology2011，，3： | 1 |
| 13 | Response to“Discussion on the systematic position of the Early Cambrian priapulomorph worms”显示文摘 | HAN Jian HU Shixue | 2006 | Chinese Science Bulletin2006，51，2： | 1 |
| 14 | Isotopic dating of the Chengjiang Fauna-bearing horizon in Central Yunnan Province, China显示文摘Twenty black shale samples, which are free from the influence of weathering, were collected from the Chengjiang Fauna-bearing horizon, central Yunnan Province, yielding a Pb-Pb isochron age of 534±60 Ma. Although this age is younger than both the Rb-Sr isochron age and 40Ar-39Ar age, it should represent the lower isotopic age limit of the Chengjiang Fauna. | CHANG Xiangyang CHEN Liangzhong HU Shixue WANG Jianghai ZHU Bingquan | 2007 | Chinese Journal Of Geochemistry2007，26，4： | 0 |
| 15 | Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma显示文摘Background Metabolism reprogramming plays a vital role in glioblastoma(GBM)progression and recurrence by producing enough energy for highly proliferating tumor cells.In addition,metabolic reprogramming is crucial for tumor growth and immune-escape mechanisms.Epidermal growth factor receptor(EGFR)amplification and EGFR-vIII mutation are often detected in GBM cells,contributing to the malignant behavior.This study aimed to investigate the functional role of the EGFR pathway on fatty acid metabolism remodeling and energy generation.Methods Clinical GBM specimens were selected for single-cell RNA sequencing and untargeted metabolomics analysis.A metabolism-associated RTK-fatty acid-gene signature was constructed and verified.MK-2206 and MK-803 were utilized to block the RTK pathway and mevalonate pathway induced abnormal metabolism.Energy metabolism in GBM with activated EGFR pathway was monitored.The antitumor effect of Osimertinib and Atorvastatin assisted by temozolomide(TMZ)was analyzed by an intracranial tumor model in vivo.Results GBM with high EGFR expression had characteristics of lipid remodeling and maintaining high cholesterol levels,supported by the single-cell RNA sequencing and metabolomics of clinical GBM samples.Inhibition of the EGFR/AKT and mevalonate pathways could remodel energy metabolism by repressing the tricarboxylic acid cycle and modulating ATP production.Mechanistically,the EGFR/AKT pathway upregulated the expressions of acyl-CoA synthetase short-chain family member 3(ACSS3),acyl-CoA synthetase long-chain family member 3(ACSL3),and long-chain fatty acid elongation-related gene ELOVL fatty acid elongase 2(ELOVL2)in an NF-κB-dependent manner.Moreover,inhibition of the mevalonate pathway reduced the EGFR level on the cell membranes,thereby affecting the signal transduction of the EGFR/AKT pathway.Therefore,targeting the EGFR/AKT and mevalonate pathways enhanced the antitumor effect of TMZ in GBM cells and animal models.Conclusions Our findings not only uncovered the mechanism of metabolic reprogramming in EGFR-activated GBM but also provided a combinatorial therapeutic strategy for clinical GBM management. | Xiaoteng Cui Jixing Zhao Guanzhang Li Chao Yang Shixue Yang Qi Zhan Junhu Zhou Yunfei Wang Menglin Xiao Biao Hong Kaikai Yi Fei Tong Yanli Tan Hu Wang Qixue Wang Tao Jiang Chuan Fang Chunsheng Kang | 2023 | Cancer Communications2023，43，12： | 0 |
| 16 | Biodiversity and taphonomy of the early Cambrian Guanshan biota,eastern Yunnan显示文摘趋势生物多样性和早寒武纪的 Guanshan 生物区系的 taphonomy。 | ShiXue Hu MaoYan Zhu Michael Steiner HuiLin Luo FangChen Zhao et al. | 2011 | Chinese Science Bulletin2011，56，11： | 0 |
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